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IBE Reverse: What do you think?

Are you interested in IBE's Reverse?

  • Definitely! This is honestly the most novel combination of ingredients available!

    Votes: 47 74.6%

  • Not so much, I don't really care about health supplements.

    Votes: 16 25.4%
  • Total voters
    63
LakeMountD said:
I haven't really been around many boards lately honestly. I used to go over there but it seemed it was mainly a ster. discussion board.
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people who chose gear want something guaranteed to work and are willing to accept the risks associated with it. while I want the former, I cannot accept the latter....I have a family. so I stick with what works here....and right now I only found a few things that I know work. I tried epistane when it first came out and was not impressed, but it seems to be a fav among folks here. I can only guess that i either did not take enough or it was under-dosed at the time.
I may try it again, but I hope I do not get disappointed again.
if you have suggestions regarding it, let me know.
Lake, it is wasn't for for you, I may not have ever considered PHs or PSs. So I appreciate that.
BTW, this Reverse...sounds like it would be best if taken with a Multi. Am I right?
 
bioman said:
In defense of Lake, I didn't get the feeling his post about Alzheimer's was directed at scaring us into buying IBE's new fangled B-12 rather, I read it as a positive endorsement of Glut-B12's ability to reduce free radicals and inflammation. Basically, anything that reduces inflammation in the body is a good thing and translates into health benefits IMO.

Now, if you are a BBer with Alzheimer's..then yes, run right out and buy this supplement. lol
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There are supplements and food already out there to reduce inflammation -read on -FATS

Although the word emits a negative connotation, FATS are essential to good health and consuming a fair amount of high quality fats is critical to reducing inflammation in the body.

Most omega-6 fats, found in margarine and corn and safflower oils, are inflammation-causing substances. In contrast omega-3 fats, found in fish (wild salmon, mackerel, sardines and anchovies especially) and vegetables, have an inflammation-suppressing effect.

Gamma-linolenic acid (GLA) is an omega-6 fat that enhances the anti- inflammatory effect of omega-3 fats. Both GLA and omega-3 fish oils have been found helpful in arthritis and other inflammatory disorders. GLA is found in leafy green vegetables, olive oil, walnut oil, sunflower oil, soybean oil, canola oil, avocados, nut butters and macadamia nuts and (again) have anti-inflammatory properties.

When it comes to getting good fats, I highly recommend taking a high quality fish oil ever day. This can do wonders for your long-term health!

SIMPLE CARBS

One of the reasons inflammation occurs is from a rapid rise in blood sugar, which causes biochemical changes in the cell. Staying away from sugar and high-glycemic (simple) carbohydrates, which the body rapidly converts to sugar, is one of the best ways to decrease inflammation.

When blood sugar goes up rapidly, sugar can attach itself to collagen in a process called “glycosylation,” or the Browning Reaction, increasing inflammation

Good (complex) carbohydrates, which are low on the glycemic index include: apples, apsaragus, beans, broccoli, blackberries, blueberries, cabbage, cantaloupe, citrus fruits, green beans, honeydew melon, kiwi, leafy greens, peaches, pears, plums, raspberries, spinach, strawberries

Bad (simple) carbohydrates, which are high on the glycemic index include: bananas, breads, carrots, cereals processed with added sugar, corn, French fries, fruit juices, mangos, pancakes, papaya, pasta, peas, popcorn, white potatoes, white rice, sugar, waffles.
 
corsaking said:
There are supplements and food already out there to reduce inflammation -read on -FATS

Although the word emits a negative connotation, FATS are essential to good health and consuming a fair amount of high quality fats is critical to reducing inflammation in the body.

Most omega-6 fats, found in margarine and corn and safflower oils, are inflammation-causing substances....
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Corsaking this is a cut and paste word for word from a 2007 article entitled "How To Reduce Inflammation In The Body (And Why You NEED To Do This)!" written by Todd.

That article shamefully was "derived" almost directly from a 2002 article entitled "The Inflammation Syndrome" by Jack Challem. Todd failed to reference the article as his source just as you failed to reference him.

The original appeared in "Great Life magazine".

