The Official OL UK Ghar1ne Q&A

Does this stuff cause any anxiety? Took first dose yesterday feeling a bit anxious last night and today
 
I don't know of any MOA that would cause it to produce anxiety. I do believe I may be experiencing a little lethargy that some people describe.
 
Yates, I'm thinking of picking up some huperzine A to run with the Gharine. I've got a question though: I ready use an acetylcholine precursor pre-training. Do you think it would be overstimulating acetylcholine levels to use two precursors in the same day?
 
crowbar46 said:
Yates, I'm thinking of picking up some huperzine A to run with the Gharine. I've got a question though: I ready use an acetylcholine precursor pre-training. Do you think it would be overstimulating acetylcholine levels to use two precursors in the same day?
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Huperzine has a pretty long half life so you might already be covered. If you added any more huperzine a I wouldn't go over 200mcg
 
yates84 said:
Huperzine has a pretty long half life so you might already be covered. If you added any more huperzine a I wouldn't go over 200mcg
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The acetylcholine precursor I use is alpha-gpc. I guess I shouldn 't refer to huperzine as a precursor, but you get the idea. If I use the alpha-gpc earlier in the day, do you think it would be too much to use the huperzine before bed with the Gharine?
 
So with the long-term use of Ghar1ne, would I be able to group it into my staple supps category when running my next ph cycle?
 
crowbar46 said:
The acetylcholine precursor I use is alpha-gpc. I guess I shouldn 't refer to huperzine as a precursor, but you get the idea. If I use the alpha-gpc earlier in the day, do you think it would be too much to use the huperzine before bed with the Gharine?
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I dont see any problem with that at all
 
strester said:
So with the long-term use of Ghar1ne, would I be able to group it into my staple supps category when running my next ph cycle?
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We reccomend cycling off of gharine every 3 months but human studies have been done for up to 2 years with no bad side effects. It is really up to you if it is a staple supplement or not
 
I'm feeling it good at 10mg..Very happy yates suggested to run it lower before staggering it up
 
Olympus Labs said:
I'm feeling it good at 10mg..Very happy yates suggested to run it lower before staggering it up
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From the logs Ive seen at various places those that start dosing conservatively and gradually ramp up appear to fare better side-effect wise than those who go all-in from the get go.
 
NewAgeMayan said:
From the logs Ive seen at various places those that start dosing conservatively and gradually ramp up appear to fare better side-effect wise than those who go all-in from the get go.
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At 10mg, I'm feeling deeper sleep, slight lethargy when waking and numbness in hands. I also feel fuller even though I'm in a caloric deficit.
 
Olympus Labs said:
At 10mg, I'm feeling deeper sleep, slight lethargy when waking and numbness in hands. I also feel fuller even though I'm in a caloric deficit.
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That's interesting, I just don't really feel it @ 10mg. Could it be that I'm not taking it on an empty enough stomach? I've seen studies where it was administered in the morning, after an overnight fast, so I assume it may be important to take it on an empty stomach.

I allow myself a minimum of 4 hours between meals--5, sometimes more, if I can--in order to help .maintain metabolic flexibility (I.e., you force your body to not rely so heavily on burning carbs for fuel, and you give your body a break from constant insulin spikes). So, this usually means I have about 4 hrs. between my previous meal before I take my Gharine, then my pre-bed whey shake and little solid food 45 min. after taking the Gharine.

Do you think 4 hours is enough time between my previous meal and taking the Gharine? Is it even important to take it on an empty stomach? It does seem an empty stomach might augment the Ghrelin stimulation from the MK
 
I was taking my mk 677 with a protein shake before bed and had plenty of effect from it
 
Godstrength said:
I'm at 10 mg right now. Can you take the stuff with Finaflex G8?
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I don't see any reason why you couldn't. You probably won't need the g8 though as good as the sleep on gharine is
 
Update:

1) last night (Thur., July 30th) was night 9 on Gharine, night 2 @20 mg. I'm finally getting the deep sleep and tingling hands. I'm looking forward to the longer term effects-- raised IGF-1 levels, leaning out, tighter skin, improved recovery, etc.
 
I am curious about users that have joint pain when starting and before starting the Ghar1ne if those pain subside some throughout the cycle. Maybe some can comment on the improvements (if any)they notice after a couple of months of use.
 
