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EvoMuse Presents: Clear Edge PRESALE

Appreciate all of your continued support, guys.

I help Matt out as much as I can from another state, but the bottom line is I'm just a big fan of his products like the rest of you more-so than a part of the company/employee. It means a lot to see others out there who understand his heart in all this and show kindness in the face of crummy situations like this.
 
Plus a refund would only hurt matt and hinder any further progress in getting our beloved products restocked so what's a little waiting if it pays off in the long run.
 
dsade said:
Unfortunately my partner has an avoidance type of personality. After reassurances for the past month that we were right on schedule, the deadline came and went.

My emails went unanswered until this morning when I was finally informed that there has been a 2 week delay.

At the same time, the Supernova restock was shorted 2 ingredients, leaving me in a really really bad spot.

Refunds will be issued if you want one for the Clear Edge preorders, but right now I'm racking my brain trying to come up with something that won't stagnate the forward progress of the company. Pretty much couldn't be worse timing.
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dsade

it could always be worse, youll figure it out, like you always do
 
Disapointing, as I've been anticipating this since the sale went up. No refund wanted though. A few delays do not deter me from spending my money with one of the best conpanies. I want my hard earned cash to go into regenerating more innovation.

That said, I hope you got my PM earlier in the week. Have one or two things I forgot to mention, ask about.
 
Thanks guys, I appreciate all of the support. This has certainly been a week I would have rather not had. Hoping to have the tracking number by Monday, and I'll figure out a way to get you guys another sale going to make up for this.

Other than the BF7, which I think I can get elsewhere, I'm going to grab everything I need for another run from my backup supplier and run another good promo sale. I know a lot of you guys missed the initial release. I really didn't expect the demand for this to be this high.
 
dsade said:
Thanks guys, I appreciate all of the support. This has certainly been a week I would have rather not had. Hoping to have the tracking number by Monday, and I'll figure out a way to get you guys another sale going to make up for this.

Other than the BF7, which I think I can get elsewhere, I'm going to grab everything I need for another run from my backup supplier and run another good promo sale. I know a lot of you guys missed the initial release. I really didn't expect the demand for this to be this high.
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Since I can't understand any of the chemistry on what I googled for Isatin, could anybody chime in on what it is and what the exact mechanisms are? I can only find mention of it as a reactant for some reactions and research purposes.

Also bless you Matt for doing what you do, sourcing these ingredients is a HUGE hurdle.
 
Should be here this week!

CGunna said:
Since I can't understand any of the chemistry on what I googled for Isatin, could anybody chime in on what it is and what the exact mechanisms are? I can only find mention of it as a reactant for some reactions and research purposes.

Also bless you Matt for doing what you do, sourcing these ingredients is a HUGE hurdle.
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CG - first let's start with the straitum in the brain:

Invalid Link Removed
Ann N Y Acad Sci. 2008;1129:35-46. doi: 10.1196/annals.1417.003.
Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice.
Palmiter RD1.
Author information
Abstract

Genetically engineered mice that lack tyrosine hydroxylase in all dopaminergic neurons become hypoactive and aphagic, and they starve by 4 weeks of age. However, they can be rescued by daily treatment with l-dopa, which restores activity and feeding for about 10 hours. Thus, these mice can be examined in both dopamine-depleted and dopamine-replete states. A series of behavioral experiments lead to the primary conclusion that in the dopamine-depleted state these mice are not motivated to engage in goal-directed behaviors. Nevertheless, they still have a preference for sucrose, they can learn the location of food rewards, and they can form a conditioned-place preference for drugs. Dopamine signaling can be restored to the striatum by several different viral gene-therapy procedures. Restoring dopamine signaling selectively to the dorsal striatum is sufficient to allow feeding, locomotion, and reward-based learning. The rescued mice appear to have normal motivation to engage in all goal-directed behaviors that have been tested. The results suggest that dopamine facilitates the output from dorsal striatum, which provides a permissive signal allowing feeding and other goal-directed behaviors.

PMID:
18591467
PMCID:
PMC2720267
DOI:
10.1196/annals.1417.003

Dopaminergic activity in the striatum, a mid brain structure, is important for motivation and reward reinforcement. It is rich in dopaminergic and cholinergic neurons. Isatin is an MAO inhibitor, specifically potent in the straitum to prevent breakdown/enhance levels of both dopamine and acetylCholine - leading to both motivational behaviour and the subsequent reward reinforcement, which will help to tie the reward "kick", which is pleasurable, with the accomplishment of goals. This helps to encourage goal-seeking behaviour and positively reinforces your reward center when you accomplish those goals.

