getswole
Active member
Imagine w/ steroids and proper training...it would be a brand new Monster,you know he's gonna be into bodybuilding when he's doing iron cross's at 5 months old,lol..
Myostatin Peptide,Could DOUBLE your MUSCLE!!
- Thread starter getswole
- Start date
getswole
Active member
First off,the problem with infants is they need a certain amount of fat for proper brain development and other organs,as a matured adult you have already developed,so whether or not the baby died,it makes no difference,also you are not altering your genetic code,as in a "mutant" you are just temporarily blocking myostating receptor accessability,therefor fooling the body into allowing increased hyperplasia and hypertrophy(laymans term,getting huge),and yes your right this could replace gear as you know it,medical wise,but for fools like us,NEVER:head: It will just add one more bomb to the arsenal,but it will be more of a Nuclear type bomb to say the least:smite:
ItsHectic
Registered User
If that dog is the equivilent to a 400lb human then I think doctors would advise the kid not to train for getting too big. Imagine in 20 years anyone who wants to become huge will be, just hit MYO-029 and eat like an animal, and train how ever you want. Its going to be amazing, so many huge people everywhere.
Patrick Arnold
Featured Author
i am not nearly as worried about myostatin blocking therapy as i am with harsh anabolic steroids or non-muscle specific peptide growth factors. and like you said, the therapy is not permanent
Patrick Arnold
Featured Author
i dunno. i would not be surprised if some of today's big ripped guys out there do not have the same mutation
yes they have a big head start but they still need to juice and train hard to be Mr. O
Patrick Arnold
Featured Author
There are 2 substances and personally I wouldn't trust getting either from any type research company...All I will say is I have both of these priced from quite few different places...And I know for a fact the quality would not be of any question with a few of those,Seriously ...who even buys from the Research sites anyways?Except for the board sponsors of course
there is also trichostatin a, which upregulates follistatin (an endogenous myostatin blocker)
Patrick Arnold
Featured Author
myostatin blockers are not an anabolic agent per se
it is removal of the brake on muscle growth.
if you want to really hit a particular muscle you have to train it, and then the anabolic response to training will be greatly exaggerated
EasyEJL
Never enough
Patrick Arnold
Featured Author
hmm new ergopharm product perhaps?
not a chance. way too expensive to manufacture and its not natural.
getswole
Active member
yes thats pretty much all correct,it opens your body up to produce some nice new virgin mucle tissue that you can then obviously train...but even untrained,even a 50% increase in tissue will give you that "swole" look ,no doubt,and with more muscle your gonna be alot stronger and far less prone to injury,to an extent....good stuff
BigVrunga
Well-known member
I dont know if someone born with this gene would really be motivated enough to do what it takes to become world champion - a lot of naturally muscular guys dont really get crazy serious about bodybuilding. They tend to 'coast on their genetics' and dont have the drive to become huge that the skinny kids who always get passed on by chicks and picked on do.
Then again, the naturally gifted kids that *do* get into bodybuilding end up like Arnold.
BV
Then again, the naturally gifted kids that *do* get into bodybuilding end up like Arnold.
BV
bigrick345
New member
Heres all i could find:
Invalid Link Removed
Cancer drug slows muscular dystrophy in mice
Roxanne Khamsi An experimental cancer drug has slowed muscular dystrophy in mice with the disease, raising hopes that a simple pill could one day treat the fatal condition in humans. “The results the researchers are reporting are very dramatic and impressive,” says Jeff Chamberlain at the University of Washington School of Medicine in Seattle, US. The researchers caution that the results are preliminary, but say that the approach might offer advantages over other medicines for muscular dystrophy currently in clinical trials. There are many forms of the muscle-wasting disease, but no cure for any of them. The most common form of the illness among children, known as Duchenne muscular dystrophy, involves a mutation for a muscle protein known as dystrophin. Without functioning copies of this protein, muscles weaken, leading to breathing problems and, ultimately, death in the victims' teens or early twenties. Pier Puri at the Burnham Institute in La Jolla, California and colleagues tried to boost muscle function in mice carrying a mutation in the dystrophin gene, by treating the animals with a cancer drug called trichostatin A (TSA). © Copyright Reed Business Information Ltd.
See also: Chapter 11: Motor Control and Plasticity
Invalid Link Removed
An experimental cancer drug has slowed muscular dystrophy in mice with the disease, raising hopes that a simple pill could one day treat the fatal condition in humans.
