Irishobrien
Member
Arachidonic acid + COX = PGE2
“…short-term exposure of aged [muscle stem cells] to PGE2 augments their long-term regenerative capacity”
“Strikingly, PGE2 injections following … exercise-induced injury overcome the aged niche, leading to enhanced regenerative function of endogenous tissue-resident MuSCs and an increase in strength.”
Proof of concept:
A 2014 study published in Prostaglandins, Leukotrienes and Essential Fatty Acids investigated AA supplementation (1,500 mg/day for 4 weeks) in resistance-trained males. It found increased PGE2 levels in plasma post-exercise compared to placebo, suggesting that AA supplementation can amplify PGE2 production, especially under conditions like exercise that stimulate COX activity (Roberts et al., 2014).
Back to study:
“What amazes me most is that a single dose of treatment is sufficient to restore muscle stem cell function, and that the benefit lasts far beyond the duration of the drug," said Wang.
"In addition to making new muscle, the stem cells stay in the tissue, where they sustain the effect of the PGE2 and instill the muscle with further capacity to regenerate."
www.mdlinx.com
Synthesis:
Future studies:
- Intermittent exposure of ArA to healthy and aged human populations in response to exercise (once weekly vs twice weekly vs thrice weekly and so on) with at least 6 month post surveillance
“…short-term exposure of aged [muscle stem cells] to PGE2 augments their long-term regenerative capacity”
“Strikingly, PGE2 injections following … exercise-induced injury overcome the aged niche, leading to enhanced regenerative function of endogenous tissue-resident MuSCs and an increase in strength.”
Proof of concept:
A 2014 study published in Prostaglandins, Leukotrienes and Essential Fatty Acids investigated AA supplementation (1,500 mg/day for 4 weeks) in resistance-trained males. It found increased PGE2 levels in plasma post-exercise compared to placebo, suggesting that AA supplementation can amplify PGE2 production, especially under conditions like exercise that stimulate COX activity (Roberts et al., 2014).
Back to study:
“What amazes me most is that a single dose of treatment is sufficient to restore muscle stem cell function, and that the benefit lasts far beyond the duration of the drug," said Wang.
"In addition to making new muscle, the stem cells stay in the tissue, where they sustain the effect of the PGE2 and instill the muscle with further capacity to regenerate."
| MDLinx
www.mdlinx.com
Synthesis:
- Chronic supplementation of ArA likely deleterious to muscle strength, and function, through multiple mechanisms
- Short term exposure with adequate temporal nidus (exercise) beneficial (I.e. taking pre-workout)
- Avoid COX-2 inhibitors during supplementation
- The tangible benefits with respect to muscle SC function would likely be delayed post intervention
Future studies:
- Intermittent exposure of ArA to healthy and aged human populations in response to exercise (once weekly vs twice weekly vs thrice weekly and so on) with at least 6 month post surveillance