The Official OL UK Ghar1ne Q&A

ELROCK said:
I am curious about users that have joint pain when starting and before starting the Ghar1ne if those pain subside some throughout the cycle. Maybe some can comment on the improvements (if any)they notice after a couple of months of use.
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I'm riddled with it joint and muscle pain (hips and shoulders) and doctors don't really know why.. I'll let u know happens when i start/through out
 
Update: **WARNING**

1) Be warned: when Yates says to take it easy at first with Gharine, take him seriously! I jumped the gun and went up to 20 mg./night after 6 days @ 10 mg.

2) today I awoke after 9 1/2 hrs. sleep when I usually have a hard time sleeping more than 7 Hrs. At one point I woke up because my hand felt like it was asleep! However, the lethargy was there today. Even after my pre-workout Brain Candy-which would normally have me jamming--I didn't have much zip. So, if I had it to do again, I'd run 10 mg./night for at least 2 weeks to allow my body time to adjust. However, I don't feel much water retention.

3) now the good news: I was able to increase the weight in 2 movements, keep 2 the same and decrease my time by ~6 %. In fact, since increasing the weight on 2 movements would normally have increased my time, I estimate this represents more like a 12-13% decrease in time.

4) note that I'm also using 21 mg. Cardarine.






ter
 
I am 2 days in myself, 10mg is just as strong as 25mg of the rc mk677 that I've done in the past. I'm seriously not feeling good about my old rc source anymore
 
I'm 2 days in with the Ghar1ne. I take it at night before bed. 10mg. Last night I woke up puking my guts out and today I haven't got out of bed due to feeling like I got hit by a truck. There is no way that the MK would have these side effects would it? Should I continue my dose tonight?
 
yates84 said:
It is a very pricey drug to manufacture. I was paying almost 100$ for rc mk677 that was 25mg per ml and had only 30ML. That's why I have only run mk twice!
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crowbar46 said:
So, 20 mg. last night. Again, I slept better than I usually do, but nothing spectacular. I am waking in the night to pee very hungry and its a battle to resist!

I'm still not experiencing any real tingling in my hands, just a slight bit of numbness. I'll give the 20 mg./night dose a week; if I don't experience better sleep quality and tingling hands, I'll up it to 30 mg.

I can't say at this point as it hasn't been long enough, but OL may need to up the dosage In these caps to, say, 12 mg. each. This way 2 caps gets you to the dosage used in the vast majority of the studies, and 3 caps gets you about ~50% above. As the studies show, MK is well tolerated in high doses and the effect does not plateau until 100 mg. in healthy males.

If Gharine needs to be ran at 25-30 mg./night (or higher) to see significant effects, it makes it a pretty pricey drug at $70.00 for 90, 10 mg. caps.
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crowbar46 said:
Update:

1) will be going up to 20 mg. tonight--one night earlier than planned--as sleep has been better than usual, but not as deep as I think this drug can help with. Also no tingling in hands really, just a slight bit of numbness in fingers. So, it's time to get the dose up and see what this can really do!

I'll let you know how it goes.
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For legal purposes, it might be a good idea to not refer to Ghar1ne as a DRUG.
 
araldo said:
I'm 2 days in with the Ghar1ne. I take it at night before bed. 10mg. Last night I woke up puking my guts out and today I haven't got out of bed due to feeling like I got hit by a truck. There is no way that the MK would have these side effects would it? Should I continue my dose tonight?
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Any other flu like symptoms?

I would discontinue use tonight until you feel better and then maybe try again.
 
tempted to pick up 2 bottles to run during my cut. just worried about the hunger lol also might run with some dopadex, and Hup A pre bed.
 
Auslifter said:
tempted to pick up 2 bottles to run during my cut. just worried about the hunger lol also might run with some dopadex, and Hup A pre bed.
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If you take pre bed you should get around some of the hunger pangs...
 
GNO said:
Any other flu like symptoms?

I would discontinue use tonight until you feel better and then maybe try again.
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Running a mild fever. Like 99.5. Whole body aches. I feel a little better. I continued my dosing and just took 10mg. I think I caught something. I'm in the healthcare field.
 
rascal14 said:
I want to run this for PCT, but tiredness and lethargy is not what I want during that time. Lol
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Yeah I'm noticing the benefits for sure, so far it hasn't been overbearing. Would probably go nice in pct. I want to run it longer to see the rewards/sides
 
My experience thus far:

Ran 10 mg with 200 hup A and couldn't sleep. I was a nightmare the next day,

Ran 10 mg with no hup A and felt fine the next day.
Ran 10mg with 50mg hup and was fine
Went to 20 mg with 50 hup and was fine.
Ran 20 mg with 100 hup and insomnia crankiness
Ran 20 mg alone and feel great.

