DCP 3.0 formula is complete. As posted on the facebook page:
For those that were with me and Par Deus during the heyday of Avant Labs, and the release of Sesamin - with the immediate amazing fat loss, but subsequent discovery of lignan-induced libido crash we have a very good surprise for you. We have isolated and commercialized Sesamol - with no chance to any of those negative side effects. I have promised, and will deliver next week, a boosted Absolutely Abliderated, but I will also be pulling this in for EvoMuse DCP 3.0
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J Nutr Biochem. 2012 Nov;23(11):1482-9. doi: 10.1016/j.jnutbio.2011.09.011. Epub 2012 Mar 6.
Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS.
Sharma AK1, Bharti S, Bhatia J, Nepal S, Malik S, Ray R, Kumari S, Arya DS.
Author information
Abstract
Increased oxidative stress and inflammation in obesity are the central and causal components in the pathogenesis and progression of cardiometabolic syndrome (CMetS). The aim of the study was to determine the potential role of sesamol (a natural powerful antioxidant and anti-inflammatory phenol derivative of sesame oil) in chronic high-cholesterol/high-fat diet (HFD)-induced CMetS in rats and to explore the molecular mechanism driving this activity. Rats were fed with HFD (55% calorie from fat and 2% cholesterol) for 60 days to induce obesity, dyslipidemia, insulin resistance (IR), hepatic steatosis and hypertension. On the 30th day, rats with total cholesterol >150 mg/dl were considered hypercholesterolemic and administered sesamol 2, 4 and 8 mg/kg per day for the next 30 days. Sesamol treatment decreased IR, hyperinsulinemia, hyperglycemia, dyslipidemia, TNF-α, IL-6, leptin, resistin, highly sensitive C-reactive protein (hs-CRP), hepatic transaminases and alkaline phosphatase, along with normalization of adiponectin, nitric oxide and arterial pressures in a dose-dependent fashion. Increased TBARS, nitrotyrosine and decreased antioxidant enzyme activities were also amended in HFD rats. Similarly, sesamol normalized hepatic steatosis and ultrastructural pathological alteration in hepatocytes, although the effect was more pronounced at 8 mg/kg. Furthermore, hepatic PPARγ, PPARα and e-NOS protein expressions were increased, whereas LXRα, SERBP-1c, P-JNK and NF-κB expression were decreased by sesamol treatment. These results suggest that sesamol attenuates oxidative stress, inflammation, IR, hepatic steatosis and hypertension in HFD-fed rats via modulating PPARγ, NF-κB, P-JNK, PPARα, LXRα, SREBP-1c and e-NOS protein expressions, thereby preventing CMetS. Thus, the present study demonstrates the therapeutic potential of sesamol in alleviating CMetS.
Copyright © 2012 Elsevier Inc. All rights reserved.
PMID:
22398194
We have maintained the unbeatable PPAR-alpha activation of sesamin, without the danger of the lignan side effects. This will truly be glorious, and a fitting addition to the highest standards of EvoMuse formulas.