“The results the researchers are reporting are very dramatic and impressive,” says Jeff Chamberlain at the University of Washington School of Medicine in Seattle, US.
The researchers caution that the results are preliminary, but say that the approach might offer advantages over other medicines for muscular dystrophy currently in clinical trials.
There are many forms of the muscle-wasting disease, but no cure for any of them. The most common form of the illness among children, known as Duchenne muscular dystrophy, involves a mutation for a muscle protein known as dystrophin.
Without functioning copies of this protein, muscles weaken, leading to breathing problems and, ultimately, death in the victims' teens or early twenties.
Counteracted deterioration
Pier Puri at the Burnham Institute in La Jolla, California and colleagues tried to boost muscle function in mice carrying a mutation in the dystrophin gene, by treating the animals with a cancer drug called trichostatin A (TSA).
The compound, which is being tested as a treatment for melanoma, causes a change in certain proteins.
Puri says that these changes somehow affect the production of a molecule known as follistatin, which can indirectly cause muscle growth and counteract the deterioration caused by faulty dystrophin.
Muscle-boost abolished
The team gave the mutant mice a daily dose of TSA for three months, after which the rodents underwent a fitness test on a treadmill. Those on TSA managed to last 20 minutes on the treadmill, compared to just 12.5 minutes for the control group.
In a second part of the experiment, Puri’s team gave the mice a compound that blocks the effects of follistatin. This had the effect of abolishing the muscle-boosting power of TSA, demonstrating that the cancer treatment works against the symptoms of muscular dystrophy by boosting follistatin, Puri says.
An advantage of TSA is that it can be taken in simple pill form, unlike some of the other treatments in development, such as those involving gene therapy.
But experts stress that, unlike gene therapy, it would have to be continuously administered. “You would have to give this for the lifespan of the patient,” Chamberlain notes, adding that the potential side effects of long-term TSA use are unknown.
Does it help?
Invalid Link Removed
Cancer drug slows muscular dystrophy in mice
Roxanne Khamsi An experimental cancer drug has slowed muscular dystrophy in mice with the disease, raising hopes that a simple pill could one day treat the fatal condition in humans. “The results the researchers are reporting are very dramatic and impressive,” says Jeff Chamberlain at the University of Washington School of Medicine in Seattle, US. The researchers caution that the results are preliminary, but say that the approach might offer advantages over other medicines for muscular dystrophy currently in clinical trials. There are many forms of the muscle-wasting disease, but no cure for any of them. The most common form of the illness among children, known as Duchenne muscular dystrophy, involves a mutation for a muscle protein known as dystrophin. Without functioning copies of this protein, muscles weaken, leading to breathing problems and, ultimately, death in the victims' teens or early twenties. Pier Puri at the Burnham Institute in La Jolla, California and colleagues tried to boost muscle function in mice carrying a mutation in the dystrophin gene, by treating the animals with a cancer drug called trichostatin A (TSA). © Copyright Reed Business Information Ltd.
See also: Chapter 11: Motor Control and Plasticity
Invalid Link Removed
An experimental cancer drug has slowed muscular dystrophy in mice with the disease, raising hopes that a simple pill could one day treat the fatal condition in humans.
“The results the researchers are reporting are very dramatic and impressive,” says Jeff Chamberlain at the University of Washington School of Medicine in Seattle, US.
The researchers caution that the results are preliminary, but say that the approach might offer advantages over other medicines for muscular dystrophy currently in clinical trials.
There are many forms of the muscle-wasting disease, but no cure for any of them. The most common form of the illness among children, known as Duchenne muscular dystrophy, involves a mutation for a muscle protein known as dystrophin.
Without functioning copies of this protein, muscles weaken, leading to breathing problems and, ultimately, death in the victims' teens or early twenties.
Counteracted deterioration
Pier Puri at the Burnham Institute in La Jolla, California and colleagues tried to boost muscle function in mice carrying a mutation in the dystrophin gene, by treating the animals with a cancer drug called trichostatin A (TSA).
The compound, which is being tested as a treatment for melanoma, causes a change in certain proteins.
Puri says that these changes somehow affect the production of a molecule known as follistatin, which can indirectly cause muscle growth and counteract the deterioration caused by faulty dystrophin.
