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Pregnenolone Transdermal?

yeh..i might have been using too much isopropryl alcohol than was needed. i tried washing the app site with some glycerin aloe all natural naked soap, applied a small amount of rubbing alcohol, and than applied a layer of dmso with a thin layer of PREG sprinkled on top. i didnt suffer any real ill irritation.

SWEET FANCY MOSES THOUGH
the residue that i reported earlier, attributing it too non-absorbed PREG, in actuality ( i think) was dissolved saran wrap!!! the consistency is too rubbery and smells like burnt plastic...FYI don't apply any type of plastic covering in the future to an application site!!! it will eat through the saran wrap and partially dissolve it!!!

thesinner said:
I don't think rubbing alcohol is the culprit behind any skin irritation you may be experiencing with this stack.
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dsade said:
The localized carriers were pioneered by Avant Labs.

The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.
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Thanks for that: BA in TD now snaps into focus for me!

You must spread some Reputation around before giving it to dsade again.
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BodyWizard said:
Bump for BAC - been doing business w/ them for what, 15 years?
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I've been doing with them for about 6 years...always excellent quality, and a nice bunch of guys. He runs it with his family.

before I go into production with a new-ish ingredient, I always check them to see if they have it in small quantities for experimentation.
 
living2die said:
yeh..i might have been using too much isopropryl alcohol than was needed. i tried washing the app site with some glycerin aloe all natural naked soap, applied a small amount of rubbing alcohol, and than applied a layer of dmso with a thin layer of PREG sprinkled on top. i didnt suffer any real ill irritation.

SWEET FANCY MOSES THOUGH
the residue that i reported earlier, attributing it too non-absorbed PREG, in actuality ( i think) was dissolved saran wrap!!! the consistency is too rubbery and smells like burnt plastic...FYI don't apply any type of plastic covering in the future to an application site!!! it will eat through the saran wrap and partially dissolve it!!!
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Honestly, DMSO is insanely potent. this is what I would do -

Dissolve the Preg into Iso Alcohol. Then, in an open bowl start spooning in the DMSO gel. Keep stirring with a wooden stick as you add. While the Preg solution will thin out the DMSO gel, you will also get a good dispersion. You don't need much at all .

When you've added sufficient amount to give you the concentration preg/ml you want, simply apply the combined product on.

Seems like you are making this needlessly multistep.
 
Thanks for the advice dsade. i agree with you that the dmso that i am using at 98% purity might be simply too strong. it would be ideal to dilute it with a little bit of isopropyl alcohol. the iso isnt pure, it is 70% iso, which i think would be beneficial as it seems like i am having irritiation issues from using too strongly potent dmso and iso ingredients.

the wooden stick is also a good idea because the dmso willn't dissolve wood laden products, but it does show an affinity for dissolving plastic compounds.

respekt

dsade said:
Honestly, DMSO is insanely potent. this is what I would do -

Dissolve the Preg into Iso Alcohol. Then, in an open bowl start spooning in the DMSO gel. Keep stirring with a wooden stick as you add. While the Preg solution will thin out the DMSO gel, you will also get a good dispersion. You don't need much at all .

When you've added sufficient amount to give you the concentration preg/ml you want, simply apply the combined product on.

Seems like you are making this needlessly multistep.
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I've read that DMSO needs to be diluted to around 75% (which would be 3 parts DMSO to 1 part distilled water). Had good luck so far using it that way - it 'solvents' better & supposedly improves penetration and carrying capacity
 
bodywizard:
you must be correct, because i am using only small amounts of 98% vet grade pure DMSO, and even if i use sparse amounts, it still is quite irritating on contact. i think i might combine your method along with a lil ISO alcohol.

also, what transdermal hormone are you using? I am using preg. what is your washing, cleaning protocol prior to application. i wash myself down with axe bodywash(no i am not one of the those low rise brief guys) and then use a aloe/glycerin soap free of fragrances and dyes on the application site, all prior to applying the dmso and PREG.

peace



BodyWizard said:
I've read that DMSO needs to be diluted to around 75% (which would be 3 parts DMSO to 1 part distilled water). Had good luck so far using it that way - it 'solvents' better & supposedly improves penetration and carrying capacity
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Formestane.

Washing is straightforward. I scrub all over lightly with an unscented glycerine soap. I get most of the water off w/ a regular towel, then use a hand towel to briskly rub the application areas until they are red and stimulated - and dry.

BTW - DMSO is a penetration agent, and a solvent - great at both those - but it's not the greatest carrier; you really should be using an actual medium like Phlogel, or Penetrate. Your results are almost certain to be hit-or-miss otherwise.
 
ideally, yes i should prolly be using a better carrier. but for me, it comes down to economics: 1) i only use doses of +/- 25mg PREG in each DMSO application. Basically, I am using such a small quantity of PREG on a mg for mg basis, that I dont really need an effective carrier because there simply arent a lot of mg's that i need to be carried. 2) i am also using the DMSO gel, which i think is better able to hold the PREG together in an almost paste like vehicle that is better than just DMSO liquid in holding the PREG together.

i guess i wont really know how much absorption i am getting from the DMSO carrier until i get some blood work done, and even then, that is sketchy business because the PREG assay is worthless supposedly. better to test for pregnanediol (PROG metabolite) to surmise the effectiveness of absorption.

