machorox123
Well-known member
JudoJosh said:My head hurts
BTW did you guys know there exist a diet grape juice? I'm so excited about this!
Yumm! Welches?
JudoJosh said:My head hurts
BTW did you guys know there exist a diet grape juice? I'm so excited about this!
I love aspartame
as I sip on my 44oz diet cherry limeade
Are any of the posters that are against artificial sweeteners, etc. in products willing to post what supplements they do use? I always find it amusing that some are willing to mess around with their body chemistry, but step up on the soap box over what others put in their coffee.
And as for the "natural" sweeteners...sugar alcohols can cause or exacerbate inflammatory GI syndromes. What do artificial sweeteners do in this regard? Nothing.
thills said:Lol Aleksandar, you are not going to rope me in that easy, but yeah I see your point. It is like the lady that feeds her cat nothing but organic food but smokes 4 packs a day.
thills said:Maybe not in THIS regard, but in other regards much. No offense to you personally mr. cooper, you are one of those rare individuals that one can not help but like.
Here is a fun fact: there is not a single piece of placebo-controlled, double-blind, and randomized trial which demonstrates that 'artificial' sweeteners do, or are even capable of, leading to tangible adverse health effects in humans. Yet, a certain segment of the population is insistent on propagating this half-witted nonsense about the 'dangers' of artificial sweeteners, all the while touting the health benefits of processed sugar - the irony in principle and application is thick enough to cut with a knife.
I wrote this little ditty some time ago, and I like to use it sparingly - like fine china - only to admonish the most insistent, yet ill-informed hippies.
Now, on to questions about harmful side effects for long-term use. To put a very complex issue simply, there is no reliable and competent scientific data to suggest that sucralose has significant toxic potential. With regard to acute toxicity, doses of 50,000 times the RDI have not produced any detectable effects whatever [1]. These doses were 10,000 and 16,000 mg/kg bw/day, respectively. The long term assays speak to the same safety.
To wit, 104 week (two year) oncogenicity and chronic toxicity studies in both rat and mice concluded that sucralose possessed no direct effects on the generation of oncoblasts or proliferation of cancer, nor possessed any direct toxicity in all tissue types studied. Minor decreases in organ and body weight, like the majority of other sucralose studies, were concluded to be peripheral to sucralose's direct physiological effects, and were consequences of the inpalatability of the compound [2, 3].
The doses used in the rat and mice studies were exbortinant, far exceeding what is either mechanically or physiologically possible in humans. The NOEL (no observed effect levels) was 1500mg/kg bw/day, with the LOEL (lowest observed effect level) being 4500mg/kg bw/day. To put this into more relevant terms, I would personally need to consume 1/2 lb of sucralose a day, everyday, for two consecutive years in order to broach the level at which no evidence for direct toxic effects were demonstrated.
These results are not alone. In a 12 month dietary study in Beagle dogs fed 875mg/kg bw/day of sucralose by galvage, no immunotoxic or carcinogenic effects were seen at statistically significant levels, and as in the prior rodent studies, any alterations in body weight or organ weight were concluded to be secondary [4]. Studies on pregnant rabbits and rats using doses of up to 1000mg/kg bw/day and 2000mg/kg bw/day for the duration of the 28 week pregnancies did not evince any in utero developmental damage, while the mothers were subject, again, to secondary effects resulting from inpalatability to sucralose [5,6,7].
Finally, while they were not traditional toxicity assays, clinical trials in humans with durations up to and including 6 months, of doses up to and including 1000mg/day, found no significant alterations to major haemotological parameters, nor significant adverse effects.
Put quite simply, there is a complete dearth of evidence to suggest that sucralose is in any way harmful to human health. Unfortunately, the strictures of the scientific community do not apply to the distressing new trend of "new age health" gurus who promulgate this or that in an attempt, in the majority of cases, to push a, "natural sweetener."
