Best strategy for long term anti aging

Supercellular

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I'm now in my 40's so beginning to look at a systematic way to delay the aging process, something I never considered much when my focus was muscle gain and fat loss.

With that in mind, what would be the place to start in terms of medications as well as more advanced options out there?

With so many different things to consider (anabolic hormones, fat burning ones, peptides, cognitive function, libido, hair loss etc etc) I'd be interested in knowing how you'd approach this if your goal was to maintain your current state for as long as possible?
 
SFreed

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My opinion, which admittedly may not be the best one, is to forget the anabolics. Some peptides show some promise, and certainly there are some advances being made in regards to cognitive issues. But honestly, keep moving. The older I get (soon to be 54) the more I'm convinced that just continuing an exercise regime is the real key.
 
GreekTheBrick

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Sign me up youngsters! On my 40 feeling younger than ever. And yes Sfeed is right, a man is like a shark, he dies when he stops moving. But thats for show!

I kno TRT is a great option and I am finally on it after a decade of non existent test levels. What else? What peptides will slow down the process and in the meantime they wont put us 6f under, earlier than it is meant to?
 
kenpoengineer

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57 here. I've been interested in anti aging for about 8 years now. So far I've found the following to help:

1) TRT if you need it.
2) Metformin to help reduce the insulin spikes and reduce HBA1C.
3) Vitamin D3 as most of us are deficient
4) Folate and Iodine correction via supplementation.
5) Regular lifting being very aware of injury and tendon/joint health.
 
GreekTheBrick

GreekTheBrick

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57 here. I've been interested in anti aging for about 8 years now. So far I've found the following to help:

1) TRT if you need it.
2) Metformin to help reduce the insulin spikes and reduce HBA1C.
3) Vitamin D3 as most of us are deficient
4) Folate and Iodine correction via supplementation.
5) Regular lifting being very aware of injury and tendon/joint health.
Will look them up, thanks man
 

CatSnake

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fish oil.... I recall Dan Duchaine talking about EFA's in the 90's and didn't pay much attention. now that I'm in my early 40's and have beat up joints, I have to say that I will not go without my fish oil supplementation. helps with my memory, too...

I've dabbled with MK677 and had hoped it would be the poor man's hGH, but I gained a lot of fat/water on it. I might try some low dose Ipamorelin down the road, tho.

optimizing hormone levels would minimize the side effects of aging, too.
 
GreekTheBrick

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fish oil.... I recall Dan Duchaine talking about EFA's in the 90's and didn't pay much attention. now that I'm in my early 40's and have beat up joints, I have to say that I will not go without my fish oil supplementation. helps with my memory, too...

I've dabbled with MK677 and had hoped it would be the poor man's hGH, but I gained a lot of fat/water on it. I might try some low dose Ipamorelin down the road, tho.

optimizing hormone levels would minimize the side effects of aging, too.
Very true for fish oil, Ipamorelin is something that interests me too!
 
The Matrix

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Cell membrane permeability is top priority. Phosphatdytial choline and
NAD IV works wonders on multiple levels. They are like the liquid draino for cells and mitochondrion. With out those hormones will not be utilized to full capacity
 

Mr.TT

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A baby aspirin a day.
Low dose Liposomal Curcumin.
Liposomal Vitamin C.
Great oral hygiene ( oil pulling works well, also use homemade Ionic/colloidal Silver as mouthwash).
High fiber diet. Raw Nuts. Beans. Fruit. Vegetables.
Control Insulin spikes, low glycemic index/load foods,
take in enough salt, it lowers uric acid and insulin resistance,
Check your D3. (get it into the 60-70 range (30-100 lab range))
Low dose Vitamin K2-M7, low dose DHA - EPA fish oil
Stay at (or get to) a good BMI.
Don't SMOKE, (I know this one will bother most of you) Don't Drink Alcohol.
Get 7-8 hours of deep sleep, Exercise (HIIT).
8hour eating/16hour Intermittent Fasting(IF), I play with Ketogenics for 7 day periods.
I reach AUTOPHAGY by Carb and Protein restriction and IF.
AUTOPHAGY will be the next big anti-aging answer!!!!
 
Supercellular

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I forgot I had made this post but thanks for replying.

Thinking on this I see the following issues.

1. Muscle mass is lost and fat gained as you age which even with anabolics (which I wanna avoid) is hard to avoid.
2. Hair loss
3. Sexual potency decline
4. Greying of body hair/hair is annoying
5. Loss of cognitive function is a biggie
6. Age related diseases like enlarged prostate is a problem

Looking at the suggestions above, they are largely dealing with issues using supplements without exploring and treating the underlying genetic problems that cause these types of age related declines.

If we look at pharmaceutical treatments, you can run into issues where fixing one issue can aggravate another (e.g propecia can cause foggy thinking and sexual dysfunction).

What about new, experimental treatments like NSI-189, new wave nootropics like 9-mbc etc?
 
THOR 70

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Everything mentioned is amazing but one thing I think that is more important than we fully understand is sense of purpose and community. Mindset/outlook and living a wholesome life will do a lot for longevity and health. Anyone read the book “outliers” when they speak of the people dying of old age, despite poor diets and lack or working out?
 
Supercellular

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HGH is definitely good but it’s very much only one angle and I’m looking at others.

I’ve seen a lot excitement around NSI-189 and Cycloastragenol lately. Does anyone have much experience with these?
 

