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EvoMuse presents...HUNG

Shh was the hint, and this is the pathway.

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The section (one of them) of interest.

The SHH pathway and CN regeneration

After CN injury, profound changes in neurotrophic factor signaling occur in the CN. Schwann cells crucially contribute to successful regeneration by mechanical and paracrine influences in the injured nerve. Schwann cells have been successfully used to promote CN regeneration54 and Schwann cell seeded nerve guidance tubes have been used to restore erections and promote regeneration after bilateral CN cut in rats55. The addition of neurotrophic factors, extra cellular matrix components and Schwann cells have been shown to promote regeneration56–59. Several molecules have been described to have neurotrophic effects in the penis including VEGF60–61, which is a target of SHH signaling62. In normal adult rats, SHH is abundant in NOSI positive neurons of the pelvic ganglia that innervate the penis and in Schwann cells of the CN45. These results suggest that SHH may be a factor of the Schwann cells that is required for CN regeneration and that SHH may play a regulatory role in regeneration after CN injury.

Again, we are talking regeneration which will accompany mechanical stimulus.
 
Interesting article.
 
You've also seen me throw around references to EP4....this one is harder to target singly, so I will probably go the obvious way.

Br J Pharmacol. 2002 May;136(1):23-30.
Regulation of human penile smooth muscle tone by prostanoid receptors.
Angulo J1, Cuevas P, La Fuente JM, Pomerol JM, Ruiz-Castañé E, Puigvert A, Gabancho S, Fernández A, Ney P, Sáenz De Tejada I.
Author information
Abstract

We have characterized the prostanoid receptors involved in the regulation of human penile arterial and trabecular smooth muscle tone. Arachidonic acid induced relaxation of human corpus cavernosum strips (HCCS) that was blocked by the cyclo-oxygenase inhibitor, indomethacin, and augmented by the thromboxane receptor (TP) antagonist, SQ29548, suggesting that endogenous production of prostanoids regulates penile smooth muscle tone. TP-receptors mediate contraction of HCCS and penile resistance arteries (HPRA), since the agonist of these receptors, U46619, potently contracted HCCS (EC50 8.3+/-2.8 nM) and HPRA (EC50 6.2+/-2.2 nM), and the contractions produced by prostaglandin F(2alpha) at high concentrations (EC50 6460+/-3220 nM in HCCS and 8900+/-6700 nM in HPRA) were inhibited by the selective TP-receptor antagonist, SQ29548 (0.02 microM). EP-receptors are responsible for prostanoid-induced relaxant effects in HCCS because only prostaglandin E1 (PGE1), prostaglandin E2 and the EP2/EP4-receptor agonist, butaprost, produced consistent relaxation of this tissue (EC50 93.8+/-31.5, 16.3+/-3.8 and 1820+/-1284 nM, respectively). In HPRA, both prostacyclin and PGE1 (EC50 60.1+/-18.4 and 109.0+/-30.9 nM, respectively) as well as the selective IP receptor agonist, cicaprost, and butaprost (EC50 25.2+/-15.2 and 7050+/-6020 nM, respectively) caused relaxation, suggesting co-existence of IP- and EP-receptors (EP2 and/or EP4). In summary, endogenous production of prostanoids may regulate penile smooth muscle contractility by way of specific receptors. TP-receptors mediate contraction in HCCS and HPRA, while the relaxant effects of prostanoids are mediated by EP2- and/or EP4-receptors in HCCS and by EP- and IP-receptors in HPRA.

PMID:
11976264
PMCID:
PMC1762108
DOI:
10.1038/sj.bjp.0704675
 
EP4 receptor. Relaxation of the smooth muscle of the penis by EP4 agonism will allow for increased pressure on the cavern walls, and increasing nerve growth (duh, for anyone missing the reference here) and angiogenesis in the local tissues will increase blood "holding" capacity, therefore size.

Should also greatly increase erection hardness.

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Give the people what they want!

Just saying I would log with pics
 
There are a few more pathways to settle out, then fine tuning the carrier to not cause irritation, then I'll have some betas available. Testers will have to be willing to do the accompanying exercises.
 
dsade said:
There are a few more pathways to settle out, then fine tuning the carrier to not cause irritation, then I'll have some betas available. Testers will have to be willing to do the accompanying exercises.
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I read a document some time ago, that “stem cells” will help make downthere grow after exercises breakage, the trick wAs to direct the brain to repair down below... using blue green algae as a supplement.. but the supp i didnt buy as upon research is toxic
 
00A said:
I read a document some time ago, that “stem cells” will help make downthere grow after exercises breakage, the trick wAs to direct the brain to repair down below... using blue green algae as a supplement.. but the supp i didnt buy as upon research is toxic
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My BMP research, as well as the Defuse Perpetua, helped a ton here. I'm definitely bringing in stem cell differentiation to this.
 