Ironically enough, what the new age health community pejoratively deems "the chemical sweeteners" haveexponentially more scientific data on their various metabolic, physiologic, and pharmacological effects than do newer, "organic" sweeteners such as Stevia. Again, this seems lost amongst the uninformed fervor!
I hope that adequately answers your questions with regard to sucralose safety.
1. Tate & Lyle Speciality Sweeteners (1989). Sucralose monographs. Unpublishedsubmission by Tate & Lyle Speciality Sweeteners, UK, to the EC Scientific Committee
for Food, August 1989.
2. Rhenius ST, Ryder JR and Aymes SJ (1986).1,6-dichloro-1,6-dideoxy-ß-Dfructofuranosyl-4-chloro-4-deoxy a-D-galactopyranoside (TGS): 104 week combined toxicity and oncogenicity study in CD rats with ‘in utero’ exposure. Life Science Research Limited, UK. Report No 86/MSPO33/638. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK.
3. Aymes SJ, Ashby R and Aughton P (1986). 1,6-dichloro 1,6-dideoxy-ß-Dfructofuranosyl-4-chloro-4-deoxy a-D-galactopyranoside (TGS): 104 week oncogenicity study in mice. Life Science Research Limited, UK. Report No 86/MSPO35/179. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK.
4. Goldsmith LA (1985). Twelve-month oral toxicity study in dogs: 1,6-dichloro-1,6-dideoxy-ß-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside (TGS). Unpublished report from Hazleton Laboratories America, Inc. submitted by Tate & Lyle Speciality Sweeteners, UK.
5. Joint Food Safety and Standards Group (1998). Evaluation of sucralose by the Scientific Committee on Food (SCF). Conclusions of the UK Committee on Toxicity on teratology studies. Letter dated April 17, 1998. MAFF/DH Joint Food Safety and Standards Group, London, UK.
6. Tesh JM, Willoughby CR, Hough AJ, Tesh SA and Wilby OK (1983). 1,6-dichloro-1,6-dideoxy-ß-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside (TGS): Effects of
oral administration upon pregnancy in the rat. Life Science Research Limited, UK. Report No 82/MSPO22/311. Unpublished report submitted by Tate & Lyle Speciality
Sweeteners, UK.
7. Tesh JM, Ross FW, Bailey GP, Wilby OK and Tesh SA (1987). 1,6-dichloro-1,6-dideoxy-ß-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside (TGS): Teratology study in the rabbit. Life Science Research Limited, UK. Report No 82/TYLO95/046. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK.
8. A six-month study of the effect of sucralose versus placebo on glucose homeostasis in patients with non-insulin dependent diabetes mellitus. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK. (Study No. E-157)
9. An evaluation of specific clinical chemistry parameters and methods in study E-157: A six-month study of the effect of sucralose versus placebo on glucose homeostasis in patients with non-insulin dependent diabetes mellitus. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK. (Study No. E-168)
10. A 12-week study of the effect of sucralose on glucose homeostasis and HbA1c in normal healthy volunteers. Unpublished report submitted by Tate & Lyle Speciality Sweeteners, UK. (Study No. E-169)
Get off your knees
Very clever Sir. And original too. Lets see is it the name calling game we are to engage in. Now I am a little out of practice so forgive me if I misquote this one that my son taught me which he learned in the playground. I think it goes, "I am rubber you are glue, what you say bounces of me and sticks on you."
The application for approval as a food additive was actually turned down by an FDA expert panel-"The information submitted for our review is inadepquate to permit a scientific evaluation of clinical safety (Freeman, FDA Division of Metabolic and Enocrine Drug Products, September 1973).
However, these objections, demanding more carful research were overturned by a new FDA commissioner on the basis of studies, 80% of which were sponsored by the manufacturer, Searle.
The FDA approved aspartame for limited use on July 26, 1974. This approval came despite the fact that FDA scientists found serious deficiencies in all of the 13 test related to genetic damage which were submitted by G.D. Searle.
