Ecklonia Cava

[ws65]

Starting this thread for a healthy debate about Ecklonia Cava Extract. There is one from 2010, but it's only 1 page and there is much more to discuss about this extract then in that thread. EC is one of the main ingredients in a very popular supp known 'round here as FD2 (which I'm very much looking forward to trying sometime). But I'd like to discuss just EC by itself as there are many FD2 threads, all positive btw.

I'll start with an article I found and we'll go from there. From all that I've read on this extract, it might fall into the category of daily staple for all it's purported benefits...

From Ortho Nutrition's website

Ecklonia cava is a form of edible brown algae (seaweed) that grows at a depth of about 100 feet in the ocean off of the coasts of Korea and Japan. It is a potent, fat soluble antioxidant (40% fat soluble, making it a fat and water-soluble antioxidant) that has been recognized as a rich source of bioactive derivatives (primarily, phlorotannins). These phlorotannins exhibit various beneficial biological activities such as antioxidant, anti-cancer, anti-diabetic, anti-human immunodeficiency virus, anti-hypertensive, matrix metalloproteinase enzyme inhibition, hyaluronidase enzyme inhibition, radioprotective, and anti-allergic activities. [12]

Due to the partial fat solubility of ecklonia cava, its polyphenols can last from 12 to 14 hours in human metabolism, whereas most plant-based tannins have a small half-life of approximately 30 minutes. In addition to a significantly longer half-life, ecklonia cava's Oxygen Radical Absorbance Capacity (ORAC) value for anti-oxidation potential is 8,300; much higher than land-based polyphenols. These traits make ecklonia cava one of the most powerful and versatile plant tannins in existence, providing benefits such as cortisol regulation, lower blood pressure, increase in growth hormone levels, and lower triglycerides.

Ecklonia cava makes up a complex structure of phenolic molecules that possess very potent electron (free radical) absorbing mechanisms. Numerous health-promoting metabolic effects have been observed in extensive scientific tests (in-vitro, in-vivo animal model tests, and human clinical studies) from extracts of ecklonia cava. Additionally, ecklonia cava has been found to be the most powerful inhibitor of Matrix Metalloproteinase-9 (MMP-9), an enzyme responsible for collagen degradation that can result in wrinkle formation amongst other detriments. The polyphenol structure of ecklonia cava has an interconnected phenolic ring structure that is capable of trapping 10 to 100 times the free radicals of either green tea or resveratrol extracts. [1]

Ecklonia cava possesses significant anti-inflammatory activity via COX-2 and iNOS, MAP kinase, NF-kappaB pathways, and through the suppression of cytokine signaling. [2], [3], [4], [5]

It also offers protective effects of enzymatic digest against high glucose-induced oxidative stress. [6]

It's been demonstrated that ecklonia cava may also help to improve glucose regulation by possessing antibacterial activity. For example, the eckol fraction of Ecklonia cava shows excellent antibacterial activity against all bacteria, including methicillin-resistant Staphylococcus aureus and Salmonella spp. [7]

Further research has demonstrated that ecklonia cava assists in increasing trans-cranial blood flow, providing a potent release in alpha brain waves and parasympathetic nerve response. This creates a heightened sense of relaxation and mental alertness. Animal research shows a positive increase in gamma-aminobutyric acid (GABA), noripenepherine, and serotonin levels, which may be why a large number of human users report improved sleep. [8]

Ecklonia Cava has also been shown to possess potent anti-DGAT activity. Diacylglycerol acyltransferase (DGAT) is an enzyme that catalyzes triacylgycerol in adipocytes. The current scientific hypothesis is that if DGAT were to be inhibited, it may potentially help with obesity. It is for this reason that DGAT-inhibitors are being explored as drug targets for assistance with obesity. However, pharmaceutical drugs that possess anti-DGAT activity also come with a risk of multiple side-effects, whereas ecklonia cava has demonstrated effective anti-DGAT activity with little to no side-effects.

