The New King of Pre-Workouts Is Almost Here!

Segansational

Segansational

Well-known member
Awards
3
  • Established
  • First Up Vote
  • RockStar
Remind me did you ever try re1gn? It’ll be way more tamed since there’s no j.Regia as well and how genistein helps the signaling, breakdown, and processing of these stims
Nope, so won't be able to compare. But so many alpha-y pre's these days... my experiences as example, both Muscle Addiction Pump Fix (1.5mg/scoop), Appollon Assassin v7 (1mg Y/0.75mg alpha-y), C&P Cannibal Ferox (too many versions, can't recall). But I've basically had issues with all, whether or not it had other stims in them. I get the coldness/heart racing feeling. I keep trying thinking it'll be different this time, and then I'm reminded
J. Regia doesn’t overstimulate people the way Y and AY does.

Personally, I did get overstimulated from Re1gn (shaky, cold sweats and anxious). That’s why I always much preferred CU. That was smooth feel good energy.
I totally agree. Everyone gives the DMHA/DMAA type stims a bad rap. Personally, they are still my favorite. And DMHA has always been easier/less hard hitting to me than any of the others (amp being the most "dirty").
 

Jbtwentytwo

Member
Awards
0
I still haven’t received my order… I checked on my strong supplement account no update… checked the USPS site no update. I don’t think all the orders went out when stated..
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Got mine today. I will try one scoop Sunday morning. Hopefully I react well to it and have no negative sides.
Nice! Glad to see it getting into peoples hands!
 
LeanEngineer

LeanEngineer

Legend
Awards
4
  • RockStar
  • Established
  • Best Answer
  • First Up Vote
Got mine today. I will try one scoop Sunday morning. Hopefully I react well to it and have no negative sides.
Excited to see how it treats you!
 
Ripped_warrior

Ripped_warrior

New member
Awards
0
How strong is the maoi actually? I ask because I’m on antidepressants and you are not supposed to mix them.
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
How strong is the maoi actually? I ask because I’m on antidepressants and you are not supposed to mix them.
Always a consult with a real health professional but my two cents is that most drug maois themselves are just full of side effects even stand-alone . I’m on Effexor and never felt the effects of overstimulation or serotonin syndrome.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
workout done but give me another day to run two full scoops and then give my thoughts….
excited to hear your thoughts on the full ride? Guessing because you can ramp it up you didnt feel negative sides?
 
lionking999

lionking999

Member
Awards
2
  • First Up Vote
  • Established
excited to hear your thoughts on the full ride? Guessing because you can ramp it up you didnt feel negative sides?
nothing too negative to report. I took 1.5 first dose because of the alpha y. but the only y feelings I got was during the end of a couple drop sets (which is of course normal) and 20 mins of low intensity cardio had me sweating. but yeah I wanna do the full two scoops before I say any more
 

madmuscle24

Member
Awards
1
  • First Up Vote
Took two full scoops today before my workout. the stim effect feels similar to alpha lion super human extreme or dvst8 of the Union. With both being superior to me because of the added pump ingredients. Nothing really unique or exciting about oracle for me personally. I’d say it’s a good every day pre stim wise, But could use some more nitric Oxide boosters. S7 is just a new trendy filler ingredient that doesn’t do much IMO. Overall I like Oracle better than reign or CU if we’re talking strictly stim effects. It feels cleaner than reign for whatever reason even though the stim profile is similar and destroys CU as that was the weakest 2amino 5/ dmha product I’ve ever used. It was worth the intro price for sure but not sure I’d pay full price for this personally.
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Took two full scoops today before my workout. the stim effect feels similar to alpha lion super human extreme or dvst8 of the Union. With both being superior to me because of the added pump ingredients. Nothing really unique or exciting about oracle for me personally. I’d say it’s a good every day pre stim wise, But could use some more nitric Oxide boosters. S7 is just a new trendy filler ingredient that doesn’t do much IMO. Overall I like Oracle better than reign or CU if we’re talking strictly stim effects. It feels cleaner than reign for whatever reason even though the stim profile is similar and destroys CU as that was the weakest 2amino 5/ dmha product I’ve ever used. It was worth the intro price for sure but not sure I’d pay full price for this personally.
Glad it’s a clean stim feel for you. I loved the feel of both super human extreme and dvst8 of the union so I’m stoked to run it shortly. Those pres got me amped up energy wise. Appreciate the feedback.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Took two full scoops today before my workout. the stim effect feels similar to alpha lion super human extreme or dvst8 of the Union. With both being superior to me because of the added pump ingredients. Nothing really unique or exciting about oracle for me personally. I’d say it’s a good every day pre stim wise, But could use some more nitric Oxide boosters. S7 is just a new trendy filler ingredient that doesn’t do much IMO. Overall I like Oracle better than reign or CU if we’re talking strictly stim effects. It feels cleaner than reign for whatever reason even though the stim profile is similar and destroys CU as that was the weakest 2amino 5/ dmha product I’ve ever used. It was worth the intro price for sure but not sure I’d pay full price for this personally.
The ligustrazine phosphate for me is single-handedly the best pump ingredient I’ve come across. I get it doesn’t have as much pump but I wanted to make our product stackable with AlphaBulk and the rest of the lineup so we purposefully didn’t overstress the cumulative amount of pump ingredients. Personally if my pump is overpowering it takes away from the length of my workout. But thank you for the feedback and hopefully you continue to enjoy it 😊
 
