11-oxo

So 11-oxo is the same exact thing as 3AD, just dosed differently. Well, dosed lower. The effects of dosing it lower are mostly anti-estrogen and anti-cortisol. The effects of dosing it higher are more anabolic.

But it will be able to same price per bottle. The 3AD will have more of the compound per pill and the 11-oxo will have less. I am not sure which will have more pills per bottle and which will cost less per bottle.

Am I getting the correct? I just popped back into the whole thing and I'm trying to get the facts straight.
 
PumpingIron said:
So 11-oxo is the same exact thing as 3AD, just dosed differently. Well, dosed lower. The effects of dosing it lower are mostly anti-estrogen and anti-cortisol. The effects of dosing it higher are more anabolic.

But it will be able to same price per bottle. The 3AD will have more of the compound per pill and the 11-oxo will have less. I am not sure which will have more pills per bottle and which will cost less per bottle.

Am I getting the correct? I just popped back into the whole thing and I'm trying to get the facts straight.
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...
Eightpak said:
I would believe so.

Ergo: 60 caps @ 75mg/cap x 6 caps/day = 450mg/day
60/6 caps=10 day supply

AX: 90 caps @ 150mg/cap x 3 caps/day = 450mg/day
90/3 caps=30 day supply

Both about the same price from what I hear.
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Gee, now I really don't know about this product. In the 3AD thread that was first started they were saying it was comparable to injectible test. A little bit later the tester threads were saying its a good cutting compound. Now its being described as an anti-cortisol supplement at normal doses and an anabolic ph at high doses. That brings up another question...With other anti-cortisol supps you are not supposed to go that high because you want to lower cortisol that completely get rid of it. Also at higher doses anti-cortisol products will cause joint problems and aches and pains....This product to me now really has some questions to it. I guess I'll wait and see what happens with everyone that purchases it first. As for me, now I don't know about this ph/anti-cortisol "supplement"..
 
T-Bone said:
Gee, now I really don't know about this product. In the 3AD thread that was first started they were saying it was comparable to injectible test. A little bit later the tester threads were saying its a good cutting compound. Now its being described as an anti-cortisol supplement at normal doses and an anabolic ph at high doses. That brings up another question...With other anti-cortisol supps you are not supposed to go that high because you want to lower cortisol that completely get rid of it. Also at higher doses anti-cortisol products will cause joint problems and aches and pains....This product to me now really has some questions to it. I guess I'll wait and see what happens with everyone that purchases it first. As for me, now I don't know about this ph/anti-cortisol "supplement"..
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this is not your typical "anti-cortisol" supplement

11-OXO is the first cortisol modulator that is selective for 11beta-hydroxysteroid dehydrogenase type 1 reductase

what this means is that it only reduces 11beta-HSD1r dependent cortisol level. it does not affect cortisol level in the blood

i have not come across any literature suggesting that 11beta-HSD1 is present in connective tissue and neither has patrick

as far as anabolic/androgenic activity, i don't know what to tell you
 
I am curious how exactly the "Supplement Facts" label will be written. Because any "Andro" prefix will make it risky when trying to get through Canada customs.

Assuming they open it.
 
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11-OXO SOUNDING OFF, SIR!!!
 
Finishing off a 6OXO/Activate/Tribosten cycle...
can I roll right into the 11-OXO?

Also, how long a 11-OXO cycle is suggested?
 
T-Bone said:
Can you explain this in lamens terms?




This part also.
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basically 11beta-HSD1r is an enzyme that converts the inactive cortisone into the active cortisol in muscle, fat, liver and some parts of the brain. under normal conditions, there is a lot more cortisone in the blood than cortisol so the cortisol level in the aforementioned tissues is highly dependent on 11beta-HSD1r

under stress however, cortisol level in the blood spikes and is free to go wherever which is good because acute cortisol is lipolytic and also plays a major role in muscle growth. chronic cortisol however is lipogenic and plays a major role in muscle atrophy (shrinkage)

11-OXO selectively inhibits 11beta-HSD1r so that it cannot supply those tissues with all of that bad chronic cortisol. by selective i mean it does not inhibit 11beta-HSD1 dehydrogenase which is responsible for converting the active cortisol into the inactive cortisone which is a good thing. it also does not affect 11beta-HSD2 which, when inhibited, causes bad sodium and water retention by reducing cortisol in the kidneys
 
Cordeen said:
I am curious how exactly the "Supplement Facts" label will be written. Because any "Andro" prefix will make it risky when trying to get through Canada customs.

Assuming they open it.
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it says 11-OXO with adrenosterone in parenthesis
 
How do I know what dose to take?
I am 5'9 and 175 lbs

Also, what is best time to take doses and do you split doses or all at once?
 
