Formestane - Estrogen Control Agent - Topical

gamer2be08 said:
My kinda sex :fing02:

I saw your post on putting form under your armpits, can you apply it there if you have hair; seems like that would hinder the effectiveness..?
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hair is no problem under the pits-it will sting bad enough with hair-i would be yelling if i shaved pits then put it on. trust me it is very effective under pits-just don't use deodorant for at least an hour.
 
I'm interested in running formestane and had a question, would there be any benefit running it stacked with a natural test booster like PCT Assist or Activate Xtreme?
 
DA6 said:
I'm interested in running formestane and had a question, would there be any benefit running it stacked with a natural test booster like PCT Assist or Activate Xtreme?
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absolutely!!!
 
Thanks for the speedy response! Would you suggest I keep the form at the full dose or reduce it a bit?
 
DA6 said:
Thanks for the speedy response! Would you suggest I keep the form at the full dose or reduce it a bit?
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whatever works best for you. td form is fast acting so start off low and see if you get the effect you want if not in a day or so bump it up until you get what you want. personally i like to run it high, i get anabolic like effects at high doses.
 
I am a part time lifeguard during the summer. Would it effect the trans form in any way if it were applied and hour or so before getting into the water?
 
gamer2be08 said:
I am a part time lifeguard during the summer. Would it effect the trans form in any way if it were applied and hour or so before getting into the water?
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an hour should be fine. apply it 2x day and make the 2nd dose before bed to absorb through the night.
 
CompEdgeLabs said:
Suppress-C would stack nicely with the Topical Formestane as well.
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Agreed. This is a good stack option for a cut b/c the liver is essentially removed from the equation and the HPTA is only minimally suppressed. Also pretty cost effective given that minimal support/PCT supps are needed/useful.
 
dumbhick3 said:
Agreed. This is a good stack option for a cut b/c the liver is essentially removed from the equation and the HPTA is only minimally suppressed. Also pretty cost effective given that minimal support/PCT supps are needed/useful.
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No HPTA suppression from form at the doses and average person would use.. I heard it may even stimulate the HPTA.. Correct me if im wrong CEL or BIGT...
 
dumbhick3 said:
Agreed. This is a good stack option for a cut b/c the liver is essentially removed from the equation and the HPTA is only minimally suppressed. Also pretty cost effective given that minimal support/PCT supps are needed/useful.
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actually there is no need for any pct or support supps with a td formestane/suppress-c cycle, imo. it wouldn't hurt to use some hb prior and during if prone to high bp, throw in some milk thistle if you like and you have a complete and effective cycle. hb and milk thistle are both very inexpensive.
 
gamer2be08 said:
No HPTA suppression from form at the doses and average person would use.. I heard it may even stimulate the HPTA.. Correct me if im wrong CEL or BIGT...
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I wouldn't go so far as to say "No HPTA suppression [occurs at typical doses]", but that is just my opinion.

[The conversion of 4-OHA to 4-OHT] most likely occurs in only very small amounts. Furthermore, [4-OHT] is a weaker androgen than testosterone and therefore will have less of a suppressive effect on the HPGA.
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Anabolic Pharmacology 2009, Seth Roberts

J Enzyme Inhib. 1992;6(2):141-7.

Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor.
Davies JH, Shearer RJ, Rowlands MG, Poon GK, Houghton J, Jarman M, Dowsett M.

Department of Urology, St. Georges Hospital, London, England, UK.

