Nitrates and ephedrine?

mcc23

Active member
Would stacking ephedrine with nitrates, negate the effectiveness of the nitrates ( in terms of vaso-dilation)?
 
was actually thinking this same thing, using Condense as my source for caffeine in ECA stack
 
Didn't you say you were way ahead of me on this in the other thread? I'm confused :(.

Nitrates are NO donors, and ephedrine may actually improve skeletal muscle vasodilation while exercising since it is a beta-agonist chiefly. Even if ephedrine was a significant vasoconstrictor, NO donation from nitrates occurs at higher rates in hypoxic regions, so nitrates would offset any local vasoconstriction.
 
mr.cooper69 said:
Didn't you say you were way ahead of me on this in the other thread? I'm confused :(.

Nitrates are NO donors, and ephedrine may actually improve skeletal muscle vasodilation while exercising since it is a beta-agonist chiefly. Even if ephedrine was a significant vasoconstrictor, NO donation from nitrates occurs at higher rates in hypoxic regions, so nitrates would offset any local vasoconstriction.
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Yea I guess I did say that.. That was my mistake..
The answer you just gave just now is perfecto.. Thanks Coop
 
I know this is an old thread so if there's so response, it's all good. But isn't it characteristic of epinephrine to cause vaso-constriction?
 
mr.cooper69 said:
Epinephrine is a vasodilator, so no...
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Okay, I had it in my notes that it increases renin secretion from the kidney, therefore increasing Angiotensin I (vaso-constrictor). And II would produce aldosterone to reabsorb sodium & water and in turn raising BP... You've mentioned previously that the body responds to exercise with vaso-dilation anyways, and that combined with the nitrates, would still yield optimal levels of blood flow..


Edit: Perhaps it just diverts blood flow from non-essential organs to skeletal muscle..Therefore its both constriction and dilation.
 
mcc23 said:
Okay, I had it in my notes that it increases renin secretion from the kidney, therefore increasing Angiotensin I (vaso-constrictor). And II would produce aldosterone to reabsorb sodium & water and in turn raising BP... You've mentioned previously that the body responds to exercise with vaso-dilation anyways, and that combined with the nitrates, would still yield optimal levels of blood flow..


Edit: Perhaps it just diverts blood flow from non-essential organs to skeletal muscle..Therefore its both constriction and dilation.
Click to expand...

First, it is angiotensin II, not I, that is the strongest vasoconstrictor in the body. Second, yes epinephrine has that effect, but in skeletal muscle it is a vasodilator. This discussion is not about gi viscera and other regions. Exercise is a vasodilator BECAUSE of epinephrine secretion. Epinephrine increases preload as well, but nitrates reduce both preload and afterload.
 
good discussion here
 
mr.cooper69 said:
First, it is angiotensin II, not I, that is the strongest vasoconstrictor in the body. Second, yes epinephrine has that effect, but in skeletal muscle it is a vasodilator. This discussion is not about gi viscera and other regions. Exercise is a vasodilator BECAUSE of epinephrine secretion. Epinephrine increases preload as well, but nitrates reduce both preload and afterload.
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Yes, II not I, that's my mistake. So the aldosterone secretion, Angiotensin II and thus vasoconstriction is isolated to non-skeletal muscle tissue following epinepherine secretion..
 
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