strategicmove
Legend
Did that respected member also furnish studies to support his position?
Alpha-Yohimbine capsules
- Thread starter dsade
- Start date
strategicmove
Legend
I thought as much!
justreading
Banned
Yeah but I saw it to and coming from who came from as well as the studies I've seen, I am think yoh is prob a waste. I still bought some Alphaburn but am questioning it... oh well cheap enough to try
dsade
NutraPlanet Fanatic
a waste?
So someone posts an unsupported opinion on, likely, a competitor's product and suddenly rumor and drama has you thinking it's a waste?
It has different affinities on the a2 subtypes, and works more centrally to control satiation and central energy expenditure, as well as the effects on motivation and libido.
Yohimbine works less centrally and more peripherally, which contributes significantly to the NASTY side effects of yohimbine. It is a potent alternative, much safer, to Yohimbine - and that is exactly what is the product has been positioned as.
EasyEJL
Never enough
well wait, thats 30 raw right? i've been (but not last few days) dosing 150mg raw. I gotta find that bottle of bioperine tabsi've got 10mg tabs that are scored to break easy
well, i found the bioperine, so tried that with 100mg raw/ 30mg AY but not empty stomach and still yeah, big difference with bioperine even in just initial hit. we'll see how it feels over time
CHAPS
Registered User
Dsade every product of yours i've used i've loved, I have complete faith in you and your products and of course i'll continue to use Alphaburn, I was just curious why this particular member would say this. FYI he doesn't work for a competitor, and the post was on professionalmuscle.
SokVichet
Active member
Random thoughts
9-10 days of use with Alpha-Burn in a cutting stack. Losing fat more rapidly than I ever have (however, my supp stack is comprehensive and stronger than I ever have tried as well). Adding mid-dosed CLA per suggestion tomorrow.
The sensation is unlike anything else I could give as an example. I have a terrible time waking up in the morning (feel like a thousand pounds and takes about 30-45 min to actually get up), and have tried several different stimulants upon waking. While those worked, they were unpleasant on an empty stomach and the wakeup was just too startling for my grumpy ass.
Lately, I've been taking a single Alpha-Burn as soon as I'm aware enough to do so. I think I read DSade call it a "snapawake" feeling, and I'd have to agree. It is like what I would imagine a well-adjusted person's (my wife) wakeup period to feel like. I just... wake up. It's pleasant, doesn't upset my stomach, and I just feel awake. The subsequent doses yield a clean calm energy without the anxiety/panic/heart-pounding response I get to Y-hcl. Fasted cardio doesn't feel as forced or lethargic either.
9-10 days of use with Alpha-Burn in a cutting stack. Losing fat more rapidly than I ever have (however, my supp stack is comprehensive and stronger than I ever have tried as well). Adding mid-dosed CLA per suggestion tomorrow.
The sensation is unlike anything else I could give as an example. I have a terrible time waking up in the morning (feel like a thousand pounds and takes about 30-45 min to actually get up), and have tried several different stimulants upon waking. While those worked, they were unpleasant on an empty stomach and the wakeup was just too startling for my grumpy ass.
Lately, I've been taking a single Alpha-Burn as soon as I'm aware enough to do so. I think I read DSade call it a "snapawake" feeling, and I'd have to agree. It is like what I would imagine a well-adjusted person's (my wife) wakeup period to feel like. I just... wake up. It's pleasant, doesn't upset my stomach, and I just feel awake. The subsequent doses yield a clean calm energy without the anxiety/panic/heart-pounding response I get to Y-hcl. Fasted cardio doesn't feel as forced or lethargic either.
dsade
NutraPlanet Fanatic
If he was referring to STRAIGHT NE induced lipolysis, technically he would be correct. However, the effect of Alpha-Y especially when stacked with the right other compounds, will yield better and safer results. The POINT of Alpha-Y is to yield the most effective results within the limitations of safety and pleasantness of use - as well as the myriad psychological/neuro benefits that Y just can't offer to the same degree.
To simplify and call one superior without context is just incorrect.
dsade
NutraPlanet Fanatic
I would give anything to have this effect naturally. I hate morning people.
john123131
Well-known member
haha....im a morning person, hate wasting my day sleeping in.
CHAPS
Registered User
So am i incorrect in assuming i'll get the same results from Alpha-Y that i did from Yohimbine HCl when it comes to cutting up my oblique region?
dsade
NutraPlanet Fanatic
WEre you using Yohimbine transdermally?
The effects you will get will depend on your entire protocol. What does your stack look like?
