Transdermal application of methyl prodcuts??

bake

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heyloow i have a question here about transdermal ap. of methyl products such as phera. superdrol. halodrol.
I have herd that because they are methyl that hey require breakdown in the liver and thus using transdermal application inhibits the ability for these compounds to be broken down in the liver. THis seems right but, isnt everything that is applied through transdermal ap. entering the blood streem basicaly .... and if its entering the blood streem then wont i soon enough pass through the liver anyways...i am confused by this contradiciton or perhaps im mis understanding something. Any help is greatly appriciated before i wash my bottle of stuff into a transport matrix
 

weakestlink

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heyloow i have a question here about transdermal ap. of methyl products such as phera. superdrol. halodrol.
I have herd that because they are methyl that hey require breakdown in the liver and thus using transdermal application inhibits the ability for these compounds to be broken down in the liver. THis seems right but, isnt everything that is applied through transdermal ap. entering the blood streem basicaly .... and if its entering the blood streem then wont i soon enough pass through the liver anyways...i am confused by this contradiciton or perhaps im mis understanding something. Any help is greatly appriciated before i wash my bottle of stuff into a transport matrix
I think I read that it still passes through the liver but at the same time it was a bit less toxic. Not sure if I am correct I found that in the TD section a while ago.
 

jsp0785

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heyloow i have a question here about transdermal ap. of methyl products such as phera. superdrol. halodrol.
I have herd that because they are methyl that hey require breakdown in the liver and thus using transdermal application inhibits the ability for these compounds to be broken down in the liver. THis seems right but, isnt everything that is applied through transdermal ap. entering the blood streem basicaly .... and if its entering the blood streem then wont i soon enough pass through the liver anyways...i am confused by this contradiciton or perhaps im mis understanding something. Any help is greatly appriciated before i wash my bottle of stuff into a transport matrix
i dont' think it necessarily requires a break down in the liver. most products are methylated so they don't get broken down as fast so more of the product gets into your body. this is hard on the liver because it passes through over and over again until it's finally broken down. if they weren't methylated they wouldn't have a very good biovalibility. the problem is that the liver breaks the products down an the methylated compounds try to counteract that by making it much harder to break down.
 

bake

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so a transdermal ap. of a methyl product such as superdrol would WORK... correct?
 

jsp0785

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so a transdermal ap. of a methyl product such as superdrol would WORK... correct?
that i would not know. i dont think every product can penetrate the skin but i dont' have much experience with transdermals.
 
joeymutz

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it all depends on the molecular weight of the product on whether it can be used transdermally or not.
 
AnonyMoose

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search on this - i believe there was a related thread on this. not that that is my answer but i think you might find more there than the responces so far here.
 

bake

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ive searched alot and read madddd threads on it but i think all of them dont mention specific prohormones.. . . and about the molecular weight yea i read about that before but i have NO idea on how to find that info out iv typed in the chem name for superdrol etc in google with +molecular weight etc and i cant find anything related.. . . .
 
Thanos

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so a transdermal ap. of a methyl product such as superdrol would WORK... correct?
Depends on the driver used. But really, why bother? Just take the stuff. Practical application works best.
 

bake

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transdermal is shown to have a much higher conversion rate
 
Thanos

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transdermal is shown to have a much higher conversion rate
paper paper paper. At the end of the day your not going to be 100% better than if just swallowed. Its ok to want to maximize and Im not taking anything away from that, but its a lot of work to get it all driven in and there is noway to tell how much did get in.
 

bake

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that is very tru
im just tryin to experiment w. somtin diff here. when you said depends on the driver.. i have dermabolics transport matrix. would that be sufficient
 
Thanos

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that is very tru
im just tryin to experiment w. somtin diff here. when you said depends on the driver.. i have dermabolics transport matrix. would that be sufficient
I would think so or you could go old school with some regular old DMSO. I have not personally tried this spray but I have seen people who like it. Keep us posted on how it goes.
 
Thanos

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PS....
I just looked down in the transdermal section and you may spark an idea or two by looking there. Some different stuff I have not seen yet down there
 

bake

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yea i read that adding dmso to the solution could help a little mybe 5% but thats it realy... i realy hope i dont wast 60 bux splitting my pills and throwin em in a spray bottle lol
 
Thanos

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yea i read that adding dmso to the solution could help a little mybe 5% but thats it realy... i realy hope i dont wast 60 bux splitting my pills and throwin em in a spray bottle lol
Could go old school with the dmso paste but you will smell like garlic. If it were me I would just swallow and go kill it in the gym. There are people who swear by doing stuff transdermal, I know I personally would feel better about swallowing these.
 

jsp0785

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just go buy some penetrate mix what you want in it and see if it works
 
nattydisaster

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Methylated compounds are methylated to become bioavailable. Taking them transdermally would be counter-productive. If these compounds were not bio-available, then you could look to take it transdermally.
 
bound

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The other thing that you'll have to deal with is the fillers in the pill, you probably won't be able to disolve much of the active in your carrier. Most of the stuff in a mdrol pill is filler, for instance.
 

jsp0785

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but if its already active wat conversion rate is there?
i dont' think he means conversion rate in the normal sense. he means that if you take 25mg of the compound orally you might only absorb 15mg of it, but taking transdermally you'd absorb 20mg. which is pointless it seems with a methylated compound.
 
dsade

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i dont' think he means conversion rate in the normal sense. he means that if you take 25mg of the compound orally you might only absorb 15mg of it, but taking transdermally you'd absorb 20mg. which is pointless it seems with a methylated compound.
Correct. With a methyl, the comparison would be more like taking 25mg orally, absorbing 22mg versus 25mg transdermally and absorbing 10.
 

jsp0785

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Correct. With a methyl, the comparison would be more like taking 25mg orally, absorbing 22mg versus 25mg transdermally and absorbing 10.
i think the problems with the liver and methylated substances is completely overblown. i mean how many years does it take for an alcoholic to get liver problems? the liver is very resilient. preload with milk thistle, taking NAC while on cycle and then going post with more milk thistle is going to get rid of any negatives effects.
 

mattakaspeedy

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what is the point of making it a transdermal ? you do relize that it lowers the potency of the product by approx. 70% dont you ?
 

jsp0785

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what is the point of making it a transdermal ? you do relize that it lowers the potency of the product by approx. 70% dont you ?
is that the same with all transdermal products, or are there some that absorb better though the skin which would normally get destroyed by the digestive process? cause there are well were some very potent transdermal roids
 
ralph4u2c

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transdermal is shown to have a much higher conversion rate
for some bases yes .... but the reason you are taking a methyl. oral is so that it survives the first pass and can be absorbed. common things you would add into a trans-matrix would be formestane, RK/Cap, 1test, 4AD, test base (TNE), and others will a molecular weight < ~300.
 

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