Myostatin Peptide,Could DOUBLE your MUSCLE!!

Patrick Arnold said:
yeah right

anyway, one of the most exciting prospects for these newly advanced gene therapies is the possbility for targeting specific bodyparts. a researcher described this in a recent article in scientific american magazine

lets say you were a runner who needed more mass in your legs specifically. they could tie off your blood supply from your femoral artery and whatever the main vein is their on both your legs and recirculate the blood while adding in the gene modified adenovirus. then after a washout period you patch them up and you end up with someone with the anabolic gene modified leg muscles
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That does sound quite interesting,I'm really looking forward to seeing these type advances in our lifetime,this and the entire approach to life sciences/extension in general,there are already alot of advances in HRT,TRT,HGH therapy,etc...and now with this type of gene therapy I think we are just beginning to see the light.
 
Sub7 said:
the ones that work, as opposed to egg yolk derived follistatin or the ones in BS supplements.
Click to expand...
:toofunny: Lol,patrick runs his own supp company,he might take offense to that one,although I know we all agree that, that stuff is BS for sure;),too bad gene therapy doesn't come in a bottle for $26.95...if only it were that simple.:frustrate
 
getswole said:
:toofunny: Lol,patrick runs his own supp company,he might take offense to that one,although I know we all agree that, that stuff is BS for sure;),too bad gene therapy doesn't come in a bottle for $26.95...if only it were that simple.:frustrate
Click to expand...

If Patrick wants to manufacture a myostatin blocker I am up for trying it. He has said that there is no such chance because it wouldn't qualify as a supplement. Why not? Follastatin (spelling?) is found in fertilized egg yolks, no? If there was a way to produce it in sufficient quality at a reasonable price, would it not potentially qualify as a supplement?
 
Sub7 said:
If Patrick wants to manufacture a myostatin blocker I am up for trying it. He has said that there is no such chance because it wouldn't qualify as a supplement. Why not? Follastatin (spelling?) is found in fertilized egg yolks, no? If there was a way to produce it in sufficient quality at a reasonable price, would it not potentially qualify as a supplement?
Click to expand...
well as you read through this thread,just orally there is nothing to date that can produce profound,and seeing as its peptide/protien based at this point these particulars probably never will be an oral app...after all this isn't some igf or hgh,.this is some serious sh1t,hence the serious price and not so much availability,this stuf is one of the tightest things I've seen as for getting your hands on,not to even mention the cost...theres planty of BS myo-this myo-thats supps at your local GNC's if you really wanna drop the cash,but they're BS just as you mentioned
 
getswole said:
after all this isn't some igf or hgh,.this is some serious sh1t,hence the serious price
Click to expand...

This (the serious results produced by the compound) shouldn't really determine the price so much. With the degree of competition, I think, if production was feasible, price would come down.

Also, in the other thread, it sounded like the egg yolks constituent that has the capability to block mysotatin was going to be orally available and bioactive. I understand that the ingredient has not yet produced results for anyone but pretty much everyone including PA were in agreement that the oral compound was scientifically feasible -at least as of now and on paper. Maybe I misunderstood...?
 
Not being a downer, The future is zuper zexy but I live in the here and now baby, so give it to me nowwwwwwww!

Much Love,

Neoborn
 
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Gixxer82 said:
that would be the balls. But on the same page, then anyone could get relatively big. Then it wouldn't be "special" anymore to be above and beyond average because it would be achievable for anyone. We all work hard for our bodies. Thinking about it, I would rather this stuff never come out.
Click to expand...

