xR1pp3Rx
Legend
You'll be using it in a week
don't threaten me with a good time!!! :dance:
ANY NEW NATURAL ANABOLICS
- Thread starter Rishy
- Start date
don't threaten me with a good time!!! :dance:
brundel
Board Sponsor
Wont be ready for you guys in a week no.
Will be testing 2 final ingredients this coming week. I dont want to say anything because we are using ingredients not used currently in any supplements and the time line from when we release something new to when other companies start using the ingredient is frequently weeks or a month.
So I cant tell you whats in it at all until the day or release or just before.
I also dont want to say too much because we are doing things a bit differently and I want other companies to continue doing what they are doing now so people can see the difference
I can tell you that =
1. this will be he cutting edge of pre workout supplementation.
2. We will be using novel ingredients. Not just to try to claim we do so but because they are better than whats currently available.
3. We are approaching things from a different angle. It will look familiar but the overall goals are more well defined and the ingredients are synchronous.
We are NOT just tossing whatever we think is the hot new ingredients into a kitchen sink product (what 99% of companies do)
There is no creatine, beta alanine, agmatine, citrulline. If you want these things buy them in bulk and add them. They are VASTLY cheaper this way.
Will tell you guys more once we get closer.
Will be testing 2 final ingredients this coming week. I dont want to say anything because we are using ingredients not used currently in any supplements and the time line from when we release something new to when other companies start using the ingredient is frequently weeks or a month.
So I cant tell you whats in it at all until the day or release or just before.
I also dont want to say too much because we are doing things a bit differently and I want other companies to continue doing what they are doing now so people can see the difference
I can tell you that =
1. this will be he cutting edge of pre workout supplementation.
2. We will be using novel ingredients. Not just to try to claim we do so but because they are better than whats currently available.
3. We are approaching things from a different angle. It will look familiar but the overall goals are more well defined and the ingredients are synchronous.
We are NOT just tossing whatever we think is the hot new ingredients into a kitchen sink product (what 99% of companies do)
There is no creatine, beta alanine, agmatine, citrulline. If you want these things buy them in bulk and add them. They are VASTLY cheaper this way.
Will tell you guys more once we get closer.
rowz4broz
Well-known member
Wont be ready for you guys in a week no.
Will be testing 2 final ingredients this coming week. I dont want to say anything because we are using ingredients not used currently in any supplements and the time line from when we release something new to when other companies start using the ingredient is frequently weeks or a month.
So I cant tell you whats in it at all until the day or release or just before.
I also dont want to say too much because we are doing things a bit differently and I want other companies to continue doing what they are doing now so people can see the difference
I can tell you that =
1. this will be he cutting edge of pre workout supplementation.
2. We will be using novel ingredients. Not just to try to claim we do so but because they are better than whats currently available.
3. We are approaching things from a different angle. It will look familiar but the overall goals are more well defined and the ingredients are synchronous.
We are NOT just tossing whatever we think is the hot new ingredients into a kitchen sink product (what 99% of companies do)
There is no creatine, beta alanine, agmatine, citrulline. If you want these things buy them in bulk and add them. They are VASTLY cheaper this way.
Will tell you guys more once we get closer.
I ALWAYS have bulk citrulline and bulk agmatine on hand. Soon as bulk VASO is available I will have that as well. Very excited to see the pre you are formulating
iamyourfather
Active member
you can already buy bulk VASO6 - 25kg+ from compound solutions lol
its about 5800€ for 25kg, so not even that expensive
i really hope that there will be a 250g+ bulk VASO6 product; i can hardly believe there will be other, better pump products on the market soon. VASO is THE sh1t imo
u_e_s_i
Well-known member
Wont be ready for you guys in a week no.
Will be testing 2 final ingredients this coming week. I dont want to say anything because we are using ingredients not used currently in any supplements and the time line from when we release something new to when other companies start using the ingredient is frequently weeks or a month.
So I cant tell you whats in it at all until the day or release or just before.
I also dont want to say too much because we are doing things a bit differently and I want other companies to continue doing what they are doing now so people can see the difference
I can tell you that =
1. this will be he cutting edge of pre workout supplementation.
2. We will be using novel ingredients. Not just to try to claim we do so but because they are better than whats currently available.
3. We are approaching things from a different angle. It will look familiar but the overall goals are more well defined and the ingredients are synchronous.
We are NOT just tossing whatever we think is the hot new ingredients into a kitchen sink product (what 99% of companies do)
There is no creatine, beta alanine, agmatine, citrulline. If you want these things buy them in bulk and add them. They are VASTLY cheaper this way.
