3,4-divanillyltetrahydrofuran _ Studies?

HIT4ME

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Alright, people seem to really believe stinging nettle increases free testosterone. I cannot find any studies, however, that show it actually increases testosterone in vivo. I did find 1-2 studies suggesting it would impact shag, but that means we are talking theory still. Is there hard evidence this stuff actually increases testosterone?
 
VaughnTrue

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no current human/in-vivo studies on the compound individually that I have ever seen
 
HIT4ME

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no current human/in-vivo studies on the compound individually that I have ever seen
What is your take on the ingredient in Vaughan? Do you think it even works?
 
VaughnTrue

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I do believe it works, although in the absence of clinical studies, I cannot prove so, even with my own bloodwork showing that it worked for me individually.

I enjoy using it on cycle more than anything. I find it allows me to get a bigger result from my usual dose, or my usual results from a slightly smaller dose.


it's no magic compound, but I definitely notice a big big big difference when utilizing it.
 
HIT4ME

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Awesome. Did you do bloodworm and see results?

I've seen on various sites that people have done blood work and seen no free test improvement...so that combined with the lack of evidence makes me wonder. Your experience and thoughts carry some weight with me though. Thanks for the input.
 
VaughnTrue

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Awesome. Did you do bloodworm and see results?

I've seen on various sites that people have done blood work and seen no free test improvement...so that combined with the lack of evidence makes me wonder. Your experience and thoughts carry some weight with me though. Thanks for the input.

Yup, I have done blood work numerous times while on it, and my results showed that it was in fact working. We also had some end users post blood work(during PCT utilizing nothing but Testabolan + Reversitol v2) and showed incredible results.


Testabolan is one of the few products that I never hesitate to suggest for anyone, as every time someone tries it they come back and tell me "oh my god...what is in that stuff?" and its just a simple combo of divanil/ALCAR/naringin. The stuff just flat out works when using a legit extract
 
john.patterson

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http://www.ncbi.nlm.nih.gov/pubmed/21806658

I know this isn't a human study, and I'm sure you've found this on your own, but I think its worth a read through.

Divanil binds with very high affinity to sex hormone binding globulin (SHBG), which will increase the concentration of free testosterone; as a result, giving the athlete all the wonderful things more testosterone will give. Studies have shown, Divanil does bind to SHBG, so, thereotically, your free testosterone levels will rise even if your total testosterone stays the same. In simple terms, Divanil is an incredible weapon to help you raise your free testoerone levels without suppressing your LH.

-Steve Smi, Evolutionary
I haven't gotten blood work done, but I can feel a noticable difference in libido while using 3,4 Divanil. The only product I've used with stinging nettle is Alphamax XT, and I noticed a significant increase in libido and I felt that it helped with strength gain. Its tough to narrow it down directly to the stinging nettle, but I think its worth experimenting with to see if you benefit from it. Alphamax XT also contains a solid profile of other studied ingredients for helping to increase natural test. With the feedback from others, and the studies done, there's no reason not to test it out. I've only been hearing positive feedback so far from 3,4 Divanil users, and Alphamax XT users alike.
 
The_Old_Guy

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Yup, I have done blood work numerous times while on it, and my results showed that it was in fact working. We also had some end users post blood work(during PCT utilizing nothing but Testabolan + Reversitol v2) and showed incredible results.


Testabolan is one of the few products that I never hesitate to suggest for anyone, as every time someone tries it they come back and tell me "oh my god...what is in that stuff?" and its just a simple combo of divanil/ALCAR/naringin. The stuff just flat out works when using a legit extract
So 3,4 Div was the *only* thing you were taking? I found one study catered to BPA, but where they checked T levels:

After using Stinging Nettle Root for 6 months at a thrice daily dose of 120mg, 81% of the intervention group had improved symptoms of Benign Prostatic Hyperplasia while 14% of placebo did.

Stinging Nettle continued to alleviate symptoms with no side effects as long as it was used, with no differences between experimental and placebo when experimental ended usage of the supplement. A band-aid effect rather than curative.

Testosterone levels were unaffected, and no size changes in the prostate were noted.
Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. - PubMed - NCBI
 
VaughnTrue

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So 3,4 Div was the *only* thing you were taking? I found one study catered to BPA, but where they checked T levels:



Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. - PubMed - NCBI
I have used it on its own, but it was a long long time ago, and have no bloods.

I traditionally like to stack it with hormonal agents, from which I have gotten blood done before, during, and after.


it would be interesting to see what a full dose can do for someone who is natural, as well as someone running testosterone
 
The_Old_Guy

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Let's not all forget about the 2010 Research Triangle Park scandal with so called "95%" 3,4 Div -

Tempe, AZ January 27, 2010

In an effort to provide top-quality products and accurate labeling, X recently partnered with Y to examine a potential problem with one of X’s ingredients, 3,4-divanillyltetrahydrofuran.