Yeah but imagine a world where everybody was freaking ripped like spartans. Now, think about this, what if the US was the only country that develped this and blocked its export? Imagine everyone in the entire country being ripped as hell while people in other countries being normal. We would be a society of rediculously good looking people that would rip people from anywhere else in half with our pinky fingers. sounds awesome to me!
 
brywal312 said:
Now, think about this, what if the US was the only country that develped this and blocked its export? Imagine everyone in the entire country being ripped as hell while people in other countries being normal. We would be a society of rediculously good looking people that would rip people from anywhere else in half with our pinky fingers. sounds awesome to me!
Click to expand...
Sounds familiar,oh yeah,HITLER...lol,hitler was juicing his troops to the gills w/ test,this was a breakthrough at the time,test had just been synthesized if I am correct,I forget the specifics... besides the whole white power arian nation deal,Hitler juicing his troops was some serious sh1t at the time,Actually Hitler was a pretty smart dude and was quite ahead of his time,there were some kinks in his plan;)but just imagine if Hitler would have had the technology of the here/and now,with all the cutting edge gene doping breakthrough's/cloning/...I bet he'd a had his scientist all over this myostatin sh1t...we'd all be fvcked,we'd be fightin' some cloned/neg-myo gene having/nazi's /w/o nerve endings,looking like some monsters outta Gears of War or some sh1t,,,,w/ 10 livers and 4 sets of kidneys and eating bowlz of dbol's for breakfast and straight test runnin' through there veins instead of blood,...:box:

Hope I didn't come off all pro-hitler there for a second..:study:

I mean just Imagine,george Bush releasing a press anouncment stating he has teamed up online w/ the AM member "GetSwole" and will be now juicing our soldiers with 10g of gear a week per getswole's advice and will now be putting a stop to the use of guns in the military and instead replacing them with Rambo Knifes and Icepicks and giving pep talks to the troops saying Osama is fvckin' your chick...you know they'd find him and rip him apart in a week;)
 
Sub7 said:
The ones discussed in this thread thus far, costing thousand plus $ per mg. I.e. the ones that work, as opposed to egg yolk derived follistatin or the ones in BS supplements.
Click to expand...

research chems of that sort always cost an inordinate amount of money. until (and if) they are ever manufactured "en masse" that is
 
Sub7 said:
If Patrick wants to manufacture a myostatin blocker I am up for trying it. He has said that there is no such chance because it wouldn't qualify as a supplement. Why not? Follastatin (spelling?) is found in fertilized egg yolks, no? If there was a way to produce it in sufficient quality at a reasonable price, would it not potentially qualify as a supplement?
Click to expand...


its a pretty big and proteolytically sensitive peptide. Remember, oral administration is the only approved delivery form for supplements.

i think this is where your theory might crumble
 
getswole said:
well as you read through this thread,just orally there is nothing to date that can produce profound,and seeing as its peptide/protien based at this point these particulars probably never will be an oral app...after all this isn't some igf or hgh,.this is some serious sh1t,hence the serious price and not so much availability,this stuf is one of the tightest things I've seen as for getting your hands on,not to even mention the cost...theres planty of BS myo-this myo-thats supps at your local GNC's if you really wanna drop the cash,but they're BS just as you mentioned
Click to expand...

the concept behind the old BS myostatin supps was not theoretically unsound. alot of polysaccharide type compounds can bind to proteins like myostatin.

the trick would be to find one that was specific enough to myostatin, that was orally absorbable, and could penetrate into the muscle cell in sufficient quantity.

the one they used obviously did not work
 
Gixxer82 said:
wait, if I had the funds, I could actually buy this stuff and pin myself with it?
Click to expand...

what happens if you save up all that money and buy it and then find out it really does not work that well?

a generation ago people thought GH was the key to unlimited muscle growth. It was extremely hard to obtain and was incredibly expensive. People would spend a fortune on a tiny bit

today we know that GH, although useful, was nothing like we once imagined
 
Sub7 said:
This (the serious results produced by the compound) shouldn't really determine the price so much. With the degree of competition, I think, if production was feasible, price would come down.