Below are a number of positive benefits that have been shown to be attributed to ecklonia cava in scientific tests and studies:

Ecklonia cava helps to prevent premature wrinkling by increasing the enzyme activity of elastase. [9]

Ecklonia cava offers influenza virus neuraminidase inhibitory activity, and showed extremely high NA-inhibitory activity (72.1% inhibition at 30 µg/mL). [10]

Ecklonia cava protects against lethal irradiation by accelerating hemopoiesis (process of making blood) and by curtailing immunosuppression. [11]

Ecklonia cava possesses anti-hypertensive (anti-blood pressure) effects such as the inhibition of angiotensin I-converting enzyme (ACE) activity, and an inducible effect on the production of Nitric Oxide (NO) without having cytotoxic effect. [13]

References:
[1]. Life Sci. 2006 Sep 5;79(15):1436-43
[2]. Food Chem Toxicol. 2010 Jun;48(6):1682-7.
[3]. J Agric Food Chem. 2009 May 27;57(10):4439-46.
[4]. Food Chem Toxicol. 2009 Feb;47(2):410-7.
[5]. Biomed Pharmacother. 2008 Jun;62(5):289-96.
[6]. J Sci Food Agric. 2010 Jan 30;90(2):349-56.
[7]. Foodborne Pathog Dis. 2010 Apr;7(4):435-41.
[8]. JP Renew | Renewed Health From The Sea
[9]. Biol Pharm Bull. 2006 Aug;29(8):1735-9.
[10]. J Agric Food Chem. 2011 May 17
[11]. Int J Radiat Biol. 2010 Oct;86(10):848-59
[12]. Biofactors. 2010 Nov-Dec;36(6):408-14.
[13]. Nutr Res Pract. 2011 Apr;5(2):93-100

 

[muscleupcrohn]

I know of a few human studies showing a variety of benefits. I'll post up links to them along with the doses used probably sometime tomorrow. It's an interesting ingredient for sure, I have some standalone extract I'm trying ATM.

Edit: I'll post some up now I guess.

ECP supplementation increased time to exhaustion (2.39 min) compared with placebo. This result was accompanied by a 6.5% higher mean VO2max in the ECP group, although the difference was not statistically significant. The blood glucose level in the ECP group at 3 min after exhaustive exercise was significantly higher than that of the placebo group (+ 9.9%).

Dose used: 72mg Ecklonia cava polyphenols

Subjects were randomly allocated into three groups designated as PC (placebo), LD (low‐dose, 72mg‐ECP/day) and HD (high‐dose, 144mg‐ECP/day). Both LD and HD groups showed significant decreases in BMI, body fat ratio, waist circumference, waist/hip ratio, total cholesterol, low‐density lipoprotein (LDL) cholesterol, total cholesterol/high‐density lipoprotein (HDL) cholesterol and atherogenic index (AI) after 12 weeks, as compared with the placebo group. The HD group also showed a significant increase in serum HDL cholesterol as compared with the placebo group. Only the HD group showed significant decreases in serum glucose and systolic blood pressure after 12weeks.

https://www.ncbi.nlm.nih.gov/m/pubmed/21717516/

Now, there have been references to EC vs Viagra, but I haven't been able to find this study. If anyone can provide me with a link to it, that'd be awesome. I see it referenced frequently on various sites selling ecklonia cava, sometimes even summarized, but I have yet to see a link or proper citation for this study.

With that said, I have seen a study comparing Tadalafil (Cialis) to a supplement containing "150 mg of Alga Ecklonia Bicyclis, 396 mg of Tribulus Terrestris and 144 mg of D-Glucosamine and N-Acetyl-D-Glucosamine." So it's not standalone, and it's not technically ecklonia cava, but it did do pretty well, although it didn't improve erectile function quite as well as Tadalafil.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499213/

There's also relatively frequent mentions of a study that reads something like this:

ECE Beverage: 2-Week Clinical Trial

In a human study, 141 young adults were given a beverage containing ECE at 200 mg daily. In two weeks their average weight dropped nearly 2.5 pounds, muscle mass increased by nearly 2.5 pounds, and body fat dropped by 4 pounds, or 7.48%. ECE stimulates the body to burn fat by increasing muscle mass.

but I have not been able to find a proper reference/link/text/etc for this study.

So we do have studies showing it's a good, healthy compound that can help with our fitness goals and help in the bedroom, but it's interesting that the two most promising, incredible studies seem to elude me.

 

[mmorso]

Subbed

 

[muscleupcrohn]

ws65, referring to your post in the other thread comparing Seanol and Ortho Nutrition's extract, it seems that Ortho's just says "98% pure ecklonia cava extract." That sounds nice, but what does it really mean? That's not saying it's standardized for 98% of anything, only that 98% of the extract is pure ecklonia cava; it could simply be a 2:1 extract of ecklonia cava, with 2% of something else that's not ecklonia cava, giving you 98% pure ecklonia cava. With Seanol, at least you know you're getting something standardized (ECP), which is something that is used in some human studies on ecklonia cava that showed pretty nice effects. I'd be hesitant to rely solely on the write-up and info on ecklonia cava from a website who is selling it.