LeanEngineer

LeanEngineer

Legend
Awards
4
  • RockStar
  • Established
  • Best Answer
  • First Up Vote
Took two full scoops today before my workout. the stim effect feels similar to alpha lion super human extreme or dvst8 of the Union. With both being superior to me because of the added pump ingredients. Nothing really unique or exciting about oracle for me personally. I’d say it’s a good every day pre stim wise, But could use some more nitric Oxide boosters. S7 is just a new trendy filler ingredient that doesn’t do much IMO. Overall I like Oracle better than reign or CU if we’re talking strictly stim effects. It feels cleaner than reign for whatever reason even though the stim profile is similar and destroys CU as that was the weakest 2amino 5/ dmha product I’ve ever used. It was worth the intro price for sure but not sure I’d pay full price for this personally.
Thanks for the review! Glad you liked it!
 

Jbtwentytwo

Member
Awards
0
My mini little review for oracle. I dosed it at a scoop and half 30 minutes prior to working out.

Taste: Surprisingly it doesn’t taste bad at all. It is definitely one of the better tasting preworkouts I’ve tried. Doesn’t have a chemical/nasty after taste. Smooth and easy to drink. 9/10

Mixability: It seemed to mix really easy and dissolve pretty well. There was no chalky/graininess to it at all. 9/10

Performance: For the most part it felt like I had consist energy and was focused. I did start sweating probably half way through my workout which I typically don’t sweat.



I think overall it’s a decent pre-workout and worth a shot. It’s not my all time favorite but got the job done.

Overall I give it a 7/10
 

Sculptor

Member
Awards
2
  • Established
  • First Up Vote
Anyone else’s tub only half full? Supposed to be 180 grams and mine is 90 according to the scale. That’s not great.

Tried 1 scoop and tried it at 2. Like it at 1, definitely clean for having the alpha y. At 2 I get the typical yohimbine side effects that I don’t love.
 

determination

Active member
Awards
2
  • Established
  • First Up Vote
Anyone else’s tub only half full? Supposed to be 180 grams and mine is 90 according to the scale. That’s not great.

Tried 1 scoop and tried it at 2. Like it at 1, definitely clean for having the alpha y. At 2 I get the typical yohimbine side effects that I don’t love.
My scale says 180g after taking two scoops out. That is including the container and scoop
 

Jbtwentytwo

Member
Awards
0
Anyone else’s tub only half full? Supposed to be 180 grams and mine is 90 according to the scale. That’s not great.

Tried 1 scoop and tried it at 2. Like it at 1, definitely clean for having the alpha y. At 2 I get the typical yohimbine side effects that I don’t love.
Yeah I noticed the tub wasn’t very full either for the size of it.
 
BigGame84

BigGame84

Well-known member
Awards
3
  • Established
  • First Up Vote
  • RockStar
Here's my Oracle review:

Did 1.5 scoops.

