25 Year old UK guy, low testosterone / adrenal dysfunction?

[The Matrix]

But if I'm not sure what I need to buy to support myself or correct the imbalances? The only imbalance I can see in my tests so far is low testosterone, lowish cortisol and high RT3, low body temperature.

Out of all of the supplements I have tried so far only pregnenolone seems to have had a real tangible benefit.

I will have the money in a month so I suppose it is worth the investment as I have no other path to go down with Dr's. No Dr in the UK is worth paying to see as non will prescribe TRT at that testosterone level.

So I suppose I will just look at it as £700 investment in Nutreval ---> if that doesn't work then £40 a month investment in testosterone, HCG and AI.

I can't thank you enough for your help and advice matrix, you have taken more of an interest than paid NHS employees ever have.

Why I got into this field my friend, I am still working on getting in contact with Dr in UK, I have my more people then you know on looking for one. Once I get a one to take a leap of faith ..it will be well worth it. I have people here in the USA and europe which are just a year or so from finishing med school then you will see a what I am truly capable off. It took me years to net work here and also in europe to get to the level as I am. Its only a matter of time....

 

[qwerty42]

Hi matrix- think I may have a nutreval in the next couple of weeks as have moved back in with the parents so I can spend all of my salary on treatment.

I wanted to ask something though while I think on. Have you got any links to studies on mdma / cocaine affect on neurotransmitters or hpta axis? Only in 2010,about 4 months before I began overtraining I was using some of the above at weekends. Obviously I haven't since that small foolish spell but am wondering if there could be some kind of dopamine / serotonin issue that has precluded the low cortisol and low testosterone? Does the nutreval reliably test neurotransmitters etc?

Thanks

 

[The Matrix]

Hi matrix- think I may have a nutreval in the next couple of weeks as have moved back in with the parents so I can spend all of my salary on treatment.

I wanted to ask something though while I think on. Have you got any links to studies on mdma / cocaine affect on neurotransmitters or hpta axis? Only in 2010,about 4 months before I began overtraining I was using some of the above at weekends. Obviously I haven't since that small foolish spell but am wondering if there could be some kind of dopamine / serotonin issue that has precluded the low cortisol and low testosterone? Does the nutreval reliably test neurotransmitters etc?

Thanks

Yes there could be multiple factors for how you are feeling. You just have to look at the entire pics

 

[qwerty42]

Matrix - I am in need of your help once more. Your persistance with me and in encouraging me to test for minerals / nutritional imbalances may finally have paid off.

I received the results of an iron panel this morning amongst some other results and was suprised by the findings. I had been advised by various members of ATM and on other sites to ensure my iron was adequate before attempting to lower my RT3 with T3.

I was therefore really suprised to see my Iron so high:

BIOCHEMISTRY
SODIUM *151 mmol/L 135 - 145
POTASSIUM ? Storage changes
CHLORIDE 100 mmol/L 98 - 107
BICARBONATE 24 mmol/l 22 - 29
UREA 7.8 mmol/L 1.7 - 8.3
CREATININE *121 umol/L 66 - 112
BILIRUBIN 13 umol/L 0 - 20
ALKALINE PHOSPHATASE 54 IU/L 40 - 129
ASPARTATE TRANSFERASE 27 IU/L 0 - 37
ALANINE TRANSFERASE 35 IU/L 10 - 50
LDH 221 IU/L 135 - 225
CK 121 IU/L 38 - 204
GAMMA GT 17 IU/L 10 - 71
TOTAL PROTEIN 71 g/L 63 - 83
ALBUMIN 49 g/L 34 - 50
GLOBULIN 22 g/L 19 - 35
CALCIUM 2.52 mmol/L 2.15 - 2.55
Corrected Calcium 2.43 mmol/L 2.15 - 2.55
PHOSPHATE ? Storage changes
URIC ACID *206 umol/L 266 - 474
RANDOM BLOOD GLUCOSE (FL) 4.7 mmol/L 3.5 - 7.9
TRIGLYCERIDES 0.7 mmol/L < 2.3
CHOLESTEROL *6.0 mmol/L Optimum <5.0
HDL CHOLESTEROL *1.9 mmol/L 0.9 - 1.5
HDL % of total 32 % 20 and over
LDL CHOLESTEROL *3.8 mmol/L Up to 3.0
IRON *35.5 umol/L 10.6 - 28.3
T.I.B.C 53 umol/L 41 - 77
TRANSFERRIN SATURATION *67 % 20 - 55