BodyWizard said:
Formestane.

Washing is straightforward. I scrub all over lightly with an unscented glycerine soap. I get most of the water off w/ a regular towel, then use a hand towel to briskly rub the application areas until they are red and stimulated - and dry.

BTW - DMSO is a penetration agent, and a solvent - great at both those - but it's not the greatest carrier; you really should be using an actual medium like Phlogel, or Penetrate. Your results are almost certain to be hit-or-miss otherwise.
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body wizard,
have you experienced any PROG/e2 related sides with using PREG/DMSO topical in the manner that you are using it?

Do you have any bloodwork to verify that the DMSO/PREG Topical you are using is working?

Respekt.
It is in my understanding that PREG TD/Topical has many added benefits over oral PREG in that it doesn't convert as readily into the feminizing hormones? correct?

BodyWizard said:
Formestane.

Washing is straightforward. I scrub all over lightly with an unscented glycerine soap. I get most of the water off w/ a regular towel, then use a hand towel to briskly rub the application areas until they are red and stimulated - and dry.

BTW - DMSO is a penetration agent, and a solvent - great at both those - but it's not the greatest carrier; you really should be using an actual medium like Phlogel, or Penetrate. Your results are almost certain to be hit-or-miss otherwise.
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living2die said:
body wizard,
have you experienced any PROG/e2 related sides with using PREG/DMSO topical in the manner that you are using it?
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Not using PREG, using formestane
living2die said:
Do you have any bloodwork to verify that the DMSO/PREG Topical you are using is working?
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Not using PREG, using formestane
living2die said:
It is in my understanding that PREG TD/Topical has many added benefits over oral PREG in that it doesn't convert as readily into the feminizing hormones? correct?
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That is my understanding, but based on representations for Dermacrine - I cannot rule on the correctness of the idea.
 
Is there an advantage of Pregnenolone over DHEA for TD?
It seems DHEA would be better since it's further "downstream" in the pathway.
 
GotTest said:
Is there an advantage of Pregnenolone over DHEA for TD?
It seems DHEA would be better since it's further "downstream" in the pathway.
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What are you using the transdermal for?

Pregnenolone would be more of a nootropic and anti-aging supplement. You're not using prenenolone in hopes to increase testosterone.


If you're going for anabolism or increasing test, I don't particularly recommend either of these.
 
neither DHEA or PREG will influence your total T very much if at all. but as i understand it, if you supplement with DHEA alone, you will suppress PREG levels, and possibly decrease corticosteroid hormone/glucocorticoid and other related stress hormones, which might lead to decreased resistance to stress.

also, PREG actually is a powerful GABA antagonist which in vitro studies increases aggression. DHEA, by indirect means of reducing PREG S concentrations, reduces aggression and increases anxiety.



GotTest said:
Is there an advantage of Pregnenolone over DHEA for TD?
It seems DHEA would be better since it's further "downstream" in the pathway.
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i have used the ISO/PREG/DMSO method listed in previous post in this thread. I am using the saran wrap however. I had thought that 'hey, this DMSO stuff isn't so bad..." but today in class a kid sitting two seats behind be commented that it smelled like 'peas' in the classroom, and than another student sitting beside her said that it did indeed smell a bit funky in the classroom?!?!

so what do you think??? should i use the same application method, just use the DMSO at night before going to bed, rather than in the early morning when the DMSO is still diffusing?

Also, is it true that pure 99.98 % grade DMSO is odorless/doesnt emit garlic odor when applied to skin? maybe i should just get ahold of that...

i know gaylord chemicals has patented a DMSO that is odorless, and doesnt produce smelly sides...does anyone know where i can get it ?
 
Antigravity said:
Interesting: So if one doesnt want to use DMSO -
would MCT oil + (Preg) + IPA make a decent minimal homemade TD formula?
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get some HOT water and add some lecithin until it dissolves. Then, mix this with your mixture and you will create a sort of emulsion that will be effective.
 
dsade said:
slight euphoria ... and an instant calming effect. HUGE sense of well-being.

I used the Eviscerate carrier (it also has 7-OXO DHEA) as it is localized, but now I would probably modify the carrier with Emu Oil as that particular carrier can tend to irritate delicate skin.
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Did you notice that sense of well being/ euphoria from 7-keto aswell?
 
I applied 7-keto TD behind the knees and on wrists- and I get this relaxed -sense of well being- feeling not too long after...
 
Antigravity said:
I am assuming the lecithin is used due to the Phosphatidyl Choline content?
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No...for it emulsifying qualities to be able to make a stable consistent carrier or alcohol, oils, and water.
 
Has anyone with thyroid/adrenal issues run TD Preg for any amount of time? If so what did you experience?

I'm looking for a fix for my wife who's on Armour thyroid but seems to have a skewed T3:T4 ratio and experiences cracked skin on her fingertips.
 
Im not too sure how helpful this is- but I take Cytomel for my thyroid and added in TD DHEA blend (7 keto + regular) not too long ago- so far I havent noticed any side effects except for a mild relaxation/euphoric feeling after I apply the TD formulation.
Is your wife taking Preg as well as Armour? Correct me if Im wrong, but aren't cracked/chapped fingertips a symptom of hypothyroidism (particularly exacerbated during winter months) ?
 
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