What would be the strongest supplements for muscle building, strength gains that don't require a PCT?
The best OTC supps for building muscle are going to be those products which most closely perform the functions of "REAL" hormones (testosterone, AAS, GH, IGF-1, insulin, and myostatin inhibitors) in the body. Everyone knows that those drugs are the very best muscle builders in existence, which is why every top bodybuilder and strength athlete uses them to gain strength & size...and why the supp industry has traditionally attempted to design products which mimic them.
Are there any supps available on the OTC market today which effectively mimic these hormones to even a moderate degree? Well, let's look at each class one by one, so you will know without any doubt whatsoever how to answer your own question.
1.) Testosterone/AAS: Sorry, but these days there are ZERO products on the supplement market that can effectively mimic these drugs. We used to have real designer steroids at our disposal, like Superdrol, Epistane, etc...but those days are gone. Prior to that we actually had some decent prohormones, which were only one conversion step away from reaching the target hormone and provided fairly impressive results. Now all we have are DHEA-based prohormones that are a half-dozen conversion steps away from becoming the target hormone. Most of them are total **** due to multiple factors (horrible oral bioavailability, poor pharmacokinetics, and as previously mentioned, they are multiple conversion steps away from converting into anything meaningfully effective). There are a few DHEA-based prohormone products that can provide mild gains (1-testosterone based DHEA PH's are the most effective) in novice and intermediate level bodybuilders, but the product must utilize an effective delivery system, as the drug will not survive the digestive system/first-pass through the liver without it, thereby making it totally worthless. Unfortunately, even the best delivery systems in use today are OLD technology that supp companies were using 20 years ago, but because everything good was banned in the last 10 years supp companies have been forced to start using outdated, inferior technology. Of course, they market it as if it is something new and radical, but the truth is that even the best PH-based delivery systems in use today are only moderately effective, at best....and nowhere near as effective as methyl-based delivery systems (which are used in oral AAS). In reality, even the best DHEA-based PH's are good for a few pounds of muscle at the most...usually over several months.
What about test boosters? Forget it. A total waste of money...at least from a muscle growth standpoint. One class of test boosters (the aromatase inhibitors) can effectively restore testosterone production after a cycle of AAS, but in non-suppressed individuals they will not raise testosterone levels high enough to cross the anabolic threshold. In other words, test levels will not reach into the supraphysiological range, so you are not going to experience anywhere near "drug-like" results. At best a novice and perhaps intermediate bodybuilder may gain 1-2 pounds of muscle over an extended period of time (as a direct result of minor testosterone elevation), but for more advanced bodybuilders they will do nothing.
How about those "other" test boosters made out of various herbs, plants, and minerals, such Tribulus, DAA, Coleus, ZMA, etc? Nope. They barely raise testosterone levels at all...and even if you happen to see advertising that says "raises testosterone levels by 300%", keep in mind that in the average man, who has a testosterone score of 500 (normal today), that is only going to bring him up to about 1,500 ng/dl, which is barely outside of the normal range. A testosterone level in that range will result in improved growth over time (nothing dramatic), as long as those levels are maintained throughout the day. The problem with these products is that they only maintain those levels for a few hours at best, which isn't going to do jack**** for muscle growth. You want proof? Even when effective test boosters like the original "Noxadex XT" (by Gaspari nutrition; back when Gaspari was innovative and making great stuff) was around (pre-ban), it was not known to cause significant gains in muscle mass...and that product was capable of elevating free test levels by 600% and total test levels over 300%...all day long! Yet, significant gains in muscle mass were not reported. It was mostly used as a PCT drug or just to give guys that extra mental "edge" and increase sex drive. It certainly did not provide dramatic growth benefits. It's the same with prescription aromatase inhibitors (letrozole, arimidex, aromasin, etc); they raise testosterone more effectively than any of the aromatase inhibitors on the OTC market today, yet none of them have EVER been shown to build significant amounts of muscle mass, either clinically or in the real-world, when when used as "test boosting" agents.
So, if even Novadex XT and the other prescription-based aromatase inhibitors aren't able to produce significant gains in muscle mass, which promote greater elevations in testosterone levels than OTC aromatase inhibitors (and much greater and longer-lasting elevations than the herbal class of test boosters), it is only reasonable to conclude that today's test boosters aren't going to do much for muscle growth. They never have and they never will. We know very well what amount of testosterone is required to produce significant gains in muscle mass...and non-supraphysiological elevations for a few hours per day certainly isn't it! Oh, and don't get sucked into the "reviews" on these products, in which under-developed trainers (i.e nowhere near reaching their natural genetic potential) claim to have gained 10 pounds in 2 months, or similarly impressive gains. These products will not cause anywhere NEAR that amount of muscle growth. If anyone in those circumstances gains that amount of muscle mass, you can be rest-assured that nearly all of it is due to their training and diet, not having a moderately elevated testosterone level for a couple hours each day. Believe that. When I first started serious training, I gained 64 pounds of bodyweight (at least 75% muscle) in my first year of training...100% drug-free (I went from 167 lbs to 231 lbs at 6'1 height). This may be hard to believe for some, but it's the truth. I only mention it to show where these type of gains are really coming from (training and diet)--not mild, short-lived elevations in testosterone levels.