Taste: Really enjoyed the taste. As somebody else said, very similar to PEZ candy. Easy to mix. 9/10

Effects: My biggest takeaway here is the mind/muscle connection. It's very noticeable. Stim-wise, it's smooth. Nothing crazy. Could definitely move up to 2 scoops, probably will next time. Pumps were good. Other than the mind/muscle connection and pumps, nothing special here in regards to energy. Didn't feel any extra motivation or any kind of Alpha-feeling. 7.5/10

Summary: Right now, I'm not running to buy another tub. But this was only my first time trying so I'll need to give it more of a chance. I will move up to 2 scoops next time. The mind-muscle connection was nice and it's also nice to have something once in a while where you don't feel all cracked out. 1.5 scoops did have me thinking it was lacking some horsepower though.
 
lionking999

lionking999

Member
Awards
2
  • First Up Vote
  • Established
Okay two scoops today. Taste is good. A lot better than some other pwos I’ve been taking. yesterday 1.5 scoops was very underwhelming so I didn’t want to comment too much on it. Two full scoops did the trick. Nice smooth energy, decent pumps, no jitters. yesterday I sweat a lot. today for some reason didn’t sweat that much. I do like it. I’m glad I tried it, but as others have said, it’s nothing special, however I actually would consider buying again solely based off the smooth lasting energy.

About 6 weeks into alpha bulk and enjoying that as well
 

Jbtwentytwo

Member
Awards
0
Here's my Oracle review:

Did 1.5 scoops.

Taste: Really enjoyed the taste. As somebody else said, very similar to PEZ candy. Easy to mix. 9/10

Effects: My biggest takeaway here is the mind/muscle connection. It's very noticeable. Stim-wise, it's smooth. Nothing crazy. Could definitely move up to 2 scoops, probably will next time. Pumps were good. Other than the mind/muscle connection and pumps, nothing special here in regards to energy. Didn't feel any extra motivation or any kind of Alpha-feeling. 7.5/10

Summary: Right now, I'm not running to buy another tub. But this was only my first time trying so I'll need to give it more of a chance. I will move up to 2 scoops next time. The mind-muscle connection was nice and it's also nice to have something once in a while where you don't feel all cracked out. 1.5 scoops did have me thinking it was lacking some horsepower though.
Yeah that taste was actually impressive. Not very over powering and chemical tasting.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
My mini little review for oracle. I dosed it at a scoop and half 30 minutes prior to working out.

Taste: Surprisingly it doesn’t taste bad at all. It is definitely one of the better tasting preworkouts I’ve tried. Doesn’t have a chemical/nasty after taste. Smooth and easy to drink. 9/10

Mixability: It seemed to mix really easy and dissolve pretty well. There was no chalky/graininess to it at all. 9/10

Performance: For the most part it felt like I had consist energy and was focused. I did start sweating probably half way through my workout which I typically don’t sweat.



I think overall it’s a decent pre-workout and worth a shot. It’s not my all time favorite but got the job done.

Overall I give it a 7/10
Hey thanks for the review give it a shot at the full 3 scoops size and it may change that 7 into something better 😊
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Anyone else’s tub only half full? Supposed to be 180 grams and mine is 90 according to the scale. That’s not great.

Tried 1 scoop and tried it at 2. Like it at 1, definitely clean for having the alpha y. At 2 I get the typical yohimbine side effects that I don’t love.
It should be around ~120g

that was the first label issue discovered with the label, 3g per 1 serve and 6g per 2 serve
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Anyone else’s tub only half full? Supposed to be 180 grams and mine is 90 according to the scale. That’s not great.

Tried 1 scoop and tried it at 2. Like it at 1, definitely clean for having the alpha y. At 2 I get the typical yohimbine side effects that I don’t love.
May 1 or 2 scoops how was the cumulative effects outside the alpha-y feeling for you? Curious to know!!
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Okay two scoops today. Taste is good. A lot better than some other pwos I’ve been taking. yesterday 1.5 scoops was very underwhelming so I didn’t want to comment too much on it. Two full scoops did the trick. Nice smooth energy, decent pumps, no jitters. yesterday I sweat a lot. today for some reason didn’t sweat that much. I do like it. I’m glad I tried it, but as others have said, it’s nothing special, however I actually would consider buying again solely based off the smooth lasting energy.

About 6 weeks into alpha bulk and enjoying that as well
Awesome to see that 2 scoops made the difference for you and hopefully does for biggame84 as well. For those who are limited to taking one scoop because of the stim effects I’m hoping stacking with something like AlphaBulk or the added servings will make it worthwhile for now until we release some other stim stuff to stack with in the future
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Okay two scoops today. Taste is good. A lot better than some other pwos I’ve been taking. yesterday 1.5 scoops was very underwhelming so I didn’t want to comment too much on it. Two full scoops did the trick. Nice smooth energy, decent pumps, no jitters. yesterday I sweat a lot. today for some reason didn’t sweat that much. I do like it. I’m glad I tried it, but as others have said, it’s nothing special, however I actually would consider buying again solely based off the smooth lasting energy.

