Driven2lift
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Not in humans, but an area of interest for AM'ers and fresh of the JISSN presses
http://www.jissn.com/content/12/1/32
http://www.jissn.com/content/12/1/32
Just briefed over it real quick and I think you are correct.From what I read, it proves that PA stimulates mTOR without ingesting protein or doing physical activity, as we've been assuming all along, right?
Yeah, that's why we still choose (or most of us anyway) to dose on off days as well.Just briefed over it real quick and I think you are correct.
Confirming what we already knew. PA will indeed increase mTOR with or without protein and with or without physical activity (though to a greater extent with the addition of exercise stressors).
I dose on off days for sure.Yeah, that's why we still choose (or most of us anyway) to dose on off days as well.
Well it's probably different for those who spent 60 dollars on the concentrated PA products vs the 7 dollar Soy Lecithin Granule containers.I dose on off days for sure.
Besides, we all know muscle is built outside of the gym during recovery...so why anyone would NOT want to use PA on an off day when recovering is beyond me.
True.Well it's probably different for those who spent 60 dollars on the concentrated PA products vs the 7 dollar Soy Lecithin Granule containers.
I would just add to this that, to my reading, it also suggests that PA may slightly blunt/delay mTOR singaling from leucine/whey protein when taken simultaneously:Just briefed over it real quick and I think you are correct.
Confirming what we already knew. PA will indeed increase mTOR with or without protein and with or without physical activity (though to a greater extent with the addition of exercise stressors).
This!Just briefed over it real quick and I think you are correct.
Confirming what we already knew. PA will indeed increase mTOR with or without protein and with or without physical activity (though to a greater extent with the addition of exercise stressors).
I really see no point taking PA with Whey anywayThe main limitations in the study are the doses used and exercise -- but it seems the main point is that it may not be in your greatest benefit to dose Whey Protein Concentrate with your Phosphatidic Acid.
Another interesting aspect of the study is PA ability on GLUT-4.
I wouldnt over think it too much. Increases in MPS over time do not necessarily equate to more muscle mass. Its just an optimization of the pathwaySoooo the point is, take it away from quality protein sources, or just effing take it whenever off days and pre-workout training days like I have been doing?? I am much confused lolz
Agreed.I really see no point taking PA with Whey anyway
They point out all the limitations.MPS was only measured at the 3h mark. They point out this weakness in the discussion
Very good point.I wouldnt over think it too much. Increases in MPS over time do not necessarily equate to more muscle mass. Its just an optimization of the pathway
That study is saying the opposite; an anorectic is an appetite suppressant, not a stimulant. The conclusion here is saying that PA may be useful as a weight loss aid in overweight populations.I know many people (including me) have experienced increased Appetite with PA/SL.
"It should also be noted that serum was not obtained from these animals and, given that Glut-4 mRNA transiently increases in PA-fed rats, future research should examine how dietary PA effects the post-prandial hormonal milieu (i.e., potential PA-mediated increases in insulin). Finally, the potential metabolic effects of PA supplementation beyond skeletal muscle hypertrophy (i.e., the effects of PA supplementation on glucose tolerance and/or appetite given that hypothalamic mTORC1 activation is anorectic*[38]) may unveil PA as a nutraceutical candidate in populations beyond resistance-trained athletes."
For what it's worth, I found my SL-enhanced oatmeal noticeably more "filling;" then again, I threw protein powder in there, so I was doing it wrongActivation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia).
I do know anorectic is an appetite suppressant BUT dont forget the power of GLUT4. Keep in mind, those words below are from a scientist:That study is saying the opposite; an anorectic is an appetite suppressant, not a stimulant. The conclusion here is saying that PA may be useful as a weight loss aid in overweight populations.
From the FT of the referenced article (38, "Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression"):
For what it's worth, I found my SL-enhanced oatmeal noticeably more "filling;" then again, I threw protein powder in there, so I was doing it wrong