NewAgeMayan
Well-known member
Im not sure of the mechanism, it wasnt specified in the study, but it did note that the transient increase in cort and prl was comparable to what one would normally see during sleep, exercise, and emotional stress.
The Official OL UK Ghar1ne Q&A
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Im not sure of the mechanism, it wasnt specified in the study, but it did note that the transient increase in cort and prl was comparable to what one would normally see during sleep, exercise, and emotional stress.
NoAddedHmones
Well-known member
Makes sense. Thanks.
edje007
Well-known member
edje007
Well-known member
aovereem
Member
Lot of great things happened with MK no doubt. Skin cleared up, strength was all time high, rapid weight gain, it basically seemed to enhance the effects of my androgens. But for me the lethargy was getting worse every week, until the point where I was barely functioning either at work or socially. If I would have some stim products maybe it could have worked out, eca or some eth-amphetamine like the old gaspari detonate or something similar. Recommend to have a stim on hand.
M.I.D
Well-known member
Once you go Olympus, you never go back
I agree, I have a draw full of dermatren, trest, halo-100, triumph, dmz, transform, dermastrength, epic unleashed, super pct..........
So you get the picture, i love Olympus lol...
But there was nowhere in UK I could find the Ghar1ne so had to do brawn
aovereem
Member
Brawn is sh1t. Ran their osta for 2 months and it was bunk
Dragoninho
Member
I've ran their Osta as well and got quite good results from it and a lot of people swear by their products. I'm on their LGD right now (same reason as MID, OL wasn't available when buying...), and I see results. Nothing crazy but ok. I looking forward to give LeGenD a try and compare.
digitalpimp
Member
I'm beginning to wonder if Huperzine A doesn't have a long half-life. I normally take 1 dose in the morning but a few weeks ago I took a double dose a couple of mornings and could not sleep at all those nights.
crowbar46
Active member
UPDATE:
1) Sat., August 1st was day 11 on Gharine, day 5 @ 20mg.
2) I had ready started noticing deeper sleep and tingling hands by this point, but I added 200 mcg. huperzine on Sat. and got excellent sleep!
3) yes, lethargy is there but it's not overwhelming. In fact, it seems to have subsided quite a bit. I no longer regret going up to 20 mg. on day 7.
4) I do seem less achy in my joints, which is very nice, since at 54yo I'm still squatting (in some form) 3 x week in a caloric deficit!
5) fat loss is definitely up, but keep in mind I'm also using 21 mg. Cardarine.
1) Sat., August 1st was day 11 on Gharine, day 5 @ 20mg.
2) I had ready started noticing deeper sleep and tingling hands by this point, but I added 200 mcg. huperzine on Sat. and got excellent sleep!
3) yes, lethargy is there but it's not overwhelming. In fact, it seems to have subsided quite a bit. I no longer regret going up to 20 mg. on day 7.
4) I do seem less achy in my joints, which is very nice, since at 54yo I'm still squatting (in some form) 3 x week in a caloric deficit!
5) fat loss is definitely up, but keep in mind I'm also using 21 mg. Cardarine.
yates84
Well-known member
Tbh huperzine a did not treat me nice at bedtime. For me, 200mcg in the morning and dosing my gharine at night has worked the best for me. Sleep has been great and the huperzine almost gives me a boost in the morning. I noticed my face looked really clear this morning and I look very full. I am really enjoying this run so far.
chedapalooza
Legend
You guys think the huperzine is essential for MK?
crowbar46
Active member
I can't say as I have no experience with huperzine (until now). I'm trying to figure out if using another acetylcholine precursor (Alpha-GPC) earlier in the day (on training days only) will be acetylcholine overkill if I also throw in 200 mcg. of huperzine pre-bed. I guess the only way to find out is be the guinea pig. I may have had a slightly restless sleep night, but it is so much better on Gharine that, honestly, I can't complain.
chedapalooza
Legend
The Official OL UK Ghar1ne Q&A
Well considering I use conqu3r which has both, I'm gonna be getting it anyway. Guess I'll have to see how I personally respond
Well considering I use conqu3r which has both, I'm gonna be getting it anyway. Guess I'll have to see how I personally respond
koi1214
Well-known member
I noticed both smoother/clearer from both of my mk677 runs.I will be starting GHAR1NE,huperzine and green tea extract log soon in Anabolic section.This will be my 3rd run with mk677 but my 1st using huperzine and green tea extract with it..
Huperzine-A is an acetylcholinesterase inhibitor, which deactivates the enzyme responsible for breaking down acetylcholine in the synapse, increasing endogenous acetylcholine levels.Theoretically, an increase in acetylcholine should lower somatostatin allowing for an increase in growth hormone levels.Huperzine A When the body recognizes elevated HGH levels it releases somatostatin to bind to the HGH so it can't fit into it's receptors. Huperzine A binds to somatostatin so the somatostatin can't render HGH useless. It allows for higher levels of HGH in your system.
Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
AndrewMcD
Member
Do you think the Green Tea Extract in EP1C Unleashed will be enough?
koi1214
Well-known member
I am not sure. Maybe Olympus UK Olympus Labs or yates84 can answer that.
I know I will be using 500mgs of GTE to begin with 200mcgs of huperzine though. I will post a link to my log as soon as I start.
yates84
Well-known member
Huperzine a has a half life around 24 hours
yates84
Well-known member
I bought seperate egcg but haven't used it yet just because of that fact. I think that the egcg dose in epic unleashed will be plenty to cover your egcg dose to assist with Huperzine-A
chedapalooza
Legend
For those curious I plan on using ghar1ne and cardar1ne in my ongoing HRT log I just started Invalid Link Removed
yates84
Well-known member
You can ramp mk up to 100mg before you start to hit the point of diminishing returns
M.I.D
Well-known member
And if you have a break for X amount of months, can you go back on and start a fresh at 10mg with similar results? or will you again need to up the dose again to see similar results?
yates84
Well-known member
From my experience you go back to baseline. I've run mk twice for 3 months each time and ramped up the dose (not too crazy) and am back seeing results with 10mg now after a few months break. Tbh I never would have come off mk if it wasn't so expensive before
crowbar46
Active member
UPDATE:
1) yesterday ( Mon., August 3rd), I did feel tired enough to take a nap.
2) Holy Crap! Last night (Mon., August 3rd) was night 13 on Gharine, night 7 @ 20 mg., night 3 with the addition of 200 mcg. huperzine.
3) I sleep like a zombie--9 1/2 solid Hrs.! Both my hands and my feet were tingling! I woke up feeling very relaxed and rested.
4) skin is looking plumper and smother, slightly more oily (I don't know if the oil has anything to do with the GH increase).
1) yesterday ( Mon., August 3rd), I did feel tired enough to take a nap.
2) Holy Crap! Last night (Mon., August 3rd) was night 13 on Gharine, night 7 @ 20 mg., night 3 with the addition of 200 mcg. huperzine.
3) I sleep like a zombie--9 1/2 solid Hrs.! Both my hands and my feet were tingling! I woke up feeling very relaxed and rested.
4) skin is looking plumper and smother, slightly more oily (I don't know if the oil has anything to do with the GH increase).
digitalpimp
Member
How would I use this with Mucuna Pruriens? I also take 5-HTP at night
peepingyoda
New member
This was my experience yesterday per your recommendations. I did a full 200mg on waking, enjoyed the alertness from the hup A, and fell and stayed asleep just fine. I am also going to do keto for a bit to see if I feel any additional effect.
AndrewMcD
Member
Do you think dosing Hup A that far away from the mk-667 dose has less effect on somatostatin inhibition?
yates84
Well-known member
I'm doing keto myself right now, still look nice and full with gharine. The huperzine a is a nice little boost in the morning, I think this dosing protocol is ideal
yates84
Well-known member
No. Huperzine a has a 24 hour half life so continual daily dosing, no matter the time, should do its job 100%
AndrewMcD
Member
NICE! And are you guys dosing in the morning because you feel a stimulating effect if taken at night?
yates84
Well-known member
Yep, made sleep kinda restless. It has been working great with am huperzine doses and pm gharine doses
AndrewMcD
Member
mmm I haven't noticed restless sleep! I'll have to try dosing in the morning so see if I notice a difference!
Hastur
Well-known member
This is an excellent post, I just had to point that out. People keep asking about Huperzine A and EGCG with MK-677, and this is one of the most informative but bite-sized explanations I've come across yet.
I'm still liking what I'm hearing, and apparently others are too. This thread has really taken off as far as the product threads are concerned in the Olympus UK sub-forum. Clearly there is a lot of interest in MK-677/Ghar1ne, and good discussion and anecdotal reports to be had here.
From what I've read in the past on several sites, specifically nootropic sites, Huperzine A taken close to sleep does tend to interfere with sleep quality in a considerable number of individuals supplementing it. Mind you, this is based off anecdotal reports. If you're unaffected, that's great. But if you start to notice issues over time, I'd definitely suspect that the Huperzine A is the culprit.
crowbar46
Active member
I have to mention a couple of things:
1) I'm experiencing as much energy today as lethargy I was experiencing yesterday. This must be due to the length, but more importantly the incredible quality, of the sleep I got last night. I also notice a definite mood elevation--again, because of the increase in quality of sleep (I normally have pretty poor sleep).
2) some claim that the half-life of huperzine is GREATER than 24 Hrs., and over time can build up in your system. This combined with the fact that constant inhibition of acetylcholinesterase increases expression of acetylcholinesterase Mrna, indicates huperzine needs to be cycled.
3) does anyone know how long of constant use it takes before huperzine causes this increase in acetylcholinesterase expression?
1) I'm experiencing as much energy today as lethargy I was experiencing yesterday. This must be due to the length, but more importantly the incredible quality, of the sleep I got last night. I also notice a definite mood elevation--again, because of the increase in quality of sleep (I normally have pretty poor sleep).
