i missed out i guess,,,so lets go at it again please...
http://www.ncbi.nlm.nih.gov/pubmed/9651103
Life Sci. 1998;62(26):2369-77.
Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats.
Moreno M, Lombardi A, Lombardi P, Goglia F, Lanni A.
Dipartimento di Chimica, Facoltà di Scienze, Università degli Studi di Salerno, Italy.
Abstract
We have investigated the biological effects of physiological doses of 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) (at doses from 2.5 to 10 microg/100 g BW) on serum TSH and GH levels in rats made hypothyroid by propylthiouracil and iopanoic acid administration. In such animals deiodinase activities were inhibited and thyroid hormones serum levels strongly reduced. The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW).The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats. By
contrast, 3,3'-T2 had no effect on TSH, whatever the dose. The serum GH level was much lower in hypothyroid rats than in euthyroid ones.
T3 administration increased the GH level by about 5-fold, restoring it to the value seen in euthyroid rats. 3,5-T2-treated hypothyroid rats, at all the doses used (from 2.5 to 10 microg/100 g BW), showed increased serum GH levels: at a dose of 10 microg/100 g BW the level reached a value about 5-fold higher than that in hypothyroid rats. This value was not significantly different from those of euthyroid and T3-treated rats.
3,3'-T2 did not affect GH levels whatever the dose. Thus, 3,5-T2 (but not 3,3'-T2) seems to mimic the effects of T3 on serum TSH and GH levels in rats.
PMID: 9651103 [PubMed - indexed for MEDLINE]
okay so you have a compound thats supposed to work on metabolic rate but you are saying that wont lower TSH?
thats like saying i have a compound taht will work on androgenic receptor and wont shut you down, lowering LH/FSH,,,,sounds too good.
i would use 3,5 version and compensate lowered TSH and it will rise to normal, so same as coming off T3,,,taper off, and careful with diet during thryoid 'pct' or take stimulants then or something,,,,i see using 3,5's benefit is that it is OTC, if anybody is selling them still
now i would like to see a study or two showing 3,3' diiodo doing samething to RMR like 3,5 or 3,5,3 because i was unable to find one. Im not saying other folks with good results arent bs'ng i just want to see how it differs other than what ive seen is that 3,3 is non thyromimetic.