About 6 weeks into alpha bulk and enjoying that as well
Win win. Appreciate everyone’s feedback for sure. Thanks guys.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Yeah that taste was actually impressive. Not very over powering and chemical tasting.
Might be the first product where everyone agrees the taste is on point! Thank you. Genistein is a very interesting ingredient. Interested to see if anyone finds chronic use benefit for it over the course of using Oracle and whether the difference between 1 full serving size (2 scoops) will turn the ratings higher.

I did not want cracked out stims or arm numbing pumps since this is a supplement that’s designed to aid your work out not counteract it. Thank you for the great feedback so far!!!
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Here's my Oracle review:

Did 1.5 scoops.

Taste: Really enjoyed the taste. As somebody else said, very similar to PEZ candy. Easy to mix. 9/10

Effects: My biggest takeaway here is the mind/muscle connection. It's very noticeable. Stim-wise, it's smooth. Nothing crazy. Could definitely move up to 2 scoops, probably will next time. Pumps were good. Other than the mind/muscle connection and pumps, nothing special here in regards to energy. Didn't feel any extra motivation or any kind of Alpha-feeling. 7.5/10

Summary: Right now, I'm not running to buy another tub. But this was only my first time trying so I'll need to give it more of a chance. I will move up to 2 scoops next time. The mind-muscle connection was nice and it's also nice to have something once in a while where you don't feel all cracked out. 1.5 scoops did have me thinking it was lacking some horsepower though.
Appreciate the feedback. Interested in seeing how two scoops treats you
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Any ideas for new flavors, each one should be introduced with a similar launch sale, for people to try. We tested a blue ice pop that was exquisite more coming out this week that I could sample baggy for whoever’s interested in trying
 

Jbtwentytwo

Member
Awards
0
Any ideas for new flavors, each one should be introduced with a similar launch sale, for people to try. We tested a blue ice pop that was exquisite more coming out this week that I could sample baggy for whoever’s interested in trying
I always liked grape flavors.
 
lionking999

lionking999

Member
Awards
2
  • First Up Vote
  • Established
big fan of blue raspberry/ rocket pop type flavors. Sometimes sour apple
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
big fan of blue raspberry/ rocket pop type flavors. Sometimes sour apple
If anyone is interested in trying flavors email me [email protected] . I’ve noted the ones you’ve recommended. I love grapes but I’ve never tasted a good grape flavor. Idk about you all but red grapes are my jam.
Also disclaimer there is some variance between prototyping flavors and when flavors are added via production mixing
 

Jbtwentytwo

Member
Awards
0
If anyone is interested in trying flavors email me [email protected] . I’ve noted the ones you’ve recommended. I love grapes but I’ve never tasted a good grape flavor. Idk about you all but red grapes are my jam.
Also disclaimer there is some variance between prototyping flavors and when flavors are added via production mixing
you should note a orange citrus flavor too!
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
I like grape and I always liked controlled labs electric lemonade. Just a straight lemonade flavor. No extras.
 
Segansational

Segansational

Well-known member
Awards
3
  • Established
  • First Up Vote
  • RockStar
Ok, thoughts post-workout with 1 scoop:

Took 1 scoop on the way to the gym. Effects started to come on about 25 mins into my drive. Light sensation of fast heart rate, consistent, but less intense than what I experience with alpha-y pre's. Like just under the surface. By 40 mins in (traffic/accident on the highway) started to feel that nervous energy, as if my muscles had to start moving. Too bad I was stuck in traffic.

Pretty light in terms of stim effect otherwise or focus, but also I want to give it another proper go when I don't hit a delay in getting to the gym. Was probably close to an hour by the time I actually started my first set. Taste is pretty sweet, Smarties would be the flavor I'd peg it as. Has a bit of a "slick" mouthfeel also is how I'd describe it, likely due to the sugary flavoring. Good, given the sort of hit or miss flavoring in the past. May try 1.5 scoops next, but that'll probably be my limit in terms of alpha-y tolerance.
 
lionking999

lionking999

Member
Awards
2
  • First Up Vote
  • Established
Ok, thoughts post-workout with 1 scoop:

Took 1 scoop on the way to the gym. Effects started to come on about 25 mins into my drive. Light sensation of fast heart rate, consistent, but less intense than what I experience with alpha-y pre's. Like just under the surface. By 40 mins in (traffic/accident on the highway) started to feel that nervous energy, as if my muscles had to start moving. Too bad I was stuck in traffic.

