Most age-related losses derive from multiple mini-strokes over many years. My father experienced that and I aimed to avoid it
First make sure that blood pressure and cholesterol are under control. Recently targets for both have been reduced. ACEIs, ARBs and some CCBs show significant reduction in these events. So do statins for cholesterol. The lipid-soluble versions in each drug class seem more effective but also seem to have more side effects.
Men benefit from alpha blockers because some like doxazosin help BPH and ED while reducing blood pressure. The same is true for the inexpensive ARB losartan which also helps with ED. I tolerate the maximum recommended doses of 8mg and 100mg.
Women are quite sensitive to CCBs. The normal starting dose of amlodipine is 10mg for men but 5mg for women. I experienced ankle edema at 10mg and dropped to 5mg. The combination resulted in 110/70 and LDL of 30. Low doses of multiple drugs are preferred and your mother would find a different mix.
Go next for nutrients that have improved cognitive function (as much as 20 IQ points) in repeated trials, 5gr creatine and 2gr taurine.
Having tried those nootropics and many others, save them for last as benefits are not reliable and side effects more probable.