sns8778
Board Sponsor
I look forward to hearing your feedback on it. I think and hope that you'll really enjoy it.
TTA-500 - Now Available - Get it While Supplies Last!
- Thread starter sns8778
- Start date
I look forward to hearing your feedback on it. I think and hope that you'll really enjoy it.
sns8778
Board Sponsor
It varies by the person. Most people never experience it or at least not to any noticeable degree.
I think TTA works well for pretty much any level of leanness. I don't think its one of those that's only good for a certain level.
sns8778
Board Sponsor
That's great to hear. I'm glad that its working so well for you.
I'm glad that you like Focus XT too. Another nice bonus with Focus XT is that it has quite a few ingredients that work for fat loss as well. It's mostly thought of as a nootropic energy drink, but could also be viewed as a fat burning nootropic energy drink bc it has a great dose of ALCAR and L-Tyrosine in it.
khall1974
Well-known member
And you are running l carnitine as well???...I bet they are synergistically working together
sns8778
Board Sponsor
That was something I mentioned in my post above - that Focus XT has great synergy with it bc it has ALCAR in it (and Tyrosine)
Rocket3015
Legend
Yes I am using 200mg pre workout.
Rocket3015
Legend
I am on day (4) and have taken it 30 minutes before each meal working good so far.
I have not noticed any water retention so far.....
BigSWOLE25
Member
Looking forward to this run after my current stack. They were out of glycophase but I'll add that also.
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sns8778
Board Sponsor
That should be a great stack. We hope to have GlycoPhase back in stock in the next couple of weeks as well.
Rocket3015
Legend
Nice looking stack !!
aaronuconn
Well-known member
Awesome stack. Also the Green Coffee Bean is underrated for general health purposes
sns8778
Board Sponsor
I agree, I think that Green Coffee Bean and also Raspberry Ketones are very underrated.
aaronuconn
Well-known member
Unfortunately they were hyped to be something they never could be. Now I feel they get an underserved reputation of being bunk or something along those lines
GQdaLEGEND
Legend
Yeah def forgotten, i would say for me too as well.
but Raspberry Ketones were studied to be one of the best thing, and i do know people who won't touch these new fat burners or new stuff like capsimax , GBB etc and would only run green coffee, raspberry
I guess the old school/og genernation .. now so much new stuff and we all need to keep up and get the latest stuff out ( same goes with tech and stuff right .. like old iphone 7 will work but every year we want that upgrade )
speaking of this my next DPS order i need to get me some 540caps of RK for $4
Rocket3015
Legend
Good Deal !!
GQdaLEGEND
Legend
nice glad you got it and for future you know where to go *wink wink*
sns8778
Board Sponsor
I'm glad that you received it and that the duties were inexpensive.
Just always keep in mind though that as a shipper that's what we hope for but we can't guarantee anything when it comes to customs, duties, etc. We do the best we can from our side but there are never guarantees on how customs will handle anything haha.
aaronuconn
Well-known member
Interesting (and old) rat study.
Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets
Aim: The pan-peroxisome proliferator-activated receptor (PPAR) ligand and fatty acid analogue tetradecylthioacetic acid (TTA) may reduce plasma lipids and enhance hepatic lipid metabolism, as well as reduce adipose tissue sizes in rats fed on high-fat diets. This study further explores the effects of TTA on weight gain, feed intake and adipose tissue functions in rats that are fed a high-fat diet for 7 weeks.
Methods: The effects on feed intake and body weight during 7 weeks' dietary supplement with TTA ( approximately 200 mg/kg bw) were studied in male Wistar rats fed on a lard-based diet containing approximately 40% energy from fat. Adipose tissue mass, body composition and expression of relevant genes in fat depots and liver were measured at the end of the feeding.
