I’m not stupidbut please DONT use any additional discount codes, that is absolutely not allowed.
I’m not stupidbut please DONT use any additional discount codes, that is absolutely not allowed.
I need to pick up some more amnes1a myself, been trying to hold off getting any more CU until nutriverse come back around, hopefully. That BOGO was a sweet dealI just ordered two more bottles of AMNES1A yesterday....keeping the run going! I actually bought way too many other things as well. All necessities though...including 2 tubs of CU. I am not quite sure how long I will still be able to obtain that....had to grab some!
Yeah...I was holding out as well...I need to pick up some more amnes1a myself, been trying to hold off getting any more CU until nutriverse come back around, hopefully. That BOGO was a sweet deal
I do know that use of a Melatonin is not advised with an MAOI or SSRI. However, I believe Bupropion(Wellbutrin) is an NRDI and a bit different. A quick search didn’t list any specific interactions but further research is needed. I would pose this question to a Pharmacologist.Anyone know if any of the ingredients might negatively interact with bupropion? I'd love to give Amnes1a a try (wake multiple times each night and have averaged 4-5 hours of sleep a night over the last few years). My doctor isn't very knowledgeable when it comes to supplements, so can't really get a good answer there. However, I would understand if this is a question that a rep (or anyone else) might be leery of answering.
Thanks, I appreciate the response. I'll try to find a pharmacologist to ask.I do know that use of a Melatonin is not advised with an MAOI or SSRI. However, I believe Bupropion(Wellbutrin) is an NRDI and a bit different. A quick search didn’t list any specific interactions but further research is needed. I would pose this question to a Pharmacologist.
Cool. There’s a few on here. Can’t remember exactly who. 2kvette might be in that field IIRC?Thanks, I appreciate the response. I'll try to find a pharmacologist to ask.
Hey, bupropion works through dopamine and norepi reuptake inhibition. Human receptor binding shows 5-HT receptor inhibition at around 2%. So 5-HT supplements are not likely to be a big deal. Now, this stuff has a lot of herbal products in it which are very difficult to find receptor binding assays on. So I can't speak to what the effects of each ingredient would be without really doing some in depth research on substances that may or may have not been appropriately studied.Anyone know if any of the ingredients might negatively interact with bupropion? I'd love to give Amnes1a a try (wake multiple times each night and have averaged 4-5 hours of sleep a night over the last few years). My doctor isn't very knowledgeable when it comes to supplements, so can't really get a good answer there. However, I would understand if this is a question that a rep (or anyone else) might be leery of answering.
Thanks for the info. I'll read up more on all the ingredients to make sure there are no interactions. Unfortunately, the problem isn't the Bupropion as I just started taking it a couple months ago and have had issues with sleep for years (no better, no worse since starting Bupropion). However, if I do take the second dose (150 mg sr) in the afternoon, then sleep is definitely worse (which is why I stick with just a single morning dose).Hey, bupropion works through dopamine and norepi reuptake inhibition. Human receptor binding shows 5-HT receptor inhibition at around 2%. So 5-HT supplements are not likely to be a big deal. Now, this stuff has a lot of herbal products in it which are very difficult to find receptor binding assays on. So I can't speak to what the effects of each ingredient would be without really doing some in depth research on substances that may or may have not been appropriately studied.
BUT! I will say this, the buproprion is likely whats keeping you awake at night. It's one of the most common side effects, and I almost expect everyone who is on it to experience it in some form.
Try a quarter of a doxylamine and cut stims and coffee. Could be stress too; don’t go for ambien. It looses effects after two weeks man.Thanks for the info. I'll read up more on all the ingredients to make sure there are no interactions. Unfortunately, the problem isn't the Bupropion as I just started taking it a couple months ago and have had issues with sleep for years (no better, no worse since starting Bupropion). However, if I do take the second dose (150 mg sr) in the afternoon, then sleep is definitely worse (which is why I stick with just a single morning dose).
Thank you for the suggestions. Have been taking 12.5-25 mg benadryl many nights (which helps some) but will check out doxylamine. Also, I don't take stims...can't tolerate them. Will stay clear of ambien (mom and brother take it and both have commented on it not working as well over time and other issues). Thanks again.Try a quarter of a doxylamine and cut stims and coffee. Could be stress too; don’t go for ambien. It looses effects after two weeks man.
I use SLEEP AID from Cosco, I think Kirkland is the brand, once in awhile and I always get deep sleep from it no matter how much I been overdosing on stim. Only problem is that if you don’t give you enough hours to sleep you wake up feeling groggy.Thank you for the suggestions. Have been taking 12.5-25 mg benadryl many nights (which helps some) but will check out doxylamine. Also, I don't take stims...can't tolerate them. Will stay clear of ambien (mom and brother take it and both have commented on it not working as well over time and other issues). Thanks again.
You’re lucky to respond well to that. Doxylamine Succinate doesn’t help me at all. Diphenhydramine does well for a week or so bit leaves grogginess for me.I use SLEEP AID from Cosco, I think Kirkland is the brand, once in awhile and I always get deep sleep from it no matter how much I been overdosing on stim. Only problem is that if you don’t give you enough hours to sleep you wake up feeling groggy.
