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cortisol and estrogen relationship

hardasnails1973

Registered User
Even though this article is for a female from my own expereince I can believe that this same mechanism could also apply to a males body as well. It nicely explains the correlation between the estrogen and how it affects the free cortisol levels in the the blood vs serum not giving a true indication of free amount of cortisol bioavailable to the body.

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hardasnails1973 said:
Even though this article is for a female from my own expereince I can believe that this same mechanism could also apply to a males body as well. It nicely explains the correlation between the estrogen and how it affects the free cortisol levels in the the blood vs serum not giving a true indication of free amount of cortisol bioavailable to the body.

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Nice find. I could use refresher on Free Cortisol.
Only in Dr Marianco's extensive blood testing I have seen test for Cortisol-Binding Globulin.
What to do with it, how to react to incorrect level.
Do not recall anything on Free Cortisol.
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What estrogen they are refering to?
There is so many different estrogens including right and left with the same names.

Quote:
Like hypothyroidism, adrenal fatigue affects women much more frequently than men. High levels of estrogen cause a corresponding increase in levels of cortisol-binding globulin. Like other hormone-binding globulins, cortisol-binding globulin interferes with hormone function. It circulates in the bloodstream, binds to cortisol, and renders it inactive. A woman with estrogen dominance may have adequate levels of total cortisol in her bloodstream, but her free, available cortisol level may be very low. Only free cortisol can pass through cell membranes and activate receptors inside the cell.
:dance:
 
Here is what I am gathering i am coming to conclsuion that a person can have normal estrodial levels, but either to genetic defect in the methioinne synthase or 5 mtffr, or other almients that they have problem with estrogen metabolism in general. With this being said people that i have known to respond to DIM are majority percentage classified as unmethylenated. A possible theory come to the fact that there is a not a malfunction in processing estrodial but rather due to the undermethylation some thing goes awry it causes an excess of bad estrogen to good estrogen. This can be seen in people that are hypomethylated like cancer, diabetes, MS and severe zinc deficeincy, absnormal folate, methyl b-12 metabolism, excessive estrogen and also estrogen deficeincy. So with this in mind how many people are possible running around undiagnosed suffering from a mafunctioin in estrogen metabolism and not even knowing it and tecnhincally they would be a breeding ground for cancer later on in life.

NOW THOSE ARE TESTS COMING EVERY ANGLE !!
 
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