2) some claim that the half-life of huperzine is GREATER than 24 Hrs., and over time can build up in your system. This combined with the fact that constant inhibition of acetylcholinesterase increases expression of acetylcholinesterase Mrna, indicates huperzine needs to be cycled.
3) does anyone know how long of constant use it takes before huperzine causes this increase in acetylcholinesterase expression?
mechka_grizli
Well-known member
The lethargy is brutal. Have taken 1 to 2 hr naps for the last three days. 10mg before bed
crowbar46
Active member
The more I look at huperzine the more fascinating it becomes. One thing is for certain, huperzine is, in fact, a potent drug--more potent and longer acting than two of the most common pharmaceutical acetylcholinesterase inhibitors! I've been digesting information for hours now about huperzine. I'll comment later after I clear up some questions I have. I'll leave you with this:
1) 200 mcg. of huperzine 30 min. before bed increases REM sleep by 20-30%!
People really should not think of huperzine as an innocuous herb; it has a number of powerful effects and is not for everyone. It can carry some side effects, though they seem relatively rare. These include restlessness, headache, nausea , vomiting, dizziness, sweating, slow heart rate, and a few others I'm probably forgetting. Most of these are similar to general acetylcholine overdose.
1) 200 mcg. of huperzine 30 min. before bed increases REM sleep by 20-30%!
People really should not think of huperzine as an innocuous herb; it has a number of powerful effects and is not for everyone. It can carry some side effects, though they seem relatively rare. These include restlessness, headache, nausea , vomiting, dizziness, sweating, slow heart rate, and a few others I'm probably forgetting. Most of these are similar to general acetylcholine overdose.
Hastur
Well-known member
Huperzine A's effects on sleep are pretty notable, you'll see it used heavily in lucid dreaming circles. It seems to induce lucid dreams fairly frequently and is a favorite amongst practitioners. So it's effects on REM sleep don't really surprise me, though a lot of lucid dreamers express that they are left less refreshed upon awakening after having such dreams, and if Huperzine A is linked to this phenomenon, I would say that's one more reason to preferentially dose it in the morning versus the evening.
hsk
Active member
A few questions about Ghar1ne:
I am interested in using Ghar1ne to help heal a recent shoulder and trap injury. Do you think it can be used for this purpose?
Would running an AI such as OL Elim1nate, SNS Inhibit E, or PES Erase Pro be effective at minimizing the possible water retention/bloat?
I don't want to take anything supressive but would still like to use something that would maximize or enhance my own natural testosterone production while using Ghar1ne. Would running it with a natty herbal testosterone enhancers such as AnaBeta Elite, Bulbine, Icariin, LJ100, and or Fadogia have any additional benefit?
I am pre-diabetic and have decreased insulin sensitivity. I use GDA's and bulk supps like Na-Rala, Berberine, Gymnema, and Cinnamon to manage my insulin sensitivity. Will Ghar1ne affect insulin sensitivity and if so to what extent?
I am interested in using Ghar1ne to help heal a recent shoulder and trap injury. Do you think it can be used for this purpose?
Would running an AI such as OL Elim1nate, SNS Inhibit E, or PES Erase Pro be effective at minimizing the possible water retention/bloat?
I don't want to take anything supressive but would still like to use something that would maximize or enhance my own natural testosterone production while using Ghar1ne. Would running it with a natty herbal testosterone enhancers such as AnaBeta Elite, Bulbine, Icariin, LJ100, and or Fadogia have any additional benefit?
I am pre-diabetic and have decreased insulin sensitivity. I use GDA's and bulk supps like Na-Rala, Berberine, Gymnema, and Cinnamon to manage my insulin sensitivity. Will Ghar1ne affect insulin sensitivity and if so to what extent?
chedapalooza
Legend
I'll let someone else chime in on the insulin aspect.
Can you elaborate on the injury?
Elim1nate will definitely help keep any water retention down, though there shouldn't be too too much.. You can adjust the dose of 1-3 caps daily too so it wouldn't hurt to have on hand by any means. That plus LJ100 is a solid option for natty test levels/free test and cortisol management.
hsk
Active member
Thank you for the response. I have a large knot and cyst on my right lower middle trapezius muscle, and this injury causd my right shoulder/rotator cuff to become inflamed leading to bursitis/tendonitis of the right shoulder. The impingement of the shoulder has gradually improved but the knot and cyst on my trap is taking a long time to heal. Its been 3 weeks. I just want to speed the healing up and hopefully bring the entire right shoulder back to 100%.
chedapalooza
Legend
Funny I have something similar from an injury two years ago that never properly healed. My best advice is to cease all activity and focus on getting that area healed 100% or it simply won't.. And the condition will worsen. Ghar1ne should definitely help with this, as would joint force by epharm- I believe evomuse is selling it as well under a different name on license from epharm
chedapalooza
Legend
Yep. After playing football thru college and literally never taking more than 7-10 days off a couple times a year since age 14, my joints are fried! This is the first reason I ever looked into MK.... Laxogenin did seem to help slightly as well tbh and that can be found in OL str3ngth