ENDOCRINOLOGY
THYROID STIMULATING HORMONE 0.81 mIU/L 0.27 - 4.2
FREE THYROXINE 16.0 pmol/l 12.0 - 22.0
TESTOSTERONE 12.5 nmol/L 7.6 - 31.4
Reference Ranges apply to adults

Could it be that I all along this past 18 months, doctors have missed a relatively easy diagnosis of haemochromatosis which could explain all of symptoms, including reduced testosterone? Are blood levels like that diagnostic of it?

I am going my GP tomorrow to insist on a referral to a haemotologist but I wonder if this could be the missing link?

 

[The Matrix]

Matrix - I am in need of your help once more. Your persistance with me and in encouraging me to test for minerals / nutritional imbalances may finally have paid off.

I received the results of an iron panel this morning amongst some other results and was suprised by the findings. I had been advised by various members of ATM and on other sites to ensure my iron was adequate before attempting to lower my RT3 with T3.

I was therefore really suprised to see my Iron so high:

BIOCHEMISTRY
SODIUM *151 mmol/L 135 - 145
POTASSIUM ? Storage changes
CHLORIDE 100 mmol/L 98 - 107
BICARBONATE 24 mmol/l 22 - 29
UREA 7.8 mmol/L 1.7 - 8.3
CREATININE *121 umol/L 66 - 112
BILIRUBIN 13 umol/L 0 - 20
ALKALINE PHOSPHATASE 54 IU/L 40 - 129
ASPARTATE TRANSFERASE 27 IU/L 0 - 37
ALANINE TRANSFERASE 35 IU/L 10 - 50
LDH 221 IU/L 135 - 225
CK 121 IU/L 38 - 204
GAMMA GT 17 IU/L 10 - 71
TOTAL PROTEIN 71 g/L 63 - 83
ALBUMIN 49 g/L 34 - 50
GLOBULIN 22 g/L 19 - 35
CALCIUM 2.52 mmol/L 2.15 - 2.55
Corrected Calcium 2.43 mmol/L 2.15 - 2.55
PHOSPHATE ? Storage changes
URIC ACID *206 umol/L 266 - 474
RANDOM BLOOD GLUCOSE (FL) 4.7 mmol/L 3.5 - 7.9
TRIGLYCERIDES 0.7 mmol/L < 2.3
CHOLESTEROL *6.0 mmol/L Optimum <5.0
HDL CHOLESTEROL *1.9 mmol/L 0.9 - 1.5
HDL % of total 32 % 20 and over
LDL CHOLESTEROL *3.8 mmol/L Up to 3.0
IRON *35.5 umol/L 10.6 - 28.3
T.I.B.C 53 umol/L 41 - 77
TRANSFERRIN SATURATION *67 % 20 - 55

ENDOCRINOLOGY
THYROID STIMULATING HORMONE 0.81 mIU/L 0.27 - 4.2
FREE THYROXINE 16.0 pmol/l 12.0 - 22.0
TESTOSTERONE 12.5 nmol/L 7.6 - 31.4
Reference Ranges apply to adults

Could it be that I all along this past 18 months, doctors have missed a relatively easy diagnosis of haemochromatosis which could explain all of symptoms, including reduced testosterone? Are blood levels like that diagnostic of it?

