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The Official OL UK Ghar1ne Q&A

chedapalooza said:
Yep. After playing football thru college and literally never taking more than 7-10 days off a couple times a year since age 14, my joints are fried! This is the first reason I ever looked into MK.... Laxogenin did seem to help slightly as well tbh and that can be found in OL str3ngth
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Baseball for 12 years and working out the past 4 or so has killed my joints. I have horrible elbows and shoulders, nerve problems in both hands because of my elbows, bad knees, and every step I take my ankles crack and pop like crazy. Lol
 
One study showed a decrease in insulin sensitivity, and positive effects as to bone mineral density, though Im not sure of the quantitative measures of these offhand.

Depending on how long you intend to take mk for water retention will dissipate, though given one theory as to the retention mechanism Im not sure how successful supplementing with an ai would be.
 
hsk said:
A few questions about Ghar1ne:

I am interested in using Ghar1ne to help heal a recent shoulder and trap injury. Do you think it can be used for this purpose?

Would running an AI such as OL Elim1nate, SNS Inhibit E, or PES Erase Pro be effective at minimizing the possible water retention/bloat?

I don't want to take anything supressive but would still like to use something that would maximize or enhance my own natural testosterone production while using Ghar1ne. Would running it with a natty herbal testosterone enhancers such as AnaBeta Elite, Bulbine, Icariin, LJ100, and or Fadogia have any additional benefit?

I am pre-diabetic and have decreased insulin sensitivity. I use GDA's and bulk supps like Na-Rala, Berberine, Gymnema, and Cinnamon to manage my insulin sensitivity. Will Ghar1ne affect insulin sensitivity and if so to what extent?
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Ghar1ne can absolutely help with such an injury, growth hormone is infamous for it's healing properties. Running a cycle of Ghar1ne, Elim1nate, and LJ100 would help with healing, keep bloat and water retention to a minimum, and keep natural testosterone levels high without being suppressive. However, you could stack any of the other testosterone boosters you mentioned as well without ill effect. Now, for the important question, insulin sensitivity. It sounds like you take quite a few supplements to help with insulin sensitivity, and being pre-diabetic I think that's a great idea. Excess growth hormone CAN cause insulin sensitivity issues in some people, however it's typically associated with high dosage exogenous Growth Hormone usage, as in injecting actual Growth Hormone in large dosages. Ghar1ne works by causing your body to release larger amounts of growth hormone, but not to the extent of injecting Growth Hormone. So one cannot really compare HGH to Ghar1ne accurately in terms of insulin resistance.

chedapalooza said:
I'll let someone else chime in on the insulin aspect.

Can you elaborate on the injury?

Elim1nate will definitely help keep any water retention down, though there shouldn't be too too much.. You can adjust the dose of 1-3 caps daily too so it wouldn't hurt to have on hand by any means. That plus LJ100 is a solid option for natty test levels/free test and cortisol management.
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I agree with both recommendations here, solid choices.

hsk said:
Thank you for the response. I have a large knot and cyst on my right lower middle trapezius muscle, and this injury causd my right shoulder/rotator cuff to become inflamed leading to bursitis/tendonitis of the right shoulder. The impingement of the shoulder has gradually improved but the knot and cyst on my trap is taking a long time to heal. Its been 3 weeks. I just want to speed the healing up and hopefully bring the entire right shoulder back to 100%.
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Ouch, man. I've had quite a few injuries in my time since starting training, and I know the feeling. Well if you decide that Ghar1ne isn't for you due to concerns over insulin resistance, and don't mind mildly suppressive compounds, Ostar1ne is quite well known for being beneficial to joints, tendons, injuries. There are many logs out there with people talking about how it's helped them recover quickly, and take away discomfort or pain from old injuries. Personally, if I had an injury at this point in time, and I'm not concerned about suppressive substances, I'd stack Ghar1ne and Ostar1ne for a one-two combination to attack it.
 
Hastur said:
Ghar1ne can absolutely help with such an injury, growth hormone is infamous for it's healing properties. Running a cycle of Ghar1ne, Elim1nate, and LJ100 would help with healing, keep bloat and water retention to a minimum, and keep natural testosterone levels high without being suppressive. However, you could stack any of the other testosterone boosters you mentioned as well without ill effect. Now, for the important question, insulin sensitivity. It sounds like you take quite a few supplements to help with insulin sensitivity, and being pre-diabetic I think that's a great idea. Excess growth hormone CAN cause insulin sensitivity issues in some people, however it's typically associated with high dosage exogenous Growth Hormone usage, as in injecting actual Growth Hormone in large dosages. Ghar1ne works by causing your body to release larger amounts of growth hormone, but not to the extent of injecting Growth Hormone. So one cannot really compare HGH to Ghar1ne accurately in terms of insulin resistance.



I agree with both recommendations here, solid choices.