CHAPS
Registered User
Posted by Par Deus on bodybuilding.com
Alpha-Yohimbine
A yohimbine-isomer that works with far more potent MAOI-inhibiting properties (normally, yohimbine isn't very strong in this regard). Because of this, it basically works as an amphetemine-potentiator, because it prevents the neuro-breakdown of the brain's 'big three'-- serotonin, noradrenaline, and dopamine. It also has similar alpha-2 antagonistic properties to yohimbine HCl, but is also less vasoconstrictive in areas, making it less likely to induce large increases in BP.
Quote:
Originally Posted by Par Deus
"Alpha-yohimbine (Alpha-Y) is an analogue of yohimbine, but its potency at the subreceptors of alpha2 differ quite a bit--most notably at the alpha2b and alpha2c adrenergic subreceptors. It is 3 times more potent at alpha2b and 4 times more potent at alpha2c. It is equipotent at alpha2a. The differing ratios of activity is where it allows us to do good stuff with it that we could not do with yohimbine.
Alpha2a mediates most the classic effects of alpha2 receptor agonists and antagonists. There is plenty of info on this in regard to the equipotent yohimbine, so I will not get into it, except to say its superior potency at the other receptors lets us use less to hit them, so we can minimize the negatives here – namely, an increase in heart rate, blood pressure, anxiety, and norepinephrine (NE) hyperactivity, centrally.
The alpha2c receptor plays a minor role in the negative feedback signal on NE, but it plays a major role in certain brain areas where sympathetic innervation is low, and the dopamine system is prominent, which just happen to be the areas that are critical for reward, reinforcement, and metabolic control, such as the VTA and striatum. In these areas, dopamine--not NE--is the primary agonist at alpha 2 receptors, and alpha2c makes up the majority of these receptors. So, it will block dopamine’s negative feedback signal, thus increasing dopaminergic tone, which is lacking in the obese, and ****ed up by dieting and high NE levels.
If that were not handy enough, the only other place the alpha2c receptors are highly expressed is in the adrenal medulla, where it modulates negative feedback on epinephrine (E), much like alpha2a does on NE. In other word, alpha-y allows for a much greater increase in E levels, with its superior effect on thermogenesis, energy expenditure, and nutrient partitioning.
The alpha2b receptor is prominent in development (it is the only adrenergic deletion that impacts survival), but in adults, it only affects blood pressure. Namely, it increases the hell out of it, especially in regard to salt loading. In the obese, and with overfeeding, receptor levels are upregulated. Not coincidentally, it also increases Arginine vasopressin activity. And, if you have read my Ab-Solved write-up, and the leptin series on our site, you might note how strongly tied in obesity, blood pressure, and the renin-angiotensin/cortisol systems are. So, not only are we minimizing the increase in the alpha2b agonist NE, we are blocking the receptor more strongly than with yohimbine. "
Alpha-Yohimbine
A yohimbine-isomer that works with far more potent MAOI-inhibiting properties (normally, yohimbine isn't very strong in this regard). Because of this, it basically works as an amphetemine-potentiator, because it prevents the neuro-breakdown of the brain's 'big three'-- serotonin, noradrenaline, and dopamine. It also has similar alpha-2 antagonistic properties to yohimbine HCl, but is also less vasoconstrictive in areas, making it less likely to induce large increases in BP.
Quote:
Originally Posted by Par Deus
"Alpha-yohimbine (Alpha-Y) is an analogue of yohimbine, but its potency at the subreceptors of alpha2 differ quite a bit--most notably at the alpha2b and alpha2c adrenergic subreceptors. It is 3 times more potent at alpha2b and 4 times more potent at alpha2c. It is equipotent at alpha2a. The differing ratios of activity is where it allows us to do good stuff with it that we could not do with yohimbine.
Alpha2a mediates most the classic effects of alpha2 receptor agonists and antagonists. There is plenty of info on this in regard to the equipotent yohimbine, so I will not get into it, except to say its superior potency at the other receptors lets us use less to hit them, so we can minimize the negatives here – namely, an increase in heart rate, blood pressure, anxiety, and norepinephrine (NE) hyperactivity, centrally.
The alpha2c receptor plays a minor role in the negative feedback signal on NE, but it plays a major role in certain brain areas where sympathetic innervation is low, and the dopamine system is prominent, which just happen to be the areas that are critical for reward, reinforcement, and metabolic control, such as the VTA and striatum. In these areas, dopamine--not NE--is the primary agonist at alpha 2 receptors, and alpha2c makes up the majority of these receptors. So, it will block dopamine’s negative feedback signal, thus increasing dopaminergic tone, which is lacking in the obese, and ****ed up by dieting and high NE levels.