Muscle-boost abolished
The team gave the mutant mice a daily dose of TSA for three months, after which the rodents underwent a fitness test on a treadmill. Those on TSA managed to last 20 minutes on the treadmill, compared to just 12.5 minutes for the control group.
In a second part of the experiment, Puri’s team gave the mice a compound that blocks the effects of follistatin. This had the effect of abolishing the muscle-boosting power of TSA, demonstrating that the cancer treatment works against the symptoms of muscular dystrophy by boosting follistatin, Puri says.
An advantage of TSA is that it can be taken in simple pill form, unlike some of the other treatments in development, such as those involving gene therapy.
But experts stress that, unlike gene therapy, it would have to be continuously administered. “You would have to give this for the lifespan of the patient,” Chamberlain notes, adding that the potential side effects of long-term TSA use are unknown.
Does it help?
getswole
Active member
Thats not either of the protiens this thread is concerning.But that does touch on the Trichostan A.Which affect Follistatin levels,but this still have nothing to do with blocking myostatin.which is the MAIN cause for the limit of tissue growth,although yes other protiens such as those do play a role also.with more research this could also be promising.also who the hell would want to HAVE to take a pill their entire life.That would suck
CDB
Registered User
getswole
Active member
the info I posted is current,updated in May of this yr(2 months ago) ,I will update any further updates or info oin the kid.He's alot healthier looks like than the german kid yes
STeGoR
New member
awesome. thats what I like to hear.. er, read.
Tiberius
Member
Last I checked there was NOTHING wrong with the German kid. In the meantime the American kid had a hole in his heart and couldn't eat food without vomitting.
getswole
Active member
First off ,regardless of these kids ,again this has zero to do with these peptides that can affect myostatin levels...no matter what protiens you were to experiment with you are still not going to be reborn as an infant with an inactive myostatin gene,so why does it even matter about the kids health...it doesn't,Also if your gonna say you read this and that,add link to the study or some research to back it up,that always makes things much more relaible,I've never been one to even pay attention to anything I havn't read a documented case file,or experienced it first hand...lets keep the "he said,she said to a minimum,Thanks
Tiberius
Member
Calm down chief.
People keep saying "the German kid has X problems" but no one has EVER posted ANY evidence supporting this. No article I have ever seen has ever said anything about helath problem the german kid has. You're asking me to back up that statement with an article? My whole point was that there are none? I can't prove a negative bro.
As for the other point, I seem to recall that a lot of scientists have said it is entirely possible, but not proven either way, that myostatin only plays a significant role in EARLY muscle development. i.e. that inhibiting myostatin may only have an effect in children and not adults. I've yet to see a study conducted on fully grown animals (or humans) who are not mutants.
getswole
Active member
The names not "Chief"...
But anyways your right,people do keep saying this and that about the german kid...thats exactly what I was talking about...the articles are all there,I've read the majority of anything to do with these 2 compounds .I wasn't just talking about your comment....its just that is one of the bigger problems with some forums,is you end up having half a thread of he said/she said...and the facts get lost in the bs...and I have to say I completely disagree with you as far as that "myostatin only affects children,or early muscle development"...Again where's at least an article to back that statement up...That comment has been completely disproven through documented studies,the myostatin gene is in ALL mammals...human or mouse alike,same protiens,same code...
But thanks for your input and negativity:clap2:
I've learned alot from your post:think:
But anyways your right,people do keep saying this and that about the german kid...thats exactly what I was talking about...the articles are all there,I've read the majority of anything to do with these 2 compounds .I wasn't just talking about your comment....its just that is one of the bigger problems with some forums,is you end up having half a thread of he said/she said...and the facts get lost in the bs...and I have to say I completely disagree with you as far as that "myostatin only affects children,or early muscle development"...Again where's at least an article to back that statement up...That comment has been completely disproven through documented studies,the myostatin gene is in ALL mammals...human or mouse alike,same protiens,same code...
But thanks for your input and negativity:clap2:
I've learned alot from your post:think:
pudzian2
Banned
Oh how much more and quickly we could all learn and get to the point if threads just didnt have the BS in between the facts. Your right, by half way through a thread about macronutrients someone is talking about someone else's mom...
getswole
Active member
Thats the stuff everyone says is the BS supps that are just feeding off this newly developed technology and making "claims" that arent true....kinda like those crap supplements that came out called Winny-V,and Dbal,Dianabrawl,or whatever the hell they are...but I havn't personally experianced either so if they are actually helpful even in the slightest I would also be interested
brywal312
Member
doing some searching it looks like pretty much all of them are crap. Even the companies themselves say it could take years before the effects even begin to show. I think this is because the highes claim I have seen of reduction was like 34%. In comparison those huge kids and mice had 100% reductions. There is the protien called formestolin or something like that which is supposed to be a natural inhibitor but according to PA it would HAVE to be injectable.