Rushi said:
under stress however, cortisol level in the blood spikes and is free to go wherever which is good because acute cortisol is lipolytic and also plays a major role in muscle growth. chronic cortisol however is lipogenic and plays a major role in muscle atrophy (shrinkage)
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Now, in this modern society full of noise pollution, crime, toxins, competition for dwindling resources, high taxes, bills, etc would we think there could possibly be a problem with chronic high-levels of cortisol?
 
RHB31 said:
How do I know what dose to take?
I am 5'9 and 175 lbs

Also, what is best time to take doses and do you split doses or all at once?
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start with 3 caps daily and take it from there

take with food in the morning and post workout
 
dsade said:
Now, in this modern society full of noise pollution, crime, toxins, competition for dwindling resources, high taxes, bills, etc would we think there could possibly be a problem with chronic high-levels of cortisol?
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I think you are really paranoid,




Sorry I am addicted to posting youtube clips.
 
dsade said:
Now, in this modern society full of noise pollution, crime, toxins, competition for dwindling resources, high taxes, bills, etc would we think there could possibly be a problem with chronic high-levels of cortisol?
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don't forget crazy women
 
Rushi said:
start with 3 caps daily and take it from there

take with food in the morning and post workout
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Can you slow or reduce the cortisol release from cardio. In other words could I use it with lower calories and a large amount of cardio without losing muscle?. Taking it pre-cardio?. Or would it matter when I took it?.
 
Rushi said:
don't forget crazy women
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Try as we might, can we possibly forget crazy women?

Which brings up yet another cause of elevated cortisol...alcohol anyone?
 
I browsed the 11 Oxo thread on the bb.com forums, but there's more stupid in that thread than at a flat worlder's convention. Can anybody copy/paste some literature and/or science on this beast? of a compound?
 
this is being put out with zero beta testing so i dont hink youll see any blood values until this has been out a month or so... if even that. although its unmethylated aso expect it will be VERY mild on the body.
 
poopypants said:
this is being put out with zero beta testing so i dont hink youll see any blood values until this has been out a month or so... if even that. although its unmethylated aso expect it will be VERY mild on the body.
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I think Kev and the AX boys might have been getting bloodwork done.
 
Now On Presale At "The Planet"!!!

So everyone wants 11-OXO, eh? Well, then come and get it!!!

11-OXO is now on presale and it will be available for shipment by Monday, the 21st! This product is in VERY HIGH DEMAND! Therefore, now is your chance to jump on the bandwagon, while there is still room for the ride!

Invalid Link Removed

Invalid Link Removed

ERGOPHARM proudly introduces 11-OXO™, the first selective inhibitor of 11-hydroxysteroid dehydrogenase type I reductase.

Finally, cortisol control that delivers on the promises.

ERGOPHARM has found the key to obtaining:

• Decreased bodyfat (especially visceral adipose tissue)

• Increased muscle density (hardness)

• Enhanced insulin sensitivity and glycogen deposition

• Increased strength

• Improved brain and CNS function

Ergopharm started the prohormone era... Welcome to day one of the SCM era!
 
Since it is touted as an incredible fat burning PH...
still need to do Cardio with it, or is Diet and Weights good enough?
 
RHB31 said:
Since it is touted as an incredible fat burning PH...
still need to do Cardio with it, or is Diet and Weights good enough?
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I think thats more of a personal choice. Some people are big believers in cardio, others...not so much. I believe you can lose fat without cardio. As long as your lowering your calories enough. If you add cardio it will come off faster, but its not a requirement. I like cardio, its just how much and what kind you have to worry about, or choose. I don't know of any company yet though who has claimed "cardio in a bottle"....
 
True.
Want to keep/build muscle and if this burns fat, don;t want to overburn other things...like muscle
 
I'll bet you could run a mean Epistane, Formestane, 11-oxo pulse for one hell of a cutting cycle... hrm...
 
Great...we got the word that initial quantities are limited for each location. Presale numbers are already off the charts.

Expect these to ship by Friday or Monday, and then we will probably be sold out until the second shipment.
 
T-Bone said:
Can you slow or reduce the cortisol release from cardio. In other words could I use it with lower calories and a large amount of cardio without losing muscle?. Taking it pre-cardio?. Or would it matter when I took it?.
Click to expand...

11-OXO does not affect natural cortisol release. it only affects 11beta-HSD1 reduction of cortisone

because of this, timing is not that important
 
dsade said:
Great...we got the word that initial quantities are limited for each location. Presale numbers are already off the charts.

Expect these to ship by Friday or Monday, and then we will probably be sold out until the second shipment.
Click to expand...

Well, I just placed my order...
 
Rushi said:
correct

11beta-HSD1r expression is not present in the hypothalamus of the human brain
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i should clarify that it is 11beta-HSD1r upregulation and/or stimulation of corticotropin-releasing hormone (CRH) that we are worried about when it comes to modulating cortisol

no need to worry about this with 11-OXO
 
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