There's no need to pass off someone elses work as your own bro. I don't use the Rep system here but if you are that desperate for acknowledgement let me know and I'll "rep" you.

I ask that you not respond to this post and that you clutter this thread no more.

Thank you bro.
 
Hardluck im replying. The piece was not intended to be passed on as my work. Fish oil(OMEGA 3) is antiflammatory -do you not accept that? Similarly GLA . This was just one reference i picked from searching on Google "reducing inflammation in the body" The knowledge is already out there,it only needs sourcing and it doesnt need a new product to convince people that reducing inflammation is important.

Also I am not your bro and i dont need anyinput from you

everyone has a right to Freedom of speech -consequently i will continue to have an input in whatever forum.
 
corsaking said:
Hardluck im replying. The piece was not intended to be passed on as my work. Fish oil(OMEGA 3) is antiflammatory -do you not accept that? Similarly GLA . This was just one reference i picked from searching on Google "reducing inflammation in the body" The knowledge is already out there,it only needs sourcing and it doesnt need a new product to convince people that reducing inflammation is important.

Also I am not your bro and i dont need anyinput from you

everyone has a right to Freedom of speech -consequently i will continue to have an input in whatever forum.
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I am sorry but he does have a point. it should be common knowledge by now that whenever you cite a website that you at least acknowledge and give credit to it's creator and location. of course, if you aren't in high school yet, i will forgive you since they don't teach that until 9th grade....well, at least when i was going to school way back.

BTW Freedom of speech does not give license to plagiarize.
 
[everyone has a right to Freedom of speech -consequently i will continue to have an input in whatever forum.]

Not if they ban you from the forum. You have no rights here. The owner of the board ALLOWS us to post. He owns it. The constitution does not apply here.
 
corsaking said:
...Fish oil(OMEGA 3) is antiflammatory -do you not accept that?
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Sure. Thats why I posted "Evolutionary Aspects of Diet, the Omega-6/Omega-3 Ratio, and Gene Expression" by Artemis P. Simopoulos back in March at:

Invalid Link Removed

as well as "Omega-3 Fatty Acids and Other Polyunsaturated Fatty Acids and Weight Control" by M. Sörhede Winzell and B. Ahrén, Lund University, Sweden in that very same thread.


corsaking said:
Also I am not your bro and i dont need anyinput from you
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:FUfinger:
 
alan1973 said:
I am sorry but he does have a point. it should be common knowledge by now that whenever you cite a website that you at least acknowledge and give credit to it's creator and location. of course, if you aren't in high school yet, i will forgive you since they don't teach that until 9th grade....well, at least when i was going to school way back.

BTW Freedom of speech does not give license to plagiarize.
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Its only plagiarism if i were to claim ownership of the text. You will see from reading other posts that I made no claim that this was mine "The piece was not intended to be passed on as my work"

did they have schools way back?
 
When you post a piece of information like you did above without giving a cite of where you got it from, it is often thought of as the poster's thought/opinion ec. You do not have to 'claim' anything. You only need to make it seem as it's your own. Even if it doesn't fall under plagiarism, you still need to acknowledge the source of information when it isn't your own.
 
Everyone has a right to freedom of speech outside of this forum and in the United States but the owner of this forum has their rules and not following those rules will get you a ticket out of here.


You can feel free to reference the First Amendment all you want but it does not live here.

did they have schools way back?
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Why yes they did... Do they now?
 
Jayhawkk said:
Everyone has a right to freedom of speech outside of this forum and in the United States but the owner of this forum has their rules and not following those rules will get you a ticket out of here.


You can feel free to reference the First Amendment all you want but it does not live here.