CDB
Registered User
Look at it this way, if there is something that works we will hear about it, because there's no keeping that kind of secrety for very long. Likely when it is available we will not be able to afford it for a decent run. There's also no data on long term effects one way or another really, so who knows ones way or another? I find it hard to believe something with such potentially dramatic effects comes with little to no sides. I say to hell with it. Keep lifting and eating. One day there may be a magic pill and if you're in shape then you can call everyone who takes it to get in shape a pussy.
Patrick Arnold
Featured Author
I dont know if someone born with this gene would really be motivated enough to do what it takes to become world champion - a lot of naturally muscular guys dont really get crazy serious about bodybuilding. They tend to 'coast on their genetics' and dont have the drive to become huge that the skinny kids who always get passed on by chicks and picked on do.
Then again, the naturally gifted kids that *do* get into bodybuilding end up like Arnold.
BV
gifted people are often competitive when they run into other gifted people. if they are never challenged they become complacent
pretty common sense here
Patrick Arnold
Featured Author
follistatin is intimately tied into myostatin
follistatin is an endogenous myostatin inhibitor.
so the TSA ultimately IS building muscle by inhibiting myostatin
Patrick Arnold
Featured Author
there is ample research out there demonstrating that myostatin inhibition performed on adults results in the dramatic muscle hypertrophy
Patrick Arnold
Featured Author
yeah thats the high follistatin egg yolk thing
anyway, myostatin inhibition results in rapid muscle accretion. did you all forget the articles posted at the top of this thread (60% increase in 2 weeks)
Patrick Arnold
Featured Author
brywal312
Member
Yeah, I saw them... I was mainly talking about the two supplements I had seen on the market that supposedly inhibited myostatin. If if I could find some of the agent they were talking about they used on the mice I would love to get some for my research monkeys :thumbsup:
getswole
Active member
What Is Myostatin?
Myostatin is a secreted protein that acts as a negative regulator (inhibitor) of skeletal muscle growth. Myostatin is a member of the transforming growth factor beta (TGF-B) superfamily of growth factors and is technically referred to as growth and differentiation factor 8 (GDF-8). Myostatin actually inhibits the growth of skeletal muscle by downregulating almost every myogenic (muscle building) factor known to induce skeletal muscle growth. Myostatin also influences special stem cells known as satellite cells away from myogenesis (the formation of new muscle cells) and toward adipogenesis (the formation of new fat cells). Myostatin is almost certainly the most powerful repartitioning substance that is produced in mammals and methods that will be used to suppress this protein will change the world forever.
Cattle with a myostatin deficiency accumulate an impressive amount of muscle tissue.
Myostatin And Humans
Have you ever seen a muscular individual that can eat whatever they want and not get fat? Are you envious that this person doesn't even have to exercise to look the way they do? Chances are this person was born with some form of myostatin deficiency. The myostatin protein was only discovered in 1997 and the identification of individuals with a deficiency of this protein has not occured until recently. While there are certainly many individuals that possess a myostatin deficiency there are only a few cases where a myostatin mutation has been detected in humans. The infant in the photo below is one of them.
An unidentified German male infant with a myostatin deficiency.
This child will grow up and possess enhanced skeletal muscle mass and super endurance. It is probable that many professional athletes today possess some form of a myostatin deficiency that allows them to excel in their chosen sport. Obviously not everyone was fortunate enough to be born with a myostatin mutation, however the future holds promise for a number methods to suppress myostatin and provide numerous benefits for those that undertake one these therapies.
Myostatin And Obesity
Americans spend billions and billions each year on ways to lose weight. Weight-loss drugs and supplements, special diets, and even surgical interventions (liposuction and gastric bypass) are utilized in an attempt to win the battle of the bulge. As I mentioned earliar the suppression of myostatin can induce a powerful repartitioning effect away from fat deposition and towards skeletal muscle accretion even in animals fed a high fat diet. Once an effective method for controlling myostatin is made available to the public the weight loss industry will go bankrupt. No more weight-loss pills, no more weird diets and no more expensive surgeries will accompany this revolution. This is not an exagerration, true myostatin suppression will make these measures obsolete. Some of you (especially women) may be concerned that too much muscle will be gained by using a myostatin inhibitor. This is not likely to be an issue as there will be a means to modulate and not eliminate myostatin activity.