Results: Despite higher feed intake during the final 2 weeks of the study, rats fed on TTA gained less body weight than lard-fed rats and had markedly decreased subcutaneous, epididymal, perirenal and mesenteric adipose depots. The effects of TTA feeding with reduced body weight gain and energy efficiency (weight gain/feed intake) started between day 10 and 13. Body contents of fat, protein and water were reduced after feeding lard plus TTA, with a stronger decrease in fat relative to protein. Plasma lipids, including Non-Esterified Fatty Acids (NEFA), were significantly reduced, whereas fatty acid beta-oxidation in liver and heart was enhanced in lard plus TTA-fed rats. Hepatic UCP3 was expressed ectopically both at protein and mRNA level (>1900-fold), whereas Ucp1 mRNA was increased approximately 30-fold in epididymal and approximately 90-fold in mesenteric fat after lard plus TTA feeding.
Conclusion: Our data support the hypothesis that TTA feeding may increase hepatic fatty acid beta-oxidation, and thereby reduce the size of adipose tissues. The functional importance of ectopic hepatic UCP3 is unknown, but might be associated with enhanced energy expenditure and thus the reduced feed efficiency.
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Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets
Aim: The pan-peroxisome proliferator-activated receptor (PPAR) ligand and fatty acid analogue tetradecylthioacetic acid (TTA) may reduce plasma lipids and enhance hepatic lipid metabolism, as well as reduce adipose tissue sizes in rats fed on high-fat diets. This study further explores the effects of TTA on weight gain, feed intake and adipose tissue functions in rats that are fed a high-fat diet for 7 weeks.
Methods: The effects on feed intake and body weight during 7 weeks' dietary supplement with TTA ( approximately 200 mg/kg bw) were studied in male Wistar rats fed on a lard-based diet containing approximately 40% energy from fat. Adipose tissue mass, body composition and expression of relevant genes in fat depots and liver were measured at the end of the feeding.
Results: Despite higher feed intake during the final 2 weeks of the study, rats fed on TTA gained less body weight than lard-fed rats and had markedly decreased subcutaneous, epididymal, perirenal and mesenteric adipose depots. The effects of TTA feeding with reduced body weight gain and energy efficiency (weight gain/feed intake) started between day 10 and 13. Body contents of fat, protein and water were reduced after feeding lard plus TTA, with a stronger decrease in fat relative to protein. Plasma lipids, including Non-Esterified Fatty Acids (NEFA), were significantly reduced, whereas fatty acid beta-oxidation in liver and heart was enhanced in lard plus TTA-fed rats. Hepatic UCP3 was expressed ectopically both at protein and mRNA level (>1900-fold), whereas Ucp1 mRNA was increased approximately 30-fold in epididymal and approximately 90-fold in mesenteric fat after lard plus TTA feeding.
Conclusion: Our data support the hypothesis that TTA feeding may increase hepatic fatty acid beta-oxidation, and thereby reduce the size of adipose tissues. The functional importance of ectopic hepatic UCP3 is unknown, but might be associated with enhanced energy expenditure and thus the reduced feed efficiency.
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Segansational
Well-known member
That is very interesting! Lately I have been feeling hunger attacks - and while I'm cutting cals, so that's somewhat normal - this might help explain my cravings.
Rocket3015
Legend
So if I am reading this right I need 200mg per Kg of body weight ??
jmero2
Active member
So a person weighing 80 kg would need 1.6 grams. So 8 capsules per day?
aaronuconn
Well-known member
No, you can’t use mouse models as 1:1 when comparing. You need to find the human equivalent dosage (HED).
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Rocket3015
Legend
Is that like dog years ??
Rocket3015
Legend
I would like to hear @sns8778 take on this ???
aaronuconn
Well-known member
To use the specific study, they used rats at 200mg/kg. To translate that, if you weigh 80kg, that means 16g. This would be an insane dosage for TTA. The HED paper I linked stated to then take the 16g figure and multiply by .162 for rats. This is assuming the rats used in the TTA study are the exact size specified in Table 1 in the HED conversion paper. Obviously not going to be the case, but for the sake of simplicity, let’s assume they are.
