forskolin bad for you?
- Thread starter jhferry
- Start date
jhferry
Member
I am sure they wouldnt knowingly do that but there could be information that comes out in research that shows danger to using something. I am just looking for someone to debunk the research presented in that thread.
jhferry
Member
Thats what Im saying, I am not in here trying to start trouble, I want to take the product. I just want to know a little more about the info presented there.
ozarkaBRAND
Well-known member
Care to elaborate? What's wrong with forskolin, and what's wrong with TTA?
BigNutz
Member
I personally dont like Forskolin because every time I use any supp containing it I get naseous.
TTA has been known to cause Rhabdo, not a very good thing by any stretch:
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http://www.*************/forum/ask-dr-houser/2455-tta-rhabdo.html
"In short, I do NOT care for TTA and actually think it is unneeded in many regards since being prematurely rushed to the market.
What you bring up is a great point, and I would encourage you guys to check how long it hangs out around cardiac tissue. This is mildly scary. Supplement companies seek out novelty, yet rather than do it with a safety profile that is noteworthy try and proclaim the next best thing, despite what is readily available. Truly unfortunate." - Dana Houser, MD
Funny how most of the supp companies have slowly and quietly dropped there TTA products (Melting Point, Lipid-FX)
TTA has been known to cause Rhabdo, not a very good thing by any stretch:
Invalid Link Removed
Invalid Link Removed
http://www.*************/forum/ask-dr-houser/2455-tta-rhabdo.html
"In short, I do NOT care for TTA and actually think it is unneeded in many regards since being prematurely rushed to the market.
What you bring up is a great point, and I would encourage you guys to check how long it hangs out around cardiac tissue. This is mildly scary. Supplement companies seek out novelty, yet rather than do it with a safety profile that is noteworthy try and proclaim the next best thing, despite what is readily available. Truly unfortunate." - Dana Houser, MD
Funny how most of the supp companies have slowly and quietly dropped there TTA products (Melting Point, Lipid-FX)
thebigt
Legend
dcp continues to be a best seller, with alot of people singing it's praises. ive used drive which contains forskolin, and it destroyed my stomach. am considering using dcp, would like to hear from more people on this topic.
DreamWeaver
Legend
While Drive did give me some discomfort at first I was ok when I adjusted to it.
thebigt
Legend
several products have given me stomach issues, but for me drive was the worse. not saying it is a bad product, but for me it wasn't worth it. would like to hear more about dcp.
DreamWeaver
Legend
I don't remember any issues with DCP.
thebigt
Legend
what is your position on why tta is so bad?
CHAPS
Registered User
I don't know what it was but i felt terrible on Drive and, it's hard to describe just not well, i didn't last long on it i sold the rest off to a buddy of mine, and i'm fine on straight Forskolin.
Invalid Link Removed, this is an article also from mindandmuscle talking about how good Forskolin is.
Good Shepherd
Member
I would love to get Dsade's take on this.
dsade
NutraPlanet Fanatic
1: J Cardiovasc Pharmacol. 2008 Apr;51(4):410-7.Links
Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 study.
Pettersen RJ, Salem M, Skorve J, Ulvik RJ, Berge RK, Nordrehaug JE.
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. [email protected]
This study describes the clinical, hematological, and biochemical safety of tetradecylthioacetic acid (TTA). A total of 18 healthy volunteers were included. Subjects were randomly assigned into 3 groups according to the daily given dose of TTA: group 1 (200 mg), group 2 (600 mg), and group 3 (1000 mg). TTA was given as a single oral dose for 7 consecutive days. Safety was evaluated by following the adverse events, vital signs, and hematological and biochemical parameters in blood and urine samples. Efficacy was estimated through its effects on plasma lipids profile. Few adverse events of mild severity were reported. No clinically significant changes were observed in the hematological or clinical chemical parameters in blood/urine. TTA did not induce significant changes in the blood lipids or free fatty acids, but it did result in an increase in plasma concentration of Delta9 desaturated TTA (TTA: 1n-8). Serum concentration pattern of TTA at day 1 showed a 1.5-hour lag time followed by a rapid absorption and a slower elimination phase. The median peak values were 2.9 mg/L (range, 1.1 to 5.4 mg/L), 11.5 mg/L (range, 4 to 35 mg/L), and 11 mg/L (range, 5 to 25 mg/L), in groups 1, 2, and 3, respectively (P = 0.006). The time to peak levels were 3.5 hours (range, 2.5 to 6.5 hours), 2.5 hours (range, 2.5 to 4.5 hours), and 4.5 hours (range, 2.5 to 12 hours), respectively (P = 0.2). TTA is safe and well tolerated.
Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 study.
Pettersen RJ, Salem M, Skorve J, Ulvik RJ, Berge RK, Nordrehaug JE.
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. [email protected]
This study describes the clinical, hematological, and biochemical safety of tetradecylthioacetic acid (TTA). A total of 18 healthy volunteers were included. Subjects were randomly assigned into 3 groups according to the daily given dose of TTA: group 1 (200 mg), group 2 (600 mg), and group 3 (1000 mg). TTA was given as a single oral dose for 7 consecutive days. Safety was evaluated by following the adverse events, vital signs, and hematological and biochemical parameters in blood and urine samples. Efficacy was estimated through its effects on plasma lipids profile. Few adverse events of mild severity were reported. No clinically significant changes were observed in the hematological or clinical chemical parameters in blood/urine. TTA did not induce significant changes in the blood lipids or free fatty acids, but it did result in an increase in plasma concentration of Delta9 desaturated TTA (TTA: 1n-8). Serum concentration pattern of TTA at day 1 showed a 1.5-hour lag time followed by a rapid absorption and a slower elimination phase. The median peak values were 2.9 mg/L (range, 1.1 to 5.4 mg/L), 11.5 mg/L (range, 4 to 35 mg/L), and 11 mg/L (range, 5 to 25 mg/L), in groups 1, 2, and 3, respectively (P = 0.006). The time to peak levels were 3.5 hours (range, 2.5 to 6.5 hours), 2.5 hours (range, 2.5 to 4.5 hours), and 4.5 hours (range, 2.5 to 12 hours), respectively (P = 0.2). TTA is safe and well tolerated.
dsade
NutraPlanet Fanatic
There were safety issues brought up, strictly, hypothetical, which I worked to address by lowering the dosage into a reasonable range. As real world feedback shows, increased CPT1 activity and increase in DGAT1 activity, being side effects of TTA supplementation, are able to be taken advantage of with the rest of the ingredients.