Myostatin suppression and other future therapies will make obesity a thing of the past.
Myostatin And Muscle
By now it should be clear that myostatin suppression will induce skeletal muscle growth, but at this point I want to clear up a popular misconception. When I attempt to describe the benefits of myostatin suppression to anyone the inevitable comparison to anabolic steroids is made. You can think of an anabolic steroid like testosterone as the "gas" and the myostatin protein as the "brake" in relation to skeletal muscle growth. Anabolic steroids are able to enhance skeletal muscle growth because they overcome the inhibitory influence of myostatin on this process. The reason that myostatin suppression is an effective method for building new skeletal muscle is because you body produces it's own growth factors (testoterone, estrogen, Insulin, GH, IGF-I, HGF, FGF, IL-4, IL-15, PGF2a, others) and with no "brake" (growth arrest) in place these growth factors can proceed uninhibited. A major difference between anabolic steroid administration and myostatin suppression boils down to the side effects. Anabolic steroids induce numerous side effects while myostatin inhibition appears to be largely void of any serious side effects. Myostatin suppression therapy will be sought after by a large percentage of American men (almost all of them) that want to develop a lean muscular body with little or no exercise. Women will also want the benefit of added strength and muscle mass that accompanies this therapy and modulation of myostatin activity will be able to prevent gross muscle hypertrophy in females that seek this treatment.
Few people have the potential to build muscle like Arnold. Myostatin suppression therapy will help change that.
Myostatin And Disease
At this point in time all the research on myostatin suppression is focused on the treatment of muscle wasting diseases. Muscular dystrophy, AIDS, sarcopenia, cancer cachexia, and other states where extreme skeletal muscle breakdown is an issue could in part be treated through myostatin inhibition. Suppression of the myostatin protein will not only help improve our appearance, it will actually save lives. There are numerous diseases that will benefit from myostatin inhibition and in fact this will be one of the biggest markets for this type of therapy.
Myostatin suppression therapy will help patients recover from potentially fatal muscle wasting diseases.
Myostatin Suppression Therapies
Now that the benefits of myostatin suppression are understood the question is how best to inhibit the activity of this protein. There are a number of supplements that claim to be myostatin inhibitors, but in reality all of these products are a scam and have never demonstrated an in vivo ability to inhibit myostatin. It may be that true myostatin suppression is only possible with the development of drugs designed for this purpose. At this time there are three pharmaceutical corporations that are developing these specific myostatin inhibitors, Acceleron Pharma Inc, Amgen, and Wyeth Pharmaceuticals.
Myostatin control will allow men and women to shed fat and build muscle.
Acceleron Pharma has produced a powerful myostatin inhibitor based on ACVR2B. The designation given to this drug is ACE-031, the first in a series of myostatin inhibiting substances that this company is working on. Mutant activin type II receptors inhibit myostatin activity and ACE-031 utilizes this pathway to suppress myostatin.
Amgen is developing AMG 745, a peptide based drug designed to bind with and suppress the activity of myostatin. AMG 745 may be similar to the myostatin propeptide. The myostatin propeptide is produced in the body and binds with myostatin thereby reducing the availability of the protein to available receptors.
Wyeth pharmaceuticals has developed MYO-029, an antibody that binds to and inhibits myostatin activity. The Wyeth myostatin antibodies should be approved in the near future for use in patients with muscular dystrophy.
An actual vaccine has been produced that would allow for the endogenous production of antibodies that inhibit myostatin. A myostatin vaccine may never be used in humans but it would be wildly popular with those individuals that raise livestock for a living. Click the link below for an abstract about the myostatin vaccine.
Invalid Link Removed
Follistatin and follistatin related gene (FLRG) are two other proteins that are produced by the body that also bind with myostatin and act as inhibitors of the protein. While there is no question that follistatin and FLRG act as endogenous myostatin inhibitors, the overexpression of these two proteins has been associated with reproductive organ abnormalities in both males and females. This may be the reason that these companies are not pursuing the development of myostatin suppressing drugs that based on these two proteins.