Also, in the other thread, it sounded like the egg yolks constituent that has the capability to block mysotatin was going to be orally available and bioactive. I understand that the ingredient has not yet produced results for anyone but pretty much everyone including PA were in agreement that the oral compound was scientifically feasible -at least as of now and on paper. Maybe I misunderstood...?
Click to expand...

there are ways to increase the oral bioavailability of peptides like that but you still are only talking a few percent maximum. If you need, say 10mg per day of follistatin and you only get avg. 3% oral bioavailability than that means you need to ingest 3.3 grams of follistatin

thats gonna take alot of fertilized eggs
 
Gixxer82 said:
that would be the balls. But on the same page, then anyone could get relatively big. Then it wouldn't be "special" anymore to be above and beyond average because it would be achievable for anyone. We all work hard for our bodies. Thinking about it, I would rather this stuff never come out.
Click to expand...

i don't think this is gonna be the case. we all thought that about every drug advancement up until this point. yes this stuff will set the bar higher, but people will still have to work and the best will still be the best.

besides, only the ones really in the know are gonna get access at least for a long time
 
brywal312 said:
Yeah but imagine a world where everybody was freaking ripped like spartans. Now, think about this, what if the US was the only country that develped this and blocked its export? Imagine everyone in the entire country being ripped as hell while people in other countries being normal. We would be a society of rediculously good looking people that would rip people from anywhere else in half with our pinky fingers. sounds awesome to me!
Click to expand...

meanwhile the chinese will make a drug that makes them 100 times smarter than everyone and block its export.

after that, they will use that US hardy stock as their slaves
 
getswole said:
Sounds familiar,oh yeah,HITLER...lol,hitler was juicing his troops to the gills w/ test,this was a breakthrough at the time,test had just been synthesized if I am correct,I forget the specifics... besides the whole white power arian nation deal,Hitler juicing his troops was some serious sh1t at the time,Actually Hitler was a pretty smart dude and was quite ahead of his time,there were some kinks in his plan;)but just imagine if Hitler would have had the technology of the here/and now,with all the cutting edge gene doping breakthrough's/cloning/...I bet he'd a had his scientist all over this myostatin sh1t...we'd all be fvcked,we'd be fightin' some cloned/neg-myo gene having/nazi's /w/o nerve endings,looking like some monsters outta Gears of War or some sh1t,,,,w/ 10 livers and 4 sets of kidneys and eating bowlz of dbol's for breakfast and straight test runnin' through there veins instead of blood,...:box:

Hope I didn't come off all pro-hitler there for a second..:study:

I mean just Imagine,george Bush releasing a press anouncment stating he has teamed up online w/ the AM member "GetSwole" and will be now juicing our soldiers with 10g of gear a week per getswole's advice and will now be putting a stop to the use of guns in the military and instead replacing them with Rambo Knifes and Icepicks and giving pep talks to the troops saying Osama is fvckin' your chick...you know they'd find him and rip him apart in a week;)
Click to expand...



wow this thread plumetted fast
 
Thanks a lot for the replies PA
I still think that with the degree of interest in this compound, and the existing patents out there, it will be released into the mainstream sooner than people expect
 
Bumping this thread to the top, because I am possibly not seeing the new posts as is. I keep receiving notification that there was a new post, but when I come to this thread and check, there is nothing new...

Let me also use this opportunity to ask a question, especially to PA: I understand that such a novel compound will inevitably be very expensive to produce at the beginning, but is there something special here with this compound that makes it even more costly to manufacture? Things like GHRP and other exotic peptides are talked about and used by a lot of people. I have never used any of these but I understand that their prices are pretty reasonable, yet they are also produced in very small quantities. When you look at the Myostatin inhibitors (not talking about fertilized egg yolks, but the patented compounds), is there any special property they have, chemically, that would make them much harder to work with? The prices quoted just sound unreal and I am trying to figure out why...
 
Sub7 said:
Bumping this thread to the top, because I am possibly not seeing the new posts as is. I keep receiving notification that there was a new post, but when I come to this thread and check, there is nothing new...

Let me also use this opportunity to ask a question, especially to PA: I understand that such a novel compound will inevitably be very expensive to produce at the beginning, but is there something special here with this compound that makes it even more costly to manufacture? Things like GHRP and other exotic peptides are talked about and used by a lot of people. I have never used any of these but I understand that their prices are pretty reasonable, yet they are also produced in very small quantities. When you look at the Myostatin inhibitors (not talking about fertilized egg yolks, but the patented compounds), is there any special property they have, chemically, that would make them much harder to work with? The prices quoted just sound unreal and I am trying to figure out why...
Click to expand...

the technology for their manufacture may be more closely guarded, which makes it tougher for those chinese peptide houses to knock them off
 
Patrick Arnold said:
the technology for their manufacture may be more closely guarded, which makes it tougher for those chinese peptide houses to knock them off
Click to expand...