Ok, guys, I'm going to have to rub some HUNG on my inbox. I will go ahead and put together betas of the formula (about 90% complete), and put out for testers. STRICT guidelines will be required, so this is not for the weak.
 
dsade said:
Ok, guys, I'm going to have to rub some HUNG on my inbox. I will go ahead and put together betas of the formula (about 90% complete), and put out for testers. STRICT guidelines will be required, so this is not for the weak.
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I am IN there like swim wear 8====>
 
I would love to try this, but my wife would probably be pissed. But when you get the beta ready. I'm ready to log it
 
DemntedCowboy said:
I would love to try this, but my wife would probably be pissed. But when you get the beta ready. I'm ready to log it
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That’s what I’m thinking! She honestly would fight me but I’m trying to see something actually extraordinary here!!!
 
Hey..I will definitely do it dsade! This is truly one of those rare opportunities that I would love to be a part of..

Not a stranger to jelqing/stretching techniques either..:)
 
muree said:
definitely in for the beta tester.. very familiar with PE.. went from 5 to a 7 erect (true story)..
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For those in this thread unfamiliar, can you post your regimen? Those are impressive gains. What kind of time frame are we talking about.

From the data I've seen, 3cm should be very possible easy.
 
dsade said:
For those in this thread unfamiliar, can you post your regimen? Those are impressive gains. What kind of time frame are we talking about.

From the data I've seen, 3cm should be very possible easy.
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If 3cm is pretty easy, to what degree do you feel HUNG would boost that? I'd imagine everyone is different.
 
cubsfan815 said:
If 3cm is pretty easy, to what degree do you feel HUNG would boost that? I'd imagine everyone is different.
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The 3cm number is what i've seen in my research using various (single pathway) treatments, so I'm just throwing that out as a "reasonable" number. The formula is far more extensive than anything else out, and combined with a good complete regimen, we should easily exceed that.

Even still, 3cm is over an inch.
 
dsade said:
The 3cm number is what i've seen in my research using various (single pathway) treatments, so I'm just throwing that out as a "reasonable" number. The formula is far more extensive than anything else out, and combined with a good complete regimen, we should easily exceed that.

Even still, 3cm is over an inch.
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When you say 3cm lenght I assume?
What about girth?
 
00A said:
When you say 3cm lenght I assume?
What about girth?
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Girth wasn't measured in the studies, but since we are targeting sinusoidal tissues in the Corpus Cavernosum, causing formation of new blood vessels as well as increasing expansion capacity, girth should increase dramatically.
 
dsade said:
Girth wasn't measured in the studies, but since we are targeting sinusoidal tissues in the Corpus Cavernosum, causing formation of new blood vessels as well as increasing expansion capacity, girth should increase dramatically.
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Cool man, intresting stuff .. cant wait to know more.ps dont rush the last 10%of the work because the thread has become alive :)
 
00A said:
Cool man, intresting stuff .. cant wait to know more.ps dont rush the last 10%of the work because the thread has become alive :)
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I never rush anything. My name goes on all of my work, and I know that my reputation is on the line with everything I put out. This will be done right.

I will consider sending this with a small bottle of DMSO. It will be *optional to add it into the formula and shake really well. It's the ideal solvent/carrier, especially for ingredients such as the Arachidnonic Acid.
 
Any chance you could sell a few betas for those of us that have been anticipating this but might not want to log?
 
I hope i get to log this man! Hometown boy here. Question im sure everyone is thinking... Are the d!ck gainz permanent or go back to normal after you're done with the product
 
ZachH said:
I hope i get to log this man! Hometown boy here. Question im sure everyone is thinking... Are the d!ck gainz permanent or go back to normal after you're done with the product
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We're talking smooth muscle hypertrophy as well as stem cell differentiation into penile structural tissue (and elongation of limiting connective tissue) and formation of new blood vessels. The gains are going to be permanent.
 
warnerve said:
Any chance you could sell a few betas for those of us that have been anticipating this but might not want to log?
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Yeah, I'm shooting for an initial beta batch of around 50. There should be some left over to offer.
 
muree said:
definitely in for the beta tester.. very familiar with PE.. went from 5 to a 7 erect (true story)..
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Sounds like a nice horn. Seeing that this is for the sake of a revolutionary product, hopefully the board will allow you to show us pics of your girthy beefer.
 