I am going my GP tomorrow to insist on a referral to a haemotologist but I wonder if this could be the missing link?

Yep,
I have dealt with hemochromatosis in the past with a few people, and if their Dr's would have been doing proper investigation as they should have. Instead of placing them on HRT which created a whole slew of metabolic mishaps resulting in going on cortef, and completely barking up they, should have keep digging for the root cause, As I have heard, I do not know anything. I create messes for other people to clean up. Seems to be the other way around .....

Ok your
ALK - is on low end identifying gas pedal is not being applied which may refer to low vitamin D , thyroid, adrenal,or testosterone, imbalance. ALK I have learn to refer to as hidden metabolic past pedal >65 is a good <55 tends to be red flag for issues.

Low uric acid could mean low molybednum which GUESS WHAT HELPS METABOLIZE IRON FROM STORES !! Uric acid is also a powerful antioxident, low levels may also indicate heavy metals toxicity. May also indicate copper imbalances which uric acid is highly assoicated with

Cholesterol - Could indicate thyroid issues - given
LDH is on high end, but these markers are representation of what is happening in the blood, and are 3-6 months behind what is happening in the tissue. Indicating the process may have started months ago...

Need to check ferritin levels to be sure. Anything over 250 with these other readings may be a flag for further investigation

Where is SHBG

 

[qwerty42]

Only have SHBG and Ferritin from January but they are:

Ferritin 203 ugl (30-330)
SHBG 30nmoll (13-71)

Is the only way to confirm a diagnosis of haemochromatosis through genetic testing? Is a Haemotologist my best bet?

If it is not that then are there other causes for high iron, other than supplements or transfusions?

If I was to reduce Iron by giving blood - would it be likely that my endocrine system may pick up , or is the damage likely to be lasting?

Going to try and get copper, zinc, magnesium and maganese tested.

Thank you for the speedy reply, ATM is missing out on a valuable member without you on hand there.

 

[The Matrix]

Only have SHBG and Ferritin from January but they are:

Ferritin 203 ugl (30-330)
SHBG 30nmoll (13-71)

Is the only way to confirm a diagnosis of haemochromatosis through genetic testing? Is a Haemotologist my best bet?

If it is not that then are there other causes for high iron, other than supplements or transfusions?

If I was to reduce Iron by giving blood - would it be likely that my endocrine system may pick up , or is the damage likely to be lasting?

Going to try and get copper, zinc, magnesium and maganese tested.

Thank you for the speedy reply, ATM is missing out on a valuable member without you on hand there.

My friend silence is golden...As mentioned before I do not have to say a word nature will take over..
You need to have this confirmed, iron serum being high could be from high dietary intake, so this need to be medically ruled out properly so you need to have a good hemotologist, but there are signs in your blood something is going on and its not all in your head.

 

[qwerty42]

Thanks Matrix. Would be useful to get RBC mineral testing but nowhere in the UK offers it unfortunately.

 

[qwerty42]

Appointment with new endo today was laughable. You'd think I'd be frustrated or annoyed but unfortunately its just the sub-standard care I've come to expect from the NHS.

Told it likely wasn't a hormone problem, that despite being just inside the reference range I should have zero symptoms of low test, levels shouldn't be adjusted for age, there was no merit in getting my levels up to the top of the reference range to see if symptoms improve and all the usual NHS bs. Also told RT3 was a worthless lab and the theory it affected T3 was not accepted.

Then to really endear himself to me he said 'If your bloods come back 'normal again', we will re-refer you to the Chronic Fatigue Specialist for another look" (Background: I saw the top CFS expert in the country recently who categorically ruled out CFS and said I didn't fit the profile and it wasn't a helpful diagnosis for me. Todays endo has seen a copy of that letter!!!)

So basially having failed to label me once they want to try and have another crack.