Later it turned out that important findings in one study, indicating harmful effects (liver cancer) of aspartame had not been reported to FDA until August 18, 1975, 27 months after it had been given to G.D. Searle and over one year after it had been approved. In another study seven infant monkeys were given aspartame with milk. One died after 300 days. Five others (out of seven total) had grand mal (epileptic) seizures. The actual results were hidden from the FDA when G.D. Searle supmitted its initial applications.
PreciseNstuff said:Don't let these shills get you down Sir. You obviously are trying to help those who are uneducated on a subject which directly concerns their health and are having to deal with immature adolescent idiot in the process.
The application for approval as a food additive was actually turned down by an FDA expert panel-"The information submitted for our review is inadepquate to permit a scientific evaluation of clinical safety (Freeman, FDA Division of Metabolic and Enocrine Drug Products, September 1973).
However, these objections, demanding more carful research were overturned by a new FDA commissioner on the basis of studies, 80% of which were sponsored by the manufacturer,Searle.
The FDA approved aspartame for limited use on July 26, 1974. This approval came despite the fact that FDA scientists found serious deficiencies in all of the 13 test related to genetic damage which were submitted by G.D. Searle.
Later it turned out that important findings in one study, indicating harmful effects (liver cancer) of aspartame had not been reported to FDA until August 18, 1975, 27 months after it had been given to G.D. Searle and over one year after it had been approved. In another study seven infant monkeys were given aspartame with milk. One died after 300 days. Five others (out of seven total) had grand mal (epileptic) seizures. The actual results were hidden from the FDA when G.D. Searle supmitted its initial applications.
Are you really this delusional?
PreciseNstuff said:Nothing delusional about that post Filly.
thills said:The application for approval as a food additive was actually turned down by an FDA expert panel-"The information submitted for our review is inadepquate to permit a scientific evaluation of clinical safety (Freeman, FDA Division of Metabolic and Enocrine Drug Products, September 1973).
However, these objections, demanding more carful research were overturned by a new FDA commissioner on the basis of studies, 80% of which were sponsored by the manufacturer, Searle.
The FDA approved aspartame for limited use on July 26, 1974. This approval came despite the fact that FDA scientists found serious deficiencies in all of the 13 test related to genetic damage which were submitted by G.D. Searle.
Later it turned out that important findings in one study, indicating harmful effects (liver cancer) of aspartame had not been reported to FDA until August 18, 1975, 27 months after it had been given to G.D. Searle and over one year after it had been approved. In another study seven infant monkeys were given aspartame with milk. One died after 300 days. Five others (out of seven total) had grand mal (epileptic) seizures. The actual results were hidden from the FDA when G.D. Searle supmitted its initial applications.
Mulletsoldier said:For the purpose of discussion, I am going to square away the non-trivial matters of you using data prior to 1981 (when the studies you listed were found to have serious methodological deficiencies, including, though not limited to, conclusions which human morphology rendered moot), you deliberately obfuscating the timeline of approval, and you responding to a post I made about sucralose with a post on aspartame, and address your comments at face value.
Even doing so, you will once again find that the credible scientific evidence lands on the opposite side of the fence.
To wit:
"Questions about artificial sweeteners and cancer arose when early studies showed that cyclamate in combination with saccharin caused bladder cancer in laboratory animals. However, results from subsequent carcinogenicity studies (studies that examine whether a substance can cause cancer) of these sweeteners have not provided clear evidence of an association with cancer in humans. Similarly, studies of other FDA-approved sweeteners have not demonstrated clear evidence of an association with cancer in humans."
And:
"Subsequently, NCI examined human data from the NIH-AARP Diet and Health Study of over half a million retirees. Increasing consumption of aspartame-containing beverages was not iassociated with the development of lymphoma, leukemia, or brain cancer (2)."