Why yes they did... Do they now?
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The USA and UK may be together to fight a war but really as two nations we are poles apart.The First Amendment means nothing not me , Iam English and live in the UK .Perhaps we have a better understanding of the term freedom of speech than you do. If you cannot practice freedom of speech in a forum then ineffect you are censoring what can and cannot be posted. In my view this is a step backwards and hasnt a place in 2008
 
Freedom of speech is about public venues, and this is a privately owned concern. You are able to start your own forum, and say what you'd like in it. Do you have the right to force the london times to print an article you want them to in the name of freedom of speech? no
 
Jayhawkk said:
When you post a piece of information like you did above without giving a cite of where you got it from, it is often thought of as the poster's thought/opinion ec. You do not have to 'claim' anything. You only need to make it seem as it's your own. Even if it doesn't fall under plagiarism, you still need to acknowledge the source of information when it isn't your own.
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I am not trying to inflame anything, but I had to agree with this comment! :thumbsup:
 
corsaking said:
The USA and UK may be together to fight a war but really as two nations we are poles apart.The First Amendment means nothing not me , Iam English and live in the UK .Perhaps we have a better understanding of the term freedom of speech than you do. If you cannot practice freedom of speech in a forum then ineffect you are censoring what can and cannot be posted. In my view this is a step backwards and hasnt a place in 2008
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The last two or so contributors meant to distinguish between the concept of a forum and that of the wider society. Even in a democratic environment, such as the UK and the US, just to use the countries in your comment, there are still rules governing public conduct. People simply cannot say anything they want, whenever they want to, in the name of freedom of speech, otherwise legal terms such as libel, and the rest would not exist and cannot be legally enforced. A forum is an even tighter environment. Forums, whether in the UK, the USA, China, or wherever, must be governed by a set of rules. Potential members must agree to abide by those rules before they are granted membership. Those rules are necessary. Imagine people coming to a forum such as this and asking for sources for banned substances, and related information. Or using impolite, abusive, or politically charged words to address others. These are not allowed by the board rules. The forum members in question cannot invoke their right to Freedom of Speech! That fails to apply here. Let us not stretch the subject!

I did not want to come across as pedantic, but I find this thread has been massively derailed. I hope we can soon return to the beauty of resveratrol and why IBE Reverse should be a must have! :D
 
strategicmove said:
The last two or so contributors meant to distinguish between the concept of a forum and that of the wider society. Even in a democratic environment, such as the UK and the US, just to use the countries in your comment, there are still rules governing public conduct. People simply cannot say anything they want, whenever they want to, in the name of freedom of speech, otherwise legal terms such as libel, and the rest would not exist and cannot be legally enforced. A forum is an even tighter environment. Forums, whether in the UK, the USA, China, or wherever, must be governed by a set of rules. Potential members must agree to abide by those rules before they are granted membership. Those rules are necessary. Imagine people coming to a forum such as this and asking for sources for banned substances, and related information. Or using impolite, abusive, or politically charged words to address others. These are not allowed by the board rules. The forum members in question cannot invoke their right to Freedom of Speech! That fails to apply here. Let us not stretch the subject!

I did not want to come across as pedantic, but I find this thread has been massively derailed. I hope we can soon return to the beauty of resveratrol and why IBE Reverse should be a must have! :D
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AMEN :thumbsup:
 
Further discussion in this thread needs to be on topic. If you wish to PM me your opinions or make a thread discussing the difference between complete freedom of speech and limited freedoms; feel free.
 
If your old, I'm ancient! LOL! Yea I am looking forward to trying it. Any word on what the price might be Lake?
 
O/T to the O/P why is this product not sitting in my cupboard for testing?

LMD makes me sad sometimes :(
 
ShakesAllDay said:
So, will Reverse take me back to 12 years old? Oh, the glory days.
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Sorry... not even IBE's chemist can do that (Yeah some props for your Lake).... we can only turn back to 19/20... we chose this age due to the raging sex drive that we all had known and loved. :D

Adams
 
B5150 said:
O/T to the O/P why is this product not sitting in my cupboard for testing?

LMD makes me sad sometimes :(
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Who said you won't be testing it? lol.

As for the turning back the clock, as Adams said, as we created the calabi-yau 6 dimensional time surf machines inside of Reverse, it seems as though the raging sex drive of 12-18 year olds has prevented us from pushing the time machine through this point in life; it seems as though the sex drive actually tears the fabric of space-time :). I am working on a particular "capacitor" to fix this problem though. :thumbsup:
 
It's there... Just don't vote and add a post saying "I don't care for this type of product"

Polls are usually made with a sarcastic or funny tone. I wouldn't read too much into it.
 