 

[ws65]

... I'd be hesitant to rely solely on the write-up and info on ecklonia cava from a website who is selling it.

As am I...wasn't picking one over the other, just trying to show the difference...and as you said, and I agree with, Seanol is standardized. I could've sworn I saw somewhere that the Ortho one is "full spectrum"...I'm always wary of that.
And your statement is one of the reasons I started the thread...information for all...so everyone has the facts on all aspects, ie, best extract of said substance, specific health benefits, etc.

 

[AdelV]

I've taken it in bulk, its available quite cheap here in Australia.

I did take it alongside IGNIT3 and Ep1c tho.

I'm actually 4 weeks in on FD2 ATM.

I plan to buy it again, I was dosing 3-5g a day of an extract. I did get fairly lean, but honestly I wasn't running it solo.

 

[vujade]

brundel
halfhuman

 

[Myrmidon]

Subbed for info.

 

[Ricky10]

Same here

 

[The_Old_Guy]

The data in this is probably where the Viagra association came from:

https://suppversity.blogspot.com/2012/11/human-study-otc-supplement-doubles-t.html

So how does this stuff work? Although investigations into the mechanism by which the provision of Tradamaxine did work its magic was actually not part of the study, it's actually not difficult to hypothesize what may be the underlying cause of these unquestionably astonishing results. Firstly, the brown algae Ecklonia Bicyclis (better known as Ecklonia Cava) of which each serving has 150mg has a very high content of sterols, polyphenols and tannins and is probably the main active ingredient of a formula which includes 396mg of tribulus and 144mg of d-glucosamine and n-acetyl-d-glucosamine as a 'support'. The phlototannins 7-phloro eckol and 6,6′-bieckoll that have been isolated from Ecklonia, a marine brown algae which has been used for centuries in traditional medicine in Asia, are more or less unique with respect to the potency of their antioxidant activity (Li. 2009). In conjunction with tribulus, d-glucosamine and n-acetyl-d-glucosamine, which also exhibit a certain degree of anti-inflammatory activity, a decrease in systemic inflammation is the most likely cause of the profound pro-sexual and pro-hormonal effects of this blend, which is yet by no means as unique as the producers would have it.

Still, there is one, ... no, actually there are two things I would like to ask you, before you run all spiked up to the next best supplement shop: Firstly, how accurate would you say is the authors' claim that there was "no conflict of interest", if no one else, but the lead author of the study, has been granted a patent on the formula on April 4th, 2012 (US2012/089722 A1)? And secondly, do you really believe that it is a mere coincedence that the researchers deliberate use the hardly known appellation Ecklonia Bicyclis for a brown algae all of you probably know as Ecklonia Cava throughout the whole paper without mentioning once that it is better known as "Ecklonia Cava"? I am well aware that studies are expensive and need to be financed and I am by no means suggesting that the results are - as Mark suspected - "too good to be true" (remember. the men were hypogonadal to begin with), but this paper does still have a somewhat peculiar aftertaste.

Fat loss/gain prevention seems legit if you can guarantee that you are getting 72mg (LD) or 142mg (HD) of an Ecklonia cava extract in your pills.

https://suppversity.blogspot.com/2011/07/brown-algae-extract-reduces-body-fat.html

 

[muscleupcrohn]

The data in this is probably where the Viagra association came from:

https://suppversity.blogspot.com/2012/11/human-study-otc-supplement-doubles-t.html






Fat loss/gain prevention seems legit if you can guarantee that you are getting 72mg (LD) or 142mg (HD) of an Ecklonia cava extract in your pills.

https://suppversity.blogspot.com/2011/07/brown-algae-extract-reduces-body-fat.html

I mentioned both of those studies, but Tadalafil is Cialis, not Viagra, and ecklonia didn't actually outperform it in erectile function. There are mentions, even summaries, of some mythical study comparing EC to Viagra, and they say it outperformed it, but I can't find it, and it's never actually properly referenced.

 

[ws65]

Wow, this already fell off the first page...anyways...I'd like to discuss the DHT side of EC as well..I posted this in another thread...