Abstract
The steroidal aromatase inhibitor, 4-hydroxyandrost-4-ene-3,17-dione (4OHA) and its metabolites, 4-hydroxytestosterone (4OHT), 3 beta,17-dihydroxy-5 alpha-androstan-4-one (metabolite A) and 3 alpha, 17-dihydroxy-5 beta-androstan-4-one (metabolite B) were evaluated as inhibitors of the human prostatic 5 alpha-reductase enzyme and for binding to the rat prostatic androgen receptor. 4OHA and 4OHT were weak inhibitors of 5 alpha-reductase with IC50 values of 15-29 microM. Metabolites A and B had no significant inhibitory activity. 4OHA and metabolites A and B bound weakly to the androgen receptor. The binding affinities (RBA) relative to mibolerone (RBA = 100) were 0.085, 0.485 and 0.016, respectively. However, 4OHT (RBA = 75) was a more potent binder than the endogenous androgen 5 alpha-dihydrotestosterone (RBA = 66). The ability of these metabolites, in particular 4OHT, to bind to the androgen receptor may explain the in vivo androgenic activity of 4OHA.

PMID: 1284430 [PubMed - indexed for MEDLINE]
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I thought that the mibolerone reference in the above study was a mistake, but its Androgen Receptor RBA is ~100 (108), so I guess not. It doesn't really matter in any event.

Invalid Link Removed

The question of whether steroidal AIs and their androgenic metabolites cause HPTA/HPGA suppression of any significance is a contentious one. Some people use steroidal AIs (Aromasin, Formestane, ATD, 6-oxo) as part of their PCT while others are against this practice (including some experts). And it's true that many people use form on cycle, off cycle, during PCT, etc, and don't seem to have any major issues anecdotally and experientially.

Personally, I wouldn't include a steroidal AI as part of my PCT b/c I think that the androgenic metabolites could slow HPTA recovery. I think that solo cycles of form are probably not as much of a concern in terms of HPTA effects, with dosing and cycle length kept within reason.

Don't get me wrong though; I think formestane is a high-quality AI, and I would use it in some instances when less than RX-strength estrogen suppression is desired (as an alternative to low-dosing the RX AIs).

Though it wasn't recommended per se, I wouldn't advocate running form for long periods of time without a break (e.g., 6 months) since formestane and 4-OHT have 5-AR inhibition properties that reduce DHT levels in the body which can obviously have some undesirable effects (Ibid; Anabolic Pharmacology 2009, Seth Roberts).

Anyway, go with what works for you (of course), and to each his own.
 
thebigt said:
actually there is no need for any pct or support supps with a td formestane/suppress-c cycle, imo. it wouldn't hurt to use some hb prior and during if prone to high bp, throw in some milk thistle if you like and you have a complete and effective cycle. hb and milk thistle are both very inexpensive.
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By supports, I meant Na-R-ALA and Raspberry Ketones and similar things that might find a place in a form/suppress-c cutting cycle. I probably wouldn't even bother with the milk thistle since the Suppress C and Form are both transdermal and thus less liver stressful than orally delivered drugs. It can't hurt (thistle), but probably not necessary.

PCT would be kind of optional IMO. Some would opt for the usual suspects like a natty test booster or similar. Following the cycle up with something like Sustain Alpha might be desirable for some (budget permitting) since it acts as an estrogen modulator and LH booster (would help if estrogen levels were a tad too low from the form cycle, and some ppl say that Sustain allows them to keep their strength gains and even add to them in standard PCTs, etc). And others would opt for nothing as you suggested.
 
i taper down at end of form cycle and have never had any problem. as to pct, i like to use form on cycle and bridge into pct, then add in something like inhibit-e-again this has worked well.


as to the dht reduction of form-i once ran a high dosed form/powerful cycle and had really good results-the form lowered estrogen and raised test, and the powerful kept prolactin down even though dht was reduced. i highly suggest this stack-throw in some suppress-c for cort control and i guarantee you will lean up and keep your girl very happy.
 
bigt, I have high prolactin levels now, as I am lactating, is form going to aggravate that and make it worst? Can I use form in conjunction with a low dose of caber?
 
gamer2be08 said:
bigt, I have high prolactin levels now, as I am lactating, is form going to aggravate that and make it worst? Can I use form in conjunction with a low dose of caber?
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hold off on the form until you get it under control, also throw in some p5p-it will stop the lactating within days.
 