If you make it in China, you might as well put instructions on how to make it on a giant light-up billboard.

Copycatting and counterfeiting are a huge risk in that country, regardless of the industry.
 
thesinner said:
If you make it in China, you might as well put instructions on how to make it on a giant light-up billboard.

Copycatting and counterfeiting are a huge risk in that country, regardless of the industry.
Click to expand...


it could be that with these advanced anabolic therapies, and especially with gene therapy, the technology is kept very secret. I can see governments, at the behest of the olympic sports lobby, putting great pressures on these pharm companies to make sure these things do not get into the hands of athletes
 
Patrick Arnold said:
it could be that with these advanced anabolic therapies, and especially with gene therapy, the technology is kept very secret. I can see governments, at the behest of the olympic sports lobby, putting great pressures on these pharm companies to make sure these things do not get into the hands of athletes
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I see this as a major possibility myself, my issue here is, what about the people who just wanna scare people while walking down the street to check their mail? Not an athlete, just 'filled out' a bit. heh. Anyways, to get into this is like opening a can of worms, to much political governing and to little intelligence to govern it properly. I give our modern day and age 50 years before corruption and simple self indulgences become the norm and everybody just accepts that and moves onward despite the fact that life is pathetically hopeless in a sense that unless you're on your knees, you're not going ANYWHERE. Money buys money, not hard work. My tip to all: be born into a rich family or prepare for hell.
 
Patrick Arnold said:
it could be that with these advanced anabolic therapies, and especially with gene therapy, the technology is kept very secret. I can see governments, at the behest of the olympic sports lobby, putting great pressures on these pharm companies to make sure these things do not get into the hands of athletes
Click to expand...

I see... though if it is patented, at least one can openly se the structure of the peptide, right? Some patents would also cover manufacturing methods, but I guess most companies would keep the manufacturing methods as "trade secrets".

In this case, it comes down to some of the peptide houses' ability to manufacture a peptide whose structure they know on paper...
 
RisingAgainst said:
Yes.. before modern times.. the point I was stressing is that in TODAY's society.. it is backwards.
Click to expand...

Then you need not worry about it..
It's exactly the same now, as was then, as it will be.
Only the arena for execellence will change.

Anyways- remember when MGF came out, and ther ewere studies for the 25% growth,..
I remember tring it when it was available for us, through sponsors.
No dice.

THEN, there was the "It needed to be delivered through a virus" aspect.. (assumption then that it's expression needed to be much longer)..
So along with the PEG-MGF.
Nothing special with that either :(

I am not bashing MGF here, but I am making a comparrision, as to what I might be able to get, and what is actually used in the studies.

Then you have actual delivery.. basicly, it's oral, dermal, or inj. Would any of these methoeds even match up to the delevery of what's being used in the studies to produce these results?? (and I really dont know what the methoed is).

If I were to be able to go out and purchass this inhibitor right now, were talking injections now I beleive...
Is that the same way this inhibitor is being introduced in the studies?
 
xtraflossy said:
Then you need not worry about it..
It's exactly the same now, as was then, as it will be.
Only the arena for execellence will change.

Anyways- remember when MGF came out, and ther ewere studies for the 25% growth,..
I remember tring it when it was available for us, through sponsors.
No dice.

THEN, there was the "It needed to be delivered through a virus" aspect.. (assumption then that it's expression needed to be much longer)..
So along with the PEG-MGF.
Nothing special with that either :(

I am not bashing MGF here, but I am making a comparrision, as to what I might be able to get, and what is actually used in the studies.

Then you have actual delivery.. basicly, it's oral, dermal, or inj. Would any of these methoeds even match up to the delevery of what's being used in the studies to produce these results?? (and I really dont know what the methoed is).

If I were to be able to go out and purchass this inhibitor right now, were talking injections now I beleive...
Is that the same way this inhibitor is being introduced in the studies?
Click to expand...