It was found that Ecklonia Cava extract increased the growth phase (anagen) of the hair follicle, increased the growth potentiation of the hair cells (dermal papilla), and results in the reduction of 5α-reductase activity, an enzyme responsible for the production of DHT (dihydrotestosterone). (Int J Mol Sci. 2012;13(5):6407-23)

And...
Ecklonia cava also decreases activity of 5α-reductase and therefore reduces the amount of DHT (di-hydro testosterone) in the body. Dieckol is the most active component in Ecklonia cava for the reduction of 5α-reductase (Kang et al., 2012).

And this...see section 2.5, and section 3, paragraph 5, and lastly section 4.9...really the whole article is good.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382810/

Ricky10 posted this in another thread about the last link...
Somebody came across this interesting research that was done on Ecklonia Cava and its apparent ability to potentially lower DHT; hence the improved hair reports. I know that you are not a fan of anything that has the potential to lower DHT. Any thoughts on this? Here is the link to what that member was referencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382810/

And brundel response...

This is a study using a pitri dish and rodent prostate extract. Chopped up rat parts in a dish.
This doesnt at all imply oral administration of EC extract will lower DHT.

It does seem to help with hair though and nails. I dont think its DHT related. Seems to make my Girlfriends hair and nails grow faster and it cant be DHT related in her.

ECs hair growth benefits are likely related to other things entirely.

Ecklonia cava promotes hair growth.
Bak SS1, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK.
Author information
Abstract
BACKGROUND:

Previous studies have reported the protective effects on skin elasticity of the edible marine seaweed Ecklonia cava, which acts through regulation of both antioxidative and anti-inflammatory responses.
AIM:

We evaluated the effect of E. cava and one of its components, dioxinodehydroeckol, on hair-shaft growth in cultured human hair follicles and on hair growth in mice.
METHODS:

The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to check cell viability of human dermal papilla cells (DPCs) and outer root sheath (ORS) cells after treatment with E. cava and its metabolite, dioxinodehydroeckol. Hair-shaft growth was measured using the in vitro hair-follicle organ-culture system, in the presence or absence of E. cava and dioxinodehydroeckol. Anagen induction activity was examined by topical application of E. cava to the dorsal skin of C57BL/6 mice. Insulin-like growth factor (IGF)-1 expression was measured by reverse transcriptase PCR and ELISA.
RESULTS:

The proliferation activity was found to be highest for the ethyl acetate-soluble fraction of E. cava (EAFE) in DPCs and in ORS cells. Treatment with EAFE resulted in elongation of the hair shaft in cultured human hair follicles, and promoted transition of the hair cycle from the telogen to the anagen phase in the dorsal skin of C57BL/6 mice. In addition, EAFE induced an increase in IGF-1 expression in DPCs. Dioxinodehydroeckol, a component of E. cava, induced elongation of the hair shaft, an increase in proliferation of DPCs and ORS cells, and an increase in expression of IGF-1 in DPCs.
CONCLUSIONS:

These results suggest that E. cava containing dioxinodehydroeckol promotes hair growth through stimulation of DPCs and ORS cells.

Interesting information coming from both sides...keep on discussing...

 

[Volvo140G]

Got that FD2 plus the whole BLR line at 25% off at Nutriverse with code AM5 stacked atop our autodiscount. This is a rare and limited time offer, check it out!

http://anabolicminds.com/forum/supplement-deals/289812-valentines-day-sale.html

 

[dsade]

Wow, this already fell off the first page...anyways...I'd like to discuss the DHT side of EC as well..I posted this in another thread...

It was found that Ecklonia Cava extract increased the growth phase (anagen) of the hair follicle, increased the growth potentiation of the hair cells (dermal papilla), and results in the reduction of 5α-reductase activity, an enzyme responsible for the production of DHT (dihydrotestosterone). (Int J Mol Sci. 2012;13(5):6407-23)

And...
Ecklonia cava also decreases activity of 5α-reductase and therefore reduces the amount of DHT (di-hydro testosterone) in the body. Dieckol is the most active component in Ecklonia cava for the reduction of 5α-reductase (Kang et al., 2012).

And this...see section 2.5, and section 3, paragraph 5, and lastly section 4.9...really the whole article is good.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382810/

Ricky10 posted this in another thread about the last link...
Somebody came across this interesting research that was done on Ecklonia Cava and its apparent ability to potentially lower DHT; hence the improved hair reports. I know that you are not a fan of anything that has the potential to lower DHT. Any thoughts on this? Here is the link to what that member was referencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382810/

And brundel response...

