elivvt
New member
"Phenyl-pyrrolidinyltoluene, the claimed ingredient named on the product label, is said to actually be 2-(diphenylmethyl) pyrrolidine, a potentially cardiac-toxic designer drug related to the stimulants modafinil and pipradrol."
"One of the key features of peripheral adrenergic (alpha and beta) activity is a hydroxyl in the beta-position, which explains the apparent cardiotoxicity."
"Originally Posted by neuron
Keep in mind, one of the metabolites (if not the ONLY metabolite) of 2-diphenylmethylpyrrolidine is its hydroxylated metabolite diphenylprolinol.
Pho3nix:
So in english ... when you digest 2-DPMP you can naturally form the other drug which has shown cardiovascular toxicity"
"Case Report: A male patient with no risk factors for ischemic heart disease, presented to our emergency department with agitation and chest pain characteristic of ischemia following the ingestion of two units of ?Head Candy.? He improved with oral diazepam over a period of 12 hours and there was no biochemical evidence of myocardial damage. Serum analysis demonstrated the presence
of diphenylprolinol (diphenyl-2-pyrrolidinemethanol [D2PM]) and glaucine at concentrations of 0.17 mg/L and 0.10 mg/L, respectively. No other recreational drugs were detected in an extensive toxicological screen of blood and urine samples.
Discussion: This is the first reported case of confirmed toxicity associated with recreational use of diphenylprolinol in combination with glaucine. In our view, this case provides further support for the need for a systematic approach to toxicological screening of patients with recreational drug toxicity to identify emerging drugs and provide evidence for legislative authorities to assist in revising the legal status of recreational drugs."
"Diphenylprolinol (D2PM), or (R,S)(+,-)-diphenyl-2-pyrrolidinyl-methanol, is a relatively mild dopamine and norepinephrine reuptake inhibitor which is used as a designer drug.[1][2] The dextrorotary (R,+) enantiomer is the most pharmacologically active. Anecdotally, the dextrorotary enantiomer is orally active in the 25-100mg range, with a duration of 5-8 hours. The effects are said to be similar to other NDRIs, producing mild stimulation (at least in relation to substances like methamphetamine or cocaine) which is productive for working or studying, but with relatively little euphoria. Similar drugs to diphenylprolinol include pipradrol, desoxypipradrol, and to a lesser extent methylphenidate.
There have been some recent indications (e.g. detailed reports posted on forums dedicated to researching this compound) that diphenylprolinol may not be as benign as its mild effects seem to suggest. At higher doses and with more frequent administration, its effects on dopamine appear to become significant enough that binging and addiction can enter the picture. Several large overdoses requiring hospitalization have been reported, possibly related to addiction issues. It seems prudent to exercise caution when administering this compound, even for occasional work/study applications, as most dopamine reuptake inhibitors are addictive. Precautions to take might include limiting access and watching closely for symptoms of addiction, such as loss of control over dosage or difficulty stopping use once it has started.
Side effects including chest pain, possibly suggestive of cardiovascular toxicity, have been seen following recreational use of diphenylprolinol, although as it was combined with glaucine in a party pill product ("Head Candy" brand) it is impossible to say for certain which drug was responsible.[3] "
Well after finding more information this morning you are certainly correct.
Yet it does seem that the bad side effects tend to occur at high doses and from the case report you cannot rule out that the glaucine isn't the cause of the majority of heart related side effects.
