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How many use agmatine for health benefits?

NattyForLife said:
Is vitamin C proven to be beneficial preworkout?
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The opposite, actually. Typically, anti-oxidants should be avoided ~ 4 hours or so peri-workout when the anti-oxidant has COX-2 inhibitory properties.

Utilizing Vitamin C with Potassium Nitrate is thought to reduce the formation of nitrosamines.
 
aaronuconn said:
The opposite, actually. Typically, anti-oxidants should be avoided ~ 4 hours or so peri-workout when the anti-oxidant has COX-2 inhibitory properties.

Utilizing Vitamin C with Potassium Nitrate is thought to reduce the formation of nitrosamines.
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Actually;

1500mg vitamin c, 120mg coq10 and 400mg vit e pre workout has been shown to enhance ucp3 expression

Just saying

I've posted a link before
 
EBF Inc said:
Actually;

1500mg vitamin c, 120mg coq10 and 400mg vit e pre workout has been shown to enhance ucp3 expression

Just saying

I've posted a link before
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Personally, I'll still avoid anti-oxidants around my workouts. Maybe it will help me expend a few more calories via thermogenesis, but how much is this helping me from a performance standpoint? Doesn't muscle-contraction and exercise in general increases UCP3?
 
aaronuconn said:
Personally, I'll still avoid anti-oxidants around my workouts. Maybe it will help me expend a few more calories via thermogenesis, but how much is this helping me from a performance standpoint? Doesn't muscle-contraction and exercise in general increases UCP3?
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Yes it does. Here's the link

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aaronuconn said:
Yes, I saw that. However, isn't the COX-2 pathway, from a recovery/muscle-building standpoint, one we would wish not to inhibit around our workouts?
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Well ,

Muscle building yes as it will affect protein synthesis, but, cannot do both.

I wonder the outcome with Intra carbs
 
EBF Inc said:
Actually;

1500mg vitamin c, 120mg coq10 and 400mg vit e pre workout has been shown to enhance ucp3 expression

Just saying

I've posted a link before
Click to expand...

And 1000mg vitamin C has been shown to worsen hypertrophy and recovery, which are real human endpoints. Biochemical pathways interweave to a point that only endpoints are of concern in this case. Similarly, that much vitamin E is associated with increased mortality. In this case an association, but I'd rather take none with that knowledge in mind
 
Dirty Dan said:
So with that understanding, it has always been said to buy fish oils with vitamin E because I believe it helps with the absorption rate, would that essentially mean that too much fish oil with vitamin E can potential be deadly? Or at least those who take way to much fish oil can run that risk?
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Yes, and another cause for concern is Selenium.
 
Synapsin said:
Yes, and another cause for concern is Selenium.
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What is the specific concern with selenium? I googled and just saw a few articles about fish oil not having selenium, and whole fish being better because it has more selenium. Does some fish oil actually have too much of it? Or is it a concern because it isn't in there and it should be?
 
tyrub42 said:
What is the specific concern with selenium? I googled and just saw a few articles about fish oil not having selenium, and whole fish being better because it has more selenium. Does some fish oil actually have too much of it? Or is it a concern because it isn't in there and it should be?
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I meant that its a common thing in products such as multivitamins that individuals should be wary about consuming.
 
New Zealand ftw Brazil




Brazil nuts: an effective way to improve selenium status.

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Abstract

BACKGROUND:

Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans.
OBJECTIVE:

We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine.
DESIGN:

A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to provide approximately 100 mug Se, 100 mug Se as selenomethionine, or placebo daily for 12 wk. Actual intake from nuts averaged 53 mug Se/d (possible range: 20-84 mug Se). Plasma selenium and plasma and whole blood glutathione peroxidase (GPx) activities were measured at baseline and at 2, 4, 8, and 12 wk, and effects of treatments were compared.
RESULTS:

Plasma selenium increased by 64.2%, 61.0%, and 7.6%; plasma GPx by 8.3%, 3.4%, and -1.2%; and whole blood GPx by 13.2%, 5.3%, and 1.9% in the Brazil nut, selenomethionine, and placebo groups, respectively. Change over time at 12 wk in plasma selenium (P < 0.0001 for both groups) and plasma GPx activity in the Brazil nut (P < 0.001) and selenomethionine (P = 0.014) groups differed significantly from the placebo group but not from each other. The change in whole blood GPx activity was greater in the Brazil nut group than in the placebo (P = 0.002) and selenomethionine (P = 0.032) groups.
CONCLUSION:

Consumption of 2 Brazil nuts daily is as effective for increasing selenium status and enhancing GPx activity as 100 mug Se as selenomethionine. Inclusion of this high-selenium food in the diet could avoid the need for fortification or supplements to improve the selenium status of New Zealanders.

Invalid Link Removed 2011;63(3):367-75. doi: 10.1080/01635581.2011.535967.
Association of selenium status and blood glutathione concentrations in blacks and whites.