Ouch, man. I've had quite a few injuries in my time since starting training, and I know the feeling. Well if you decide that Ghar1ne isn't for you due to concerns over insulin resistance, and don't mind mildly suppressive compounds, Ostar1ne is quite well known for being beneficial to joints, tendons, injuries. There are many logs out there with people talking about how it's helped them recover quickly, and take away discomfort or pain from old injuries. Personally, if I had an injury at this point in time, and I'm not concerned about suppressive substances, I'd stack Ghar1ne and Ostar1ne for a one-two combination to attack it.
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I'd rather give Ghar1ne a shot first before trying anything suppressive. Most likely I will run with LJ100 and SNS Inhibit E or Bulbine first. I will pick up some Eliminate down the road to test as well but I I got really dry achy joints from the original Erase so I am expecting the same issue with Eliminate. And that was while using 10g of fish oil daily.
 
hsk said:
I'd rather give Ghar1ne a shot first before trying anything suppressive. Most likely I will run with LJ100 and SNS Inhibit E or Bulbine first. I will pick up some Eliminate down the road to test as well but I I got really dry achy joints from the original Erase so I am expecting the same issue with Eliminate. And that was while using 10g of fish oil daily.
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Sounds like a good plan to me! Best of luck with your Ghar1ne/LJ100/Inhibit E stack! I think you'll see good results, and if you have any more questions regarding dosing or things of that nature, by all means ask!
 
hsk said:
I'd rather give Ghar1ne a shot first before trying anything suppressive. Most likely I will run with LJ100 and SNS Inhibit E or Bulbine first. I will pick up some Eliminate down the road to test as well but I I got really dry achy joints from the original Erase so I am expecting the same issue with Eliminate. And that was while using 10g of fish oil daily.
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Hey if you worried about becoming insulin resistant while on GHarn1ne you may want to look into gw-1516(OL UK has it under the name Cardar1ne). It is by far the strongest GDA. I was marked as pre- prediebetic(so i was at the very top end of normal). Now while taking it i consistently get low blood sugar sides. I make sure that i have something with carbs around me just in case.
 
rtmilburn said:
Hey if you worried about becoming insulin resistant while on GHarn1ne you may want to look into gw-1516(OL UK has it under the name Cardar1ne). It is by far the strongest GDA. I was marked as pre- prediebetic(so i was at the very top end of normal). Now while taking it i consistently get low blood sugar sides. I make sure that i have something with carbs around me just in case.
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That's a good call, I know people who dose too highly on Cardar1ne or go too low carb on it have expressed hypoglycemic type side effects. It might be a good combination with Ghar1ne for such purposes, and hey it comes with the added benefit of increased endurance, fat loss, etc... It's a solid compound in its own right.

chedapalooza said:
Why would MK make one insulin resistant
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It COULD make one insulin resistant, much like excess exogenous growth hormone could, but it depends on a lot of confounding factors. In healthy, exercising individuals I would say the risk is extremely low judging by the studies done on MK-677, he likely isn't a sedentary elderly man with a poor diet, so it's not something I would worry about personally. And it's something that you could measure, if he notices high blood sugar during Ghar1ne he could lower the dosage or discontinue it with no issue.

NewAgeMayan said:
Could be due to the increase in IGF-1 levels; IGF-1 binds to insulin receptors.
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Agreed, this is one of the possible pathways to insulin resistance. But all we can throw out are hypotheticals, I'd say it's something that depends on the individual and too many variables to account for. So far I haven't seen any logs pointing to this being an issue, so I would simply try it if one wishes to, monitor themselves, and discontinue if side effects being to surface. The exact same protocol I would recommend with any supplement though, honestly.
 
rtmilburn said:
Hey if you worried about becoming insulin resistant while on GHarn1ne you may want to look into gw-1516(OL UK has it under the name Cardar1ne). It is by far the strongest GDA. I was marked as pre- prediebetic(so i was at the very top end of normal). Now while taking it i consistently get low blood sugar sides. I make sure that i have something with carbs around me just in case.
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I am considering this, and also I am thinking of trying it just for the fat burning effects. I am still undecided though as I want to see some logs and experiences first. Btw, what dosage did you run it at and how soon did you notice the low blood sugar effects?
 
Btw, are there any discount codes this month for OL UK products on nutriverse or any other retailer for that matter? I am looking to pick up 4 bottles of Ghar1ne to test out. I missed the intro sale last month dues to a busy work schedule and an injury so I am just getting back into forums. I can't believe I missed out and such a good insider deal.
 
Nutriverse always has a 5% code, and make sure if u shop there to try the bulk buy option for 4 single bottles, or if that dosnt apply get 2 of the two stack combos...hope that makes sense
 
I believe bulk is not available on all products and this is one of those products. Tried to do bulk for forskolin 95+ also but it didn't work.
 