After Y notified X about purity issues with Turkesterone, X’s formulators performed a series of tests to evaluate the purity of the ingredient. The tests, however, did not yield conclusive results and what passed as Turkesterone in the past could not be substantiated. Consequently X has proceeded to remove the ingredient from its new Z product.

While X began formulating a new version of Z, they encountered similar problems during testing of the ingredient characterized by it’s founders as 95% 3,4-divanillyltetrahydrofuran (3,4-D). As a result, X turned to Y, which has one of most stringent quality control and testing programs in the industry.

Y commissioned an independent lab to analyze all the material in the market for this specific compound to obtain proper identification. After extensive tests, botanical analysis, and chromograph fingerprints, the material was identified to have a purity of less than 5% 3,4-D, no illegal steroidal structures, and to stem from the Urtica diocia (Nettle) botanical family. The testing procedure was repeated for several additional samples from every known supplier and various products on the market labeled 95% 3,4-D. All of the tests reached the same conclusion of less than 5% 3,4-D purity.

While confident that the ingredient formerly known as 3,4-D “works,” due to the enormous amount of consumer feedback and the Z University study, the information provided from the results of Y’s independent market analysis of the compound has responsibly led X to change its labels to identify the material as “a proprietary extract of the Urtica dioca plant” to comply with federal labeling regulations.

“We are very happy to have the correct label information for this ingredient,” noted Steve Bonnell, Chief Operations Officer of X. “Y’s testing helped reveal a purity misrepresentation, and now we can be sure we are providing correctly indentified products for our loyal customers,” he added.

According to third party testing companies, more than a quarter of finished dietary supplement products sold in the US, and as much as 85% of certain ingredients, have been adulterated or mislabeled in some way. As a result of the 3,4-D testing, X has pledged to employ several new quality control procedures that range from adulteration and contamination testing to additional material screenings. With help from highly regarded manufacturers such as Y, X aims to expand its quality assurance testing and develop the highest quality products in the industry.
 
VaughnTrue

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Let's not all forget about the 2010 Research Triangle Park scandal with so called "95%" 3,4 Div -
yup, there was an industry wide mislabeling of UD extract for quite some time.
 
HIT4ME

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HIT4ME

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http://www.ncbi.nlm.nih.gov/pubmed/21806658

I know this isn't a human study, and I'm sure you've found this on your own, but I think its worth a read through.



I haven't gotten blood work done, but I can feel a noticable difference in libido while using 3,4 Divanil. The only product I've used with stinging nettle is Alphamax XT, and I noticed a significant increase in libido and I felt that it helped with strength gain. Its tough to narrow it down directly to the stinging nettle, but I think its worth experimenting with to see if you benefit from it. Alphamax XT also contains a solid profile of other studied ingredients for helping to increase natural test. With the feedback from others, and the studies done, there's no reason not to test it out. I've only been hearing positive feedback so far from 3,4 Divanil users, and Alphamax XT users alike.
John, I've used Alphamax OG a couple times, which had Divanil, and I liked the product a lot and have recommended it to others. It's actually the only test booster I've ever used. I *think* it did what it claimed, but I didn't get any blood work and there are a few ingredients, so the effects could have been confounded. Alphamax is a great product, but I'm not sure 100% about what I think of Divanil. People seem to like it, but there seems to be little evidence of its efficacy for test boosting. To be quite honest, I'm wondering how anyone ever even got the idea that it is a test booster to begin with.

Having said that, user experience isn't completely worthless and I'm not willing to jump on the examine.com bandwagon and go too far in the other direction to say that just because there aren't any studies, it couldn't possibly work. There are loads of compounds that people have used for certain effects despite a lack of studies, and then when the studies are finally done they prove to be worth trying.
 
The_Old_Guy

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So, are you a non-believer? Do you think this ingredient fails at raising test?
I've never seen it raved about solo, it's always mixed in with stuff. Curiously, other than Barlowe's, nobody offers it bulk/solo (3,4 Div, not "Nettle Extract" obviously) - seems strange for something that is supposed to "work". StanleyG had bloodwork done on the AgeForce Testo100 Patches and saw a huge Free T increase. Those only list "Stinging Nettle" IIRC, but they are also full of Long Jack, which IIRC again, also has some data for Free T raising? I'd put more faith in the latter, personally.
 
john.patterson

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John, I've used Alphamax OG a couple times, which had Divanil, and I liked the product a lot and have recommended it to others. It's actually the only test booster I've ever used. I *think* it did what it claimed, but I didn't get any blood work and there are a few ingredients, so the effects could have been confounded. Alphamax is a great product, but I'm not sure 100% about what I think of Divanil. People seem to like it, but there seems to be little evidence of its efficacy for test boosting. To be quite honest, I'm wondering how anyone ever even got the idea that it is a test booster to begin with.

Having said that, user experience isn't completely worthless and I'm not willing to jump on the examine.com bandwagon and go too far in the other direction to say that just because there aren't any studies, it couldn't possibly work. There are loads of compounds that people have used for certain effects despite a lack of studies, and then when the studies are finally done they prove to be worth trying.
Thanks for the honest feedback. I agree with what you're saying. Its always a gamble when using natural ingredients with minimal studies, and everyone responds differently to different ingredients. I feel that the opposite occurs with some studies too - some ingredients work very well for some people, and end up doing poorly in studies. Combine that inconsistency with the inconsistencies of extracts, shady supplement companies, and incorrect supplement labels, and its a total toss up!

I always like to hear user feedback to see what's actually working for people. I'm glad to hear you enjoyed the OG Alphamax. I feel that there are only a few select companies out there putting out quality products that truly WORK, so its always good news to hear people enjoying Performax products
 
Jiigzz

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So, are you a non-believer? Do you think this ingredient fails at raising test?
Raising test or increasing free test and two different things. It claims the latter.
 
Jiigzz

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http://www.ncbi.nlm.nih.gov/pubmed/21806658

I know this isn't a human study, and I'm sure you've found this on your own, but I think its worth a read through.



I haven't gotten blood work done, but I can feel a noticable difference in libido while using 3,4 Divanil. The only product I've used with stinging nettle is Alphamax XT, and I noticed a significant increase in libido and I felt that it helped with strength gain. Its tough to narrow it down directly to the stinging nettle, but I think its worth experimenting with to see if you benefit from it. Alphamax XT also contains a solid profile of other studied ingredients for helping to increase natural test. With the feedback from others, and the studies done, there's no reason not to test it out. I've only been hearing positive feedback so far from 3,4 Divanil users, and Alphamax XT users alike.
He's asking about the one ingredients worth, not for a product suggestion, lol.

Way too many compounding factors to use Alphamax to evaluate the effectiveness of Divanil, no?
 
HIT4ME

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Raising test or increasing free test and two different things. It claims the latter.
Understood, that's what I meant. What do you think Jigzz? Does it raise free test?
 
john.patterson

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He's asking about the one ingredients worth, not for a product suggestion, lol.

Way too many compounding factors to use Alphamax to evaluate the effectiveness of Divanil, no?
I didn't suggest a product. I provided him with a study on the ingredient, and gave him my opinion on a product I've used containing the ingredient.
 
Jiigzz

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Understood, that's what I meant. What do you think Jigzz? Does it raise free test?
I used it in bulk a fair while ago and noticed an increase in libido, mood and breakouts IIRC.

I don't care much for T boosting anymore so havent used it in a while
 
HIT4ME

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Great, so it seems this compound does have some potential - it seems to give some of the sides associated with increased free testosterone...
 
The_Old_Guy

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Great, so it seems this compound does have some potential - it seems to give some of the sides associated with increased free testosterone...
Get this and let us know:

Barlowe's Herbal Elixirs brings you the highest grade and most targeted Nettle High Potency Extract which has been specifically designed to increase free testosterone. This is a potent extract which is generally called the 95% 3,4-divanillyltetrahydrofuran extract. This product and all the rest of our products are STEARATE FREE!
privatemdlabsDOTcom as well ??? :)
 
HIT4ME

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Get this and let us know:



privatemdlabsDOTcom as well ??? :)
My man, I'm running Sup3r-11 with T3, Ignit3, Combustion and Brite right now. If I use this, it will be in a PCT with with a bunch of other stuff, and not a good test case. Maybe in the future....
 
The_Old_Guy

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My man, I'm running Sup3r-11 with T3, Ignit3, Combustion and Brite right now. If I use this, it will be in a PCT with with a bunch of other stuff, and not a good test case. Maybe in the future....
:D Good man! I hate the 20 other compound "it works" testimonials too! :D
 
Jiigzz

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Great, so it seems this compound does have some potential - it seems to give some of the sides associated with increased free testosterone...
Yeah it does, but a lot of products do this for me. Im highly susceptible to breakouts - it's not huge but even a couple is 2x as many as I would like lol.

Libido isnt an issue for me, in fact this is the biggest reason I stopped using t boosters. Mine is high enough as is and anymore is just frustrating lol. Im not even kidding.

I prefer adaptagens, pre workouts and health based stuff now over anything else.
 

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I prefer adaptagens, pre workouts and health based stuff now over anything else.
Yeah, I'm in the same boat as you these days. But maybe 1-2 of the novel anabolics that are new just to say I've tried them.
 

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