Sorry, I blanket statement'd the hell out of things, I was referring to today society, not anything to do with myostatins and the like.. got wayy off topic on a partial rant. For all we know, the 'inhibitor' could be a suppository.. LOL
 
RisingAgainst said:
Sorry, I blanket statement'd the hell out of things, I was referring to today society, not anything to do with myostatins and the like.. got wayy off topic on a partial rant. For all we know, the 'inhibitor' could be a suppository.. LOL
Click to expand...

I knew you were :lol: The first part was geared towards that, the second, on the inhibitor.
There has always been those who come to foutune from fortune, and those who come to it from nothing. I am sure there always will be.
 
Looks like the World Anti-Doping Agency is already all over this stuff....

Invalid Link Removed

Seems like any use other than for muscle wasting disease is going to be considered abuse even though they admit that the chances for side effects would likely be much less than with regular steroids.
 
what has happen to all the post on this topic need info on what vis going on with ace-031 amg 745 myo-029
 
The Phase 1 trial for ACE-031 is pending.

October 20, 2008 - Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of tissues including bone and muscle, today announced the initiation of a Phase 1 clinical study of ACE-031, its lead compound for treating diseases involving the loss of muscle mass and function. The Phase 1 trial is a randomized, placebo-controlled single-dose, dose-escalating study to evaluate the safety and pharmacokinetics of ACE-031. This clinical trial is the first-in-human study in the global development of ACE-031 and will be conducted in Canada.

“There is a tremendous unmet medical need to treat patients suffering from a wide array of diseases involving the loss of muscle strength and function. ACE-031 has the potential to be a very important new approach to treat these serious and life-threatening conditions,” said Matthew Sherman, M.D., Chief Medical Officer of Acceleron.

“The start of this ACE-031 Phase 1 trial is another important clinical milestone for Acceleron,” said John Knopf, Ph.D., Chief Executive Officer of Acceleron. “Last week we announced the start of a Phase 2 clinical trial in patients with multiple myeloma bone disease with ACE-011, the lead compound in our bone program, and today we are proud to announce the start of the first clinical trial for ACE-031, the lead compound in our muscle program. The Acceleron pipeline continues to mature and expand, and most notably, the company remains in a strong financial position to deliver on our clinical goals. We look forward to several data presentations at major medical meetings before the end of the year that will demonstrate the progress of our pipeline.”

About ACE-031

ACE-031, a soluble molecule based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By blocking signaling though ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031 has shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases.
 
sorry if anyone posted this in the previous pages didnt look through all of them...

bioblog(dot)biotunes(dot)org/bioblog/2007/03/29/german-super-baby-revisited

latest news I could find related to the "super" baby. Theres one line in there though from what the mother appearently said...

"my father once jokingly held a washing machine in his outstretched arm, obviously considerably more than this 10 lb from the 4 yr old"...

^ makes me wonder if this whole super baby (and family) is just a hoax. But if its true.... all I have to say is :jaw:
 
ReaperX said:
The biggest thing for me about gear is the heart. Virtually all the other problems associated with it are either cosmetic or not necessarly life threatening and can be corrected with enough sustained professional medical intervention.

With the heart, when you use gear if it enlarges then your SOL. The high mortality trend with WWE wrestlers makes it a scary enough proposition for me.
Click to expand...

Hello guys,

The answer is in front of our eyes, the myostatin regulates the growth of skeletal muscle, and the heart is smooth, not skeletal.

That was mentioned by a doctor in a documentary on TV talking about the strongest toddler.