NoAddedHmones said:
Lol sounds pretty much bang on when you would come down from a stim bomb like that. Perhaps try dosing a lesser amount more frequently.
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Normally I would agree but have always dosed Stimul8 at a full scoop and proceeded with my 8hr work day (1400-2230). Never crashed until started throwing mk in the mix
 
BigRed1974 said:
Would be waiting to dose it at night work? Just asking, most GH products recommend dosing before bed
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Most users follow that dosing protocol to combat hunger.
 
hsk said:
I am considering this, and also I am thinking of trying it just for the fat burning effects. I am still undecided though as I want to see some logs and experiences first. Btw, what dosage did you run it at and how soon did you notice the low blood sugar effects?
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Im taking 14mgs and notice that starting day 3.
 
I've been using 200 mcg. huperzine along with my 20 mg. dose of Gharine pre-bed. I seem to be experiencing less lethargy. I don't know if it's connected to the huperzine use, or if the lethargy naturally subsides after a while--I've been on Gharine for 15 nights now.
 
I don't think time of dose matters too much because it increases gh pulse output over 24 hours. Right before bed helps if you don't want to deal with the hunger. I have been using MK for just over 5 weeks now. Weeks 2-3 lethargy was almost unbearable, caffeine barely helped. Week four slowly started getting better and now I feel really good, only very infrequent waves of lethargy. I did start LGD two weeks ago too so not sure if that caused any change...
 
Three full days into GHar1ne and want to know if anyone has had similar experiences. Just taking 1-10mg capsule an hour before bed, thus far haven't slept very well. First night on the stuff, couldn't sleep at all, I have higher than normal cortisol levels at night already and this worsened the effect the first night. Last night I was working out biceps and calves, while working out calves I got an incredibly tired feeling like almost overwhelming, can this be of some effect with GHar1ne? I understand GH causes lethargy but was weird how I had such good energy working out biceps like 45 minutes before calves and then it hit me like a ton of bricks. I hear it takes about a week before the deep sleep occurs, I will bump it up to 20mg come next week and introduce 200mcg of Huperzine in the mornings for further GH release. Got to say Dymethazine and Stenabol are the S***!!!!
 
hsk said:
I believe bulk is not available on all products and this is one of those products. Tried to do bulk for forskolin 95+ also but it didn't work.
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Email max at nutriverse, I'm sure he will do some kind of deal for you
 
For anyone interested, it looks like huperzine has a variable half life--as many drugs do--between 288 Min (4.75 Hrs.), and claims of over 24 Hrs. However, to be honest, all the actual pharmacokenetic studies I saw showed a half life well under 24 Hrs. That's not to say there aren't any such studies, just that I didn't run across them.

I read more than one reference to huperzine suppressing acetylcholinesterase "for 6 Hrs."

Several references to a single study which found ECG abnormalities: arrhythmias

UPDATE:

1) I've found the huperzine to increase the effectiveness of the MK. Hands are much more tingly when 200 mcg. of huperzine is added to my pre-bed Gharine dose.

2) the Gharine has caused me to hold enough water for my blood pressure to trend back up. Be aware, you my need to cut back on sodium and, or, add more potassium to your diet. I'm doing both, as well as using celery seed extract.
 
koi1214 said:
Huperzine-A is an acetylcholinesterase inhibitor, which deactivates the enzyme responsible for breaking down acetylcholine in the synapse, increasing endogenous acetylcholine levels.Theoretically, an increase in acetylcholine should lower somatostatin allowing for an increase in growth hormone levels.Huperzine A When the body recognizes elevated HGH levels it releases somatostatin to bind to the HGH so it can't fit into it's receptors. Huperzine A binds to somatostatin so the somatostatin can't render HGH useless. It allows for higher levels of HGH in your system.

Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
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muay thai
 
crowbar46 said:
I've been using 200 mcg. huperzine along with my 20 mg. dose of Gharine pre-bed. I seem to be experiencing less lethargy. I don't know if it's connected to the huperzine use, or if the lethargy naturally subsides after a while--I've been on Gharine for 15 nights now.
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crowbar46 said:
For anyone interested, it looks like huperzine has a variable half life--as many drugs do--between 288 Min (4.75 Hrs.), and claims of over 24 Hrs. However, to be honest, all the actual pharmacokenetic studies I saw showed a half life well under 24 Hrs. That's not to say there aren't any such studies, just that I didn't run across them.

I read more than one reference to huperzine suppressing acetylcholinesterase "for 6 Hrs."

Several references to a single study which found ECG abnormalities: arrhythmias

UPDATE:

1) I've found the huperzine to increase the effectiveness of the MK. Hands are much more tingly when 200 mcg. of huperzine is added to my pre-bed Gharine dose.

