NO Infuse is a topical spray.
I hadn't considered using it for joint purposes. I slather on some Icy-Hot before squats, but I may have to give this a go.
I'd imagine the carrier contributes somewhat to the joint-greasing effects too; an alcohol in there maybe, since GH elevation from arginine is systemic.
That would mean you're first getting an analgesic effect from the topical itself followed shortly by a rise in GH and anti-inflammatory action.
At least, that's what I speculate.