Will tell you guys more once we get closer.
What will it be called?
AdelV
Well-known member
Yeah, I'm keen.you can already buy bulk VASO6 - 25kg+ from compound solutions lol
its about 5800€ for 25kg, so not even that expensive
i really hope that there will be a 250g+ bulk VASO6 product; i can hardly believe there will be other, better pump products on the market soon. VASO is THE sh1t imo
I'm over PWOs atm, just stim overload and it affects my libido. 99% companies don't give a rats ass about our health. I'm slowly heading to non-stim excluding coffees etc.
00A
Well-known member
Amen Brother.. totally agree with you..
toddmuelheim
Well-known member
brundel
Board Sponsor
Not sure yet
IconicForm
Board Sponsor
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thebigt
Legend
I have been impressed by products made by you that I have tried so far....iconogenin is on my list to try!!!
bigsmall
Banned
Been using it for 3.5 weeks now and its the best transdermal laxo product out their. See my unsponsered review
King_Gainz
New member
I ran it 4 capsules per day (the recommended dosage on bottle).
I rate any natural anabolics I run on a 1 to 10 scale (this factors in ratings like results, effectiveness, value, etc.) HH6 got a 7.9/10. This favors well compared to a 7.1 with Hi-Tech Pro IGF-1, and a 7.6/10 for Olympus Labs EP1LOGUE.
rowz4broz
Well-known member
placebo is strong with this one
bloodwork was done to confirm this is in fact snake oil.
not going to dig up posts but if i remember correctly one user who double dosed product showed no increase in IGF1 and another user who used standard dose actual had lower IGF1 levels.
dont quote me on exacts but there was a lengthy thread on this awhile back and recall the general concenscious(sp?) was that it did not work.
King_Gainz
New member
Omfg thank you. I wanted to give it good ratings because I spent so much on it, however it just didn't stack up. It was a 6.8/10 until I bumped up my personal rating on it because I was so ashamed for shelling out $100.00.
Makes sense though because it's the lowest rated natty anabolic I've run. Thank you for that information sir, it gives me closure
rowz4broz
Well-known member
Omfg thank you. I wanted to give it good ratings because I spent so much on it, however it just didn't stack up. It was a 6.8/10 until I bumped up my personal rating on it because I was so ashamed for shelling out $100.00.
Makes sense though because it's the lowest rated natty anabolic I've run. Thank you for that information sir, it gives me closure
i bought a bottle or two of the stuff too and was also pretty bummed out.
jtmass
Well-known member
Omfg thank you. I wanted to give it good ratings because I spent so much on it, however it just didn't stack up. It was a 6.8/10 until I bumped up my personal rating on it because I was so ashamed for shelling out $100.00.
Makes sense though because it's the lowest rated natty anabolic I've run. Thank you for that information sir, it gives me closure
Nothing to be ashamed about. People spent a few hundreds on natty anabolics and get nothing out of it (except may be a jump in pumps). Just be honest so that others get a better idea of what they can try. I have a few stuff as well. After trying what I have in stock, will see if any of these actually work. lol
brundel
Board Sponsor
I can understand your guys disappointment.
I remember when I started training and I was super green regarding supplements. I saw all these products that claimed to add inches to my arms and increase muscle mass and make me into the guys in the ads. I wanted to believe it and I certainly bought the products only to be greatly disappointed.
0% added 2 inches to my arms and 0% made me into the guys in the ads etc. This is depressing and I lost faith in the supplement industry.
When I started Black Lion Research it was with one primary goal in mind. Create products that work really well.
Products that when you take them your not disappointed after.
Innovative formulation.
Product efficacy.
No disappointed customers.
You cant make every person happy but the vast majority of people who use our products will tell you they do in fact work.
Vector is no exception.
Invalid Link Removed
I remember when I started training and I was super green regarding supplements. I saw all these products that claimed to add inches to my arms and increase muscle mass and make me into the guys in the ads. I wanted to believe it and I certainly bought the products only to be greatly disappointed.
0% added 2 inches to my arms and 0% made me into the guys in the ads etc. This is depressing and I lost faith in the supplement industry.
When I started Black Lion Research it was with one primary goal in mind. Create products that work really well.
Products that when you take them your not disappointed after.
Innovative formulation.
Product efficacy.
No disappointed customers.
You cant make every person happy but the vast majority of people who use our products will tell you they do in fact work.
