It is most definitely effective for degradative bone disease, as the most legitimate research on Cissus Q., is conducted on osteoblasts (bone forming/remodelling cells); moreover, Cissus' main MOA is the induction of phytoestrogenic steroidal response which mitigates the increased capacity of these osteoblasts. In simpler terms, Cissus increases bone-tissue specific estrogenic activity which plays a primary role in the formation and maintenance of bone. This would be especially beneficial with osteoporosis, a condition characterized by porous bone structure and a lack of calcium.
In clinical trials, via phytoestrogenic activity, and the deliverance of beta carotene, calcium, and other necessary minerals, Cissus was shown to increase bone healing, and improve bone quality!