The future of myostatin suppression therapies
The myostatin inhibiting therapies that are being developed, as mentioned before, are for those that are suffering from a disorder that affects the development of skeletal muscle or for those experiencing an illness that induces skeletal muscle wasting. It is not likely that the FDA will approve these drugs for cosmetic enhancement (fat-loss and muscle accretion) anytime soon. However, effective myostatin inihibiting therapies will be sought after as soon as the public becomes aware of how these therapies can improve their body composition. If the American public is denied these therapies for cosmetic use by th FDA then a lucrative black market will emerge to fill the demand. Other nations in the world will not have to grapple with this issue, as these therapies will receive quick approval for the cosmetic use of these drugs. It is inevitable that the widespread availability of these drugs in other countries will make it easier for Americans to obtain these myostatin inhibitors via mail order. Independant individuals and companies will also cater to this black market demand. The genie is out of the bottle and he's not going back in. Every now and then a technology comes along that has a ripple effect on multiple industries and the various myostatin inhibiting therapies is one such technology. The revolution is about to begin.
Myostatin is a secreted protein that acts as a negative regulator (inhibitor) of skeletal muscle growth. Myostatin is a member of the transforming growth factor beta (TGF-B) superfamily of growth factors and is technically referred to as growth and differentiation factor 8 (GDF-8). Myostatin actually inhibits the growth of skeletal muscle by downregulating almost every myogenic (muscle building) factor known to induce skeletal muscle growth. Myostatin also influences special stem cells known as satellite cells away from myogenesis (the formation of new muscle cells) and toward adipogenesis (the formation of new fat cells). Myostatin is almost certainly the most powerful repartitioning substance that is produced in mammals and methods that will be used to suppress this protein will change the world forever.
Cattle with a myostatin deficiency accumulate an impressive amount of muscle tissue.
Myostatin And Humans
Have you ever seen a muscular individual that can eat whatever they want and not get fat? Are you envious that this person doesn't even have to exercise to look the way they do? Chances are this person was born with some form of myostatin deficiency. The myostatin protein was only discovered in 1997 and the identification of individuals with a deficiency of this protein has not occured until recently. While there are certainly many individuals that possess a myostatin deficiency there are only a few cases where a myostatin mutation has been detected in humans. The infant in the photo below is one of them.
An unidentified German male infant with a myostatin deficiency.
This child will grow up and possess enhanced skeletal muscle mass and super endurance. It is probable that many professional athletes today possess some form of a myostatin deficiency that allows them to excel in their chosen sport. Obviously not everyone was fortunate enough to be born with a myostatin mutation, however the future holds promise for a number methods to suppress myostatin and provide numerous benefits for those that undertake one these therapies.
Myostatin And Obesity
Americans spend billions and billions each year on ways to lose weight. Weight-loss drugs and supplements, special diets, and even surgical interventions (liposuction and gastric bypass) are utilized in an attempt to win the battle of the bulge. As I mentioned earliar the suppression of myostatin can induce a powerful repartitioning effect away from fat deposition and towards skeletal muscle accretion even in animals fed a high fat diet. Once an effective method for controlling myostatin is made available to the public the weight loss industry will go bankrupt. No more weight-loss pills, no more weird diets and no more expensive surgeries will accompany this revolution. This is not an exagerration, true myostatin suppression will make these measures obsolete. Some of you (especially women) may be concerned that too much muscle will be gained by using a myostatin inhibitor. This is not likely to be an issue as there will be a means to modulate and not eliminate myostatin activity.
Myostatin suppression and other future therapies will make obesity a thing of the past.
Myostatin And Muscle
By now it should be clear that myostatin suppression will induce skeletal muscle growth, but at this point I want to clear up a popular misconception. When I attempt to describe the benefits of myostatin suppression to anyone the inevitable comparison to anabolic steroids is made. You can think of an anabolic steroid like testosterone as the "gas" and the myostatin protein as the "brake" in relation to skeletal muscle growth. Anabolic steroids are able to enhance skeletal muscle growth because they overcome the inhibitory influence of myostatin on this process. The reason that myostatin suppression is an effective method for building new skeletal muscle is because you body produces it's own growth factors (testoterone, estrogen, Insulin, GH, IGF-I, HGF, FGF, IL-4, IL-15, PGF2a, others) and with no "brake" (growth arrest) in place these growth factors can proceed uninhibited. A major difference between anabolic steroid administration and myostatin suppression boils down to the side effects. Anabolic steroids induce numerous side effects while myostatin inhibition appears to be largely void of any serious side effects. Myostatin suppression therapy will be sought after by a large percentage of American men (almost all of them) that want to develop a lean muscular body with little or no exercise. Women will also want the benefit of added strength and muscle mass that accompanies this therapy and modulation of myostatin activity will be able to prevent gross muscle hypertrophy in females that seek this treatment.