gamer2be08 said:
Any dosing advice?
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try 150mg of p5p for a couple of days, lactating should be stopped by then, if not run 100mg until it does. then run low dose for 3-5 days.


i think i read that 150-200mg p5p daily stopped a nursing mother from lactating with 5 days.
 
thebigt said:
try 150mg of p5p for a couple of days, lactating should be stopped by then, if not run 100mg until it does. then run low dose for 3-5 days.


i think i read that 150-200mg p5p daily stopped a nursing mother from lactating with 5 days.
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Nice, isnt p5p regular vitamin b6?
 
gamer2be08 said:
I see... kinda what I figured. Do they sell it at walmart or pharmacies.. Or am I going to have to order it?
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Probably have to order it; I've never seen it at WM or CVS or similar. Maybe if you have a fancy vitamin store nearby, they might have it.

I get mine from The Vitamin Shoppe via Amazon. I don't even think most of the BB'ing sites online carry it for some strange reason.

Good luck with the leakage.
 
dumbhick3 said:
Agreed. This is a good stack option for a cut b/c the liver is essentially removed from the equation and the HPTA is only minimally suppressed. Also pretty cost effective given that minimal support/PCT supps are needed/useful.
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I dont think there would be any need for a PCT with that stack. I have seen alot of people run it, love it, and never have any problems.

thebigt said:
i taper down at end of form cycle and have never had any problem. as to pct, i like to use form on cycle and bridge into pct, then add in something like inhibit-e-again this has worked well.


as to the dht reduction of form-i once ran a high dosed form/powerful cycle and had really good results-the form lowered estrogen and raised test, and the powerful kept prolactin down even though dht was reduced. i highly suggest this stack-throw in some suppress-c for cort control and i guarantee you will lean up and keep your girl very happy.
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I agree with the tapering part, and also just wanted to say thanks for anwering the questions in this thread. Excellent advice.
 
Gamer,
I actually see better results with form for prolactin like symptoms than dopamenergics. For me, formestane would probably help, but that's not always the case for everyone.

IF you decide to run PowerFull, it has better effect when you spread out your doses throughout the day for me in terms of prolactin control... like 3-4 caps per day. The reason I mention this is because most people just dose their powerfull at night and that doesn't really help with prolactin control IME

Other dopamenergics such as SamE, tyrosine, and regular B6 have never had any effect for me for the purpose that you are looking for. Although, I do like them for other purposes like mood/focus.

If I were lactating, I would be talking to my physician (unless your symptoms aren't as bad as you're making them sound).
 
I have been away from the gym for 6 mths due to the hernia. Starded dosing. 3-4 squirts b4 bed. It's amazing stuff! Still not back to training yet but I can feel my strength increasing and I am leaning out big time, more vascular too. It's actually motivating me to get back.
 
I'm currently sitting at 195 at 9.6 % bf. Looking to get to about 6%. How should u dose, how many bottles for best results?
 
MrBigPR said:
I'm currently sitting at 195 at 9.6 % bf. Looking to get to about 6%. How should u dose, how many bottles for best results?
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BigT can probably give more input on that than me. I generally run it at 100 mg per day with a taper down at the end. I would say run for 6 weeks, but I have seen people do longer.

And for the results you are looking for, I would strongly suggest stacking it with Suppress-C.
 
Urban Monk said:
If formestane serves to lower DHT, how would it work topically in thinning areas?
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I don't think it has a localized 5AR competing effect; it is more systemic with formestane (and the extent of reduction is debatable of course).

If you want localized DHT interference, nothing works better than Nizoral/Nizoral AD IME. It works on the scalp, the forehead (the runoff, lol-no zits on my forehead on cycle), etc. Studies on the active ingredient, ketoconazone, are available to substantiate these effects. And no systemic interference (unless you take oral ketoconazole), so no negative sides associated with 5AR inhibitors like finasteride and dutasteride (gyno, low libido, etc).
 
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