Once we multiply our 16g TTA dosage by .162, we’re left with ~2.6g for TTA. Still a very high dosage, but much more realistic.
Again, I’m assuming the rats in the TTA study have the exact same body weight and surface area as the rat reference in the HED conversion paper. I highly doubt that’s the case, therefore that final number of 2.6g TTA is just for illustrative purposes
Rocket3015
Legend
Very good explanation, Thank you
Rocket3015
Legend
From Steve @ SNS
We're hoping to have it back in stock within the next couple of weeks.
MitoBurn XT - Now Available - AnabolicMinds.com
Stimulant Free Fat Burner Ultra-Potent 500 mg. Per Capsule MitoBurn™ is the first clinically tested and verified form of L-BAIBA. Increased L-BAIBA levels are associated with many of exercise’s numerous benefits, including amplifying the fat burning effects of exercise so you see results...
anabolicminds.com
sns8778
Board Sponsor
I'm buying 10 bottles. God knows I've missed TTA. Had to undergo hip surgery and gained some weight during recovery, glad it's back! SNS, you guys rock!
I'm very glad to be able to bring this one back. I mentioned I think at the beginning of the thread that when this batch sells out, there will be a period of time where we will be out of stock again on it while we wait for more raw materials to be made; and we are getting pretty low - so your idea of stocking up is probably a very good idea
I'm sorry to hear about your hip surgery. I hope that your recovery is going well.
sns8778
Board Sponsor
Rodent studies almost never have a direct dosage correlation to humans. Almost anytime one were to try to do a direct math correlation on an animal study to human study without doing relevant conversions, the number they come up with would seem to be extremely off.
The 2.6 gram dosage in the calculation is too high in my opinion. I remember years ago there was a discussion on this and it was pretty much unanimously agreed that the dosage range depending on how the calculation was done, the max dosage was around 2 grams per day, maybe slightly higher.
When we originally released TTA-500 many years ago, our suggested use had allowed for up to 4 capsules per day (2 grams per day). There were two reasons that we backed this down to a 1.5 gram per day dosage when we re-released TTA-500 recently and those are - most people used 3 caps per day anyway bc it was more convenient and because we almost never had people report issues with fluid retention or stomach distress but the few times we did, it was in people using 4 caps (2 grams) per day.
So, overall I think that 3 caps per day is the correct dosage for most people but if someone were to want to exceed the recommended dose on the bottle, I would not go any higher than 2 grams per day (4 caps).
I hope that makes sense.
sns8778
Board Sponsor
Each capsule of TTA-500 contains 500 mg. of TTA per capsule.
So 3 capsules of TTA-500 per day would be 1.5 grams of TTA per day.
I think you may have gotten TTA-500 confused with another product on the market that has only 200 mg. per capsule.
sns8778
Board Sponsor
I'm very sorry for the inconvenience. We are out of quite a few things but we have things coming back in stock pretty quickly now and you should see a lot of things back in stock over the next few weeks, including MitoBurn XT.
I would definitely go ahead with getting TTA-500 if you want it because once we run out of this batch, there will be a period of time where we will be out of stock on it while we wait for more raw materials for it. Raws are extremely hard to make on this ingredient up to our quality standards. I'm very happy that we were finally able to have it done and there are more being made now - but the testing process on these raws is also not a fast process either.
Rocket3015
Legend
Great Info !!
aaronuconn
Well-known member
Oh for sure 2.6g would be too high IMO. I hope I added enough caveats and that I wasn’t misconstrued. Just simply wanted to show that to find the human equivalence dosage, there’s a little simple math that has to be done and that we don’t just take the exact mg per kg that rats would take
Rocket3015
Legend
Oh for sure 2.6g would be too high IMO. I hope I added enough caveats and that I wasn’t misconstrued. Just simply wanted to show that to find the human equivalence dosage, there’s a little simple math that has to be done and that we don’t just take the exact mg per kg that rats would take
I will just eat the Rat after he takes it!