This is a study using a pitri dish and rodent prostate extract. Chopped up rat parts in a dish.
This doesnt at all imply oral administration of EC extract will lower DHT.

It does seem to help with hair though and nails. I dont think its DHT related. Seems to make my Girlfriends hair and nails grow faster and it cant be DHT related in her.

ECs hair growth benefits are likely related to other things entirely.

Ecklonia cava promotes hair growth.
Bak SS1, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK.
Author information
Abstract
BACKGROUND:

Previous studies have reported the protective effects on skin elasticity of the edible marine seaweed Ecklonia cava, which acts through regulation of both antioxidative and anti-inflammatory responses.
AIM:

We evaluated the effect of E. cava and one of its components, dioxinodehydroeckol, on hair-shaft growth in cultured human hair follicles and on hair growth in mice.
METHODS:

The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to check cell viability of human dermal papilla cells (DPCs) and outer root sheath (ORS) cells after treatment with E. cava and its metabolite, dioxinodehydroeckol. Hair-shaft growth was measured using the in vitro hair-follicle organ-culture system, in the presence or absence of E. cava and dioxinodehydroeckol. Anagen induction activity was examined by topical application of E. cava to the dorsal skin of C57BL/6 mice. Insulin-like growth factor (IGF)-1 expression was measured by reverse transcriptase PCR and ELISA.
RESULTS:

The proliferation activity was found to be highest for the ethyl acetate-soluble fraction of E. cava (EAFE) in DPCs and in ORS cells. Treatment with EAFE resulted in elongation of the hair shaft in cultured human hair follicles, and promoted transition of the hair cycle from the telogen to the anagen phase in the dorsal skin of C57BL/6 mice. In addition, EAFE induced an increase in IGF-1 expression in DPCs. Dioxinodehydroeckol, a component of E. cava, induced elongation of the hair shaft, an increase in proliferation of DPCs and ORS cells, and an increase in expression of IGF-1 in DPCs.
CONCLUSIONS:

These results suggest that E. cava containing dioxinodehydroeckol promotes hair growth through stimulation of DPCs and ORS cells.

Interesting information coming from both sides...keep on discussing...

This is one of the main ingredients in Virile Mane.

 

[ws65]

dsade
Matt, can you elaborate if you have some time on why you use that in Virile Mane? Also, can you share your findings/opinions on EC as far as benefits, detriments, if EC should be a daily staple?

 

[dsade]

dsade
Matt, can you elaborate if you have some time on why you use that in Virile Mane? Also, can you share your findings/opinions on EC as far as benefits, detriments, if EC should be a daily staple?

Wow, I hate to seem like I'm ducking this, but I Am about 12 months behind on all of my work.

If I can line all the stars up and find a few minutes then I'll start popping out the VM ingredients one by one with the supporting studies.

 

[ws65]

Wow, I hate to seem like I'm ducking this, but I Am about 12 months behind on all of my work.

If I can line all the stars up and find a few minutes then I'll start popping out the VM ingredients one by one with the supporting studies.

No worries brother, I already knew you were crazy busy. BTW, really looking forward to the new Gut Health.

 

[dsade]

No worries brother, I already knew you were crazy busy. BTW, really looking forward to the new Gut Health.

I offered them a bribe to finish up the end of next week.

 

[The_Old_Guy]

Unfortunately, Virile Mane did Jack for my bald spot, so that ingredient is a non-starter. The residue on the hair is also not fun. Minoxidil and Azaliac Acid *does* work, and vanishes, for the most part.

 

[ws65]

Some more info from brundel...good stuff!...

There are no studies I am aware of that indicate that oral Ecklonia cava extract will effect DHT.
There are some that indicate that if you soak hair follicles and other things in Dieckol it may effect DHT levels in the sample. Its not logical to imply that oral EC would have the same effects.

https://www.ncbi.nlm.nih.gov/pubmed/22754373
The study that was referenced above used hair follicles soaked in 35% dieckol=

"When vibrissa follicles were cultured in the presence of E. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, "


EC(ecklonia cava) extract was tested Vs viagra and beat viagra on most tests.
The vast majority of users mention an increase in sexual function.