Vector is no exception.
Invalid Link Removed
King_Gainz
New member
Vector has been the ONLY natty anabolic that I have actually noticed working, both in terms of results & feeling a performance improvement.
brundel
Board Sponsor
Good to hear this. With so many products coming out claiming to be "natural anabolics" it can be disheartening when they dont really work as advertised.
Vector is different. I appreciate your post bro.
Johnold
Well-known member
Man whats going on with MYOKEM? Are they a company still or not? I cant tell if they're still "in it" or not. They're taking forever to reintroduce themselves into the market since WHATEVER it is thats going overthere at their headquarters. Like foreal man, wtf is going on with them?!
Im so lost and confused.
Im so lost and confused.
rowz4broz
Well-known member
I feel like they were some true innovators like 3 of the forum favorites of today. It is a shame. I feel like they would have brought some quality stuff to market
Edit- actually 1 of the 3 of the forum faves is also pretty unreliable in keeping products in stock but all of the products I have tried have been amazing.
Johnold
Well-known member
Yeah im trying to understand WHERE ARE THEY!?
Why is it taking so long for them to release products etc?
Do they even care anymore?
Johnold
Well-known member
Well if that's the case it would be nice to have a heads up because it seems like they just fell off the face of the Earth.
brundel
Board Sponsor
For now you have options.
Vector I would hold up to any non steroid product on the market and have 100% confidence in its superiority. Its potential for muscle mass gains, fat loss and performance enhancement are unmatched.
Follidrone isnt far behind and when you stack these 3 its insane how well they work.
It also looks like we might have something new and tasty on the horizon.
Vector I would hold up to any non steroid product on the market and have 100% confidence in its superiority. Its potential for muscle mass gains, fat loss and performance enhancement are unmatched.
Follidrone isnt far behind and when you stack these 3 its insane how well they work.
It also looks like we might have something new and tasty on the horizon.
TommyTuffGuy
Well-known member
This seems to happen with all the "innovative" supplement companies that come out. They are super overpriced and end up re-branding for the general public or collapsing. PES did this. They came out red hot with innovation and were a forum favorite (everywhere really) then overnight stripped all the products that 'made' them the best to garbage tier blends to pump to the masses.
bigsmall
Banned
Reminds me of USP Labs too...
brundel
Board Sponsor
You have my word we won't stop doing what we are doing. Not gonna sell out.
We have already turned down some very large accounts because we know these accounts are why other brands go soft. They won't let you sell products with innovative formula's because they see it as a risk. So brands tone things down to get the sale and in turn sell out.
We will sell direct to consumer and remain with the retailers who understand innovation is almost never within the boundaries.
bigsmall
Banned
This is great news. ty for sharing.
00A
Well-known member
Actually was in stock as I bought direct!’
Rockzilla
Active member
Man I really want to try magnitropin, but they don’t ship to APO AP on their website. And I can’t find it any where else. I’ve tried Epi from Follidrone and DC from ABE I haven’t tried the other 2 ingredients though. Just to be sure you’d want to take 2 servings a day right? One bottle would last 28 days.
AdelV
Well-known member
It was, and someone mentioned me it definitely wasn't the same as the original unfortunately.
mbonheur
Active member
That is why I was making the educated guess, that they were not able to source good quality raw materials. That is actually one of the biggest problems nowadays.
And also the reason why some companies might even mix low dosed Mk677, etc. into to their herb mixes. Nobody would know anyways.
TheIronAsylum
Active member
what are the side effects for vector and follidrone?
also what was that newer stim free pre workout that was really good edit found it vaso max
what about anteus labs hydra head six and titan?
also what was that newer stim free pre workout that was really good edit found it vaso max
what about anteus labs hydra head six and titan?
justhere4comm
Banned
Vector and Follidrone are anti-inflamatory
Vector
- Hunger, which could be good or bad depending on if you are on a bulk or a cut
- Vivid Dreams, again in which case if you are ok with that, a bonus
- A few have had stomach issues but out of the majority that's maybe 3 in 250
- Bigger Fuller Muscles
- Strength Gains
- Lower Body Fat
Follidrone users will maybe suffer with
- Increased insulin sensitivity
- Increased endurance
- Reduced body fat
- Much faster recover, I had zero DOMS
We are currently working on still testing the Pre Workout and it has no name yet.
Are you referring to our Invalid Link Removed?
(Naturally flavored, and vegetarian BCAA)
bigsmall
Banned
I am using Vector, Folidrone and Vasomax - by far the best stack out their.