The only upside of it was he agreed to the laundry list of blood tests I went in with. However then when I asked when I could get a copy of the results he told me he'd give them to me at the next clinic. When I asked how soon that would be he said 'Oh quite soon, earliest one is 6 months'. Jesus f*cking wept. There will be a freedom of information request winging its way to his secretary.

As if I am going to wait that long before I am forced to self medicate or look elsewhere. I really wonder how these people get their jobs. This was a head of department as well, not some fresh faced youngster.

Just waiting on the results of my NutrEval Plus and the genetic test for HH. If it comes back normal and there is nothing to rectify in terms of imbalances or toxicities then I am ploughing full speed ahead with hydrocortisone and T3 for 12 weeks. (I stopped the last protocol I'd started early as I decided to get the NutrEval done and rule out possible causes of elevated RT3 before I reduce it.)

If theres stuff to look at though then I'll be looking for some help from you Matrix if thats alright.

 

[qwerty42]

Update:

Haemochromatosis C282y Gene - Negative

Serum Iron 18 umol/l (10-30)
Serum TIBC 53umol/l (40-70)
Saturation Iron Binding Capacity 34%

Serum Ferritin 117 (30 - 330 ug/l)

Looks like its not haemochromatosis then. Iron levels fell as expected after giving blood once. Now waiting on the results of NutrEval to hopefully see what it actually IS.

 

[MidwestBeast]

Just wanted to let you know I'm still following along, man.

 

[qwerty42]

thanks for the support man - just can't wait for these Nutreval results now. Its been 3 weeks and suspense is killing me.

On a slight positive consultant endo has agreed to an Oral Glucose Tolerance Test with Growth Hormone for a few weeks time so that will be another useful diagnostic tool

 

[The Matrix]

thanks for the support man - just can't wait for these Nutreval results now. Its been 3 weeks and suspense is killing me.

On a slight positive consultant endo has agreed to an Oral Glucose Tolerance Test with Growth Hormone for a few weeks time so that will be another useful diagnostic tool

Excellent,
OnceI get full back ground of case, nutra eval , testing results then we will tear into this ...I also can bring in other specialists from USA here if need be on your case. This is the one of the perks of going to seminars a few times a month you get to meet great medical professionals from all different fields.

 

[qwerty42]

Bump - sorry about this but need 20 more posts to be able to post links to my NutrEval tests for you guys to look at. They've just come through.

 

[qwerty42]

My NutrEval has just come through! Would really appreciate everyones help with having a look at it, especially yours Matrix.

I haven't uploaded the FACT1 part as I have zero food allergies or even intolerences to report. I'm fine with wheat and dairy which are two things I'd cut out but may not need to have.

The main body of the report though suggests I have a serious Vitamin C deficiency, a-lipoic acid deficiency and Lead only just within the reference range.

I moved into a new flat 01/10/10 and began to get ill 25/12/10. I finally moved out of the new flat 25/02/12 as my job is under the threat due to illness. Blood for the Nutreval was drawn 13/04/12 giving a few weeks for levels to fall and be just within the reference range.

I don't want to jump to conclusions but could this be the answer all along - lead poisoning. I eat 7 or 8 servings of fruit and veg per day so should be fine for Vit C, but doesn't Vit C get used up removing heavy metals?

Download link to the report is below if anyone is good with them. There are some othere values slightly high and low but lead would seem to be the stand out one due to its toxicity - explaining the RT3?

http://www.4shared.com/get/Qxw1cbZ7/Qwertynutreval.html

Also, my second adrenal stress index came back (first one earlier in the thread was December when cortisol was low) and now cortisol is HIGH! if anything. Pours further fire on the idea of adrenal 'fatigue'

http://www.4shared.com/get/oU2qF4jZ/QwertyASI.html

 

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[qwerty42]

My NutrEval has just come through! Would really appreciate everyones help with having a look at it, especially yours Matrix.

I haven't uploaded the FACT1 part as I have zero food allergies or even intolerences to report. I'm fine with wheat and dairy which are two things I'd cut out but may not need to have.