Just out of curiosity what is the molecular weight of 3,5,4’-triacetyl-trans-stilben?

I thought for some reason I recalled an interaction of transdermal res and certain skin enzymes? I'd have to go back and look though. And this isnt a transdermal so kinda a pointless question, lol.
 
Jayhawkk said:
Everyone has a right to freedom of speech outside of this forum and in the United States but the owner of this forum has their rules and not following those rules will get you a ticket out of here.


You can feel free to reference the First Amendment all you want but it does not live here.


Why yes they did... Do they now?
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makes ya wonder!
 
When does IBE intend to pick beta testers? It would be an honour to be considered. Well-dosed and well-absorbed Resveratrol is unadulterated magic!
 
strategicmove said:
When does IBE intend to pick beta testers? It would be an honour to be considered. Well-dosed and well-absorbed Resveratrol is unadulterated magic!
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for sure. i've seen such variation too based on where I got the resveratrol from. But when its good, its really good :D
 
Does anybody know what it takes to get Resveratrol to mimic calorie restriction/longevity?

Sinclair's 2006 study showed no matter what the diet resveratrol when taken later in life (i.e quivalent to 35 human years) made the life of the mice healthier (thicker bones, no cataracts, stronger heart, less mitochondria damage)...which is great but did not extend the life span.

I haven't spent much time on this but would appreciate it if someone could point to newer source material and/or give me their thoughts on what is needed.

For instance do we need to have resveratrol active constantly in blood plasma (i.e. time released)?

Is their a sweet spot...such that too much & too little don't adequately activate the SIRT1 enzyme?

Has anyone ever contemplated an injectable?

Has anyone thoughts on the difference between resveratrol bringing on a healthier life vs resveratrol bringing on both a healthier & life-span extended life?

What limitations to oral dosing of plain resveratrol will Lake's acetylation REALLY overcome. Is it just more bioavailability at once....more time released element to it... and is this experimental formulation a potential way to get resveratrol to act "more intently" on activating sirtuins?

I'm not asking anybody to do my leg work for me ...just a thought here or there would be great. Thanks guys.
 
next would be to find out if an injectable form of it would be better since we are skipping the first pass through the liver.
 
datBtrue said:
Has anyone ever contemplated an injectable?
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Got you covered on that one, as it turns out injecting DOES NOT change the bioavailability, neither does megadosing, which is a very important point to those who attempt to take 1-3g/day.



This is another reason that we made Reverse. As the article states the bioavailability is low despite the dosage and the rate of absorption is very slow.



Pharm Res. 2008 Jul 16. [Epub ahead of print]
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
Das S, Lin HS, Ho PC, Ng KY.
Department of Pharmacy, Faculty of Science, National University of Singapore, Building S4, Rm 05-02, 18 Science Drive 4, Singapore, 117543, Singapore.

PURPOSE: This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol. METHODS: Water soluble intravenous and oral formulations of resveratrol were prepared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD), respectively. Sodium salt and suspension of resveratrol in carboxymethyl cellulose (CMC) were used as the reference intravenous and oral formulations, respectively. The pharmacokinetics of resveratrol was assessed in Sprague-Dawley rats. Plasma resveratrol concentrations were measured by high performance liquid chromatography (HPLC). RESULTS: Both HP-beta-CD and RM-beta-CD enhanced the aqueous solubility of resveratrol. After intravenous administration, rapid elimination of resveratrol was observed at all tested doses (5, 10, and 25 mg kg(-1)) regardless of formulation types; with non-linear elimination occurring at the dose of 25 mg kg(-1). RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension. Furthermore, the oral bioavailability remained unchanged among all tested doses (15, 25, and 50 mg kg(-1)). CONCLUSIONS: Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption. Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol.
 
Lake you could be a lawyer. You shepardize really well. (i.e. cite the latest most up to date legal precedent). :)

I have access to the full Pharmacological Research journal but the abstract you dug up is ahead of publication. :thumbsup:

I appreciate you giving me the easy answer on this one. Wow that is pretty definitive. Actually IF we can extrapolate from the study there was no increase in bioavailability up to the equivalent of 4 grams dosing for an 80 kilo man.

