I need access to the one test that you viewed and any other info specific. If you have something scholarly that is.
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Abstract
Non-steroidal and tissue-selective anabolic agents such as selective androgen receptor modulators (SARMs) represent a promising class of therapeutics for the treatment of various diseases such as sarcopenia or cancer cachexia. Advanced compounds of SARMs are based on an arylpropionamide-derived structure and leading drug candidates have successfully completed phase-II-clinical trials. Although none of these therapeutics have been approved, their performance-enhancing qualities and the black-market availability of these products makes them a viable target for misuse in the athletic community.
In 2008, SARMs were added to the Prohibited List established by the World Anti-Doping Agency (WADA). That SARMs are the subject of misuse even without clinical approval was proved for the first time by the detection of the drug candidate Andarine (also referred to as S-4, S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide), advertised, sold and supplied via the Internet.
The oily liquids, declared as green tea extracts and face moisturizer, were assayed using state-of-the-art analytical procedures and S-4 was found at concentrations of approximately 150 mg/mL. The authenticity of the product was demonstrated in comparison to reference material by liquid chromatography, high resolution/high accuracy (tandem) mass spectrometry using positive and negative electrospray ionization, and comparison to reference material. Moreover, an impurity resulting from poor product purification was detected, accounting for approximately 10% of S-4. This consisted of 2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-3-(4-nitro-3-trifluoromethyl-phenylamino)-propionamide.
(and people wonder why they have vision sides.)
The ease of purchasing non-approved drug candidates that could potentially increase athletic performance demonstrates the need to operate proactively in the continued fight against doping. The early inclusion of emerging drugs into routine sports drug testing procedures is a key element of preventive doping research, limiting the options for cheating athletes who aim to undermine the doping control system. Copyright © 2009 John Wiley & Sons, Ltd.
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Mario Thevis was prompted by the web discussions to go in search of websites claiming to sell S4. He came across ***Products, which recently started selling S4. For research purposes, not for human consumption, we should add here.
The bottles, Thevis writes in Drug Testing & Analysis, contain 30 ml of an oily fluid. They are in a box with words with something like 'face moisturizer and green tea extract' on the packaging. One ml of the substance contains 150 mg S4, according to Thevis. This is strange. All the products we know of contain only 50mg/ml. Looks like a friendly Chinese bulk supplier was giving discount on S4.
The product that Thevis tested was not pure. Each ml also contained 15 mg of a compound that is produced when S4 is synthesised, and which the manufacturer should have purified out of the preparation. The structural formula of the contaminant is shown here below.
For Thevis this is evidence that this S4 does not come from a legally operating company. And that S4 is used by chemical athletes. "The present report demonstrates once more that the misuse of therapeutics in early or advanced clinical trials by athletes cannot be dismissed, especially when anecdotal evidence for the misuse of S4 is frequently discussed in respective Internet-based chat rooms", Thevis concludes.
Maybe it’s just a coincidence, but *** Products has published a lab analysis on its website, which states that *** Products’ Liquid S4 does not contain contaminants.