The main body of the report though suggests I have a serious Vitamin C deficiency, a-lipoic acid deficiency and Lead only just within the reference range.

I moved into a new flat 01/10/10 and began to get ill 25/12/10. I finally moved out of the new flat 25/02/12 as my job is under the threat due to illness. Blood for the Nutreval was drawn 13/04/12 giving a few weeks for levels to fall and be just within the reference range.

I don't want to jump to conclusions but could this be the answer all along - lead poisoning. I eat 7 or 8 servings of fruit and veg per day so should be fine for Vit C, but doesn't Vit C get used up removing heavy metals?

Download link to the report is below if anyone is good with them. There are some othere values slightly high and low but lead would seem to be the stand out one due to its toxicity - explaining the RT3?

http://www.4shared.com/get/Qxw1cbZ7/Qwertynutreval.html

Also, my second adrenal stress index came back (first one earlier in the thread was December when cortisol was low) and now cortisol is HIGH! if anything. Pours further fire on the idea of adrenal 'fatigue'

http://www.4shared.com/get/oU2qF4jZ/QwertyASI.html

 

[The Matrix]

My NutrEval has just come through! Would really appreciate everyones help with having a look at it, especially yours Matrix.

I haven't uploaded the FACT1 part as I have zero food allergies or even intolerences to report. I'm fine with wheat and dairy which are two things I'd cut out but may not need to have.

The main body of the report though suggests I have a serious Vitamin C deficiency, a-lipoic acid deficiency and Lead only just within the reference range.

I moved into a new flat 01/10/10 and began to get ill 25/12/10. I finally moved out of the new flat 25/02/12 as my job is under the threat due to illness. Blood for the Nutreval was drawn 13/04/12 giving a few weeks for levels to fall and be just within the reference range.

I don't want to jump to conclusions but could this be the answer all along - lead poisoning. I eat 7 or 8 servings of fruit and veg per day so should be fine for Vit C, but doesn't Vit C get used up removing heavy metals?

Download link to the report is below if anyone is good with them. There are some othere values slightly high and low but lead would seem to be the stand out one due to its toxicity - explaining the RT3?

Qwertynutreval.pdf - 4shared.com - document sharing - download - j d

Also, my second adrenal stress index came back (first one earlier in the thread was December when cortisol was low) and now cortisol is HIGH! if anything. Pours further fire on the idea of adrenal 'fatigue'

QwertyASI.pdf - 4shared.com - document sharing - download - j d

No wonder....your gut what I have been telling you all along.... I saw it with in the first 30 seconds...

 

[qwerty42]

I was listening all along my good man I just did not have the finances to get the nutreval done until now. How do I go about removing this lead then? Just increase vitamin C to a high dose? Or do I need to investigate chelation therapies?

 

[The Matrix]

I was listening all along my good man I just did not have the finances to get the nutreval done until now. How do I go about removing this lead then? Just increase vitamin C to a high dose? Or do I need to investigate chelation therapies?

Lead would be least of my concerns ....you have the evidence do not go on wild goose chase..

 

[qwerty42]

Ok if lead is the least of my concerns then I am completely lost - can you clear some inbox space so I can PM you re: a consultation. Thanks

 

[The Matrix]

Ok if lead is the least of my concerns then I am completely lost - can you clear some inbox space so I can PM you re: a consultation. Thanks

Done

 

[qwerty42]

Have just got my latest bloods back from my endo as well. Taken at 1:15pm which I know is not optimum for measuring testosterone but its rock bottom neverthless.

Cortisol over the top of the range which ties in with my salivary cortisol results. ACTH also firing to full capacity. So much for exhausted adrenals.