Invalid Link Removed
"FDA Statement on European Aspartame Study
CFSAN/Office of Food Additive Safety
April 20, 2007
FDA has completed its review concerning the long-term carcinogenicity study of aspartame entitled, "Long-Term Carcinogenicity Bioassays to Evaluate the Potential Biological Effects, in Particular Carcinogenic, of Aspartame Administered in Feed to Sprague-Dawley Rats," conducted by the European Ramazzini Foundation (ERF), located in Bologna, Italy. FDA reviewed the study data made available to them by ERF and finds that it does not support ERF's conclusion that aspartame is a carcinogen. Additionally, these data do not provide evidence to alter FDA's conclusion that the use of aspartame is safe."
Invalid Link Removed
Unless you assume that the National Cancer Institute is deliberately presenting falsified information, I hesitate to see how your position gains purchase: all the information demonstrative of adverse effects are either dubious or outright invalidated; while the methodology of studies showing no association have had their methodologies similarly vetted, and not found to be lacking.
Your intractable position lacks any credible evidence to justify it.
PreciseNstuff said:These are the kinds of post that dumb down the forum impeding constructive debate
April 20, 2007
"Long-Term Carcinogenicity Bioassays to Evaluate the Potential Biological Effects, in Particular Carcinogenic, of Aspartame Administered in Feed to Sprague-Dawley Rats," conducted by the European Ramazzini Foundation (ERF), located in Bologna, Italy. FDA reviewed the study...
thills said:The Ramazzini study was reported in the November 2005 issue of "Environmental Health Perspectives," the peer-reviewed journal of th United States' National institute of Environmental Health Sciences.
"Our study has shown that aspartame is a mulipotential carcinogenic compound whose carcinogenic effects are also evident at a daily dose of 20 milligrams per kilogram of body weight (mg/kg), notably less than the current acceptable daily intake for humans."
Aspartame has been banned in the Philippines due to its awful effects and banned in chidren's foods in others.
Government members from countries have called for it's ban. One being Member of Parliament Roger Williams cited, "compelling and reliable evidence for this carcinogenic substance to to be banned from the UK food and drinks market altogether."
As for the FDA Hull was installed a sixth member on the commission, and the vote became deadlocked. He then personally broke the tie in aspartame's favor.
Hull later left the FDA under allegations of impropriety, then took a position with Burston-Marsteller, the chief public relations firm for Searle and for Monsanto, which purchased Searle in 1985.
Based on all this it is little wonder that many avoid artificial sweeteners. For those that like aspartame it is available. Companies make products in a variety of flavors so why not have an option for products sweetened with natural things so the consumer has an option.
with sufficient veracity
Well heck I will just hang my hat on that there
The Ramazzini study was reported in the November 2005 issue of "Environmental Health Perspectives," the peer-reviewed journal of th United States' National institute of Environmental Health Sciences.
"Our study has shown that aspartame is a mulipotential carcinogenic compound whose carcinogenic effects are also evident at a daily dose of 20 milligrams per kilogram of body weight (mg/kg), notably less than the current acceptable daily intake for humans."
Aspartame has been banned in the Philippines due to its awful effects and banned in chidren's foods in others.
Government members from countries have called for it's ban. One being Member of Parliament Roger Williams cited, "compelling and reliable evidence for this carcinogenic substance to to be banned from the UK food and drinks market altogether."
As for the FDA Hull was installed a sixth member on the commission, and the vote became deadlocked. He then personally broke the tie in aspartame's favor.
Hull later left the FDA under allegations of impropriety, then took a position with Burston-Marsteller, the chief public relations firm for Searle and for Monsanto, which purchased Searle in 1985.
In the face of overwhelming evidence
I happen to care a little more about my hats Sir.
You have to be kidding me
PreciseNstuff said:I happen to care a little more about my hats Sir.
You have to be kidding me
No. If you take issue with the data I have presented, I would be interesting to know how and why it is deficient.