Yeah, that's the problem I have when taking benadryl. I don't get enough hours due to what's become normal insomnia and kids waking me when I do finally fall asleep. So, I'm always groggy when I do wake up. L-theanine helps too but no matter what I take, I'll still wake up 2 or 3 hours later and have trouble getting back to sleep. I have to then take more stuff to knock me out again...which carries into the next morning causing grogginess. That's why I'm looking at Amnes1a. Seems like a great formula that should help with the quality of sleep I get (even when woken multiple times by the kids). Just want to be careful with any possible interaction with my meds.I use SLEEP AID from Cosco, I think Kirkland is the brand, once in awhile and I always get deep sleep from it no matter how much I been overdosing on stim. Only problem is that if you don’t give you enough hours to sleep you wake up feeling groggy.
Yeah, kids are great but they do not help with sleep...Yeah, that's the problem I have when taking benadryl. I don't get enough hours due to what's become normal insomnia and kids waking me when I do finally fall asleep. So, I'm always groggy when I do wake up. L-theanine helps too but no matter what I take, I'll still wake up 2 or 3 hours later and have trouble getting back to sleep. I have to then take more stuff to knock me out again...which carries into the next morning causing grogginess. That's why I'm looking at Amnes1a. Seems like a great formula that should help with the quality of sleep I get (even when woken multiple times by the kids). Just want to be careful with any possible interaction with my meds.
You’re lucky to respond well to that. Doxylamine Succinate doesn’t help me at all. Diphenhydramine does well for a week or so bit leaves grogginess for me.
It’s actually the opposite.That’s why I like doxylamine over Benadryl. Clears the system faster, so less grogginess. Makes you cinstipsted if you take it a lot though.
Not really, they’re about the same. But diphenhydramine seems to be more susceptible to genetetic polymorphism in p450’s. Especially with 2D6. That’s why the half life ranges is so wild, from 2hr to 18hr. I haven’t seen as many people complain of doxylamien making them groggy.It’s actually the opposite.
That wasn’t your original statement. Clinically and according to the literature, it’s widely accepted that doxylamine has a longer pk clearance across the board. The range does vary for DPH, but it’s taken into account in the range and median t1/2 information.Not really, they’re about the same. But diphenhydramine seems to be more susceptible to genetetic polymorphism in p450’s. Especially with 2D6. That’s why the half life ranges is so wild, from 2hr to 18hr. I haven’t seen as many people complain of doxylamien making them groggy.
If I don’t give myself enough hours Benadryl still makes me groggy.That’s why I like doxylamine over Benadryl. Clears the system faster, so less grogginess. Makes you cinstipsted if you take it a lot though.
Did some deep digging. You sir are correct!!!That wasn’t your original statement. Clinically and according to the literature, it’s widely accepted that doxylamine has a longer pk clearance across the board. The range does vary for DPH, but it’s taken into account in the range and median t1/2 information.
No problem brother, everyone is here to learn from each other. No matter what sleep aid someone picks, there will always be a high stim preworkout to kick them back into gearDid some deep digging. You sir are correct!!!
Now, aside from 2D6 variance, I have seen far more people complain of benadryl keeping them foggy than doxylamine. Perhaps Benadryl has an active metabolite that last far longer.
So that's seven hours of sleep? Since you started using it, have you gone to bed earlier than usual?Alright so I have used this for over 2 weeks , 1to 2 hours before sleep I go to bed around 2 or 1 am , I sleep deep then out of nowhere I wake up alert around 6 am thinking it’s time to get up , but at the same time I’m tired af obviously... I though that would stop but not really.
I’m taking full dose and not sure wtf is going on and now I’m starting to feel tired more and more, maybe if I’m going to bed around 11 that would work best for me I don’t know man . I have another bottle lol n I hate wasting money.
That sucks. I loved my bottle and would have bought more if my wife didn't crack down. In her defense, I have a baby on the way and we are closing on a house. Lol. I have to cut down to just the absolutely necessary supps, so I have reverted to the sleep aid I was using (got it on B0G0), Midnight Dream. which has phenibut. It helps me sleep, but I feel like crap in the morning. AMNES1A blew it away. :/Alright so I have used this for over 2 weeks , 1to 2 hours before sleep I go to bed around 2 or 1 am , I sleep deep then out of nowhere I wake up alert around 6 am thinking it’s time to get up , but at the same time I’m tired af obviously... I though that would stop but not really.
I’m taking full dose and not sure wtf is going on and now I’m starting to feel tired more and more, maybe if I’m going to bed around 11 that would work best for me I don’t know man . I have another bottle lol n I hate wasting money.
nah always late , but I don’t get 7 hours of sleep , maybe I need to take lessSo that's seven hours of sleep? Since you started using it, have you gone to bed earlier than usual?