Endocrine

Testosterone 9.8nmol/l (9-40)
Cortisol 590 nmol/l (140-500) *
ACTH 11pmol/l (2.0-11)
SHBG 20 nmol/l (12-78)
IGF1 40nmol/l (15-64)
TSH 1.2 mU/l (0.3 -6.00)
FT4 15.6 pmol/l (10-22)
A’dione 3.4 nmol/l (1.0-8.5)
DHEAS 10.6umol/l (0.3-12.0)
LH 3.8 U/L (No range given)
FSH 5.7 U/L (No range given)
Progesterone 2.6 nmol/l (No range given)
Oestradiol <50pmol/l (No range given)
Prolactin 121 mU/l (<350)

Urea & Electrolytes
Sodium 142 mmol/L (133 – 146)
Potassium 4.2 mmol/l (3.5 – 5.3)
Chloride 102 mmol/l (95-108)
Bicarbonate 29 mmol/l (22-29)
Urea 7.8 mmol/l (2.5-7.8)
Creatinine 101 umol/l (50-130)
eGFR 77 ml/min1.73m^2>60
Anion Gap 15 mmol/L (6-16)

CMP
Total CK 137 U/L (40-320)
CRP <5 mg/L (<5)
Total LDH 311 U/L (0-450)
Albumin 50 g/l (35-50)
Total Pro 69 g/l (60-80)
Globulin 19 g/L (19-35)
Alk Phos’ase 56 U/L (30-130)
Bilirubin Total 7 umol/l (<21)
ALT 32 U/L (<35)
Gamma GT 13 U/L (<50)

FBC
HB 14.5 g/dl (13.0- 16.7)
Haematocrit 40.0 % (39-50)
Mean Cell Volume 95.5 fl (80-100)
Platelets 223 x10^9/l (150-400)
WBC 5.3 x10^9/l (3.5 -11)
Neutrophilis 2.6 x10^9/l (2.0-7.5)
Lymphocytes 1.9 x10^9/l (1.0-3.5)
Monocytes 0.5 x10^9/l (0.2-0.8)
Eosinophils 0.3 x10^9/l (0.0-0.4)
Basophils 0.0 x10^9/l (0.0 – 0.2)

 

[qwerty42]

For anyone still following along I read this article which briefly explains the gut - thyroid connection.

http://drhedberg.com/2011/02/15/the-gut-thyroid-connection/

The theory I'm currently considering:

Overtraining and calorie restriction drives up my cortisol and RT3 resulting in lowered immunity and low body temperature. Some form of dysbiosis / candida etc (don't know enough about them yet) starts spreading in my gut which would normally have been killed off at a normal body temperature with normal immunity.

They precipitate continued impaired conversion of T4 to T3 as explained in that article and continually disrupt proper absorption of nutrients resulting in continued lower immunity, hence the continued sinus problems I have been having. Now the dysbiosis remains despite good diet / no training / lots of sleep and hence me possibly chasing the wrong stressor in the overtraining, which is obviously no longer going on now.


The question is how to remove it iif it is there? One option,I am theorising, is just to use T3 for a time to increase body temperature to normal, removing the right envorinment (low temperature) for it to live.

There are of course pro biotics, things to 'heal' the gut wall, elimination diets etc but I'm not well versed in any of them. (I'm obviously not particularly well versed in T3 or the thyroid either, but its what I've focused the bulk of my research on along with the rest of the endocrine system)

I guess that is why we employ the experts, looking forward to getting matrix take on it in my consultation.

 

[MidwestBeast]

For anyone still following along I read this article which briefly explains the gut - thyroid connection.

http://drhedberg.com/2011/02/15/the-gut-thyroid-connection/

The theory I'm currently considering:

Overtraining and calorie restriction drives up my cortisol and RT3 resulting in lowered immunity and low body temperature. Some form of dysbiosis / candida etc (don't know enough about them yet) starts spreading in my gut which would normally have been killed off at a normal body temperature with normal immunity.