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Abstract

Selenium deficiency has been linked with increased cancer risk and, in some studies, selenium supplementation was protective against certain cancers. Previous studies have suggested that selenium chemoprevention may involve reduced oxidative stress through enhanced glutathione (GSH). Our objectives were to examine the relationships between selenium and GSH in the blood and the modifying effects of race and sex in free-living adults and individuals supplemented with selenium. Plasma selenium concentrations and free and bound GSH concentrations and γ-glutamyl cysteine ligase (GCL) activity in the blood were measured in 336 healthy adults (161 Blacks, 175 Whites). Plasma selenium and blood GSH were also measured in 36 healthy men from our previously conducted placebo-controlled trial of selenium-enriched yeast (247 μg/day for 9 mo). In free-living adults, selenium concentrations were associated with increased blood GSH concentration and GCL activity (P < 0.05). Further, selenium was significantly higher in Whites than in Blacks (P < 0.01). After 9 mo of supplementation, plasma selenium increased 114% in Whites and 50% in Blacks (P < 0.05), and blood GSH increased 35% in Whites (P < 0.05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor.


PMID: 21462082 [PubMed - indexed for MEDLINE] PMCID: PMC3087599 Invalid Link Removed


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Performing your original search, ncbi selenium, in PubMed will retrieve 2 records.
BJU Int. 2003 May;91(7):608-12.
Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial.
Duffield-Lillico AJ1, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, Marshall JR, Clark LC; Nutritional Prevention of Cancer Study Group.
Author information
Abstract
OBJECTIVE:
To present the results (to January 1996, the end of blinded treatment) of the Nutritional Prevention of Cancer (NPC) Trial, a randomized trial of selenium (200 micro g daily) designed to test the hypothesis that selenium supplementation (SS) could reduce the risk of recurrent nonmelanoma skin cancer among 1312 residents of the Eastern USA.
MATERIALS AND METHODS:
Original secondary analyses of the NPC to 1993 showed striking inverse associations between SS and prostate cancer incidence. A subsequent report revealed that this effect was accentuated among men with the lowest baseline plasma selenium concentrations. The effects of treatment overall and within subgroups of baseline prostate-specific antigen (PSA) and plasma selenium concentrations were examined using incidence rate ratios and Cox proportional hazards models.
RESULTS:
SS continued to significantly reduce the overall incidence (relative risk and 95% confidence interval) of prostate cancer (0.51, 0.29-0.87). The protective effect of SS appeared to be confined to those with a baseline PSA level of <or= 4 ng/mL (0.35, 0.13-0.87), although the interaction of baseline PSA and treatment was not statistically significant. Participants with baseline plasma selenium concentrations only in the lowest two tertiles (< 123.2 ng/mL) had significant reductions in prostate cancer incidence. A significant interaction between baseline plasma selenium and treatment was detected.
CONCLUSION:
To the end of the blinded treatment the NPC trial continued to show a significant protective effect of SS on the overall incidence of prostate cancer, although the effect was restricted to those with lower baseline PSA and plasma selenium concentrations.
 
Meh, the vitamin E comments remind me of the news every night. This is good for you, no wait it's bad, wait, it's good again....
 
Invalid Link Removed i ought to slap ur face for that
 
Interesting thread to skip through. Will definitely have to spend some more time in here doing research. Could definitely learn a thing or two! ;)

That's why I love this place so much. Always learning something new :)
 
For anyone using agmatine to help with spinal pain (due to a bulging or herniated disc), what dose are you using and how long before you noticed it helping. I've been taking 1 g each morning for the last couple weeks and havsn't noticed anything with regard to back pain. I wasn't sure if my dose was too low for that purpose or if it takes a few weeks or months before it starts to help.
 
jarrellt67 said:
For anyone using agmatine to help with spinal pain (due to a bulging or herniated disc), what dose are you using and how long before you noticed it helping. I've been taking 1 g each morning for the last couple weeks and havsn't noticed anything with regard to back pain. I wasn't sure if my dose was too low for that purpose or if it takes a few weeks or months before it starts to help.
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The study using agmatine for disc pain used higher doses, I would suggest trying this at 3 grams and see if there is any noticeable difference within 2 weeks.
 
Synapsin said:
The study using agmatine for disc pain used higher doses, I would suggest trying this at 3 grams and see if there is any noticeable difference within 2 weeks.
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Thank you. I'll give that a try and see how things go. I tried 1 g before bed for the first time last night and it was great. I don't recall the last time I slept so well.
 
Does agamatine work as a gda?
 
T-Bone said:
Just pour some orange juice into the entire tub of Agmatine, add about 10 caps of your favorite nitrate product, shake well and consume!. Happy lifting!
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T-BONE YA!!!! U DA MAN BONEZ DOG! Im gonna try that now
 
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