I don't think I respond well to hup a and will probably just run mk alone. I'm running this with epic unleashed for skin/joint psoriasis. I started epic one week earlier and it's nearly cleared my skin. I have pa in the last knuckle of the fingers and nails.
 
peepingyoda said:
My experience thus far:

Ran 10 mg with 200 hup A and couldn't sleep. I was a nightmare the next day,

Ran 10 mg with no hup A and felt fine the next day.
Ran 10mg with 50mg hup and was fine
Went to 20 mg with 50 hup and was fine.
Ran 20 mg with 100 hup and insomnia crankiness
Ran 20 mg alone and feel great.

I don't think I respond well to hup a and will probably just run mk alone. I'm running this with epic unleashed for skin/joint psoriasis. I started epic one week earlier and it's nearly cleared my skin. I have pa in the last knuckle of the fingers and nails.
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hows it going performance wise? do you feel tired all day or is it just upon waking then at random times during the day
 
peepingyoda said:
My experience thus far:

Ran 10 mg with 200 hup A and couldn't sleep. I was a nightmare the next day,

Ran 10 mg with no hup A and felt fine the next day.
Ran 10mg with 50mg hup and was fine
Went to 20 mg with 50 hup and was fine.
Ran 20 mg with 100 hup and insomnia crankiness
Ran 20 mg alone and feel great.

I don't think I respond well to hup a and will probably just run mk alone. I'm running this with epic unleashed for skin/joint psoriasis. I started epic one week earlier and it's nearly cleared my skin. I have pa in the last knuckle of the fingers and nails.
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I had this same problem. Dose your huperzine a in the morning and you will be able to avoid this side effect
 
I notice a bit of the tingling in the morning and slightly increased hunger. I'm only tired if I take the hup A. I'm going to try just taking 50 in the morning as Yates has suggested.
 
aovereem said:
You should be more worried about the lethargy. Hunger was manageable, tiredness was not
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The lethargy side effect is very user dependant, I have felt great on gharine so far. Lethargy was nonexistent on my last mk677 runs as well
 
aovereem said:
You should be more worried about the lethargy. Hunger was manageable, tiredness was not
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thanks. Im quite interested in mk. but yea i had one friend say it caused him to binge lol. i don't think hunger should effect me much, but the lethargy maybe. I was thinking maybe stacking it with some Adrafinil or CRL-40940 in the morning to combat that, and some Dopadex(L-Dopa) to keep prolactin in check and possibly keep energy up
 
Auslifter said:
thanks. Im quite interested in mk. but yea i had one friend say it caused him to binge lol. i don't think hunger should effect me much, but the lethargy maybe. I was thinking maybe stacking it with some Adrafinil or CRL-40940 in the morning to combat that, and some Dopadex(L-Dopa) to keep prolactin in check and possibly keep energy up
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My understanding was MK-677 does not increase prolactin or cortisol ...
 
Is anyone doing a special diet to optimize GH along with the peptide? I've seen IF mentioned several times, but I've done some digging and straight protein doesnt seem to blunt release and may even enhance and/or create a pulse. So I'm even considering protein shakes every 4 hours or so with one large moderate carb meal at dinner (maybe low/no carb if I dont get a workout in that day).
 
peepingyoda said:
Is anyone doing a special diet to optimize GH along with the peptide? I've seen IF mentioned several times, but I've done some digging and straight protein doesnt seem to blunt release and may even enhance and/or create a pulse. So I'm even considering protein shakes every 4 hours or so with one large moderate carb meal at dinner (maybe low/no carb if I dont get a workout in that day).
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I do IF year round whether on a cut, bulk, or carb cycle recomp.. Should be starting MK in the next 45-60 days and will be leaving plenty of feedback
 
GNO said:
My understanding was MK-677 does not increase prolactin or cortisol ...
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I know but I'm suspect because some say during the start it might increase prolactin slightly and the lethargy might be from an increase in cortisol I'm thinking but I'm not sure just wondering why it would cause it
 
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