They precipitate continued impaired conversion of T4 to T3 as explained in that article and continually disrupt proper absorption of nutrients resulting in continued lower immunity, hence the continued sinus problems I have been having. Now the dysbiosis remains despite good diet / no training / lots of sleep and hence me possibly chasing the wrong stressor in the overtraining, which is obviously no longer going on now.


The question is how to remove it iif it is there? One option,I am theorising, is just to use T3 for a time to increase body temperature to normal, removing the right envorinment (low temperature) for it to live.

There are of course pro biotics, things to 'heal' the gut wall, elimination diets etc but I'm not well versed in any of them. (I'm obviously not particularly well versed in T3 or the thyroid either, but its what I've focused the bulk of my research on along with the rest of the endocrine system)

I guess that is why we employ the experts, looking forward to getting matrix take on it in my consultation.

I didn't have a chance to read that article, yet, but I will.

A few things I can add are definitely don't go with just T3-only. I did that (100mcg T3/day for 10 weeks) and it crushed my rT3 (out of range low) and brought my TSH to technically hyperthyroidism (though I didn't experience any of the symptoms), but it also dropped my T4 levels low out of range, which isn't good. It also didn't bring my body temp up to 98.6 or over it, ever.

An elimination diet might not be a bad idea. I still haven't done one (aside from going gluten free and not touching anything with yeast since early January), but I may.

I'll be interested in what Shawn (The Matrix) has to say to you. I'm still working through all of my stuff, as well. Just know I'll be fighting this battle with you, buddy.

 

[qwerty42]

Thanks man- interesting to know about your experience with the T3 - as you say its likely not time to try that.

The other half of my nutreval test confirmed I have zero allergies or intolerances, including to gluten, grains or dairy. I, like you, have cut out all bread etc anyway as I don't feel its a great source of carbohydrate anyway.

The Candida diet seems to suggest a zero sugar, including fructose, diet at all to starve any growths in the stomach and there does not seem to be massive success with it anyway. I'm sure there must be a better way as fruits are too nutritious to cut out.

Cheers for the kind words, will keep updating the thread as we go.

 

[The Matrix]

Thanks man- interesting to know about your experience with the T3 - as you say its likely not time to try that.

The other half of my nutreval test confirmed I have zero allergies or intolerances, including to gluten, grains or dairy. I, like you, have cut out all bread etc anyway as I don't feel its a great source of carbohydrate anyway.

The Candida diet seems to suggest a zero sugar, including fructose, diet at all to starve any growths in the stomach and there does not seem to be massive success with it anyway. I'm sure there must be a better way as fruits are too nutritious to cut out.

Cheers for the kind words, will keep updating the thread as we go.

you got mail...

FYI the biggest mistakes made by people is going after the wrong sequence of events. You need to address the GI tract first get things moving before going after methylation or you will put your self into a potential dangerous situation..this is why havong case history is crucial. Amazing the reaction when first question out of my mouth is "how are your bowel moments"..KODAK MOMENT, but that will dicate what happens first in any case. Go back and read my post 30% of people who have altered intestinal permeablity are shown to have no Gi related issues. This is why these test are crucial it picks up hidden things.
I tried this approach and ended up bed righten for almost a week.

Analogy
Your pouring draino into a toilet full of SHIZT, you need to stop crapping in it first before the draino can do its good.

 

[qwerty42]

Have pm'd you as have not got mail yet?

I'm bowing to you on this one, as I've done zero research into the gut really or methylation. All of my effort has been spent trying to learn about hormones this past 12 months so I'm fresh out of mental energy!

You were right to call the gut early on, I just was unsure as I have good sized, frequent stools, no gas or constipation etc but the Nutreval says otherwise so its over to you!

 

[The Matrix]

Have pm'd you as have not got mail yet?

I'm bowing to you on this one, as I've done zero research into the gut really or methylation. All of my effort has been spent trying to learn about hormones this past 12 months so I'm fresh out of mental energy!

You were right to call the gut early on, I just was unsure as I have good sized, frequent stools, no gas or constipation etc but the Nutreval says otherwise so its over to you!

