SARM's, MK, & GW : A User's Guide

strickamania said:
Are you saying GW (Cardarine) is a waste, or just not the "miracle drug" it was first advertised to be? I'm currently running that with osta from OL and havent had TONS of endurance, but i have to force myself to eat
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If it was a waste I wouldn't have 10 bottles of it in my stash! Carderine is great but it was waaaay over hyped when rc companies were pushing it originally.
 
As a potent PPARbeta, I'm surprised the fat loss is not impressive.
 
Osta in pct after a PH run. Yes, like it very much.

Thoughts on Rad140 for possible use in pct? Chatter on that seems to have gone cold.

One more: Osta kicked in relatively quickly for me, but LGD has taken 5+ weeks & up to 10mg to really show me the goods.
What's thoughts on using osta as a primer for an lgd run? Say osta at 20 - 25mg for 4 weeks, add lgd at 3 - 5mg for 2 more weeks then cease osta & go full lgd at 9 - 12mg cycle for another 6 - 8 weeks? I know they compete for the same receptor site, but i'm wondering if doing this will build up to getting the lgd cranking a bit sooner.
 
Dam, all this pharma SERM and AI arrived with me today. I keep waiting for the cops to roll up and arrest me. Fully stressed right now, bros.
 
AustBenny said:
Dam, all this pharma SERM and AI arrived with me today. I keep waiting for the cops to roll up and arrest me. Fully stressed right now, bros.
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You'll be fine, they have bigger worries (I hope)
 
EDIT: I see you are an Aussie if I"m correct.

My answer was meant for US residents.
 
Lol, I'm not serious... at all. Just taking the piss out of someone for kicks. Maybe that someone can learn from this though.
 
AustBenny said:
You should leave your post up for US residents, mate. It may help some of them grow some balls.
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I have to say, it is a heavy burden walking around with this pair lol
 
What's thoughts on using osta as a primer for an lgd run? Say osta at 20 - 25mg for 4 weeks, add lgd at 3 - 5mg for 2 more weeks then cease osta & go full lgd at 9 - 12mg cycle for another 6 - 8 weeks? I know they compete for the same receptor site, but i'm wondering if doing this will build up to getting the lgd cranking a bit sooner.

Dma, Yates, anyone have thoughts on this?
Waste of time or good idea...or unknown?
 
AustBenny said:
I dunno man, this guy was saying there's all these legality issues with SERMS so now I'm fully stressed :/
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This chick is back again? I thought you were unsubscribing? Do you go on threads just to bash people? People are here to learn and ask questions. Can the admin or moderators just ban her by now?

Typical bathroom bully with no balls to say it to anyone's face. Like I said before real tough guy behind a key board. Typical keyboard warrior.
 
Like I said you are only a keyboard warrior. I must have made you so mad that I am still on your mind. You obviously can't grow up and I never even addressed you but you still bring up my screen name. Not just here but on other threads. I must be on your mind all dam day. Man that sucks. You just can't get over it. Haha.
 
I am still on your mind. Look at you. You can't even take suggestions from other members here and grow up. I must have gotten you so mad that I am all you think about. It is funny as hell. You mention me by name on other threads too. I must be on your mind all dam day. That must suck.
 
Nah, just every time someone on here makes a weak comment I think to myself that sounds like something Chrisko would say. I guerss your name is now synonymous with weak a ss p^ssy.

Love to stay and chat but gotta go make some gains.
 
cheeky1 said:
What's thoughts on using osta as a primer for an lgd run? Say osta at 20 - 25mg for 4 weeks, add lgd at 3 - 5mg for 2 more weeks then cease osta & go full lgd at 9 - 12mg cycle for another 6 - 8 weeks? I know they compete for the same receptor site, but i'm wondering if doing this will build up to getting the lgd cranking a bit sooner.

Dma, Yates, anyone have thoughts on this?
Waste of time or good idea...or unknown?
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I think it would be a nice cycle. I ran Osta into DMZ. This would kind of be the same type of set up.
 
bighulksmash said:
Can carderine be run alongside clen and tren or would they conflict?
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Sure you can run carderine with either, it's that clen and tren combo I would be worried about. I hope you know your bp very well going in to something like that.
 