Also....Not all EC extracts are the same.
Some standardize for seanol, some for dieckol, some are full spectrum. And some are very weak while some are very strong.
Ours is exceptionally strong.
The point is you cant say 1000mg of ... ec product is comparable to ... ec product without knowing how they were extracted, strength, standardization etc.

By the way the strongest EC extract I know of is in FOLLIDRONE 2.0


More info regarding EC and sexual function.
=======================

ERECTILE FUNCTION - ECE V. VIAGRAÆ

Nitric Oxide

ECE can regenerate the vascular endothelium, the cells critical to the inner lining of the blood vessels. They generate the chemical nitric oxide (NO), which keeps the arterial walls relaxed and dilated. After a six-week study of ECE, flow mediated dilation and NO mediated dilation increased by 60% and 50%. In another study, coronary artery disease patients were given ECE for six weeks. Blood flow controlled by NO increased 50-60%. These results confirm that ECE can rejuvenate damaged endothelial cells to produce NO. This effect was further confirmed in a study on erectile dysfunction (see below). Interestingly, ViagraÆ works by increasing NO in the penile artery.

ECE v.ViagraÆ: 8-Week Clinical Trial

Scientists studied 31 men with erectile dysfunction (ED) for over six months. They compared eight weeks of ECE use to ViagraÆ. They looked at orgasmic function (OF), intercourse satisfaction (IS), overall satisfaction (OS), and erectile function (EF). Over those eight weeks, ECE scored 87%, 74%, 62%, and 66%. ViagraÆ scored 27%, 44%, 39%, and 66%. No side effects were reported with ECE:

Population with 25+% Improvement in IIEF (International Index of Erectile Function) score was as high as 81%. Total IIEF score significantly increased from 29.1 ± 13.1 to 47.0 ± 14.5 with 62% of improvement. When the IIEF scores were grouped into five separate domains, mean IIEF scores at the 8th week were significantly greater than those at week 0 for all domains (all p<0.01). The degree of improvement was significant in the following order: OF (87%), IS (74%), EF (66%), and OS (62%). Scores on key questions (asking frequency of penetration and asking frequency of maintaining an erection after penetration), which directly indicate the ability to achieve and maintain an erection sufficient for sexual activity, were improved up to 74% and 77%, respectively (p<0.01).

It is very important to note that despite the marginal improvement in sexual desire (20%) that is of psychological nature, great improvements were reported in the domains directly related with erection that is of physical nature and dependent on normal vascular function of the penile artery.

Also noteworthy, was a significant increase in the orgasmic function score (87%), intercourse satisfaction (74%) and overall satisfaction (62%) as well as erectile function (66%) in comparison with the results for sildenafil reported by Marks, et al. (Marks, et al., 1999) (27%, 44%, 39% and 66%, respectively), which indicates that ECE significantly contributed to the normalization of the general vascular conditions around the sexual organ.

These results strongly indicate that the long-term administration of ECE significantly contributes to the neutralization of oxidative risk factors, thereby improving peripheral blood circulation around muscles and nerves involved in sexual function as well as the penile artery. No side effects were reported.

Vasodilation & Erectile Function

It has been reported that vasculogenic ED patients have elevated levels of angiotensin II for the duration of the erection process. The demonstrated action of ECE on ACE and resulting vasodilation is thought to play an important role in inducing successful erectile function.

Long-Term Improvement Via Vascular Protection

As discussed, ECE phlorotanins have potent antioxidant and anti-inflammatory effects. Together with ECE's ACE inhibitory activity, which is also beneficial to vascular homeostasis, these activities, upon long-term oral administration, may all contribute to supporting a healthy vascular system, including the penile artery.

and from muscleupcrohn...

"Could you please provide me with a link/reference/text/etc for that ECE vs Viagra study? I've seen it referenced and summarized all the time, but I've never actually seen a proper reference or citation, let alone anything peer reviewed. I'd like to really be able to see the methodology and data, etc. The only study on ecklonia I've seen comapring it to anything like Viagra was comparing a supplement containing ecklonia bicyclis to Tadalafil (Cialis), and it didn't outperform Tadalafil in regards to erectile function. Also, if you could, I'd really like to see that "ECE Beverage: 2-Week Clinical Trial" that gets mentioned all the time for improving body composition; I've seen studies showing benefits, but nothing to that magnitude".