Cheers!
 
myoplex

Genetics is a powerful tool to modify growth rate and body composition. Genetic selection has been shown to modify metabolism and its regulation. For example, an individual with a lean body is less responsive to insulin action than an individual with a fat body. Individuals with a high growth rate show higher circulating levels of insulin like growth factor-I (IGF-I) and higher hepatic IGF-I mRNA levels when compared to those with a low growth rate. Overexpression of the IGF-I gene can induce a general hyperplasia of muscle if circulating levels are increased, because IGF-I is a general enhancer of lean tissue growth. On the other hand, if overexpression is restricted to the muscle without marked modifications of circulating levels, simply muscle hypertrophy will occur.
 
myoplex

Muscle biopsies of the Pectoralis major (PM) muscle and the Sartorious (SART) muscle were taken at baseline, two months and six months. Muscle yields from 2 and 6 months revealed a progressive muscle fiber hyperplasia and hypertrophy over baseline, more so in the PM than in the SART muscles. IGF-I and MSTN mRNA levels were monitored along with cross-sectional area of muscle fibers. Between 2 and 6 months, IGF-I mRNA levels were significantly higher than at baseline, and MSTN mRNA levels decreased during the same period. This increase in the IGF-I/MSTN ratio suggested that it could be contributing to the explosive growth observed during that period. Our results support the hypothesis that the relative levels of IGF-I and MSTN mRNA may participate to set muscle growth rate, and that the novel monoclonal antibody Myoplex® could be an effective regulatory intervention in the clinical management of Sarcopenia of aging.
 
myoplex

Myoplex® is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human MSTN protein receptor linked to the Fc portion of human IgG1. It is produced by recombinant DNA technology in a Chinese hamster ovary. It consists of 934 amino acids, and has an apparent molecular weight of approximately 150 kilodaltons.

Myoplex® was found to bind specifically to the MSTN protein and block its interaction with cell surface MSTN protein receptors, rendering the MSTN protein inactive. A single intramuscular injection of Myoplex® 25mg to 25 patients with Sarcopenia of aging resulted in a mean half-life of the monoclonal antibody of 7 to 10 days. After six months of twice monthly injections, patients exhibited a 2 to 7 fold increase in peak serum concentrations of their endogenous (total, free and percent free) testosterone levels. There was an approximate four-fold increase in AUC (Area Under the Curve)- range 1-7 fold- with repeated dosing.
 
fgf

Satellite cells in skeletal muscle have been implicated in muscle growth processes and regeneration. However, very little is known about the regulation of their proliferation and differentiation. The effect of fibroblast growth factor (FGF) on the proliferation of myogenic cells from adult rat skeletal muscle, presumably satellite cells, has been examined, and FGF has been found to be a potent mitogen for these cells. The mitogenic properties of serum were also documented and studied in conjunction with FGF. Even under conditions of maximal stimulation by serum, the addition of FGF caused a substantial increase in proliferation of satellite cells. The additive nature of the FGF and serum-stimulatory activity suggests that FGF-like molecules are not the active agents in serum and that more than one pathway may be involved in stimulating satellite cell proliferation.
 
?

TGF-=CE=B21-positive myofibers are replaced by = mononucleated=20 cells in a time-dependent manner. Many of the TGF-=CE=B21-positive = myofibers had=20 been replaced by TGF-=CE=B21-expressing mononucleated cells (a, = arrow) 5 days after injection. These mononucleated cells were=20 continuously positive for TGF-=CE=B21 on days 5 through 7 after = injection (a=20 and b, arrows); however, few TGF-=CE=B21-positive = myofibers were=20 visible during this time period (a and b). The = mononucleated=20 cells eventually replaced the myofibers and differentiated into = fibrotic cells=20 that were visible at 7, 14, and 21 days after injection (b to = d,=20 arrowheads). By using trichrome staining, we confirmed that a = large=20 amount of collagen was deposited in the TGF-=CE=B21-positive location = (e to=20 h, arrows and arrowheads).
 
kai said:
Genetics is a powerful tool to modify growth rate and body composition. Genetic selection has been shown to modify metabolism and its regulation. For example, an individual with a lean body is less responsive to insulin action than an individual with a fat body. Individuals with a high growth rate show higher circulating levels of insulin like growth factor-I (IGF-I) and higher hepatic IGF-I mRNA levels when compared to those with a low growth rate. Overexpression of the IGF-I gene can induce a general hyperplasia of muscle if circulating levels are increased, because IGF-I is a general enhancer of lean tissue growth. On the other hand, if overexpression is restricted to the muscle without marked modifications of circulating levels, simply muscle hypertrophy will occur.
Click to expand...