Garyboy said:
Sounds like a nice horn. Seeing that this is for the sake of a revolutionary product, hopefully the board will allow you to show us pics of your girthy beefer.
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If not then I will open a picture hosting account for testers.
 
Garyboy said:
Does that mean no homosexuals are allowed? We should be accepting of all no matter their race, sexual preference, religious beliefs, etc.

I’m not a homosexual. Just want to see this guys horn.
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No sure if your being serious, but it means on chat boards, that you not wanting to see mans privates for homosexual reasons, but for product results..tbh after your comment you sound homo.. so i leave this for now and will not reply to you
 
I don't usually get too far into bringing up NRF1 and NRF2, but it wil be addressed in the writeup as it applies to HUNG.

Molecules. 2014 Oct 9;19(10):16102-21. doi: 10.3390/molecules191016102.
Resveratrol and endothelial nitric oxide.
Xia N1, Förstermann U2, Li H3.
Author information
Abstract

Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.

PMID:
25302702
DOI:
10.3390/molecules191016102

[Indexed for MEDLINE]

Free full text

And a larger paper on NRF2 activation, endothelial NO prodution/activation, blood flow in the corpus cavernosum, Free radical scavenging, and how it all fits together to enhance size/function.

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Also the obvious inclusion as an aromatase inhibitor...

Toxicol In Vitro. 2014 Oct;28(7):1215-21. doi: 10.1016/j.tiv.2014.05.015. Epub 2014 Jun 12.
Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts.
Chottanapund S1, Van Duursen MB2, Navasumrit P3, Hunsonti P4, Timtavorn S4, Ruchirawat M3, Van den Berg M2.
Author information
Abstract

Targeting the estrogen pathway has been proven effective in the treatment for estrogen receptor positive breast cancer. There are currently two common groups of anti-estrogenic compounds used in the clinic; Selective Estrogen Receptor Modulators (SERMs, e.g. tamoxifen) and Selective Estrogen Enzyme Modulators (SEEMs e.g. letrozole). Among various naturally occurring, biologically active compounds, resveratrol and melatonin have been suggested to act as aromatase inhibitors, which make them potential candidates in hormonal treatment of breast cancer. Here we used a co-culture model in which we previously demonstrated that primary human breast adipose fibroblasts (BAFs) can convert testosterone to estradiol, which subsequently results in estrogen receptor-mediated breast cancer T47D cell proliferation. In the presence of testosterone in this model, we examined the effect of letrozole, resveratrol and melatonin on cell proliferation, estradiol (E2) production and gene expression of CYP19A1, pS2 and Ki-67. Both melatonin and resveratrol were found to be aromatase inhibitors in this co-culture system, albeit at different concentrations. Our co-culture model did not provide any indications that melatonin is also a selective estrogen receptor modulator. In the T47D-BAF co-culture, a melatonin concentration of 20 nM and resveratrol concentration of 20 μM have an aromatase inhibitory effect as potent as 20 nM letrozole, which is a clinically used anti-aromatase drug in breast cancer treatment. The SEEM mechanism of action of especially melatonin clearly offers potential advantages for breast cancer treatment.

Copyright © 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:

Breast cancer; Co-culture; Human fibroblasts; Melatonin; Resveratrol

PMID:
24929094
DOI:
10.1016/j.tiv.2014.05.015
 
For those that haven't read either the MyoSynergy Elite writeup or the Testruction Writeups (referenced here a few pages ago), this is why I will be including E. Ulmoides in HUNG, and why it is a remarkable and indispensible part of the formula.

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dsade said:
For those in this thread unfamiliar, can you post your regimen? Those are impressive gains. What kind of time frame are we talking about.

From the data I've seen, 3cm should be very possible easy.
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okay here we go.. i have a full time job so most of my length work is squeezed into a regular day..

AM - 15 mins of all stretches (hold times are 30 sec, 60 sec and 90 sec - rotary, A-stretch, downward stretch)
PM - 15 mins of all stretches (hold times are 30 sec, 60 sec and 90 sec -rotary, A-stretch, downward stretch)

use a product called ESL-40 for assisting with the stretches and also wear it as an all day stretch device throughout the day.

At night I use the bathmate 3 days a week for 15-20 mins. this is my current routine but over the years I've done so many different routines, at one point I was doing 600 jelqs a day and my best gains were during that time. The gains from 5 to 7 happened over a period of 8 years :)
 
Could be interesting to see how this affects bent wieners, I forget the technical term for that, but hopefully the formula doesn’t cause the hungus to curl like a shepherd’s hook
 
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