I’ll chime in on that one. For those of you who were familiar with the LipidFX formulation by SciVation, you’ll see where I’m going with this post.
SciVation was definitely ahead of their time. The LipidFX formulation was truly amazing, so if I would be to formulate a non-stimulant fat loss supplement, I’d recreate their blend, but with some tweaking here and there.
LipidFX had the following:
- TTA 1000mg
- PhosphoLean 350mg (standardized to 24% OEA and 14% EGCG)
- SEA 250mg
OEA and SEA decrease appetite = Consuming less calories leads to fat loss.
OEA and TTA activate PPAR-alpha = Activation of PPAR-alpha increase the rate and capacity of fat oxidation.
Great blend, but personally I’d make it even more potent by adding a few more components. Here are some of the factors that I’d take into consideration:
1) A compound that blocks α2 activation (i.e., an alpha-2 blocker). Blocking α2 allows for greater fat breakdown and also increases blood flow to fatty tissue, making it perfect for targeting stubborn fat.
Berberine is a non-stimulant and has some weak alpha-receptor blocking effects. I’d use dihydroberberine. *** missing in LipidFX
2) A compound that increases the transportation of FFAs into the mitochondria and enhances fat oxidation (e.g., ALCAR).
*** missing in LipidFX
3) A compound that inhibits COMT as doing so increases lipolysis (e.g., Green Tea Extract/EGCG).
** LipidFX got that part
4) PPAR agonists blend (proliferator-activated receptors):** LipidFX got that part
A bit of science for those unfamiliar with PPARs. There are three types of PPARs that have been identified:
alpha (α),
gamma (γ), and
delta/beta (δ), when activated, they stimulate expression of genes involved in
energy homeostasis, specifically the metabolism of glucose and fatty acids.
PPAR-α influences carbohydrate-lipid metabolism, thus regulating homeostasis and body mass. Experiments have shown that
the activation of PPAR-D reduces weight gain, increases skeletal muscle metabolic rate and endurance, and improves insulin sensitivity. It was further found that the increase in PPAR-D expression suppresses atherogenic inflammation. PPARD also plays an important role in the differentiation and maturation of adipocytes. It controls the body's energy balance. Thus, this protein plays an important role in the control of body weight. So far, no studies have been conducted on gene doping with
PPAR-D in humans or in animal models.
The alpha receptor is found in the liver. When it is activated, the liver burns more fat.
The gamma receptor is mainly in fat cells. If it is stimulated, the fat cell stores fatty acids. The delta receptor is found in muscles. If that receptor is stimulated, then muscles burn more fat.
There are amazing PPAR out there. Since TTA can’t be found anymore on the market, I’d experiment with PPARs agonists such as
L-BAIBA, sesamin, Isohumulones, trans-Tiliroside, Cyanidin 3-glucoside chloride.
5) I’d add some Bioehencers to potentiate the effects.
Note this post was longer, had to cut a bit, it got a bit too scientifical