You must have mistyped. A person with a lean body is more responsive to insulin, not less

Also, circulating IGF-1 levels have little correlation with skeletal muscle size (hyperplasia or hypertrophy). OTOH it does correlate with hypertrophy of many non-skeletal muscle tissues
 
kai said:
Muscle biopsies of the Pectoralis major (PM) muscle and the Sartorious (SART) muscle were taken at baseline, two months and six months. Muscle yields from 2 and 6 months revealed a progressive muscle fiber hyperplasia and hypertrophy over baseline, more so in the PM than in the SART muscles. IGF-I and MSTN mRNA levels were monitored along with cross-sectional area of muscle fibers. Between 2 and 6 months, IGF-I mRNA levels were significantly higher than at baseline, and MSTN mRNA levels decreased during the same period. This increase in the IGF-I/MSTN ratio suggested that it could be contributing to the explosive growth observed during that period. Our results support the hypothesis that the relative levels of IGF-I and MSTN mRNA may participate to set muscle growth rate, and that the novel monoclonal antibody Myoplex® could be an effective regulatory intervention in the clinical management of Sarcopenia of aging.
Click to expand...


I can see muscle specific igf-1/mstn ratio being a potential useful measuring stick to gauge anabolic potential. However whey proteins give me gas!
 
kai said:
Myoplex® is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human MSTN protein receptor linked to the Fc portion of human IgG1. It is produced by recombinant DNA technology in a Chinese hamster ovary. It consists of 934 amino acids, and has an apparent molecular weight of approximately 150 kilodaltons.

Myoplex® was found to bind specifically to the MSTN protein and block its interaction with cell surface MSTN protein receptors, rendering the MSTN protein inactive. A single intramuscular injection of Myoplex® 25mg to 25 patients with Sarcopenia of aging resulted in a mean half-life of the monoclonal antibody of 7 to 10 days. After six months of twice monthly injections, patients exhibited a 2 to 7 fold increase in peak serum concentrations of their endogenous (total, free and percent free) testosterone levels. There was an approximate four-fold increase in AUC (Area Under the Curve)- range 1-7 fold- with repeated dosing.
Click to expand...


why would a myostatin inhibitor cause an increase in testosterone levels? Thats quite a non-sequitir you did there

btw i looked up this myoplex stuff (after i figured out you aint talking about that nasty protein drink). the only site i found was this

Invalid Link Removed


so first of all, who is that slimy looking dude in the pic and second of all why did no scientific articles or anything else come up?
 
kai said:
TGF-=CE=B21-positive myofibers are replaced by = mononucleated=20 cells in a time-dependent manner. Many of the TGF-=CE=B21-positive = myofibers had=20 been replaced by TGF-=CE=B21-expressing mononucleated cells (a, = arrow) 5 days after injection. These mononucleated cells were=20 continuously positive for TGF-=CE=B21 on days 5 through 7 after = injection (a=20 and b, arrows); however, few TGF-=CE=B21-positive = myofibers were=20 visible during this time period (a and b). The = mononucleated=20 cells eventually replaced the myofibers and differentiated into = fibrotic cells=20 that were visible at 7, 14, and 21 days after injection (b to = d,=20 arrowheads). By using trichrome staining, we confirmed that a = large=20 amount of collagen was deposited in the TGF-=CE=B21-positive location = (e to=20 h, arrows and arrowheads).
Click to expand...

i gotta admit i am kinda lost on this post. but i can weed out some stuff. I know TGF is bad for muscle. It also seems that differentiation of myofibers into fibrotic collagen gristle is about the last thing any healthy person would want. I like my steak tender and i like my muscles tender too

Anyway, this post seems to have no relevance to your previous posts. it seems to have no relevance to anything actually
 
egarres said:
Hello guys,

The answer is in front of our eyes, the myostatin regulates the growth of skeletal muscle, and the heart is smooth, not skeletal.

That was mentioned by a doctor in a documentary on TV talking about the strongest toddler.

Cheers!
Click to expand...


actually there are three types of muscle in the body. skeletal, smooth, and cardiac. so you meant cardiac

anyway, yes it has been shown myostatin really is only relevant to skeletal
 
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