I find this thread highly entertaining. Didn't Sweet n low have a disclaimer on its packaging once? (maybe it still does, Idk).
But hey, I've used sweet n low. I've used splenda, and sugar, stevia, agave, sweet serum. I have no doubt every single one of 'em is bad for some be it allergies, insulin response, reactions, interactions or whatever the hell. Does that mean we should ban it altogether? If consumers wish to educate themselves, then they can. I remember first hearing of the "dangers" of sweeteners a while back and researched all of them. Saw no reason to call any of them the devil. If ya just don't like one, pick another. This is 'Merica! F yeah! Ya got a choice.
Sorry, my 2 cents. Please continue the entertainment.
Also have to agree with bioman, aspartame tastes like ish.
thills said:Thanks for your post. My point in creating the thread was to point out that 90% of the companies selling "sports nutrition" supplements are not making options for those who wish to go with natural sweeteners, they will be the way of the future.
For those that keep on about the FDA this and the fda that, well yeah it was a deadlock that was broken by just one vote, and some of those on this site claim this makes it correct. Obamacare was decided by just one vote so this makes it correct, and all Americans should agree?
What has happened to Merica.
thills said:For those that keep on about the FDA this and the fda that, well yeah it was a deadlock that was broken by just one vote, and some of those on this site claim this makes it correct. Obamacare was decided by just one vote so this makes it correct, and all Americans should agree?
What has happened to Merica.
i give up..i thought i was thickheadedThanks for your post. My point in creating the thread was to point out that 90% of the companies selling "sports nutrition" supplements are not making options for those who wish to go with natural sweeteners, they will be the way of the future.
For those that keep on about the FDA this and the fda that, well yeah it was a deadlock that was broken by just one vote, and some of those on this site claim this makes it correct. Obamacare was decided by just one vote so this makes it correct, and all Americans should agree?
What has happened to Merica.
So, just to be clear: what are you objecting to-democracy, majoritarianism, or just any decision that does not agree with your personal tastes?
If "90%" of supplement companies are making products with sweeteners...
thills said:I did not say "supplement companies"...go in any real health food store "not G..N..C or the like" and 99% of the powdered formulas, from sports nutrition to antioxidant formulations are made with natural sweeteners. I said 90% of "sports nutrition" companies, as in those that sell on a site such as NutraPlanet, which by the way I happen to like and do buy from albeit produts with no additives.
As for low calorie sweeteners there are many natural to choose from so, "that dog don't hunt". If it would be cheaper for the companies to ad no sweetener at all that would be fine, but then again I am one of those that can drink straight Cissus powder and not bat an eye.
---oh: and cissus can cause headaches & diarrhea. Wasn't that your major complaint vs artificial sweeteners?
I poop blue aliens from the blue raspberry dark rage
Like the color leeks from my poop. I thought I was dying. Then I realized it was just my pre workout
I agree with the notion to rid of food dyes and artificial ****
Second this... artificial sweetener is fine, but stop with the heavy coloring. I don't care if my drink without artificial coloring will be the light brown color of dirty river water or the faint green-grey of stagnant pond water; I'm a big boy, I'm aware of the ingredient profile and fully aware that I'm not drinking contaminated sewage. Do you think the adults drinking your various preworkouts and nootropic blends are children who need to be further coaxed by the comforting sight of atomic blue, neon green or bright crimson?
Please cut the coloring, I don't like pooping red or blue or green and seeing this stuff seep out of my excrement, I don't really care if it's healthy or how many studies you can link proving the safety of artificial colors, I don't like the user experience. Kudos to the many vendors that have already taken steps to meet my needs and the needs of individuals that feel similarly.
You eat/drink with your eyes as well. If the food/drink is not visually appealing, many people will not eat it/drink it. In all actuality, eating/drinking is usualy done with all the senses so the ability to cater for all senses will make the product overall more enjoyable.