I think this is a good plan to try next. I have been sticking with 3 about a hour before bed time, 4 just seemed to be too much for me.I’ll take 2 tonight instead of 4 caps n see
I’d do 2 caps for 2-3 nights and adjust your timing. You will adapt quickly and be ready for 4 caps. Or you’ll be lucky and only need 2 caps which would double the valueGot my Amnesia in yesterday...took 4 caps an hour before bed and really FELT the effects at the 30min mark...but ended up laying in bed all night with zero sleep, feeling a bit sedated though. I plan to play around with the timing and dosage...Since for me it kicked in so fast, would taking it 30mins before lights out be best? I know that some people on this thread say that it takes a few nights to really work for them, wondering if i should stick with 4 caps for a week or lower the dosage tonight?
Yeah ill try just 2 caps tonight, maybe only 30mins before bed (at lights out time)?I’d do 2 caps for 2-3 nights and adjust your timing. You will adapt quickly and be ready for 4 caps. Or you’ll be lucky and only need 2 caps which would double the value
Did you notice the sedating/relaxation effects the first time you dosed it? Even if it didn't really help you actually sleep...I didnt notice much at first either. However, i have tweaked how i use it, and it works great now. Like i am waking before my alarm feeling great, and i NEVER do that.
What i did is upped my dose to 6 pills (expensive i know, but cheaper than any pharmaceutical route that doesnt fuk your sleep quality) and titrated my the pills out. I take 2 pills about an hour and 30 minutes before bed, then 2 pills about 30 minutes before bed, and 2 pills right as i lay down to sleep. Still takes me about 45 minutes to fall asleep, but thats WAY better than my normal 2-3 hours to fall asleep (and sometimes not at all).
No. No herbal has ever done that. Hell even Xanax does not do that to me.Did you notice the sedating/relaxation effects the first time you dosed it? Even if it didn't really help you actually sleep...
Its interesting to hear that food doesn't seem to have much effect when you take this...empty stomach or full. With Kratom for example, some will take it with a full stomach and it wont work at all, for me at least its best taken on a completely empty stomach. I guess Kanna is different...No. No herbal has ever done that. Hell even Xanax does not do that to me.
I started 4 caps about an hour before bed without too much effect. Then I switched to 2 caps about 45 minutes prior to bed and was out like a light. Not sure why but that’s my sweet spot.Got my Amnesia in yesterday...took 4 caps an hour before bed and really FELT the effects at the 30min mark...but ended up laying in bed all night with zero sleep, feeling a bit sedated though. I plan to play around with the timing and dosage...Since for me it kicked in so fast, would taking it 30mins before lights out be best? I know that some people on this thread say that it takes a few nights to really work for them, wondering if i should stick with 4 caps for a week or lower the dosage tonight?
Thisi wouldnt use melatonin during daytime, no matter what dose
I have and it messed up my nighti wouldnt use melatonin during daytime, no matter what dose
Ah i see. Maybe ill look in to buying just Kanna, ive heard depending on the dosage it can be either uplifting or sedating...might be perfect for daytime anxiety. Which Im full of all the damn time! Kratom helps but after years of use (and with extracts) my tolerance is high. Kanna might be the next herb i look to...I have and it messed up my night
I took my first bottle of Amnesia at 4 caps and the effect never diminished. Perhaps the onset of drowsiness lessened a bit but not much. Then I ran out for two weeks. When I hopped back on it I decided to try 2 caps and the effect was nearly as good. That’s what I’ve been using for about a month and half now to good effect. The full dose was almost overkill for me. The drowsiness onset might diminish but the sleepquality seems to get better the longer I take it. I’ve supplemented with 3-10 mg of melatonin for many years and have always maintained high natural test levels but I do plan to take 2-4 weeks off amnesia after 2-3 months.Hey guys,
Just purchased amnes1a. Been having a real rough time sleeping lately, seriously affecting my study and work.Takes me ages to get to sleep and then wake up at 1-3am feeling real hot and restless, then have trouble getting back to sleep. Tossing and turning all night.
I've used magnesium and melatonin pre bed before (both seperately) and I have a paradoxical reaction to both, find myself strangely wired all night. Was a bit wary to try amnes1a but gave it a shot. Anyway, popped 4 caps of amnes1a the last 2 nights and had a great sleep both nights, first good night sleeps in at least 2 weeks. Love it! Just a couple of questions though:
Will amnes1a's effects diminish over time?
& will taking 3mg melatonin nightly effect endogenous production?
Thanks!
All users reported the same: Amnes1a is nothing like plain melatonin.Hey guys,
Just purchased amnes1a. Been having a real rough time sleeping lately, seriously affecting my study and work.Takes me ages to get to sleep and then wake up at 1-3am feeling real hot and restless, then have trouble getting back to sleep. Tossing and turning all night.
I've used magnesium and melatonin pre bed before (both seperately) and I have a paradoxical reaction to both, find myself strangely wired all night. Was a bit wary to try amnes1a but gave it a shot. Anyway, popped 4 caps of amnes1a the last 2 nights and had a great sleep both nights, first good night sleeps in at least 2 weeks. Love it! Just a couple of questions though:
Will amnes1a's effects diminish over time?
& will taking 3mg melatonin nightly effect endogenous production?
Thanks!
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