Theres a difference between taking them or not yes, but also there are questions about liver protectors (and prostate protectors) binding to the androgen receptors and lowering gains. Basically the liver is one of the fastest to bounce back body parts and assuming you didn't abuse the hell out of it before a cycle, and take products at label dose, and don't drink on cycle that they will come back to normal levels a short while after the cycle is done anyhow. SAM-e is a nice one though, as it adds other capabilities