Few people have the potential to build muscle like Arnold. Myostatin suppression therapy will help change that.
Myostatin And Disease
At this point in time all the research on myostatin suppression is focused on the treatment of muscle wasting diseases. Muscular dystrophy, AIDS, sarcopenia, cancer cachexia, and other states where extreme skeletal muscle breakdown is an issue could in part be treated through myostatin inhibition. Suppression of the myostatin protein will not only help improve our appearance, it will actually save lives. There are numerous diseases that will benefit from myostatin inhibition and in fact this will be one of the biggest markets for this type of therapy.
Myostatin suppression therapy will help patients recover from potentially fatal muscle wasting diseases.
Myostatin Suppression Therapies
Now that the benefits of myostatin suppression are understood the question is how best to inhibit the activity of this protein. There are a number of supplements that claim to be myostatin inhibitors, but in reality all of these products are a scam and have never demonstrated an in vivo ability to inhibit myostatin. It may be that true myostatin suppression is only possible with the development of drugs designed for this purpose. At this time there are three pharmaceutical corporations that are developing these specific myostatin inhibitors, Acceleron Pharma Inc, Amgen, and Wyeth Pharmaceuticals.
Myostatin control will allow men and women to shed fat and build muscle.
Acceleron Pharma has produced a powerful myostatin inhibitor based on ACVR2B. The designation given to this drug is ACE-031, the first in a series of myostatin inhibiting substances that this company is working on. Mutant activin type II receptors inhibit myostatin activity and ACE-031 utilizes this pathway to suppress myostatin.
Amgen is developing AMG 745, a peptide based drug designed to bind with and suppress the activity of myostatin. AMG 745 may be similar to the myostatin propeptide. The myostatin propeptide is produced in the body and binds with myostatin thereby reducing the availability of the protein to available receptors.
Wyeth pharmaceuticals has developed MYO-029, an antibody that binds to and inhibits myostatin activity. The Wyeth myostatin antibodies should be approved in the near future for use in patients with muscular dystrophy.
An actual vaccine has been produced that would allow for the endogenous production of antibodies that inhibit myostatin. A myostatin vaccine may never be used in humans but it would be wildly popular with those individuals that raise livestock for a living. Click the link below for an abstract about the myostatin vaccine.
Invalid Link Removed
Follistatin and follistatin related gene (FLRG) are two other proteins that are produced by the body that also bind with myostatin and act as inhibitors of the protein. While there is no question that follistatin and FLRG act as endogenous myostatin inhibitors, the overexpression of these two proteins has been associated with reproductive organ abnormalities in both males and females. This may be the reason that these companies are not pursuing the development of myostatin suppressing drugs that based on these two proteins.
The future of myostatin suppression therapies
The myostatin inhibiting therapies that are being developed, as mentioned before, are for those that are suffering from a disorder that affects the development of skeletal muscle or for those experiencing an illness that induces skeletal muscle wasting. It is not likely that the FDA will approve these drugs for cosmetic enhancement (fat-loss and muscle accretion) anytime soon. However, effective myostatin inihibiting therapies will be sought after as soon as the public becomes aware of how these therapies can improve their body composition. If the American public is denied these therapies for cosmetic use by th FDA then a lucrative black market will emerge to fill the demand. Other nations in the world will not have to grapple with this issue, as these therapies will receive quick approval for the cosmetic use of these drugs. It is inevitable that the widespread availability of these drugs in other countries will make it easier for Americans to obtain these myostatin inhibitors via mail order. Independant individuals and companies will also cater to this black market demand. The genie is out of the bottle and he's not going back in. Every now and then a technology comes along that has a ripple effect on multiple industries and the various myostatin inhibiting therapies is one such technology. The revolution is about to begin.