2) the Gharine has caused me to hold enough water for my blood pressure to trend back up. Be aware, you my need to cut back on sodium and, or, add more potassium to your diet. I'm doing both, as well as using celery seed extract.
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I have to tip my hat to you, crowbar. Your posts have been excellent, and have actually propelled my research into MK-677 further. The anecdotal reports are invaluable! And excellent job on being self-aware enough to notice the blood pressure elevation and take the proper steps to sort it out.

hardtoget said:
Can you actually sleep well with taking huperzine that late
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Some people can, yes. Like with all things, it's highly individual.

crowbar46 said:
Yes, for me it doesn't seem to interfere with sleep. In fact, 200 mcg. huperzine taken 30 Min. prior to bed increases REM sleep by 20-30%.
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I've read that before as well, still have yet to try it, but it was a popular protocol on several life extension and nootropic boards back in the day.

mechka_grizli said:
Can we get away with only dosing Hup a with thr gharine dose or does it have to be 3 time a day? yates84
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Yes, you can. It will still amplify the GH pulses, just to a lesser degree. But it is synergistic none-the-less.

muay thai said:
purpose of hup supplementation while on MK677 is? thanks in advance for any of your time.
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Huperzine A is a reversible acetylcholinesterase inhibitor and somatostatin inhibitor, which means it allows the pituitary to secrete more Growth Hormone than it would with MK-677 alone.

And EGCG has synergy with Huperzine A by enhancing it's inhibitory effect on acetylcholinesterase:
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So stacking MK-677 with Huperzine A and EGCG is really an effective way to go about increasing Growth Hormone.
 
Im getting bad insomnia right now with 20mg gharine. Just not able to sleep and feel like my cortisol is high and need to eat. Im hearing word taking it with melatonin really helps. Im taking it pre bed can this be the issue
 
mechka_grizli said:
Can we get away with only dosing Hup a with thr gharine dose or does it have to be 3 time a day?
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Huperzine-A has a 24 hour 1/2 life & you can dose the 200mcg at 1 time

hardtoget said:
Im getting bad insomnia right now with 20mg gharine. Just not able to sleep and feel like my cortisol is high and need to eat. Im hearing word taking it with melatonin really helps. Im taking it pre bed can this be the issue
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Have you thought about dosing the gharine & huperzine in the morning instead of before bed?
 
hardtoget said:
Im getting bad insomnia right now with 20mg gharine. Just not able to sleep and feel like my cortisol is high and need to eat. Im hearing word taking it with melatonin really helps. Im taking it pre bed can this be the issue
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As mentioned I would switch up dosing to the morning or afternoon. Only downside is it might make you drowsy during the day. But I'd give it a shot.
 
I am in my 2nd week of PCT and as soon as I lower my clomid I am going to start my Gharine log for everyone to follow.This will be my 3rd run with MK677.I am also going to run huperzine and green tea extract with it and dosing all in the AM.

What I noticed was

Sleep is really good dreams have been really colorfull and vivid.
Looking full and staying pumped. Sleep continues to be solid.
Strength gains remain the same, however rest between sets seems to be shortend.
My hair grew thick and fast. My nails are growing fast as well. Trimming nails and hair a lot now. Also my skin was feeling soft and may have to do with water retention
 
If you had to choose one, would it be Ghar1ne or Cardar1ne?

During PCT of epi/halo cycle. Looking at two bottles of one of these.
 
koi1214 said:
I am in my 2nd week of PCT and as soon as I lower my clomid I am going to start my Gharine log for everyone to follow.This will be my 3rd run with MK677.I am also going to run huperzine and green tea extract with it and dosing all in the AM.

What I noticed was

Sleep is really good dreams have been really colorfull and vivid.
Looking full and staying pumped. Sleep continues to be solid.
Strength gains remain the same, however rest between sets seems to be shortend.
My hair grew thick and fast. My nails are growing fast as well. Trimming nails and hair a lot now. Also my skin was feeling soft and may have to do with water retention
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Good deal man. I'll be following that log for sure.

Two questions I always like to get feedback on with MK 677 is how fast did you drop water retention once off, and once this happened did you notice a large difference in vascularity?
 
Otheridstaken said:
If you had to choose one, would it be Ghar1ne or Cardar1ne?

During PCT of epi/halo cycle. Looking at two bottles of one of these.
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Ghar1ne for me


kboxer7 said:
Good deal man. I'll be following that log for sure.

Two questions I always like to get feedback on with MK 677 is how fast did you drop water retention once off, and once this happened did you notice a large difference in vascularity?
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The bloating for me subsided after week 3 and that is when vascularity was very noticeable. You got to remember the longer you run mk677 the better it gets.
Otheridstaken
IMO 6 months would be an excllent run and you would be able to see if results diminish on a long run.I plan on running Gharine for minimum 3 months.My previous mk runs were 26 and 40 days.
 
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