Oh heck yes. I noticed a drop off when I stopped Bio-Gro, but damn, CM is on a totally different level. Just finished the last day of my 10 days straight lifting cycle. Actually got stronger as total volume went up on heavy push pull day today. So that is two 10 days lifting cycles I've had on CM. First cycle was at the beginning of using the first bottle of CM. This second cycle came at the tail end of the second bottle.
It's a total waste of product if you just use it to avoid DOMS/fatigue from workouts. IMHO you should take advantage of it and hit everything harder and with more frequency. Adjust your training to take advantage of the headroom you are now afforded by the CM. Or if you are on a serious cut (see saucemonkey's experience thus far). If you stick with whatever training you have been doing without adjusting to account for CM, that's just a complete and total waste of money and time. Most folks train with a certain program taking into account their recovery rate. If your recovery rate improves notably, obviously you're leaving a lot of gains on the floor there because CM improves your recovery by quite a bit.