J Neurol Sci. 2003 Jan 15;206(1):79-83.
Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by Japanese encephalitis virus.
Ogata A1, Hamaue N, Terado M, Minami M, Nagashima K, Tashiro K.
Author information
Abstract

Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has an important role in the control of neurotransmitter concentration. We previously reported that exogenously administered isatin significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. In order to test the possibility of treating Parkinson's disease by isatin, we evaluated DA levels in the striatum and bradykinesia using a rat model of Parkinson's disease induced by the Japanese encephalitis virus (JEV).We have already reported that in adult Fischer rats infected with JEV at day 13, there was a marked decrease of tyrosine hydroxylase-positive neurons in the bilateral substantia nigra after 12 weeks. Effects of isatin were investigated in JEV-induced post-encephalitic parkinsonism rats by a pole test and high performance liquid chromatograph (HPLC) with an electrochemical detector (ECD). Isatin (100 mg/kg per day for 1 week, intraperitoneal injection) improved the bradykinesia observed in the JEV-induced parkinsonism rats. Dopamine (DA) concentrations in the JEV-infected rats were profoundly reduced in the striatum as compared with controls. Isatin also increased DA in the striatum of parkinsonism rats. These results suggest that isatin could be a possible treatment for Parkinson's disease as well as for post-encephalitic parkinsonism.

PMID:
12480089

And below (too large to copy/paste)

Invalid Link Removed
 
Woody said:
It's almost finals time could def use this
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Started a new job as anunion apprentice Insulator. Could really use this for class, learning on the job and really just responding to commands quicker and focusing on what Im being told and retaining it.
 
My pancreas is bleeding profusely, but I'll be there in the morning to print the orders and get Butch started. We got over 100, so we should be all finished by Friday

Any extra stock will have to be sampled out to potential retailers to try to get my Xmas present.. a large retail account where i can reach millions of people with my work..
 
dsade said:
My pancreas is bleeding profusely, but I'll be there in the morning to print the orders and get Butch started. We got over 100, so we should be all finished by Friday

Any extra stock will have to be sampled out to potential retailers to try to get my Xmas present.. a large retail account where i can reach millions of people with my work..
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As I said on facebook, please feel better and seek medical help if need be. We all want to see you stick around with us as long as possible.

Hope you saw my PM. Please get back to me at your convenience, when your feeling healthier.

EDIT: Good luck with the retail account. I'm rooting for you. You deserve the exposure.
 
dsade said:
My pancreas is bleeding profusely, but I'll be there in the morning to print the orders and get Butch started. We got over 100, so we should be all finished by Friday

Any extra stock will have to be sampled out to potential retailers to try to get my Xmas present.. a large retail account where i can reach millions of people with my work..
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With chronic pancreatitis have you thought of a Whipple, Puestow, or TPIAT procedure? My dad was in and out of the hospital for years before he decided to have the damn thing removed with an islet auto transplantation. He says it was the best decision of his life....all assuming you have chronic pancreatitis of course
 
alexcb said:
With chronic pancreatitis have you thought of a Whipple, Puestow, or TPIAT procedure? My dad was in and out of the hospital for years before he decided to have the damn thing removed with an islet auto transplantation. He says it was the best decision of his life....all assuming you have chronic pancreatitis of course
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Started in the army and misdiagnosed as acid reflux. 18 years of dealing with this.

I've been looking into that procedure. So it worked for him?
 
dsade said:
Started in the army and misdiagnosed as acid reflux. 18 years of dealing with this.

I've been looking into that procedure. So it worked for him?
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Hasn't had any complaints since. He was addicted to narcotics before because he was having flare ups biweekly. He was one of the lucky ones where the islet cells completely prevented him from getting diabetes, even without a pancreas. Just make sure if you go down that route you know ~70% of patients require insulin long term. But what do you value more, insulin daily or chronic debilitating pain.
 
alexcb said:
Hasn't had any complaints since. He was addicted to narcotics before because he was having flare ups biweekly. He was one of the lucky ones where the islet cells completely prevented him from getting diabetes, even without a pancreas. Just make sure if you go down that route you know ~70% of patients require insulin long term. But what do you value more, insulin daily or chronic debilitating pain.
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Some tangential research that I've been doing will help to make sure that the effectiveness is maximized. I just didn't get a chance to test it, Methyl Pyruvate in particular showed great promise here.
 
dsade said:
Started in the army and misdiagnosed as acid reflux. 18 years of dealing with this.