Other guy picked up on it too...intestinal permeabilit which i called AKA leaky gut...I suspect mutations because of angelo saxon background which he picked up on as well.

 

[qwerty42]

Just to update - I haven't been on in a couple of weeks as I've been trying to zone out from all the researching and reading as a means of chilling out on the stress of the whole situation.

But I am only 10 days into some of the changes that I discussed with Shawn (some of which JanSZ noted) and some of my symptoms have shown improvements already. I'm slowly adding in supplements in and logging any changes for better or worse.

As said I won't be discussing specifics supplement recommendations which may work for me may not work for others and because of individual chemistry. There is no cookie cutter approach; every ones body is different and my case seems particularly complex.

With that said we are adressing my fatty acid balance, cutting out EPA for now and upping ALA sources of Hemp Butter & Walnut oil, adding supplements to target the bacterial dysbiosis and heal the GI system and adding precursors to boost gluthatione levels.

In terms of how which symptoms have shown change already:

*Dry & Photophobic eyes - have to wear sunglasses using screens and was putting liquid tear solution in every hour. 14 days in and I'm no longer having to apply the gel as they are not really dry, just still sensitive to light. This is pretty major as it is the symptom that was most likely to stop me from working and thus paying for further treament / tests. So a definite plus.

*Fatigue - no where near as tired already, can make it 6am - 10pm with no nap and Shawn had me gradually add in some exercise. I'm currently doing 40 min 130bmp cardio (low intensity) in a sauna suit to get some sweating on to help detoxify aid the immune system. On a scale of 1-10 with 1 being bed bound and 10 peforming in added time of high level sport (where I used to be) I'd say I've gone from a 4 to a 6 in two weeks.

*Mood is better - I think because I've finally had someone explain things to me and how everything can explain some of the worrying symptoms I'd had like the previous anxiety etc

*Libido - Although no real desire or checking out women or anywhere near back to the previous v high libido I had, given it was 0% as in nothing, it makes it easy to notice a a 5-10% increase already. Weak but consistent morning erections now and flaccid member size is closer to previous usual size, and it and testicles hanging a little bit lower / more freely. Not sure about their size, never really noticed their size pre-getting sick so couldn't comment.

Some symptoms have shown no change yet - still waking at night and I'm still congested most of the time but for less than 2 full weeks in I'm very hopeful of continuing to make progress.

Matrix/Shawn sometimes doesn't come across well grammatically on the forums but the difference in person is night and day. He is articulate and really good at breaking things down. Most notably he has made me realise that unless one has a structural defect causing the low hormones then there are so many paths to investigate before jumping on HRT.

Hopefully this is the begining of some real progress for me, will keep updating.

 

[TML499]

Thanks for the update, I've been following along as I think I may have some gut problems as well. Earlier you mentioned you found out your high level of lead was causing a vitamin C deficiency, and matrix suggesting lead should not be your concern... this confused me. Is that not related to the gut-thyroid thing you are investigating with matrix?

 

[The Matrix]

Thanks for the update, I've been following along as I think I may have some gut problems as well. Earlier you mentioned you found out your high level of lead was causing a vitamin C deficiency, and matrix suggesting lead should not be your concern... this confused me. Is that not related to the gut-thyroid thing you are investigating with matrix?

As mentioned before you need to isolate the variables and see the whole impact on them systemically while matching them up to symptoms. Too many people are chasing their tail and need to pull them selve back a bit and take a look at grand scale. Failure I see in each case which comes across my desk are from people who are micomanaging their health chasing one area rather then look at the integration of all the system and how they all complement one another. I am learning new things each week from some of the top specialist in the field not talking hormones, but rather SNPS, nutragenomics, and other areas which are going to make a huge impact on the future of health.

 

[acidvoodoo]

Would love an update on this. Feel I may be in a similar situation but reading all your protocols has been very interesting