This may explain why the 2006 study showed health benefits in aged mice but no extended life span (they couldn't get resveratrol levels high enough).

Now I see why you are so excited about your "baby". Your potential market is huge...way beyond the bodybuilding community.

Make sure you file a patent application that also includes you not just IBE.

Thanks again bro... you saved me a bunch of time.


LakeMountD said:
Got you covered on that one, as it turns out injecting DOES NOT change the bioavailability, neither does megadosing, which is a very important point to those who attempt to take 1-3g/day.



This is another reason that we made Reverse. As the article states the bioavailability is low despite the dosage and the rate of absorption is very slow.



Pharm Res. 2008 Jul 16. [Epub ahead of print]
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
Das S, Lin HS, Ho PC, Ng KY.
Department of Pharmacy, Faculty of Science, National University of Singapore, Building S4, Rm 05-02, 18 Science Drive 4, Singapore, 117543, Singapore.

PURPOSE: This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol. METHODS: Water soluble intravenous and oral formulations of resveratrol were prepared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD), respectively. Sodium salt and suspension of resveratrol in carboxymethyl cellulose (CMC) were used as the reference intravenous and oral formulations, respectively. The pharmacokinetics of resveratrol was assessed in Sprague-Dawley rats. Plasma resveratrol concentrations were measured by high performance liquid chromatography (HPLC). RESULTS: Both HP-beta-CD and RM-beta-CD enhanced the aqueous solubility of resveratrol. After intravenous administration, rapid elimination of resveratrol was observed at all tested doses (5, 10, and 25 mg kg(-1)) regardless of formulation types; with non-linear elimination occurring at the dose of 25 mg kg(-1). RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension. Furthermore, the oral bioavailability remained unchanged among all tested doses (15, 25, and 50 mg kg(-1)). CONCLUSIONS: Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption. Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol.
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Eta?

Reverse seems to be one of the most promising product to be released. I have used plain resveratrol for may years now and just can't wait to try this. How much longer do we have to wait? Would this be a "feel" kinda product --i.e. you can actually tell that some positive changes are taking place in your body after using it for some time? Has this undergone any beta-testing yet?
 
rykkk said:
Reverse seems to be one of the most promising product to be released. I have used plain resveratrol for may years now and just can't wait to try this. How much longer do we have to wait? Would this be a "feel" kinda product --i.e. you can actually tell that some positive changes are taking place in your body after using it for some time? Has this undergone any beta-testing yet?
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Last time I asked was about a week ago, and Lake gave a couple week estimate, so really we should be seeing this anytime now.

I know the Shilijit is able to be "felt" by some. As for the new resv. I will let lake answer that one for you. If you have any type of B12 def. then you will definitely feel it. :)

Adams
 
datBtrue said:
Lake you could be a lawyer. You shepardize really well. (i.e. cite the latest most up to date legal precedent). :)

I have access to the full Pharmacological Research journal but the abstract you dug up is ahead of publication. :thumbsup:

I appreciate you giving me the easy answer on this one. Wow that is pretty definitive. Actually IF we can extrapolate from the study there was no increase in bioavailability up to the equivalent of 4 grams dosing for an 80 kilo man.

This may explain why the 2006 study showed health benefits in aged mice but no extended life span (they couldn't get resveratrol levels high enough).

Now I see why you are so excited about your "baby". Your potential market is huge...way beyond the bodybuilding community.

Make sure you file a patent application that also includes you not just IBE.

Thanks again bro... you saved me a bunch of time.
Click to expand...

Not a problem man, I try to keep an eye on most of the popular journals and find the pertinent ones. Over the last few years I have become very efficient at searching too ;). Yeah we really think this has HUGE potential we just need to find the right way to market it to the general public. I don't see a lot of bodybuilders spending >$45-50 on a health supplement. Most of them are young and don't understand the importance of health. Heck I'll admit that I didn't.
 
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