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11-oxo concentrations / half life?

Boris

New member
11-oxo starts off as adrenosterone, which itself is active in the body, primarily modulating the effects of cortisol.

One of the metabolites of adrenosterone is 11-oxotestosterone, AKA 11-ketotestosterone, and this is an androgen.

What I would like to know is:
- How long after taking 11-oxo does the maximum effect of the adrenosterone occur?
- What is the half life of adrenosterone?
- How long after taking 11-oxo does the maximum plasma concentration of 11-oxotestosterone occur?
- What is the half life of 11-oxotestosterone in the human body?

I'm thinking that this information will help in working out timing options relative to workouts to get maximum effect, and whether pulsing of an anabolic dose would be effective or not. Of course, the information might not be available, the searching I did just now revealed a lot of research on 11-oxotestosterone in fish rather than humans.
 
Boris said:
11-oxo starts off as adrenosterone, which itself is active in the body, primarily modulating the effects of cortisol.

One of the metabolites of adrenosterone is 11-oxotestosterone, AKA 11-ketotestosterone, and this is an androgen.

What I would like to know is:
- How long after taking 11-oxo does the maximum effect of the adrenosterone occur?
- What is the half life of adrenosterone?
- How long after taking 11-oxo does the maximum plasma concentration of 11-oxotestosterone occur?
- What is the half life of 11-oxotestosterone in the human body?

I'm thinking that this information will help in working out timing options relative to workouts to get maximum effect, and whether pulsing of an anabolic dose would be effective or not. Of course, the information might not be available, the searching I did just now revealed a lot of research on 11-oxotestosterone in fish rather than humans.
Click to expand...


since its closely related to the other andros i would expect its pharmacokinetics to be similar. so you would probably see peak blood levels about 60 minutes after ingestion and then a decline until you are back down close to baseline levels 4 to 5 hours later.

both adrenosterone and its metabolite 11-oxotest should follow this concentration curve
 
Patrick Arnold said:
since its closely related to the other andros i would expect its pharmacokinetics to be similar. so you would probably see peak blood levels about 60 minutes after ingestion and then a decline until you are back down close to baseline levels 4 to 5 hours later.

both adrenosterone and its metabolite 11-oxotest should follow this concentration curve
Click to expand...

Hey PA,

If you wanted to get maximum anti-cortisol effect from 11-oxo what would be an optimal dosing scheme? If cortisol levels are highest when getting up in the morning would it be beneficial to take a larger dose then and smaller doses every 4-5 hours after that? For example say 3 caps@8:00, 2 caps@12:00, 1 cap@16:00 and maybe 1 or 2 caps or so after workout?

Thanks!!
 
Patrick Arnold said:
since its closely related to the other andros i would expect its pharmacokinetics to be similar. so you would probably see peak blood levels about 60 minutes after ingestion and then a decline until you are back down close to baseline levels 4 to 5 hours later.

both adrenosterone and its metabolite 11-oxotest should follow this concentration curve
Click to expand...
Thanks, very interesting - certainly explains why even high doses would be mild in terms of shutdown.

I haven't received my bottles of 11-oxo yet, so don't know what the dosing advice on the label is, but from what you said, would it make sense to take the daily dose of 3 caps around a workout as 1 an hour before, 1 immediately before, and 1 immediately after? I'm thinking here in terms of maximising the effect of the 11-oxotest.
 
Boris said:
Thanks, very interesting - certainly explains why even high doses would be mild in terms of shutdown.

I haven't received my bottles of 11-oxo yet, so don't know what the dosing advice on the label is, but from what you said, would it make sense to take the daily dose of 3 caps around a workout as 1 an hour before, 1 immediately before, and 1 immediately after? I'm thinking here in terms of maximising the effect of the 11-oxotest.
Click to expand...

^^ curious too.

Also - are there any hepatototix effects associated with 11-oxo, 3-ad (and/or any of its metabolites for when considering long term or high quantity dosing). Thanks
 
1HP said:
Hey PA,

If you wanted to get maximum anti-cortisol effect from 11-oxo what would be an optimal dosing scheme? If cortisol levels are highest when getting up in the morning would it be beneficial to take a larger dose then and smaller doses every 4-5 hours after that? For example say 3 caps@8:00, 2 caps@12:00, 1 cap@16:00 and maybe 1 or 2 caps or so after workout?

Thanks!!
Click to expand...

Hmm I thought max anti-cortisol actually occurred at lower doses, i'm interested to hear PAs answer. I would have thought a 2@wakeup, and 1 - 2 @ pre-bed would be it, but thats just a wild guess
 
1HP said:
Hey PA,

If you wanted to get maximum anti-cortisol effect from 11-oxo what would be an optimal dosing scheme? If cortisol levels are highest when getting up in the morning would it be beneficial to take a larger dose then and smaller doses every 4-5 hours after that? For example say 3 caps@8:00, 2 caps@12:00, 1 cap@16:00 and maybe 1 or 2 caps or so after workout?

Thanks!!
Click to expand...


i can't really answer this question and i also can't say whether its advantageous or not to overblock the morning cortisol spike
 
Boris said:
Thanks, very interesting - certainly explains why even high doses would be mild in terms of shutdown.

I haven't received my bottles of 11-oxo yet, so don't know what the dosing advice on the label is, but from what you said, would it make sense to take the daily dose of 3 caps around a workout as 1 an hour before, 1 immediately before, and 1 immediately after? I'm thinking here in terms of maximising the effect of the 11-oxotest.
Click to expand...


i dunno whether having high levels of androgen specifically around the time of the workout is that critical. From a CNS perspective it might be, but as far as muscle metabolism goes probably not as much (since the muscle effects require gene expression and gene expression effects are not immediately manifested)

i think the most important thing is to take it with food
 
EasyEJL said:
Hmm I thought max anti-cortisol actually occurred at lower doses, i'm interested to hear PAs answer. I would have thought a 2@wakeup, and 1 - 2 @ pre-bed would be it, but thats just a wild guess
Click to expand...


maximum SELECTIVITY of anti-cortisol effects versus hormonal effects occurs at lower dosages
 
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