BigSWOLE25
Member
How long should a cycle be for tta? I read somewhere 8 weeks but can't seem to find it now.
sns8778
Board Sponsor
I don't think it necessarily needs to be stopped at the end of 8 weeks in my opinion. I would say it could be used throughout a cut. I remember in the past it was said 8 to 12 weeks but that was really kind of old school thinking that originated out of the thought that all fat burners needed to be cycled and that's really not the case.
I hope that helps.
BigSWOLE25
Member
Thanks again
sns8778
Board Sponsor
No problem at all. I'm glad to help in any way that I can.
sns8778
Board Sponsor
The SNS, Competitive Edge Labs, and Muscle Addiction Black Friday Sales are now live.
Coupon code: blackfriday30
TTA-500 - for a limited time, only 27.99 each with coupon code blackfriday30
seriousnutritionsolutions.com
Also, as an extra surprise for the Black Friday Sale, we also listed a TTA-500 - 3 Pack new to the website at an already discounted price and yes, the coupon code will work for that also!
TTA-500 - 3 Pack - for a limited time, only 76.99 with coupon code blackfriday30
https://seriousnutritionsolutions.com/product/tta-500-3-pack/
This is a while supplies last offer and we expect TTA-500 to sell out during the sale.
Coupon code: blackfriday30
TTA-500 - for a limited time, only 27.99 each with coupon code blackfriday30
TTA-500 - 90 Veg Caps | Serious Nutrition Solutions
TTA-500 - Ultra-Potent 500 Mg. Per Capsule. Stimulant Free Fat Burner. Advanced Fat Loss Support for Cutting & Body-Composition Regimens.
seriousnutritionsolutions.com
Also, as an extra surprise for the Black Friday Sale, we also listed a TTA-500 - 3 Pack new to the website at an already discounted price and yes, the coupon code will work for that also!
TTA-500 - 3 Pack - for a limited time, only 76.99 with coupon code blackfriday30
https://seriousnutritionsolutions.com/product/tta-500-3-pack/
This is a while supplies last offer and we expect TTA-500 to sell out during the sale.
Rocket3015
Legend
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Drakee
Member
I forgot all about this, TTA is very well studied! Picked up a bottle to try
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"given the ability of TTA to increase b-oxidation, reduce plasma TAG, and positively affect hepatic saturated and monounsaturated fatty acid compositions leading to an increase in the anti-inflammatory fatty acid index, indicates that TTA has a high potential to ameliorate chronic inflammation such as with obesity, arthritis or atherosclerosis."
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"rats fed on TTA gained less body weight than lard-fed rats and had markedly decreased subcutaneous, epididymal, perirenal and mesenteric adipose depots. "
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"given the ability of TTA to increase b-oxidation, reduce plasma TAG, and positively affect hepatic saturated and monounsaturated fatty acid compositions leading to an increase in the anti-inflammatory fatty acid index, indicates that TTA has a high potential to ameliorate chronic inflammation such as with obesity, arthritis or atherosclerosis."
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"rats fed on TTA gained less body weight than lard-fed rats and had markedly decreased subcutaneous, epididymal, perirenal and mesenteric adipose depots. "
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sns8778
Board Sponsor
Thank you for the detailed post.
TTA is a great ingredient and TTA-500 is a great product.
I hope that you'll enjoy it.
Tunaking14
Well-known member
Just ordered my 3 pack!!! Thanks Steve!!! I’ll have 6 in my stash now and can’t wait to start my cycle!! Trying to run a bunch of stuff but not over do it!
sns8778
Board Sponsor
Thank you. I hope that you'll be pleased with it.
I'm going to be using quite a few things soon myself. I still can't do regular workouts bc of the accident, but I've really let myself go this year after the accident and depression and all, and need to get some fat off myself so I'm going to try to start cleaning diet up gradually and TTA-500 will definitely be part of my stack.
Rocket3015
Legend
Make sure you get plenty of TTA-500 while it's on sale!