If that were not handy enough, the only other place the alpha2c receptors are highly expressed is in the adrenal medulla, where it modulates negative feedback on epinephrine (E), much like alpha2a does on NE. In other word, alpha-y allows for a much greater increase in E levels, with its superior effect on thermogenesis, energy expenditure, and nutrient partitioning.
The alpha2b receptor is prominent in development (it is the only adrenergic deletion that impacts survival), but in adults, it only affects blood pressure. Namely, it increases the hell out of it, especially in regard to salt loading. In the obese, and with overfeeding, receptor levels are upregulated. Not coincidentally, it also increases Arginine vasopressin activity. And, if you have read my Ab-Solved write-up, and the leptin series on our site, you might note how strongly tied in obesity, blood pressure, and the renin-angiotensin/cortisol systems are. So, not only are we minimizing the increase in the alpha2b agonist NE, we are blocking the receptor more strongly than with yohimbine. "
Mr.50
Board Supporter
DSADE,
I started my Alpha-Y on Monday and I have to say I am having some paradoxical effects and I was wondering what feedback you might have for me????
Since I have started Alpha-Y I have been having orthostatic hypotension. Basically every time I stand up from a sitting or lying position I feel dizzy for a few seconds. This is not normal for me.
Also my cardio seems to be suffering. My level of perceived exertion seems higher for the same work output.
Any thoughts on how those two might be possible? I have not started anything else new?
Mr.50
I started my Alpha-Y on Monday and I have to say I am having some paradoxical effects and I was wondering what feedback you might have for me????
Since I have started Alpha-Y I have been having orthostatic hypotension. Basically every time I stand up from a sitting or lying position I feel dizzy for a few seconds. This is not normal for me.
Also my cardio seems to be suffering. My level of perceived exertion seems higher for the same work output.
Any thoughts on how those two might be possible? I have not started anything else new?
Mr.50
dsade
NutraPlanet Fanatic
What kind of diet are you following? This keto is doing the same thing to me.
CHAPS
Registered User
I've used it orally and transdermally, and liked them both currently doing:
200mg Coleus Forskoli
100mg Epidrol
2 caps Alpha-Y+ 2 Cap Recreate before morning cardio 4 days a week
1 cap Yellow gold before carb meals
9 Caps Cissus daily
I have some liquid CLA i can throw in as well. Diet is carb cycling, no cheats but normally a reload on sundays, post-workout carbs from grains. Low days are 75-100 carbs. I've only been doing this stack for literally 2 days, the Coleus has been about 5 days.
dsade
NutraPlanet Fanatic
Seriously??
dsade
NutraPlanet Fanatic
BTW...this combo is gold (study included in the writeup as to why). If I send you some PLCAR, would you run an experiment for me?
CHAPS
Registered User
What do you have inmind?
dsade
NutraPlanet Fanatic
Your fasted cardio is the perfect time to dose PLCAR, and I am noticing some synergy between the Alpha-Y and PLCAR.
CHAPS
Registered User
Ya lol Hey i know i'm not the only one that's done it. But still i think i may back it down to 80mg, i just think of it like var when it comes to dosing epidrol/epistane etc.
which i attributed to the PLCAR. I'm doing H.I.T. as well 20 minutes twice a week.Mr.50
Board Supporter
I am doing a modified keto with some carbs after workout etc. I do some pretty intense boxing training and I can barely get anything done if my carbs get too low.
Its strange. Not really sure about the hypotension though. Its weird and my cardio is suffering but that may be partly related ot the low carb diet for me.
I can't possibly think of a mechanism.
Mr.50
dsade
NutraPlanet Fanatic
The hypotension is an exaggerated response that can be exacerbated by hypogycemia. Might need to try a small amount of carbs about halfway through your workout. Maybe 5-7 grams?
dsade
NutraPlanet Fanatic
Simple answer, yes. More complex answer - you really want the most functional SYSTEMIC fat burner you can find. Now Eviscerate with EC and Alpha-Burn will be extremely effective, the core functional systemic ingredient being the Ephedrine.
Any of the other systemic fat burners, in conjunction with Alpha-Burn and Eviscerate will lean you out very quickly.
rolandajoint
Well-known member
took a dose of AB and drive this morning around 9. hit me fast. lasted most of the day. didnt crash. very smooth all the way to the end.
and libido, felt great. and was able to make use of it.
after a single dose, im into it :thumbsup:
and libido, felt great. and was able to make use of it.
after a single dose, im into it :thumbsup:
LT*
Member
has anyone tried alpha burn with amp v2? i've used it with y-rd and liked it, about to run out of those and open the amp
I've been using it with X-force (Geranium, Sulbutiamine, caffeine), and I have been really liking it. Huge amounts of clean energy, my focus is higher than I've ever known it to be and I have had NO jitters at all. I'm actually going to try out a midday dose of AB today and see how that goes. I'm one that can't tolerate Yohimbine very well at all so this is very nice.