I've been looking into that procedure. So it worked for him?
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Sorry if this to personal, but what treatments have you gone through for the chronic pancreatitis? The pancrectomy with islet cell transplantation is the absolute last resort. Have you had pancreaticojejunostomy?
 
alexcb said:
Sorry if this to personal, but what treatments have you gone through for the chronic pancreatitis? The pancrectomy with islet cell transplantation is the absolute last resort. Have you had pancreaticojejunostomy?
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They have literally done nothing but painkiller shots and gallbladder removal.
 
dsade said:
They have literally done nothing but painkiller shots and gallbladder removal.
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I don't want to step over boundaries, but I'll tell you what the doc (world renowned) that treated my dad did for him. First make sure your doctor test you for pancreatic cancer as chronic pancreatitis and pancreatic cancer present similarly. This means a biopsy and two blood tests for carcinoembryonic antigen (CEA) and CA 19-9. First line treatment for my dad was pain meds and pancreatic enzyme treatment. If that doesn't work, which it usually doesn't then you should go for the pancreaticojejunostomy which relieves blockages in the ducts. If that doesn't work then partial or total (with auto islet sell transplantation) resection of the pancreas should take place.
 
alexcb said:
I don't want to step over boundaries, but I'll tell you what the doc (world renowned) that treated my dad did for him. First make sure your doctor test you for pancreatic cancer as chronic pancreatitis and pancreatic cancer present similarly. This means a biopsy and two blood tests for carcinoembryonic antigen (CEA) and CA 19-9. First line treatment for my dad was pain meds and pancreatic enzyme treatment. If that doesn't work, which it usually doesn't then you should go for the pancreaticojejunostomy which relieves blockages in the ducts. If that doesn't work then partial or total (with auto islet sell transplantation) resection of the pancreas should take place.
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The cancer tests are later this week but nobody has brought up the duct clearance technique before so I will look into that. Thanks for the info!
 
dsade said:
The cancer tests are later this week but nobody has brought up the duct clearance technique before so I will look into that. Thanks for the info!
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Best of luck, man. Get your health taken care of. Our supplements can wait. Wish you a quick diagnosis and speedy recovery.
 
alexcb said:
With chronic pancreatitis have you thought of a Whipple, Puestow, or TPIAT procedure? My dad was in and out of the hospital for years before he decided to have the damn thing removed with an islet auto transplantation. He says it was the best decision of his life....all assuming you have chronic pancreatitis of course
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My wife sat in on a Whipple procedure a while back. She is a great resource for me as she now runs the lab at the hospital. She also just finished teaching 2nd year MEd students about Labs.

She never graduated college.

If you need anything. Your a great person and a genius.
 
alexcb said:
I don't want to step over boundaries, but I'll tell you what the doc (world renowned) that treated my dad did for him. First make sure your doctor test you for pancreatic cancer as chronic pancreatitis and pancreatic cancer present similarly. This means a biopsy and two blood tests for carcinoembryonic antigen (CEA) and CA 19-9. First line treatment for my dad was pain meds and pancreatic enzyme treatment. If that doesn't work, which it usually doesn't then you should go for the pancreaticojejunostomy which relieves blockages in the ducts. If that doesn't work then partial or total (with auto islet sell transplantation) resection of the pancreas should take place.
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Major reps for all your input, brother.

And echoing everyone else, just get healthy, Matt. We love you, man, and we care far more about you than waiting on supplements (and that's saying a lot, because we really do jones for what you put out).
 
Woody said:
I saw on FB this was shipping. Still accurate?
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Yessir

Most of them have gone out, but there are still a fair number of preorders that haven't contacted me back about what to do with their orders. Again, please email d_sade@yahoo with the following:

The capsules are 40% underfilled, which makes dosage 6 caps instead of 4. Your options are:
a) full cash refund
b) 40% cash refund and keep your order
c) 50% store credit refund and keep your order

I can't complete your order until I hear back with your preference.
 
dsade said:
Yessir

Most of them have gone out, but there are still a fair number of preorders that haven't contacted me back about what to do with their orders. Again, please email d_sade@yahoo with the following:

The capsules are 40% underfilled, which makes dosage 6 caps instead of 4. Your options are:
a) full cash refund
b) 40% cash refund and keep your order
c) 50% store credit refund and keep your order

I can't complete your order until I hear back with your preference.
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Whoops! Email sent!
 
dsade said:
Yessir

Most of them have gone out, but there are still a fair number of preorders that haven't contacted me back about what to do with their orders. Again, please email d_sade@yahoo with the following:

The capsules are 40% underfilled, which makes dosage 6 caps instead of 4. Your options are:
a) full cash refund
b) 40% cash refund and keep your order
c) 50% store credit refund and keep your order

I can't complete your order until I hear back with your preference.
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Hey Matt,

Know you got a lot going on..

Just wanted to check my status on this, order #3567. Sent email last week, just wanna make sure you got it. I'm just a couple hours north of you and haven't received yet so just being selfish and impatient at the moment . Can. Not. Wait. To. Try. This!

Happy Holidays and appreciate the sales.. already spending more than I should again lol.
 
Got mine today ;) will be trying out Monday or Tuesday before work. To say I was excited to finally receive this would be a understatement
 
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