I am 50 and have tried everything and the good ones many times. Nothing like Vector has ever hit the industry.
Tons of threads and logs on AM - I would take a look at these to get a better idea of the effects.
TommyTuffGuy
Well-known member
That's awesome though when you think about it. Go mainstream and sell **** that doesn't even actually work, but gives you a caffeine buzz.
brundel
Board Sponsor
Lol thats basically what happens.
SARMS
Member
Well to give a little summary of supplements that could be considered anabolic, I'd say the following
PEDs: AAS (Of course), PHs (Weaker), SARMs (Weaker still), Peptides (IGF-1, MGF, GHRPs + GHRH), MK 677(Weakest)
Naturals: Arachidonic Acid (4 studies that show it increases mTOR activity), Leucine (Of course), Glucose Disposal Agents (Indirectly)
I'd like to add Massmax from anecdotal accounts, but I can't find any studies that show the anabolic activity of the ingredients. (Only appetite) That goes for Vector too, nothing proven. Agree?
PEDs: AAS (Of course), PHs (Weaker), SARMs (Weaker still), Peptides (IGF-1, MGF, GHRPs + GHRH), MK 677(Weakest)
Naturals: Arachidonic Acid (4 studies that show it increases mTOR activity), Leucine (Of course), Glucose Disposal Agents (Indirectly)
I'd like to add Massmax from anecdotal accounts, but I can't find any studies that show the anabolic activity of the ingredients. (Only appetite) That goes for Vector too, nothing proven. Agree?
Big_Spaz
Board Sponsor
Vector has DEFINITELY peaked my interest, I'm not going to lie. I've been following a few logs on the product, reading as much as I can and I'm officially sold. I will be picking up a bottle this Friday (pay day).
What is a normal cycle length look like? Something I can run for a very long time or is it recommended for 4 weeks on, 4 weeks off, etc.?
-Spaz
What is a normal cycle length look like? Something I can run for a very long time or is it recommended for 4 weeks on, 4 weeks off, etc.?
-Spaz
justhere4comm
Banned
I think a normal length would be 8-12 weeks based on what you may be taking with it.
I'm on a cut so at the end of my 12 weeks, I may change gears and move towards a surplus gradually until I feel comfortable. I know by day 4/5 you will know you made the right decision.
-M
justhere4comm
Banned
Strike a line through AAS etc. until you reach the next line. The thread's OP asked about any New Natural Anabolics.
Then skipping through past the old ARA, Leucine, and GDA. We are left with Massmax and Vector.
Regarding Massmax. No idea. I'll give it a look see.
As for Vector. Disagree about 'nothing proven, regarding the anabolic activity of the ingredients.' (See below)
Read through this.
VECTOR ingredient #3 Rehmannaie Radix extract
March 3, 2018
VECTOR ingredient 3 DATA
Rehmannaie radix. (RR)
RR is the third and final ingredient in VECTOR the next generation of natural anabolics. RR contains within some of the most interesting anabolic substances Ive seen and has a host of effects and properties that are of interest to us as athletes. RR has been used for aeons in ancient medicine but recently it has been demonstrated to have more than just health benefits. RR is an exceptional for performance enhancement, muscle mass building, strength and fat loss. Lets explore why.
CATALPOL
Catalpol is approx 11% of the dry weight of the Rehemannaie plant. In a strong extract like the one used in VECTOR percentages can be much higher. Think of Catalpol as.....natural Doping. I see this could be hard to wrap your head around so let me explain-
*Here is a quote from a study regarding the use of genes for doping.
"the advance of gene therapy has opened the door to the possibility of using genetic manipulation (GM) to enhance athletic performance. In such 'gene doping', exogenous genetic sequences are inserted into a specific tissue, altering cellular gene activity or leading to the expression of a protein product. The exogenous genes most likely to be utilized for gene doping include erythropoietin (EPO), vascular endothelial growth factor (VEGF), insulin-like growth factor type 1 (IGF-1), myostatin antagonists, and endorphin. However, many other genes could also be used, such as those involved in glucose metabolic pathways."
So they are saying in essence that by targeting these specific factors an athlete could augment themselves and become sort of a super human. Interestingly Catalpol targets most of these and more. EPO, VEGF, IGF1, Beta endorphins. Augmenting these can lead to MAJOR increases in muscle mass, athletic performance and fat loss.
