TexasLifter89
Well-known member
Im curious as to the reasoning behind adding SAM-e to the lean tissue generating matrix?
Sam-e is not something I would normally see in most ergogenic aids....actually this is the first time I actually notice it in one. So Im quite curious....can anyone shed a little light?
here you go bud, a response from the man himself! This will be in the tech write-up and will be talked about even more indepth shortly.
The SAM-e / methylation pathway is responsible for a variety of different biochemical reactions in the body. The pathway is also responsible for the formation of dopamine and norepinepherine plus the formation of H²S, all of which allow for greater NMDA receptor activity, greater NO activity and ultimately greater initiation of steroidogenesis.
SAM-e is a combination of ATP and methionine, and has some pronounced effects in several different areas relevant to increased product effectiveness:
· SAM-e also exerts strong effects on increasing Hydrogen Sulfide (H²S) Production, which increases NMDA receptor activity and has been shown to be synergistic with Nitric Oxide (NO) in terms of vasodilation. A great deal of the most recent research on erectile dysfunction drugs is focusing on this pathway.
· The compound has strong mood-enhancing effects via increasing serotonin and dopamine in the brain
SAM-e has been shown to have some very positive effects on joint health and regeneration
Trimethylglycine (also known as Betaine), ATP, and SAM-e directly function within the SAM-e pathway, albeit in different segments and capacities; each of which add to product effectiveness. TMG has been shown have positive effects on muscular strength, as well as having the ability to form sarcosine (an NMDA receptor co-agonist) and act as a methyl donor to fuel SAM-e formation. TMG acts in the following fashion as a methyl donor and in the SAM-e pathway (50-54,64-68,118):
TMG donates a methyl group during the formation of SAM-e, and becomes DMG (N-N-dimethylglycine).
· The donated methyl group can then form SAM-e, or be used for the production of neurotransmitters, the production of DNA, or the metabolism of fats
· The remaining DMG is then converted readily by the liver to the NR-1 agonist N-Methyl Glycine via glycine N-methyltransferase