CHAPS
Registered User
So far i've tried:
50mg Coleus+2 Alpha Y: Minimal stimulation with big jump in body temperature
32mg Ephedrine+2 Recreate+2 Alpha Y: Stimulated but the Alpha Y seems to smooth out the ephedrine if that makes sense for me atleast, i don't feel cracked out just very very hot from this combo and I normally HATE the feeling of the ephedrine.
I did the second combo today before empty stomach cardio and was drenched that is my current recommendation :wave2:
50mg Coleus+2 Alpha Y: Minimal stimulation with big jump in body temperature
32mg Ephedrine+2 Recreate+2 Alpha Y: Stimulated but the Alpha Y seems to smooth out the ephedrine if that makes sense for me atleast, i don't feel cracked out just very very hot from this combo and I normally HATE the feeling of the ephedrine.
I did the second combo today before empty stomach cardio and was drenched that is my current recommendation :wave2:
dollar662
Well-known member
SokVichet
Active member
That would be a 2nd, then!
Some initial thoughts thoughts about 8 days ago:
A few days ago (mentioned again):
Any theories as to how this happens?
SokVichet
Active member
Walgreens generic (Primatene) 12.5mg Ephedrine HCl tablets here.
I happen to be an asthmatic (sort of), and just pick them up with my inhaler. The pharmacist has been trying to talk me out of them, saying they aren't effective, lol.
CHAPS
Registered User
I thinking it's because of it's effects on dopamine and serotonin, just a guess
SokVichet
Active member
I shoulda made the same guess based on the info in this thread, thank you! Trying to fit in AM surfing on easily the most stressful work day I've had in years, lol (pushing 8 months of work to Production servers
).dollar662
Well-known member
Thanks I will pick some up tomorrow and give the combo a try with my stack
unitas27
Active member
This stuff is very nice..I hate YHCL it makes me tweak out a bit. The Alpha is nice and clean. I actually didn't notice it the first day..which was fine, but today was my second day, and I realized how relaxed I felt, and felt like my mood was very stable through the day. I am also taking Slim xtreme and 500mg free--form gaba 3x day with DMAE and vitamin b-6. It's a fantastic combo all around. When I saw this stuff on Nutra, I was pretty stoked and the price is oh so sweet. I hope Dsade keeps this in his RPN lineup. I am really impressed with RPN lately and Dsade's constant involvement in the forums. It's rare to see a busy company owner remain grounded and motivated. Must be all the Aplha-Y and prop alcar. I would love to see the Alpha Y in a formula..Here is my 2 cents for Alphaburn 2.0.
2 capsules: (mg's per ingredient tbd)
Alpha-yohimine
Alpha-GPC
long-chain vitamin b-1 analog
co-enzyme vitamin b-6 (p-5-p)
L-Carnitine Fumarate
low-dose piperine
What do you think Dsade?
PS.. When's the Nep. Krill Oil getting bottled? Looking forward to that as well. Thanks bud.
I would love to see the Alpha Y in a formula..Here is my 2 cents for Alphaburn 2.0.2 capsules: (mg's per ingredient tbd)
Alpha-yohimine
Alpha-GPC
long-chain vitamin b-1 analog
co-enzyme vitamin b-6 (p-5-p)
L-Carnitine Fumarate
low-dose piperine
What do you think Dsade?
PS.. When's the Nep. Krill Oil getting bottled? Looking forward to that as well. Thanks bud.
LoveMeSexy
New member
I can I stack this with anabolic pump and recreate?
saludable24
Active member
now if nutraplanet can get tryptophan caps back in at the same time, i'll be all set for my next order
Those won't be coming back unfortunately. I asked late last year when they would restock and was told they are gone for good.
So I got myself a capping kit and some bulk powder, problem solved.
redfury1977
New member
I use RPN Alpha Burn with my EC stack- start low dosages of E, C with your AY in beginning to assess tolerance(s). Some peeps get really jittery with E, so use caution. I have good tolerance of E,C but still ease in to them after taking breaks...I like Dsade's idea of adding B vitamins, I like to make lil potions, the latest is caffeine anhydrous with Xtend Apple flavor and the E + Alpha Burn, this gives you BCAA's for endurance/stamina during workout on top of your nice stim buzz from ECY.
I am just a user not an expert though....
I am just a user not an expert though....