Pretty light in terms of stim effect otherwise or focus, but also I want to give it another proper go when I don't hit a delay in getting to the gym. Was probably close to an hour by the time I actually started my first set. Taste is pretty sweet, Smarties would be the flavor I'd peg it as. Has a bit of a "slick" mouthfeel also is how I'd describe it, likely due to the sugary flavoring. Good, given the sort of hit or miss flavoring in the past. May try 1.5 scoops next, but that'll probably be my limit in terms of alpha-y tolerance.
Try the full 2 servings the alpha y feelings were definitely not the same as others. I felt like the product really came in at 2 scoops whereas 1.5 almost made me leave a somewhat negative review
 
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Try the full 2 servings the alpha y feelings were definitely not the same as others. I felt like the product really came in at 2 scoops whereas 1.5 almost made me leave a somewhat negative review
Nice to see some of the alpha y fears have been alleviated so far. I don’t handle alpha y that well so when I get a bottle I’m definitely gonna keep my eye on that. Stoked on everyone’s reviews so far.
 

Mike Arnold

Board Sponsor
Awards
3
  • Established
  • First Up Vote
  • RockStar
25% lower on stim-x. I think most if not all even the sensitive individuals should find the preworkout to be a great experience. The role of genistein being a potent and synergistic MAOI is underrated
Nice Job! This is exactly why I was the first one (to my knowledge) to use it in a supplement for such purposes! You guys probably saw the study comparing genistein to selegiline (n terms of MAO-B inhibition).

Furthermore, most people don't realize that genistein also has significant growth promoting effects, as it has been shown (in multiple studies) to prevent protein degradation and increase myotube thickness. Here's a few. :)

Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents via Effects on Estrogen Receptor-α
Shinya Aoyama 1, Huijuan Jia 2, Kyoko Nakazawa 2, Junki Yamamura 1, Kenji Saito 2, Hisanori Kato 3
Affiliations expand
Free article
Abstract
Background: Genistein has high estrogenic activity. Previous studies have shown beneficial effects of estrogen or hormone replacement therapy on muscle mass and muscle atrophy.
Objective: We investigated the preventive effects and underlying mechanisms of genistein on muscle atrophy.
Methods: In Expt. 1, male Wistar rats were fed a diet containing no genistein [control (CON)] or 0.05% genistein (GEN; wt:wt diet) for 24 d. On day 14, the sciatic nerve in the left hind leg was severed, and the right hind leg was sham-treated. In Expt. 2, male C57BL6J mice were subcutaneously administered a vehicle (Veh group) or the estrogen receptor (ER) antagonist ICI 182,780 (ICI group) via an osmotic pump for 27 d, and each group was subsequently fed CON or GEN diets from day 3 to day 27. Muscle atrophy was induced on day 17 as in Expt. 1. In Expt. 3, male C57BL6J mice were subcutaneously administered vehicle or a selective ER agonist-ER-α [4,4',4'-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT)] or ER-β [2,3-bis(4-hydroxyphenyl)-propionitrile (DPN)]-or genistein (GEN-sc-i) via an osmotic pump for 13 d, and muscle atrophy was induced on day 3 as in Expt. 1. The ratio of denervated soleus muscle weight to sham-operated soleus muscle weight (d/s ratio) was used as the index of muscle atrophy.
Results: Expt. 1: The d/s ratio in the GEN group was 20% higher than that in the CON group (P < 0.05). Expt. 2: The d/s ratio in the Veh-GEN group was 14% higher than that in the Veh-CON group (P < 0.05), although there was no significant difference between ICI-CON and ICI-GEN groups (P = 0.69). Expt. 3: The d/s ratio in the PPT-treated group was 20% greater than that in the Veh group (P < 0.05), but DPN and GEN-sc-i had no effect on the d/s ratio (P ≥ 0.05 compared with vehicle).
Conclusion: Genistein intake mitigated denervation-induced soleus muscle atrophy. ER-α was related to the preventive effect of genistein on muscle atrophy.


Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222
Linyuan Shen 1 2, Tianci Liao 1 2, Jingyun Chen 1 2, Jianfeng Ma 1 2, Jinyong Wang 3, Lei Chen 1 2, Shunhua Zhang 1 2, Ye Zhao 1 2, Lili Niu 1 2, Changjun Zeng 1 2, Mailin Gan 1 2, Li Zhu 1 2
Affiliations expand
Free PMC article
Abstract
Genistein (GEN), a phytoestrogen, has been reported to regulate skeletal muscle endocrine factor expression and muscle fiber type switching, but its role in skeletal muscle regeneration is poorly understood. As a class of epigenetic regulators widely involved in skeletal muscle development, microRNAs (miRNAs) have the potential to treat skeletal muscle injury. In this study, we identified miR-221 and miR-222 and their target genes MyoG and Tnnc1 as key regulators during skeletal muscle regeneration, and both were regulated by GEN. C2C12 myoblasts and C2C12 myotubes were then used to simulate the proliferation and differentiation of muscle satellite cells during skeletal muscle regeneration. The results showed that GEN could inhibit the proliferation of satellite cells and promote the differentiation of satellite cells by inhibiting the expression of miR-221/222. Subsequent in vitro and in vivo experiments showed that GEN improved skeletal muscle regeneration mainly by promoting satellite cell differentiation in the middle and late stages, by regulating miR-221/222 expression. These results suggest that miR-221/222 and their natural regulator GEN have potential applications in skeletal muscle regeneration.
 
Last edited:
Afi140

Afi140

Legend
Awards
4
  • Best Answer
  • First Up Vote
  • RockStar
  • Established
Nice Job! This is exactly why I was the first one (to my knowledge) to use it in a supplement for such purposes! You guys probably saw the study comparing genistein to selegiline (n terms of MAO-B inhibition).

Furthermore, most people don't realize that genistein also has significant growth promoting effects, as it has been shown (in multiple studies) to prevent protein degradation and increase myotube thickness. Here's a few. :)

Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents via Effects on Estrogen Receptor-α
Shinya Aoyama 1, Huijuan Jia 2, Kyoko Nakazawa 2, Junki Yamamura 1, Kenji Saito 2, Hisanori Kato 3
Affiliations expand
Free article
Abstract
Background: Genistein has high estrogenic activity. Previous studies have shown beneficial effects of estrogen or hormone replacement therapy on muscle mass and muscle atrophy.
Objective: We investigated the preventive effects and underlying mechanisms of genistein on muscle atrophy.
Methods: In Expt. 1, male Wistar rats were fed a diet containing no genistein [control (CON)] or 0.05% genistein (GEN; wt:wt diet) for 24 d. On day 14, the sciatic nerve in the left hind leg was severed, and the right hind leg was sham-treated. In Expt. 2, male C57BL6J mice were subcutaneously administered a vehicle (Veh group) or the estrogen receptor (ER) antagonist ICI 182,780 (ICI group) via an osmotic pump for 27 d, and each group was subsequently fed CON or GEN diets from day 3 to day 27. Muscle atrophy was induced on day 17 as in Expt. 1. In Expt. 3, male C57BL6J mice were subcutaneously administered vehicle or a selective ER agonist-ER-α [4,4',4'-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT)] or ER-β [2,3-bis(4-hydroxyphenyl)-propionitrile (DPN)]-or genistein (GEN-sc-i) via an osmotic pump for 13 d, and muscle atrophy was induced on day 3 as in Expt. 1. The ratio of denervated soleus muscle weight to sham-operated soleus muscle weight (d/s ratio) was used as the index of muscle atrophy.
Results: Expt. 1: The d/s ratio in the GEN group was 20% higher than that in the CON group (P < 0.05). Expt. 2: The d/s ratio in the Veh-GEN group was 14% higher than that in the Veh-CON group (P < 0.05), although there was no significant difference between ICI-CON and ICI-GEN groups (P = 0.69). Expt. 3: The d/s ratio in the PPT-treated group was 20% greater than that in the Veh group (P < 0.05), but DPN and GEN-sc-i had no effect on the d/s ratio (P ≥ 0.05 compared with vehicle).
Conclusion: Genistein intake mitigated denervation-induced soleus muscle atrophy. ER-α was related to the preventive effect of genistein on muscle atrophy.


Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222
Linyuan Shen 1 2, Tianci Liao 1 2, Jingyun Chen 1 2, Jianfeng Ma 1 2, Jinyong Wang 3, Lei Chen 1 2, Shunhua Zhang 1 2, Ye Zhao 1 2, Lili Niu 1 2, Changjun Zeng 1 2, Mailin Gan 1 2, Li Zhu 1 2
Affiliations expand
Free PMC article
Abstract
Genistein (GEN), a phytoestrogen, has been reported to regulate skeletal muscle endocrine factor expression and muscle fiber type switching, but its role in skeletal muscle regeneration is poorly understood. As a class of epigenetic regulators widely involved in skeletal muscle development, microRNAs (miRNAs) have the potential to treat skeletal muscle injury. In this study, we identified miR-221 and miR-222 and their target genes MyoG and Tnnc1 as key regulators during skeletal muscle regeneration, and both were regulated by GEN. C2C12 myoblasts and C2C12 myotubes were then used to simulate the proliferation and differentiation of muscle satellite cells during skeletal muscle regeneration. The results showed that GEN could inhibit the proliferation of satellite cells and promote the differentiation of satellite cells by inhibiting the expression of miR-221/222. Subsequent in vitro and in vivo experiments showed that GEN improved skeletal muscle regeneration mainly by promoting satellite cell differentiation in the middle and late stages, by regulating miR-221/222 expression. These results suggest that miR-221/222 and their natural regulator GEN have potential applications in skeletal muscle regeneration.
Appreciate that bro. I know you know your stuff too so glad you’re chiming in.
 
LeanEngineer

LeanEngineer

Legend
Awards
4
  • RockStar
  • Established
  • Best Answer
  • First Up Vote
Glad to see all the positive feedback and reviews on Oracle in here!
 

littlrook

Member
Awards
0
Like others have said, my tub was also 1/4- 1/3 full. I received mine on Friday and took one scoop on Sat to test it out. Felt very little. Small eupohoria/ head buzz for about 30min but that might have been the kratom also. Sunday I did not take any stims other than kratom for pain. This morning I did 2 scoops about 20min before my workout. I had a good sweat with my hoodie on, but the stim/eupohoria wore off about 30min for me. I started to crash about 45min in. Finished up and left. Taste wise- very light flavor easy to drink. Pump was decent but I was crashing by the time I got to my pump sets since I do 5/3/1. For me I would def prefer the effects of Reign at this point.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Ok, thoughts post-workout with 1 scoop:

Took 1 scoop on the way to the gym. Effects started to come on about 25 mins into my drive. Light sensation of fast heart rate, consistent, but less intense than what I experience with alpha-y pre's. Like just under the surface. By 40 mins in (traffic/accident on the highway) started to feel that nervous energy, as if my muscles had to start moving. Too bad I was stuck in traffic.

Pretty light in terms of stim effect otherwise or focus, but also I want to give it another proper go when I don't hit a delay in getting to the gym. Was probably close to an hour by the time I actually started my first set. Taste is pretty sweet, Smarties would be the flavor I'd peg it as. Has a bit of a "slick" mouthfeel also is how I'd describe it, likely due to the sugary flavoring. Good, given the sort of hit or miss flavoring in the past. May try 1.5 scoops next, but that'll probably be my limit in terms of alpha-y tolerance.
I would say slowly ramp up the dose if you can as with any other true 20 servings pre-workout you won't feel the full effectiveness otherwise, especially for the stims. When formulating the pre-workout stim efficacy was the number one priority as the acute effects are the number one priority and therefore doses were meticulously crafted albeit everything is individualistic, we made sure doses there industry high per the ingredients we were allowed to legally use.
 
Olympus Labs Rep

Olympus Labs Rep

Member
Awards
0
Like others have said, my tub was also 1/4- 1/3 full. I received mine on Friday and took one scoop on Sat to test it out. Felt very little. Small eupohoria/ head buzz for about 30min but that might have been the kratom also. Sunday I did not take any stims other than kratom for pain. This morning I did 2 scoops about 20min before my workout. I had a good sweat with my hoodie on, but the stim/eupohoria wore off about 30min for me. I started to crash about 45min in. Finished up and left. Taste wise- very light flavor easy to drink. Pump was decent but I was crashing by the time I got to my pump sets since I do 5/3/1. For me I would def prefer the effects of Reign at this point.
Unfortunately, there are going to be some contraindications between kratom use and the stimulants found in Oracle. When different ingredients and substances compete for the same pathways the results are always going to be mixed. If, and i don't know whether or not you are able to use it off kratom that would be a good way to assess it. If you used re1gn with kratom in the past than the only likely explanation is that you responded really well to the J.Regia extract
 

Similar threads


Top