Yesterday I took two caps around 4:00pm. I Noticed a very real cognitive effect, enhancing overall focus.
I normally research various topics anyway but I found myself knee deep in reading about Deoxyribonucleic acid (DNA) about 30 Min's after ingesting the 2 cap dose. So apparently something was working.
I wasn't familiar with the active 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ)
I found this about the compound-
1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous parkinsonism-preventing substance, and its 5-, 6-, and 7-hydroxy lated derivatives are reported to show in vitro neuroprotective activity against toxicity due to salsolinol in SH-SY5Y human neuroblastoma cells. In the present study, we tested the parkinsonism-preventing potential of these derivatives by means of the pole test in C57BL mice in vivo, and measured brain dopamine contents by liquid chromatography-tandem mass spectrometry. Parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydroisoquinoline (MPTP), and pretreatment with any of the 1MeTIQ derivatives prevented its induction. 6-Hydroxy-1MeTIQ showed the greatest preventive activity. The amount of dopamine in the brain was reduced by MPTP treatment, and this reduction was suppressed by pretreatment with 1MeTIQ derivatives. These hydroxy-1MeTIQ derivatives may have potential for the treatment of Parkinson's disease as well as 1MeTIQ itself.
(Biological & pharmaceutical bulletin 29(7), 1401-1403, 2006-07-01 The Pharmaceutical Society of Japan)
So, basically it has a reverse effect on dopamine reduction, and apparently giving the compound anti-parkinsons type attributes.
Nice clean compound, no nausea, or jitters. I give it two thumbs up, good job Athletic Xtreme. Would love to get my hands on some more, or maybe do a lengthy log or something to that nature. I am very interested in cognitive enhancers personally, so I would enjoy a little compare and contrast with other compounds, and what-not.
-Dan
I normally research various topics anyway but I found myself knee deep in reading about Deoxyribonucleic acid (DNA) about 30 Min's after ingesting the 2 cap dose. So apparently something was working.
I wasn't familiar with the active 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ)
I found this about the compound-
1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous parkinsonism-preventing substance, and its 5-, 6-, and 7-hydroxy lated derivatives are reported to show in vitro neuroprotective activity against toxicity due to salsolinol in SH-SY5Y human neuroblastoma cells. In the present study, we tested the parkinsonism-preventing potential of these derivatives by means of the pole test in C57BL mice in vivo, and measured brain dopamine contents by liquid chromatography-tandem mass spectrometry. Parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydroisoquinoline (MPTP), and pretreatment with any of the 1MeTIQ derivatives prevented its induction. 6-Hydroxy-1MeTIQ showed the greatest preventive activity. The amount of dopamine in the brain was reduced by MPTP treatment, and this reduction was suppressed by pretreatment with 1MeTIQ derivatives. These hydroxy-1MeTIQ derivatives may have potential for the treatment of Parkinson's disease as well as 1MeTIQ itself.
(Biological & pharmaceutical bulletin 29(7), 1401-1403, 2006-07-01 The Pharmaceutical Society of Japan)
So, basically it has a reverse effect on dopamine reduction, and apparently giving the compound anti-parkinsons type attributes.
Nice clean compound, no nausea, or jitters. I give it two thumbs up, good job Athletic Xtreme. Would love to get my hands on some more, or maybe do a lengthy log or something to that nature. I am very interested in cognitive enhancers personally, so I would enjoy a little compare and contrast with other compounds, and what-not.
-Dan