what exactly can happen with E and synephrine, or could you link me to some literature?
Only reason I ask is b/c my mom takes a lipodrene very rarely when she needs extra energy, and I believe it contains both.
sure
Mayo Clin Proc. 2006 Apr;81(4):545-8.Links
Comment in:
Mayo Clin Proc. 2006 Dec;81(12):1636; author reply 1636-7.
Variant angina associated with bitter orange in a dietary supplement.Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NA.
Division of Cardiology, Tufts-New England Medical Center, Boston, MA, USA.
[email protected]
The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.
Mayo Clin Proc. 2006 Dec;81(12):1630-1.Links
Ischemic colitis associated with use of a bitter orange-containing dietary weight-loss supplement.Sultan S, Spector J, Mitchell RM.
Department of Medicine, University of Florida Medical Center and Malcolm Randall Veterans Affairs Medical Center, Gainesville, Fla 32605, USA.
[email protected]
Since the US Food and Drug Administration banned the use of dietary supplements containing ephedra in February 2004, numerous "ephedra-free" weight-loss products have appeared on the market. Many of these supplements contain compounds such as bitter orange that are similar in structure and action to ephedra. We describe a patient in whom ischemic colitis developed 1 week after initiation of a bitter orange-containing weight-loss supplement. The patient had no other predisposing factors, and discontinuation of the supplement led to immediate improvement and ultimate resolution of her symptoms. Both consumers and health care professionals should be aware of the potential harm that bitter orange-containing dietary supplements can cause and report such adverse events to the US Food and Drug Administration.
Mayo Clin Proc. 2005 Apr;80(4):541-5.Links
Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS.
NYC Poison Control Center, New York, NY, USA.
[email protected]
In response to concerns regarding the safety of ephedra-containing dietary supplements, manufacturers have marketed "ephedra-free" products. Many of these contain synephrine, a sympathomimetic amine from the plant Citrus aurantium. Synephrine is structurally similar to ephedrine and has vasoconstrictor properties. We describe a 38-year-old patient with ischemic stroke associated with an ephedra-free dietary supplement containing synephrine and caffeine. The patient presented with memory loss and unsteady gait after taking 1 or 2 capsules per day of a dietary supplement (Stacker 2 Ephedra-Free) for 1 week. He had no notable medical history or major atherosclerotic risk factors and took no other medications. Physical examination showed a mildly ataxic gait and substantial Impairment of both concentration and memory. Computed tomography and magnetic resonance Imaging of the brain showed subacute infarctions in the left thalamus and left cerebellum in the distribution of the vertebrobasilar circulation. Other causes of ischemic stroke were evaluated, and findings were unremarkable; a vasospastic origin was considered most likely. The patient was discharged with nearly complete resolution of symptoms. Synephrine, a sympathomimetic amine related to ephedrine, may be associated with Ischemic stroke. Consumers and clinicians need to be Informed about the potential risks of ephedra-free products
Mayo Clin Proc. 2005 Apr;80(4):541-5.Links
Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS.
NYC Poison Control Center, New York, NY, USA.
[email protected]
In response to concerns regarding the safety of ephedra-containing dietary supplements, manufacturers have marketed "ephedra-free" products. Many of these contain synephrine, a sympathomimetic amine from the plant Citrus aurantium. Synephrine is structurally similar to ephedrine and has vasoconstrictor properties. We describe a 38-year-old patient with ischemic stroke associated with an ephedra-free dietary supplement containing synephrine and caffeine. The patient presented with memory loss and unsteady gait after taking 1 or 2 capsules per day of a dietary supplement (Stacker 2 Ephedra-Free) for 1 week. He had no notable medical history or major atherosclerotic risk factors and took no other medications. Physical examination showed a mildly ataxic gait and substantial Impairment of both concentration and memory. Computed tomography and magnetic resonance Imaging of the brain showed subacute infarctions in the left thalamus and left cerebellum in the distribution of the vertebrobasilar circulation. Other causes of ischemic stroke were evaluated, and findings were unremarkable; a vasospastic origin was considered most likely. The patient was discharged with nearly complete resolution of symptoms. Synephrine, a sympathomimetic amine related to ephedrine, may be associated with Ischemic stroke. Consumers and clinicians need to be Informed about the potential risks of ephedra-free products