According to WebMd, once you have built up a few initial 10mg doses it says standard dosing indeed becomes eod for maintenance.It is an RC and very weak ....... I skipped today, I think I can go every other day.
According to WebMd, once you have built up a few initial 10mg doses it says standard dosing indeed becomes eod for maintenance.It is an RC and very weak ....... I skipped today, I think I can go every other day.
This is interesting and would go against the caffeine theory, I think, at least at first. Given I am no expert here I am just thinking theoretically, but I would have thought caffeine ---> increased acetylcholine release ----> increased NO.5mg of Tadalafil EOD has fixed all problems and I'm getting better pumps in the gym !!
Honestly, just found that caffeine itself inhibits PDE. To what extent I don't know...but if that is the case, then everything is too intermingled to really say. So, yeah, I know nothing. Don't listen to meNext week I am out of town on business, so no PWO or Tadalafil, when I come back I am going to resume the PWO with out any additional Caffeine and no Tadalafil and see what happens............
I appreciate all the work you have put into this !!Honestly, just found that caffeine itself inhibits PDE. To what extent I don't know...but if that is the case, then everything is too intermingled to really say. So, yeah, I know nothing. Don't listen to me
Simple ...I think youre overcomplicating things a bit Hit. Or maybe im under complicating things. Caffeine = sympathomimetic. Sympathetic nervous system = no pee, so you dont wanna stop to piss instead of running from that. But its also a bladder irritant.
Cialis = increased cGMP = increased NO like you said = decreased smooth muscle contraction in the prostate = decreased resistance for the pee to get through as it exits the bladder.
Yeah, so this is somewhat along the lines of my initial stance. Just for, possibly, my own education - I believe NO increases cGMP, not the other way around?I think youre overcomplicating things a bit Hit. Or maybe im under complicating things. Caffeine = sympathomimetic. Sympathetic nervous system = no pee, so you dont wanna stop to piss instead of running from that (edit: lion, HGP, whatever you’re running from). But its also a bladder irritant.
Cialis = increased cGMP = increased NO like you said = decreased smooth muscle contraction in the prostate = decreased resistance for the pee to get through as it exits the bladder.
Whats this old man crap ??Yeah, so this is somewhat along the lines of my initial stance. Just for, possibly, my own education - I believe NO increases cGMP, not the other way around?
But part of the issue here is that caffeine has a lot of seemingly contradictory effects. For instance, doesn't coffee usually increase your urgency? I know that I often have to piss like a race horse in the morning after drinking a large amount of caffeine....moreso than just drinking the same amount of fluid. Plus, if coffee is a PDE inhibitor, then, it too will increase NO and thus increase cGMP. To what extent, who knows.
Still, I think the caffeine from the pre- may be pushing over limits and may be getting covered up/counteracted by the PDEi.
On the other hand, perhaps, it is a case of Benign Prostatic Hypertrophy, which is common in old men like Rocket and PDEi's are beneficial in that.
I may be over- or under-thinking it. I am not sure. But I am pretty confident that I shouldn't be thinking so much about another man's urinary issues
Yeah, it's weird, but the potential underlying pathways are pretty interesting...
Yeah, I need to study cGMP in a little more depth now, this will take many nights.I agree that the physiological mechanisms are interesting and absolutely complex..so much so that im sure to cover it in sufficient detail youd have to write a multipage article about it lol.
The diuretic effects of caffeine (with long-term use of the same or less dosages) has been dispelled I believe. As in you will get a diuretic effect with intermittent dosing but a stable long term dose the effect wears off to the point where caffeine provides a similar level of hydration to plain water (I wont lie, I havent looked at this data myself - regurgitating it from some literature review service I follow). With that said, as I mentioned, caffeine metabolites are local bladder irritants which can absolutely lead to an increased urgency. I highly doubt the PDE5 inhibition from caf holds a stick to that of the -fils but once again I cant speak to exact numbers.
If im not mistaken the cGMP leads to changes in NO, if it works similarly to how cAMP affects NO in bronchial smooth muscle anyhow. Beta agonist (albuterol) = increased cAMP = increased NO = bronchial smooth muscle dilation/relaxation.
We’re probably both over and underthinking certain parts and not even aware of half of whats going on, lol.
Did I say "old man" out loud? Oops.Whats this old man crap ??
I talked to my primary Dr yesterday, I'm good !!How bad does it have to get before you see a urologist?
You mean you don't have enlarged prostate issue? so where do the symptomes come from?I talked to my primary Dr yesterday, I'm good !!
Yes it is an enlarged prostate, but with the addition of the Tadalafil it has "Relaxed" and is back to normal. The Dr. believes something in my PWO "Aggravated" itYou mean you don't have enlarged prostate issue? so where do the symptomes come from?
Alpha 1s are the receptors you think about when dealing with the urinary tract (found it other places as well).I’m wondering why yohimbine is worsening BPH symptomes. It’s an alpha 2 adrenergic antagonist so it should not contract the sphincter but relax them, no?
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