Awesome stuff...let's keep it going

 

[dsade]

Unfortunately, Virile Mane did Jack for my bald spot, so that ingredient is a non-starter. The residue on the hair is also not fun. Minoxidil and Azaliac Acid *does* work, and vanishes, for the most part.

When was this and how long did you use it?

 

[The_Old_Guy]

When was this and how long did you use it?

First thing I tried when I noticed a balding spot. About 1.5 years ago I guess. Since I had only about a 2 inch circle, the bottle lasted 2-3 months? Did nothing for me, switched to Minox and Azaleac and stuff filled in.

 

[dsade]

First thing I tried when I noticed a balding spot. About 1.5 years ago I guess. Since I had only about a 2 inch circle, the bottle lasted 2-3 months? Did nothing for me, switched to Minox and Azaleac and stuff filled in.

Ah, you used the old version. The new version has a much more comprehensive formula and we;re getting much better results.

Minox and Azelac didn;t do a thing me, even with months of treatment.

 

[210LBS]

I never used Azelac but swear by Minox.

 

[The_Old_Guy]

Ah, you used the old version. The new version has a much more comprehensive formula and we;re getting much better results.

Minox and Azelac didn;t do a thing me, even with months of treatment.

Awesome. You should soon be the richest Mfg on AM (which really pales in comparison to all the hair loss forums for "regular Joes" - you need to get on those).

Global alopecia (hair loss treatment) market was valued at more than USD 7.2 billion in 2015, which expects to exceed USD 10 billion revenue by 2024. Approval from FDA to be sold the medication without prescription over the counter for men and women makes the product more approachable in the market.

 

[210LBS]

If ecklonia cava has been around for a while now, how come nobody is using it with all of these studies? The only time I hear of people using it is in their Follidrone 2.0. Has nobody tried ditching the epicatechin and just used the ecklonia cava?

 

[ws65]

I'm actually thinking about getting it as a single ingredient and trying it. I don't need it for the hair stuff; I'd like to see if it has all the other purported benefits.

 

[bosskardo]

Awesome. You should soon be the richest Mfg on AM (which really pales in comparison to all the hair loss forums for "regular Joes" - you need to get on those).

He would be if he wasn't giving it away nearly free.

 

[ws65]

Antioxidant Effect of Enzymatic Hydrolyzate from a Kelp, Ecklonia cava study...
http://ocean.kisti.re.kr/downfile/volume/kspc/JORHBK/2003/v18n4/JORHBK_2003_v18n4_341.pdf

 

[Ricky10]

I will say this in general. I have been taking FD2 on and off since last spring, and consistently now for the last 2 or 3 months..usually at 2 caps day. If I am to not take it now for maybe a day, I feel that I have less energy and am also in a poor mood. My hair and nails grow like crazy, and I feel that my skin looks healthier as well with virtually no acne. I have also not caught a cold since I don't even know when. I work in healthcare and am constantly surrounded by sick people coughing in my face...so that is saying something.

 

[dsade]

He would be if he wasn't giving it away nearly free.

I will be raising prices here in the next week (costs have gone up) but I know the economy still sucks and I want to make sure that everyone can afford to use the best products on the market without breaking the bank.

So, prices will be going up but that means I will have more to put towards restock of the things that have been OOS for far too long.

 

[KingErgogenic]

Did you end up trying Ecklonia Cava, solo?

 

[ManuR]

i use it
called fibroboost, patented extract
lowers bp and blood sugar + more proven effects on health

 

[djbombsquad]

https://www.drsinatra.com/seanol-powerful-antioxidant-promotes-heart-health is this the same stuff seanol?

 

[djbombsquad]

Because in that article they don’t mention myostatin. Nor do they mention it on the raw ingredients site that makes it.

 

[KingErgogenic]

The Nutricology Fibroboost?
Ecklonia cava Extract (Seanol-F) 1200 mg

or a different Fibroboost?

 

[djbombsquad]

The Nutricology Fibroboost?
Ecklonia cava Extract (Seanol-F)1200 mg

or a different Fibroboost?

I believe any of them . I know there is a few variations the has on the site but non mention myoststin. I still am curious as a super food how it would do though .

 

[KingErgogenic]

I have been using 400mg of Seanol-F, once in morning and once before training. Noticing serious benefits in recovery and pumps. But I have also started smashing down heaps of Fulvic Acid too. Been so happy with this. Also, combining with Amentoflavone seemed to deliver the most hectic pump.