Maximiliaan

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I'm 30 but struggle with occasional memory loss, also lately I've been struggling keeping focus. Have just started going back to the gym so I'm looking to get in the best shape of my life. I'm not taking any supplementation currently apart from creatine and protein powder. After reading the above and a little research I'm thinking of starting with Phospotidylserine, fish oil and vitamin d. Will keep you updated if this helps with the memory loss
 

CatSnake

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I'm 30 but struggle with occasional memory loss, also lately I've been struggling keeping focus. Have just started going back to the gym so I'm looking to get in the best shape of my life. I'm not taking any supplementation currently apart from creatine and protein powder. After reading the above and a little research I'm thinking of starting with Phospotidylserine, fish oil and vitamin d. Will keep you updated if this helps with the memory loss
have you had a checkup w/ bloodwork lately?

I have ADD, and have found that cardio really helps keep me mentally sharp... either steady state cardio, HIIT or even just yardwork where I'm moving for a while. (I do still lift, though, because I like it and for the obvious strength/LBM gains)

fish oil and eggs (yolk and white) also have helped me a lot.
 
Supercellular

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I'm 30 but struggle with occasional memory loss, also lately I've been struggling keeping focus. Have just started going back to the gym so I'm looking to get in the best shape of my life. I'm not taking any supplementation currently apart from creatine and protein powder. After reading the above and a little research I'm thinking of starting with Phospotidylserine, fish oil and vitamin d. Will keep you updated if this helps with the memory loss
That seems a bit early for you to experience that. How are you calibrating the level of your memory versus when you are younger (could it be you have a job for example which simply requires you to remember a lot more vs say 10 years ago)? Also, I think it worth adding that one thing I noticed myself is that a lack of sleep, even if only an hr or so, has a big impact on my cognitive function.
 
John Smeton

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Training helps if done creatively and intelligently. If you over-train it causes central nervous system to be depressed, which is a brain foggy, tired out feeling. Its time for a day off and some relaxation then. I like to get relaxation anyways and have been meditating , which helps me quite a bit. There are many factors.
 

edarrin

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hi guys

I'm 59 and have been interested in this for several years. After much reading I have come to the current conclusion that positively manipulating metabolism is the the most promising alternative right now.

Epigenetically altering gene exppresion as much as possible through several (whatever) means.

Currently I exercise (aerobic and anaerobic) , nicotine riboside,Hmb, pqq/co10. Also use MCT and BCAA and do a modified intermittent fasting. Seems to be helping me. Should mention also on TRT. Currently experimenting with some SARMs
 

Testing1234

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Nicotinamide Riboside, pterostilbene, metformin, rapamycin are all being looked into as anti aging medications.
 

edarrin

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HGH is definitely good but it’s very much only one angle and I’m looking at others.

I’ve seen a lot excitement around NSI-189 and Cycloastragenol lately. Does anyone have much experience with these?
I have heard of the use of cycloastragenol for increasing telemerase. I'm sort of 'wait and see' with it due to expense. Not familiar with NSI-189.Like the SARMs I'm experimenting with. Definite recomp in my case which is what I want. I am hoping to see some more detailed studies on their effects on metabolism and myokines. They seem to definitely have potential
 
NoAddedHmones

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HGH is definitely good but it’s very much only one angle and I’m looking at others.

I’ve seen a lot excitement around NSI-189 and Cycloastragenol lately. Does anyone have much experience with these?
Hgh anti-aging?? Using exogenous is deffinitely not what i would call anti-aging lol.

Whats the excitement about nsi-189? It didnt meet endpoints in its clinical trial on major depressive disorder and it doesnt even have a defined mechanism of action.
 
Jag

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Hi I'm 53 and I know this may sound boring but making sure your liver is in tip-top condition is my anti-aging tip. When my liver is working well everything else just seems to fall into place.

Any food or supp isn't going to work like it should if your liver isn't up to scratch. It's the first port-of-call for everything.

Also forget everything you've heard or been told about fat. I won't get scientific but it's really, REALLY good...........sorry, I lied, that was pretty scientific. That's the egg-head in me!!! Of course I must mention there is moderation.........but I don't apply that to MY fat intake.

I have blood test twice a year now and all have been excellent. My doctor doesn't believe me when I tell her how much butter I have. I put Olive Oil on everything.

Nutrition variety is important to. Don't eat the same thing every day. Intermittent fasting has proven to be very beneficial for me.


Do some strength training that you enjoy and can't wait to do.

Stretch often, especially if you are tight, and make sure you have the same Range Of Motion on both sides.

Cardio, for me anyway, is optional but has to be enjoyable. I love getting stuck into the heavy bag or cycling as fast as I can for a few minutes if I have too much energy, but that's not often these days and definitely NOT a priority. I just do weights with less rest or higher reps as cardio. Do 3-5 sets of heavy dumbbell rows, for example, with little rest between sets and try and have a conversation.

An Activated Vitamin B-Complex, especially in stressful times, helps...but also optional.

So does regular massage.

I've yet to find a supp that has had so much of an impact that I would include it as an "anti-aging must have" and I used to love "experimenting".

Socialise and enjoy life for what it is. Revel in your good health.

Don't focus on negative crap if it doesn't directly concern you or you have any control over. You should be focusing on what is going on in your life and improving that.....if it needs improving. You should know by now that life is short.

And when life is good I love helping people in some way. It's very satisfying.
 
trtdoc

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TRT and peptides in regards to compounds. Will need appropriate diet, nutrients-exercise
 
UCSMiami

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Eat reasonably healthy, be happy, plenty of sex, A good strength program, HIIT for cardio, rest well. Check your endocrine system to ensure hormones are within range.

That is about it unless you want to invest in more. Frankly the above is enough especially a 7 day workout program incorporating weights and Hiit on separate days.
 

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