2.) Insulin: Sorry again, but there is nothing even remotely close to capable of mimicking the effects of insulin in today's OTC supp market. It's not even worth discussing any of the products that claim to. Now, some of these "insulin senstizers/mimetics" have great health benefits and can help make it easier to stay lean. They can even provide "indirect" growth benefits (mostly by restoring insulin sensitivity in PED using bodybuilders who suffer from insulin resistance due to high-dose GH and insulin use) , but they will not have any meaningful effects on growth in those who don't suffer from insulin resistance.
3.) IGF-1: Nada...nothing...zilch...no sense in even talking about it (there is one product that raises IGF-1 levels VERY effectively, but it is listed under the GH section, as it increases IGF-1 levels via GH elevation).
4.) Myostatin Inhibitors: Some of these products have been shown to provide moderate growth benefits, although nowhere near what is seen with pharmaceutically derived myostatin inhibiting "drugs". This I can tell you from experience. Unfortunately, legitimate, properly dosed myostatin inhibiting drugs are not only difficult to source, but are also incredibly expensive (most are way under-dosed even when they are real). Furthermore, when one takes an OTC myostatin inhibitor (assuming the person is using an "effective" one to begin with), the body will attempt to neutralize the product's effects within just a few weeks by increasing production of endogenous myostatin. This is the body's way of trying to maintain homeostasis. The same thing happens (endogenous myostatin production increases) when we use AAS, which is a big part of the reason why gains start to slow way down after the first 4-6 weeks of a cycle. For this reason these products must be cycled, although they can be helpful in stimulating new gains in the short-term.
5.) GH: This is the ONLY category in which an OTC product can actually mimic the effects of 3-4 iu's of injectable growth hormone...and there is only ONE product that can do it. This is MK-677. Technically a drug, MK-677 has a mountain of clinical research behind it supporting its effectiveness in this capacity, as well as a multitude of user labs confirming this clinical research. MK-677 is the ONLY orally active GH secretagogue on the OTC market today that can actually elevate GH and IGF-1 levels (all day long) comparable to injectable growth hormone, but what kind of results does it provide? Exactly what you would expect from a drug that increase GH and IGF-1 levels to the same degree of 3-4 IU of injectable GH. In other words, it produces increases in muscle size, recovery, and growth equivalent to 3-4 IU of injectable GH...at a fraction of the cost. People who use the product typically gain about 8-10 pounds of body weight in the first 1-2 weeks. Most of this weight is in the form of intramuscular water, which is the same mechanisms by which exo. GH causes its initial burst of weight gain. Because this water is stored primarily inside the muscle and not under the skin (subcutaneous) it makes the user look like they have gained a real 8-10 pounds of muscle tissue. After all, muscle is comprised mostly of water...and anytime we can increase the amount of water stored inside the muscle it is going to look bigger, regardless of whether we accomplish this through MK-677, injectable GH, Anadrol, insulin, or even carb-loading. All of these drugs/practices have the same effect--bigger muscles within a short period of time. there is not a single "supplement" on the entire OTC market which will add as much size, or do it as quickly, as MK-677. There is a GOOD REASON why even some professional and National Level bodybuilders have switched out their injectable GH for MK-677. I know, because one of them publicly posted that after starting to use Somatozine (an enhanced version of MK-677 that I sell), he dropped his injectable GH (he was using 5 iu/daily) and decided to use Somatozine alone. He claimed he could tell no difference between the 5 iu of GH he had been using for years...and Somatozine. This is not surprising, however, as Somatozine is more effective than plain MK-677 due to the synergistic effect that MK-677 has with the other ingredients in the product.
For those of you who don't believe this, I will not only be happy to provide you with plenty of clinical research supporting my claim, but I can direct you to countless advanced, PED using bodybuilders who now include MK-677 (Somatozine) in their programs...permanently.
MK-677 also has a dramatic effect on hunger levels, causing huge increases in appetite all day long. This is understandable, as MK-677 is a ghrelin mimetic like GHRP-6 (although much more effective from a GH releasing standpoint). Whether or not the individual views this as a positive or negative trait will depend on their goals, but for those guys trying to gain mass and who struggle to eat all the calories they need to grow, this effect may prove itself to be invaluable. It certainly has for me. If anyone here can show me one OTC product that provides more dramatic effects on size, recovery, and appetite than MK-677, I will rescind my claim in full...but that's not going to happen...because no other product has the amount of clinical or real-world evidence that MK-677 does...and it works the same in everyone, regardless of how developed the individual may be to start with.