Sounds pretty logical, right? Yohimbine unblocks the blocked release of fatty acids in the "stubborn fat" areas and allows you to shed the abdominal (men) and thigh (women) fat you've been battling for years... well, there is just one problem: There is not a single credible peer-reviewed study that would support the notion that orally administered yohimbine will do just that.
On the contrary, if you do a database search, you will even find studies which found no effects of yohimbine on total and / or regional body fat, at all. A study in Lancaster General Hospital, for example reports no difference in body fat and fat distribution as measured both by waist-to-hip ratio and by CT scan (Sax. 1991) - and that in spite of the fact that the subjects in the Sax study consumed an incremental amount of yohimbine (16–43 mg), exercised thrice a week and consumed an energy restricted diet (1,800kcal / day) for 6 months!
In view of the results of the Sax study and a hand full of other studies with similar results (e.g. Berlin. 1985), in which yohimbine produced only side (impaired sleep, nervousness, headache, arthralgia; Sax. 1991) but not the desired fat loss effects, the notion that yohimbine would do anything in terms of fat loss and / or redistribution must be considered to be debunked - at least for the male part of the population.