Catalpol increases EPO
EPO has been used by athletes (illegally in most cases) to increase performance for decades. Well known for its use in cycling EPO when injected or when it is increased through other means leads to huge increases in overall performance. EPO increases red blood cells which in turn carries more oxygen to muscles. VO2Max is increased, overall power output is increased, time to exhaustion is increased. These boosts give the athlete a huge advantage in competition but also for those who are not competitors it allows for the same improvements making your everyday Clark Kent into more of a Superman. When combined with RRs second chemical constieunt, a strong vasodilator we have GREATLY improved performance as the oxygen rich overabundance of red blood cells are pumped through wide open blood vessels.
VEGF
Vascular endothelial growth factor (VEGF) is a major regulator of blood vessel formation during development and in the adult organism. Recent evidence indicates that this factor also plays an important role in sustaining the proliferation and differentiation of different cell types, including progenitor cells of different tissues, including skeletal muscle, bone marrow, bone, and the central nervous system. VEGF promotes the growth of myogenic fibers and protects the myogenic cells from apoptosis in vitro and prompt a therapeutic use for VEGF gene transfer in a variety of muscular disorders. VEGF also increases angiogenisis and blood flow to muscles.
IGF-1
Catalpol increases IGF1 which is a well known positive regulator of skeletal muscle. Vector is a fantastic muscle building agent but we all know that in order to grow we need to eat caloric surplus.
Unfortunately as we eat more, particularly carbs, blood sugar rises and IGF1 is suppressed while IGF1 sensitivity is increased.
Catalpol prevents this drop in IGF1 leading to higher IGF1 levels during a period where IGF1 sensitivity is at its highest. This contributes to Vectors muscle growth potential.
B-Endorphin
Catalpol increases Beta endorphin release. B-EP are known for causing the often referred to "runners high" and is part of what makes us feel great after exercise. B-EP have also been shown to decrease muscle fatigue and increase glucose uptake in muscles. B-EP are in a large part what gives us the Mind/muscle connection when training. B-EP improves neuromuscular function, increases the amplitude of contractions and decreases the time to peak muscle contraction in response to nerve stimulation. B-EP can increase initial, maximum and mean muscle tension meaning strength potential.
ATP
Catalpol effectively increases mitochondrial ATP production.
Catalpol is also remarkably hypoglycemic, reduces total serum cholesterol and triglycerides. Making it a powerhouse within RR and lending itself nicely to the overall structure and potential of VECTOR.
LOGANIN
- Is a well known iridoid glycoside with many sources but Loganin is present in high quantities in Rehemannaie.
Loganin is a fantastic anabolic agent in its own right. Loganin is being studied currently as a treatment for skeletal muscle atrophy. In addition Loganin seems to possess anti inflammatory, antioxidant, glucose lowering and muscle protective effects. Loganin upregulates the Atk/mTOR pathway and increases IGF1 leading to increased muscle tissue.
Loganin has also been shown to increase skeletal muscle strength in animal studies and inhibits Atrogin-1 which prevents skeletal muscle atrophy. Further anabolic potential lies in its suppression of SMAD2/3 and increased expression of SMAD7. In animals studies Loganin increased muscle mass, overall bodyweight, strength and protein synthesis making it a powerhouse anabolic.
BETAINE
Betain is a well known constituent of Beet roots. Betain has been studied and shown to increase performance as well as skeletal muscle growth making it a fantastic component of RR and ultimately VECTOR. Betain has been found to increase IGF1 expression, as well as MyHC synthesis which can both lead to increases in muscle. In addition it is a great vasodilator and improves blood flow to muscles. This vasodilation combined with Catalpols increase in RBC from EPO makes this stuff a wicked performance enhancing ingredient.
RR is
- Antioxidant
- Improves cognitive function
- Has been shown to increase testosterone
- Increase muscle mass
- Reduce blood sugar/ antidiabetic
- Helps with gastrointestinal disorders
- Is used as a feed for animals as it increases weight and muscle mass.
- Increases Beta endorphins
- Mild opioid activity/ pain killing with out the negatives of NSAIDS
- Increases GLUT4
- Improves mitochondrial function
- Increases IGF-1
- Increases EPO/Red blood cells
- Increases SMAD7 expression
- Reduces SMAD2/3 expression
- Increases performance
- Increases strength
- Prevents muscle atrophy
- Increases ATP production
- Vasodilation
VECTOR ingredient #2 Data= KOREAN MISTLETOE
February 24, 2018
Korean mistletoe (Viscum album coloratum) 1000mg @ 100:1 extract.
(KME)is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions. KME has been shown to have anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. Of interest to us as athletes KME has been reported to increase strength, muscle mass and improve overall exercise capacity. Of course we love to hear this but these days we want to know how and why so lets explore how KME works.
MUSCLE MASS
One of the primary goals of the bodybuilder is muscle mass and we know of many things that lead to increased skeletal muscle. Anabolic androgenic steroids are the first things most people think of and for good reason. Anabolic steroids are wonderfully effective and can help you reach levels of muscularity that are just not possible without them. These gains, however, are not without their costs. Anabolic steroids lead to a host of disease states and health issues along with their status as illegal drugs. This makes them less than ideal for most people. Of course there are designer steroids and prohormones and SARMS but these too have their negatives.
*There has to be a solution
Its been largely demonstrated that nature is a beast of a pharmaceutical lab. Its hard to deny nature as we see that many of the drugs we use come from plants, including most narcotics, chemo meds, nootropics etc. Why then are there not fantastic anabolic agents in nature? There are.
KME has been in use as a health agent for ages. Scientists speculated that KME may be anabolic in vivo and a number of clinical studies were conducted to validate this hypothesis. KME has been proven to not only prevent muscle atrophy but also to promote skeletal muscle hypertrophy. This is important because it means that KME both increases muscle growth and prevents muscle which makes it an ultra strong muscle mass building ingredient. Mice Fed KME for 4 weeks showed increases in muscle mass and grip strength. The research indicated multiple factors leading to this result not least of which is the well known AKT/mTOR pathway. Rats fed KME showed increased whole body weight, larger quadriceps and greatly increased strength. It was therefore determined that KME is anabolic as it directly leads to larger stronger muscles. In addition to greater muscle fiber area and diameter KME fed mice showed incredible increases in endurance and exercise capacity making KME an ideal candidate for use in physique, strength and endurance athletes.
ENDURANCE/EXERCISE
KME has been shown to decrease fatigue and increase endurance. Increased mitochondrial oxygen consumption and the increased expression of PPARy lead to increases of up to 212% in forced swim tests. KME reduces plasma ammonia levels, improves fuel utilization and enhances exercise performance. In one study researchers adminstered endurance capacity tests. KME fed animals ran TWICE AS FAR as their high fat diet only counterparts which is frankly amazing 100% increases in endurance is like no other natural anabolic currently available.
FAT LOSS
A big part of what makes anabolic steroids appealing is the ability to build muscle while losing fat. This is the Holy Grail of bodybuilding. Fat loss while building muscle.
In a 15 week experiment KME was fed to animals along with a high fat diet. Around week 9 it became evident that the KME fed animals were gaining less weight with no differences in the amount of food taken in. At the end of the experiment the KME fed animals had 20% less bodyfat than their high fat diet only animals and when tested it was determined that the loss was adipose tissue. KME increases thermogenesis and nearly triples the amount of UCP1 (uncoupling protein 1), a principal thermogenic mitochondrial molecule related to energy dissipating in subcutaneous fat. To demonstrate the inhibitory mechanism of KME on fat cells adipogenic factors were studied.
They measured the expression levels of the transcription factors PPAR, C/EBP-a, and SREBP-1c in 3T3-L1 cells treated with KME. The results show that PPAR-, C/EBP-a, and SREBP-1c mRNA levels were decreased by 64%, 60%, and 32%, respectively. Finally they also measured the mRNA expression levels of adipogenic enzymes, such as FAS, ACS, and ACC. These adipogenic enzymes were reduced by 69%, 55%, and 22%. Overall the research indicated that adipogenic factors were decreased by 89% compared to that of untreated cells giving KME an unprecidented level of fat loss power for something that is also incredibly anabolic.
EFFECTS ON HORMONES
KME has been shown to have a significant impact on the HPTA. KME leads to increased Leutinizing hormone, increased Testosterone and decreased prolactin.
This in turn makes VECTOR great for all purposes. Good alone, stacked, even during PCT.
Just a few of KME's MOAs=
AKT/mTOR
In adult skeletal muscle the akt/mTOR signaling pathway is currently recognized as the major pathway regulating protein synthesis.
VECTOR activates this pathway and in turn increases protein synthesis and muscle mass.
LH
increased leutinizing hormone leads to a significant increase in testosterone levels.
Atrogin 1
Atrogin-1 is induced in response to myostatin/TGF-b signalling leading to muscle atrophy. Atrogin-1 and MuRF-1 have been identified as important enzymes in ubiquitin-mediated proteolysis and muscle atrophy, and modulating their expression via physical activity or targeting the upstream cytokines and growth factors that regulate their expression has the potential to prevent or reverse muscle atrophy. A reduction in Atrogin 1 prevents loss of muscle. This then makes VECTOR great at helping you hold onto muscle while dieting as its anabolic, anti catabolic and increases fat burning.
SMAD2/3
Both myostatin and TGF-ß are held in an inactive form in the muscle extracellular matrix, and when activated, bind to their receptors and activate Smad2/3. Generally speaking we want to see SMAD 2 and 3 drop while seeing an increase in SMAD 7. This is what we see with KME/VECTOR.
VECTOR ingredient #1 data-ERIOBOTRYA J
February 6, 2018
ERIOBOTRYA JAPONICA -1000mg/100:1 extract.
Eriobotrya Japonica (EJ) or Loquat is a fruiting plant commonly used for food, added to alcholic beverages and sometimes used for health and longevity. EJ contains a host of interesting chemicals with a number of effects that are beneficial to those looking to build muscle, burn fat or increase athletic performance. Loquat for bodybuilders? On the surface EJ doesnt seem to be super exciting but nothing could be further from the truth. There have been a number of studies indicating that the proper extract at a high enough dose can lead to gains in muscle mass, strength and fat loss. Studies indicate EJ Increases the expression of myogenic genes MyoD, Myogenin and MyHC. This increased expression corresponds with an increase in the activity of Creatine Kinase a myogenic differentiation marker. Finally EJ activates the AKT/mTOR pathway and subsequently promotes muscle protein synthesis and a gain in lean muscle mass. In studies EJ was shown to prevent muscle atrophy and increase muscle hypertrophy so its great if your cutting and want to preserve muscle and its great if you want to bulk.
AKT/Mtor
Akt is known as effector of insulin/IGF-1 signalling and it can induce muscle hypertrophy through a pathway involving rapamycin-sensitive mTOR.
mTOR regulates PGC-1a expression, which is a key regulator of mitochondria biogenesis, and the expression of PGC-1a has been implicated in the control of skeletal muscle mass. The activation of the Akt/mTOR pathway and its downstream targets, p70S6K and PHAS-1/4E-BP1, is requisitely involved in regulating skeletal muscle fiber size. Acute AKT activation also leads to a decrease in adipose tissue (fat loss)
QUOTE
"The pathways that are sufficient to induce hypertrophy in skeletal muscle have been the subject of some controversy. We describe here the use of a novel method to produce a transgenic mouse in which a constitutively active form of Akt can be inducibly expressed in adult skeletal muscle and thereby demonstrate that acute activation of Akt is sufficient to induce rapid and significant skeletal muscle hypertrophy in vivo, accompanied by activation of the downstream Akt/p70S6 kinase protein synthesis pathway. Upon induction of Akt in skeletal muscle, there was also a significant decrease in adipose tissue. These findings suggest that pharmacologic approaches directed toward activating Akt will be useful in inducing skeletal muscle hypertrophy and that an increase in lean muscle mass is sufficient to decrease fat storage."
MyHC
*Myosin* heavy-chain* synthesis* rate* is correlated* with* measures* of* muscle* strength, circulating* insulin-like* growth* factor* 1** and dehydroepiandrosterone sulfate in men and women and free testosterone levels in men.
MyoD
Both MyoD and myogenin genes are necessary in the regenerative process for the proliferation of satellite cells (myoblasts) and for the development of early regenerating fibers (myotubes). The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell,
Lower doses or the incorrect extraction process has been shown to be ineffective so the extraction process is very important with EJ. So lets dig into whats inside the plant itself.
Just a short list of the chemical constituents of EJ
- Epicatechin
- Ursolic acid
- Chlorogenic acid
- Corosolic acid
- Oleanolic acid
- Caffeic acid
- Procyanidin B2
- Protocatechuic acid
- Ferulic acid
- Tormentic acid
- Naringenin
- Ellagic acid
- EGCG
- Quercetin
This is a pretty impressive list of actives. Lets take a look at what some of these do.
Epicatechin
EJ doesnt have as much epicatechin as something like cocoa or green tea but there is still a decent amount. Its estimated that there is about 150mg per 100g in cocoa and there is about 60mg in EJ so a little less than half. None the less there is enough that epicatechin will be active especially with Narinigenin, EGCG and quercetin in the mix as these all increase the absorption of epicatechin. Lets think of epicatechin as sort of a bonus.
Ursolic acid
There is a decent dose in here at upwards of 150mg estimated per daily dose of our EJ extract but Ursolic acid is also a major constituent of another of Vectors ingredents giving us approx 300mg + of Ursolic acid per dose. Ursolic acid orally has been show in studies to increase muscle mass, Increase strength, Increase brown fat, Increase glucose utilization and increase exercise capacity. Its been stated that UA is not viable orally but I think I disagree and it seems as though studies also indicate that it is orally active although it has a very poor absorption rate. High doses are required and studies indicate 300+ should be enough orally to produce the desired results.
Corosolic acid
Corosolic acid is a GDA generally extracted from Banaba (lagerstroemia speciosa) but a significant amount is present in Eribotrya J. Corosolic acid works orally at relatively low doses and has some interesting effects. Even doses of 10mg are viable to display its impressive effects. Most people have heard of Corosolic acid for its glucose effects as it is a major GDA. Corosolic acid can help to keep glucose down with multiple mechanisms of action. Glut4 translocation, reduced insulin resistance as well as all kinds of enzymatic suppression and or expression.
-Corosolic acid has been shown to reduce cholesterol levels and enhance lipid metabolism.
-Corosolic acid is also a great fat burner not only through antidiabetic effects but also by retarding absorption of fatty acids.
-Corosolic acid is a potent and selective inhibitor of the enzyme (11-beta hydroxysteroid dehydrogenase type 1) that converts inactive cortisone to active cortisol. Therefore, corosolic acid may prevent excessive cortisol production.
Overall Corosolic acid is one of Vectors great components. Increased Glucose uptake into muscles, decreased blood sugar, increased insulin sensitivity, increased fat utilization and decreased fat diposition plus decreased cortisol make Corosolic a powerhouse.
Oleanolic acid
Oleanolic acid (OA) is a constituent of Olea Europea, Viscum Album and Eriobotrya japonica as well as others.
Its long been used in Chinese medicine for treatment of liver disorders and other ailments. OA increases glucose utilization, is a solid vasodilator and increases expression of the AKT pathway.
Protocatechuic acid
- Insulin like activity by activating PPAPy.
- Decreases ROS
- Antiageing
- Anti inflammatory
- Antiseptic
- analgesic
- GLUT4 upregulation
- Antioxidant
- Protects the testes from damage and stress
- Cardio protective
Caffeic acid
- Increased exercise capacity
- Reduced Blood Lactate
- Increased fat loss
- Endurance
Ferulic acid, 4-hydroxy-3-methoxycinnamic acid, is one of the most ubiquitous phenolic acids, found in the
bran of grasses such as wheat, rice, and oats. It belongs to the family of plant hydroxycinnamic acids, which
include caffeic acid, sinapic acid, and p-coumaric acid.* Recent studies have provided evidence that ferulic acid reduces the risk of disease, including Alzheimer’s disease, cardiovascular disease, diabetes, and colon cancer. Currently, ferulic acid is used to enhance athletic
performance, both in humans and racehorses. Supplementation by it has been found to increase muscle strength in weight lifters.
In one animal study a single acute administration of Ferulic acid increased swimming time by 170%.
Ferulic acid prevented the decrease in catalase, superoxide dismutase and protected against the depletion* of* GST* activity* induced* by* exhaustive exercise.
Exercise can be associated with oxidative stress. Thus exercise can act as a powerful source of Reactive Oxygen Species, depending on duration and intensity. During exhaustive exercise, fat is typically used* as* the* primary* energy* source,* thus* sparing glycogen stores, which in turn retards fatigue. However, during strenuous exercise substantial production of ROS occurs via beta oxidation during the utilization of fat.
In addition, a dramatic increase in oxygen consumption in the body creates an imbalance between ROS and the antioxidant defense system resulting in fatigue.
Acute adminstration of Ferulic acid prevents fatigue, increases endurance and protects the body during exhaustive exercise.
Chlorogenic acid
CA often reffered to as green coffee extract is widely known for its antiobesity effects via PPARa agonism and by preventing proliferation of new fat cells. CA can increase muscular glucose uptake both by stimulating Non insulin dependent AMPK as well as stimulating pAKt. Great for keeping bodyfat off while promoting muscle growth.
bigsmall
Banned
Tons of comments / logs etc..and lots of them by seasoned AM folks telling that Vector is the Sh1T. I am 50 and have been using supplements for over 30 years - never has anything worked for me like Vector has - it's better than Osta and does not cause inflammation (ARA).