Dma378 said:
I think it would be fine. And probably a functional addition. Not only to the fat burning, but lowering BP, and helping combat the endurance issues associated with Tren.
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Thanks bro!!! Im looking forward to this after my pct.



yates84 said:
Sure you can run carderine with either, it's that clen and tren combo I would be worried about. I hope you know your bp very well going in to something like that.
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Yeah i planned on buying a bp/hr/bs monitor from Walmart it looks like a watch . Not sure how good that would be.
 
bighulksmash said:
Thanks bro!!! Im looking forward to this after my pct.





Yeah i planned on buying a bp/hr/bs monitor from Walmart it looks like a watch . Not sure how good that would be.
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They sell omron which I have found to be a reliable brand of bp monitor. The biggest thing to look for is to get the correct cuff size for your arm, if you have the wrong size then readings will be way off. Wrist bp monitors aren't nearly as accurate as an arm cuff equipped monitor
 
yates84 said:
They sell omron which I have found to be a reliable brand of bp monitor. The biggest thing to look for is to get the correct cuff size for your arm, if you have the wrong size then readings will be way off. Wrist bp monitors aren't nearly as accurate as an arm cuff equipped monitor
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Biceps are 19" i hope i can find one . Ill give it a shot.
 
bighulksmash said:
Biceps are 19" i hope i can find one . Ill give it a shot.
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I think a lage size cuff will cover you. Just look at the packaging, they give cuff size and arm dimensions that it's compatible with
 
Does lgd and osta compete for the same receptor? After running both separate and if they treat me good, I was thinking about stacking them together. Is it highly recommended to run the arimistane during cycle?
 
Chrisko said:
Does lgd and osta compete for the same receptor? After running both separate and if they treat me good, I was thinking about stacking them together. Is it highly recommended to run the arimistane during cycle?
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They just aren't very synergistic with each other. I would go rad/osta or rad/lgd if I was you. Armistane is personal preference tbh.
 
yates84 said:
They just aren't very synergistic with each other. I would go rad/osta or rad/lgd if I was you. Armistane is personal preference tbh.
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This.

Also FYI, the competing for the same receptor argument is dead. Bro science at its finest. Look at AAS cycles....

Test, Tren, Mast, etc. all stacked "competing for same receptor" (whatever that even means). Yet working harmoniously.

Synergy is what you want.
 
Chrisko said:
Does lgd and osta compete for the same receptor? After running both separate and if they treat me good, I was thinking about stacking them together. Is it highly recommended to run the arimistane during cycle?
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No and competing receptor sites is only an issue in bros heads or an issue of using the wrong drug cocktail.

I wouldn't run an ai unless 1. You have blood work or 2. You start having high estrogen sides. Plus...estrogen =gains in normal ranges.

Please note... Water retention is not a good gauge of estrogen side effects because some steroids (sarms too ) have water retention as an EFFECT. NOT A SIDE EFFECT.
 
Dma378 said:
This.

Also FYI, the competing for the same receptor argument is dead. Bro science at its finest. Look at AAS cycles....

Test, Tren, Mast, etc. all stacked "competing for same receptor" (whatever that even means). Yet working harmoniously.

Synergy is what you want.
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Yep. We have waaaay more androgen receptors than you could ever fill up
 
Just wanna add that arimistane is barely an AI... It's more of a cortisol blocker at this point. Probably would be better to have a real AI on hand just in case.
 
BamBam0319 said:
Just wanna add that arimistane is barely an AI... It's more of a cortisol blocker at this point. Probably would be better to have a real AI on hand just in case.
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Exactly. Once estrogen gets out of control armistane will not be enough to control it. There is no substitute for exemestane.
 
Chrisko said:
If things get out of hand I would assume 12.5 every other day or even every third day?
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I would go 12.5mg Ed until sides go down and then go to eod or e3d. No need to taper, exemestane is a suicide inhibitor
 
yates84 said:
Supposed to be very synergistic with gw, Sr effects reverbA and is supposed to really increase fat loss without any exercise! Kinda hard to believe, probably just hype the same way gw was advertised when it first hit the scene
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SR-9009 is very interesting, indeed. But unfortunately, in the studies a bioavailability of 2.2% is proven. All the logs with 30mg/ed are - in my personal opinion - not trustworthy, because you need way more than 30mg to generate a serious effect. Furthermore, the half life is aprox. 30min. At the moment absolutely not usable.

