Even though this article is for a female from my own expereince I can believe that this same mechanism could also apply to a males body as well. It nicely explains the correlation between the estrogen and how it affects the free cortisol levels in the the blood vs serum not giving a true indication of free amount of cortisol bioavailable to the body.
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Nice find. I could use refresher on Free Cortisol.
Only in Dr Marianco's extensive blood testing I have seen test for Cortisol-Binding Globulin.
What to do with it, how to react to incorrect level.
Do not recall anything on Free Cortisol.
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What estrogen they are refering to?
There is so many different estrogens including right and left with the same names.
Quote:
Like hypothyroidism, adrenal fatigue affects women much more frequently than men.
High levels of estrogen cause a corresponding increase in levels of cortisol-binding globulin.
Like other hormone-binding globulins, cortisol-binding globulin interferes with hormone function. It circulates in the bloodstream, binds to cortisol, and renders it inactive. A woman with estrogen dominance may have adequate levels of total cortisol in her bloodstream, but her free, available cortisol level may be very low. Only free cortisol can pass through cell membranes and activate receptors inside the cell.
:dance:
