Sea Kelp (Ascophyllum nodosum) is a dietary source of bio-available iodine. An additional benefit of Ascophyllum nodosum is its ability to increase glutathione peroxidase activity, an important antioxidant. Human thyrocytes synthesize and secrete extracellular glutathione peroxidase, which translocates into the intracellular space and prevents peroxidative damage of thyrocytes from diffusion of extracellular H202 during stimulation of thyroid-hormone synthesis.
Guggulsterone (Commiphora mukul) has shown an ability to support thyroid function, especially through increased conversion of T4 to T3 in the liver, the principle site of T3 generation.* The effects of guggulsterone may be due to its ability to activate multiple receptors on the nuclear membrane, including thyroid receptors (alpha & beta), retinoic acid receptors, (which pairs with thyroid receptors), and the vitamin D receptor, which also plays a role in thyroid function. Guggulsterone, a component of Commiphora mukul supports healthy cholesterol levels and affects LDL oxidation, an important feature since the oxidation of LDL may have an effect on cardiovascular health, a critical concern for those with sub-optimal thyroid function
Rosemary (Rosmarinus officinalis) provides carnosic acid, a polyphenolic diterpene that at low concentrations increases the expression of vitamin D and retinoid receptors. Retinoid-X-receptors (RXR) undergo heterodimerization with thyroid hormone receptors (TR). The RXR/TR heterodimers have been proposed to be the principle mediators of target gene regulation by T3 hormone. The ability of carnosic acid to also affect retinoic acid receptors may increase its importance as a TR agonist. Rosemary also contributes rosmarinic acid, which has significant antioxidant and anxiolytic properties. An additional constituent, carnosol, may support healthy metalloproteinase-9 activity and healthy NF-kappaB activity, which may be responsible for its support of normal immune system function.
Sage (Salvia officinalis) has long been recognized as a very rich source of the antioxidant carnosic acid which, as noted above, can increase T3 activity through improved RXR/TR heterodimerization. Important features of Salvia officinalis are also its memory supportive properties, including memory retention, more efficient memory retrieval and improved mood and cognitive task performance.
Ashwagandha (Withania somnifera) demonstrated an ability to directly act on the thyroid to raise serum levels of thyroid hormones in animal studies during the late 1990s. Though inconclusive, a case review in late 2005 indicated that Ashwagandha may have the ability to raise serum levels of thyroid hormones in humans. Ashwagandha has also been attributed as having a number of adaptogenic properties including neuroprotective properties.
Coleus (Coleus forskohlii) contains forskolin, a potent activator of the cyclic AMP-generating system in many tissues including the thyroid, and increases T3 & T4 secretion from thyrocytes in a fashion similar to TSH, though independent from TSH. Forskolin is specifically able to mimic the effect of TSH in regard to iodide uptake, organification of iodine, thyroglobulin (TG) production, and promote secretion of T3 & T4, through an increase in the expression of sodium/iodide symporter (NIS) proteins.
Brahmi (Bacopa monniera) exhibited thyroid supportive properties through an increase of T4 serum concentrations in animal studies. Brahmi may have more direct thyroid supportive properties versus an effect on hepatic conversion to T3. Brahmi may also address concerns about neurocognitive function associated with sub-optimal thyroid function. In human studies, Brahmi has been shown to improve many of the higher order cognitive processes, including the ability to significantly improve speed of visual information processing, learning rate, memory consolidation, improve memory retention, enhance retention of new information, and decrease the rate of forgetting of newly acquired information.
Hops (Humulus lupulus) can increase the uptake of iodide into the thyroid gland, a fundamental step in thyroid hormone synthesis, through interactions with sodium-iodide-symporter (NIS) proteins. This observation is quite the opposite of many other plant-derived phenolic secondary metabolites such as isoflavonoids, which can potentially inhibit iodide uptake. Xanthohumol, a chalcone found in Humulus lupulus, plays a critical role in supporting normal blood lipid and glucose metabolism.
This last is in USPlabs OxyElite Pro:
Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice.
Panda S, Kar A.
School of Life Sciences, Devi Ahilya University, Vigyan Bhavan, Indore, India.
[email protected]
Abstract
The effects of daily administration of Withania somnifera root extract (1.4 g/kg body wt.) and Bauhinia purpurea bark extract (2.5 mg/kg body wt.) for 20 days on thyroid function in female mice were investigated. While serum triiodothyronine (T3) and thyroxine (T4) concentrations were increased significantly by Bauhinia, Withania could enhance only serum T4 concentration. Both the plant extracts showed an increase in hepatic glucose-6-phosphatase (G-6-Pase) activity and antiperoxidative effects as indicated either by a decrease in hepatic lipid peroxidation (LPO) and/or by an increase in the activity of antioxidant enzyme(s). It appears that these plant extracts are capable of stimulating thyroid function in female mice.
Bauhiniastatins 1-4 from Bauhinia purpurea