What's more to say: SR-9009 is the most experimental research chemical. Imagine, you are creating a substance out of fun only to see, how it acts. That's the SR-9009. It's miles away from its final form.


Whacked said:
As a potent PPARbeta, I'm surprised the fat loss is not impressive.
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GW-501516 is a PPAR-delta, by the way. Talking about SR-9009: it's a PPAR-alpha.
 
sanmarino said:
SR-9009 is very interesting, indeed. But unfortunately, in the studies a bioavailability of 2.2% is proven. All the logs with 30mg/ed are - in my personal opinion - not trustworthy, because you need way more than 30mg to generate a serious effect. Furthermore, the half life is aprox. 30min. At the moment absolutely not usable.

What's more to say: SR-9009 is the most experimental research chemical. Imagine, you are creating a substance out of fun only to see, how it acts. That's the SR-9009. It's miles away from its final form.




GW-501516 is a PPAR-delta, by the way. Talking about SR-9009: it's a PPAR-alpha.
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We were actually in the process of working on the bioavailablity issues with sr9009 but that got put on hold indefinitely because of the uk line being discontinued. It is definitely worthless on its own, bioavailablity is a huge issue with sr9009
 
All right. Please, also research for an estered-version to increase the half life of 30min to 24h :D
With the aim, that any person who wants to try the Alpha-1-Version (worser than a beta-subtance, you may know how unpredictable and incompatible beta patches on the computer are :) ) also have a slight benefit of that. Taking it every 30min is more than annoying.

I would like to quote Prof. Burris, which is the head of the SR-9009 research team. The following text is based on an inquiry of an interested party. This was posted in a reddit-thread but I don't doubt on this legitimacy because there are facts we already know.

[...] I just recently found out that someone is selling SR9009 in a manner that is "supported" for human use in bodybuilding. I agree with your comments. The drug does in fact alter the circadian rhythm (in mice) and we would need to assume in humans – and we don't know if it is beneficial or detrimental at this point. SR9009 was designed as a "tool" molecule to determine if we should pursue making more drug like compounds that could be used to treat disease. Of course, the data is supportive of going forward – and we are designing better compounds – but the issue is that SR9009 has several issues that make it unsuitable for human use.
Firstly, it has no oral bioavailability. I know the company selling this is indicating taking it orally is ok – but it doesn't even get into the blood.
At this point that is probably not a bad thing since the drug has not been evaluated in appropriate toxicology assays to determine if there are issues like inducing disease (cancer as you indicate or others).There is going to be exposure to the gut and that is not necessarily good since we don't know the effects as of yet.
SR9009 has some functional groups that are known to have potential toxicology liabilities and it would never be developed as a drug.
It was ok as a "tool" to figure out if we should continue to spend money and effort to get better drugs – but we had to design these "bad" functional groups out since they are know to have toxic effects in humans.

So bottom line – I would never recommend using this compound at this point.

That being said – we are still working on improved compounds with one of the potential uses being sarcopenia – loss of muscle and strength due to aging. [...]
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The only thing which irritates me, that Prof. Burris is talking about no bioavailability (okay, 2.2% is in fact nothing). But it shouldn't even get in the blood...?
 
sanmarino said:
All right. Please, also research for an estered-version to increase the half life of 30min to 24h :D
With the aim, that any person who wants to try the Alpha-1-Version (worser than a beta-subtance, you may know how unpredictable and incompatible beta patches on the computer are :) ) also have a slight benefit of that. Taking it every 30min is more than annoying.

I would like to quote Prof. Burris, which is the head of the SR-9009 research team. The following text is based on an inquiry of an interested party. This was posted in a reddit-thread but I don't doubt on this legitimacy because there are facts we already know.



The only thing which irritates me, that Prof. Burris is talking about no bioavailability (okay, 2.2% is in fact nothing). But it shouldn't even get in the blood...?
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Very high doses taken every 30 minutes would have effect but who wants to take that risk? We are no longer looking into the compound so I guess we won't k ow until someone else explores these theories
 
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