Patrick Arnold
Featured Author
i disagree with the opinion that this or any other muscle anabolic therapy in development will ever gain approval for cosmetic use in other countries. In fact, most other countries are MORE strict than the united states when it comes to bodybuilding / ergogenic supplements or drugs.
The World Anti-Doping Agency, which is the watchdog organization of the IOC and other amateur athletic organizations, has succeeded in influencing the politics in most all olympic participant nations so that strict controls are put on steroids and related substances.
Years ago this was not the case, and the inverse was actually true. Years ago you could buy steroids over the counter in europe. Now you can pretty much buy steroids OTC in the US (designer steroid supplements) while in other first world countries such availability is unheard of
I will say that its entirely possible that stuff like myostatin inhibitors may be available on the black market (or discreetly through loosely controlled pharmacies) in some less developed countries. But certainly the patent holders of these therapies (which would be big pharm companies that reside in developed nations) would never allow approval for cosmetic therapy.
btw who wrote this?
getswole
Active member
Not sure,there was no author claiming the writeup,its mostly just general info,I'm just trying to continue to compile every thing I can find here on this thread,then let God sort it out
..In general I figured whoever wrote it was just saying it will be on the black market like everything else,But indeed I'd agree w/ you that this stuff will likely not be OTC for cosmetic use in general,although just like Botox...which is incredibly dangerous,and a pure toxin,is now used for cosmetic purposes and therapeutic purposes and its very easily attainable as an export' from various places around the world,I won't get into specifics,possibly by OTC he meant easily attainable just as alot of "illegal " substances are to date...and your right if you are in certain countries you can't get most things OTC,but rather as an export from that country to yours,there draws the line where many countries get away with this sort of thing,there gov's care more whats coming in/than out..just as ours does...US officials could care less whats going out of the country,its whats coming in that they are concerned with for obvious reasons,which IMO is great...
Patrick Arnold
Featured Author
well yeah, there is no such thing as "outgoing customs" of course. every country i guess figures that its the other countries responsiblity for regulating what they allow in so why should they do the police work for them?
getswole
Active member
I was unaware of ACE-031,and AMG 745...Looks like wyeth has some competetion,this is the kind of thing that makes you wanna buy up a bunch of stock in these pharm companies,just as stem cell research is slowly making progress,things continue to push forward,just not as fast as they could if unhindered
getswole
Active member
Yes,exactly...That could change one day,but it will take a world combined effort to do so and I really don't see that happening,I don't ever see the world pulling together for a true single cause...its just not gonna happen..these countries are banking on these exports,they don't care if they get seized...not their loss..
getswole
Active member
hey Patrick,If you wanna run our own "human trials" match me dollar for dollar and we can get enough of the wyeth stuff to do a 4 week human trial,and I'll gladly come up to your lab and you can test me for this/that and document my daily progress...just let me know,I'll hop on a plane same day...In return I'll gladly claim fame to 11-oxo and all the ergopharm lineups for my gains when I take the stage at Olympia...
...just let me know,I'll hop on a plane same day...In return I'll gladly claim fame to 11-oxo and all the ergopharm lineups for my gains when I take the stage at Olympia...
CDB
Registered User
hey Patrick,If you wanna run our own "human trials" match me dollar for dollar and we can get enough of the wyeth stuff to do a 4 week human trial,and I'll gladly come up to your lab and you can test me for this/that and document my daily progress
Assuming you can make it up the stairs to the stage at that point.
getswole
Active member
I'd love to take my current bench stats and make them my current curling stats...I'd be pretty tempted to start strength training at that point and win a few strongman,how nice would that be,to hold consequetive titles in Olympia,strongman,and world hot dog eating contest at the same time..You'd be the man
Patrick Arnold
Featured Author
hey Patrick,If you wanna run our own "human trials" match me dollar for dollar and we can get enough of the wyeth stuff to do a 4 week human trial,and I'll gladly come up to your lab and you can test me for this/that and document my daily progress
yeah right
anyway, one of the most exciting prospects for these newly advanced gene therapies is the possbility for targeting specific bodyparts. a researcher described this in a recent article in scientific american magazine
lets say you were a runner who needed more mass in your legs specifically. they could tie off your blood supply from your femoral artery and whatever the main vein is their on both your legs and recirculate the blood while adding in the gene modified adenovirus. then after a washout period you patch them up and you end up with someone with the anabolic gene modified leg muscles
Patrick Arnold
Featured Author
what myostatin blockers are you talking about