Normal side effects noted with other TTA supplements are pretty much nonexistent with DCP. We do not recommend the multi GRAM daily doses of TTA, rather use a more subtle manipulation of the systems involved to actually yield superior results.
I stand by DCP 100%.
Normal side effects noted with other TTA supplements are pretty much nonexistent with DCP. We do not recommend the multi GRAM daily doses of TTA, rather use a more subtle manipulation of the systems involved to actually yield superior results.
I stand by DCP 100%.
dsade
NutraPlanet Fanatic
In addition, reported cases of Rhabdomyolysis are extremely rare, and could be caused by:
Improper hydration while under heavy exertion
Carnitine deficiency
CPT-1 deficiency.
Since TTA increases CPT-1 activity, we used Propionyl-L-Carnitine, a form of carnitine with a very high affinity for muscle and cardiac cells, in order to provide the carnitine necessary to "keep up" with the increased demand - not only from an efficacy factor, but from a view of safety. To counteract electrolyte imbalance, we also included the potassium form of Pyruvate.
Improper hydration while under heavy exertion
Carnitine deficiency
CPT-1 deficiency.
Since TTA increases CPT-1 activity, we used Propionyl-L-Carnitine, a form of carnitine with a very high affinity for muscle and cardiac cells, in order to provide the carnitine necessary to "keep up" with the increased demand - not only from an efficacy factor, but from a view of safety. To counteract electrolyte imbalance, we also included the potassium form of Pyruvate.
ozarkaBRAND
Well-known member
dsade 1/ naysayers 0
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dsade
NutraPlanet Fanatic
I wish I could recommend the DCP/Recreate stack (considering the subforum here) but I have yet to try it. I traded Jacob some GUT Health for some Recreate, but it has not arrived yet.
I find great synergy between DCP and Leviathan Reloaded, with something like Lean Extreme or especially Napalm added for cortisol control.
Green Tea caps and even ephedrine are both great additions.
The key hitting the different pathways/mechanisms of fat burning without overloading any one (OD on stims, too much restriction of cortisol, etc.).
thebigt
Legend
i didn't know that there was a recreate/dcp stack. thats the one i will get. ive got a couple bottles of original leviathan im working on now. will add dcp to the leviathan and save the recreate for later. thanks d.
Good Shepherd
Member
Very nice my friend. Great work giving the case study to back everthing up.
DreamWeaver
Legend
I like Leviathan and DCP as well, I was adding drive but it seemed a bit really noticed the synergy between Leviathan and DCP more when I stopped using Drive. The 3 together might have been too much in retrospect, although all in all it was a successful experience over all.
maurice02
Active member
I just passed one week on DCP/Recreate. I ran Recreate for a month and didn't get the results I was hoping for so now stacked the two of them. I am also using Anabolic Pump and Xyience Growth Factor along with Fish Oil, BCAA, NoxCG3, and a multivitamin.
I have been feeling VERY tired but I think it is my allergies beating my ass from the change in weather around here. I can say last night I had a wonderful back workout. I took 2 DCP and 2 Recreate before the gym. Worked out really well. Sweat and endurance. My sleep has not been too good though, but I think I am taking DCP a tad late...but not sure if that is the effect.
Anyways, for the stack so far, I have a chubby stomach, and now I can see a line in the top of where my abs should be, just have to shed the bottom. So far, it seems they are working well together.
DreamWeaver
Legend
Make sure you increase your water intake with the weather change. I learned this the hard way and am up to close to 6 litres during the hotter more humid days.
maurice02
Active member
good point. I have been killing the water cooler at work now lol. I prob could use a stim for energy but i am on an anti-hypertensive so that might not be the best idea lol.
thebigt
Legend
you might take dsade's advice and add lean extreme or napalm to get rid of the gut. i highly recommend the lean extreme, but although i haven't tried napalm the reviews have been outstanding. i think i react very good to lean extreme because i have a high stress, physically demanding job and work 3rd shift with a lot of ot. the forskolin is an added plus,imo.
dsade
NutraPlanet Fanatic
boh dcp and recreate increase fat burning and the capability to burn fat....lean extreme and napalm wil reduce cortisol, which will free the fat specifically around the gut area, which will then be burned by the upregulated mitochondria.....I would add it in now.
Good Shepherd
Member
What do you think about adding Usplab's Camphobolic product, (w/ forkolin, green tea etc,) to the above stack- its supposed to be geared to be taken at night....When do you get to the point of overkill with forskolin?
CHAPS
Registered User
In this case i would leave the Lean Extreme out of the mix, Recreate has potent cortisol suppressing effects as it is, Napalm would be smart to add though to free up more fatty acids and site specifically lower cortisol a tad more. I'm just thinking that Recreate+Lean Extreme= Too much cortisol suppression and the result is the joints of an elderly man.
dsade
NutraPlanet Fanatic
How long do you find it takes?