Guest viewing limit reached
  • You have reached the maximum number of guest views allowed
  • Please register below to remove this limitation

The Potential Benefits of Ursolic Acid

henryv

Active member
There's been a lot of press coverage recently of a natural substance called Ursolic Acid - and the potential health and fitness benefits it may hold.

A number of studies have been done on this compound, and the list of positive effects are impressive.

Invalid Link Removed

Ursolic Acid is believed to:

Reduce fat storage and increase fat burning, through inhibition of pancreatic lipase and enhanced lipolysis in fat cells. [1]

Reduce the conversion of blood sugar to fat, through inhibition of fatty acid synthase. [2]

Increase energy reserves in muscles by enhancing glycogen storage. [3]

Reduce abdominal (visceral) fat through the inhibition of 11bHSD1. [4]

Be anti-carcinogenic through inhibition of the STAT3 activation pathway. [5]

Lower cholesterol through the activation of peroxisome proliferator-activated receptor (PPAR)-α. [6]

Reduce estrogen levels through aromatase inhibition. [7]

Strengthen bones by enhancing differentiation and mineralization of osteoblasts. [8]

Increase lean muscle mass through enhanced sensitivity to IGF-1 and insulin and inhibition of atrogin-1 and MuRF1. [9]


Always make sure you buy a high quality Invalid Link Removed like Invalid Link Removed.

Invalid Link Removed

Press articles:

Invalid Link Removed

Invalid Link Removed

Invalid Link Removed

Invalid Link Removed

Invalid Link Removed

References:

[1] Arch Pharm Res. 2009 Jul;32(7):983-7.
Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta.

[2] Biochem Biophys Res Commun. 2010 Feb 12;392(3):386-90.
Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism.

[3] Issled. Mekh. Vliyaniya Bal'neol. Faktorov Regul. Sist. Org. (1976), 101-2.
Effect of ursolic acid on the energy and carbohydrate metabolism of muscles

[4] Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.

[5] Mol Cancer Res. 2007 Sep;5(9):943-55.
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.

[6] Bioorg Med Chem Lett. 2011 Oct 1;21(19):5876-80.
Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.

[7] Eur J Med Chem. 2008 Sep;43(9):1865-77.
Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.

[8] Pharmacol Res. 2008 Nov-Dec;58(5-6):290-6.
Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo.

[9] Cell Metabolism. Volume 13, Issue 6, 8 June 2011, Pages 627-638
mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass
 
Ehh I dont want to look like a dumbass but where can we pick this up? I checked the online retailers listed but none seem to carry it.
 
I dont think its out yet Tomahawk. I'm definitely ready to give this stuff a run.
 
This looks very interesting... Wonder how it would do on a bulk, Anything natural that "helps" me build muscle is something i'm definitely interested in.

**Edit**

Just read that it shouldn't be used for bulking, Any particular reason to that?
 
ICJLM said:
Interesting. I'd also like to know... And this is obviously considered "natural" right?
Click to expand...

I think the main reason it is not a bulker is because it doesn't help you retain mass. Overall mass gaining phases actually benefit from the water retention because more mass equals more mass you are able to move. Which usually means more mass gains. If you're goal is to recomp I would say this would be perfect. Provided the claims are real.

And yes it is natural. 50mgs of this chemical are found in an apple peal. So eating three apples with the peals will be equal to 150mgs of this. Which I believe is the product's suggested dose.
 
thetinyguy said:
This looks very interesting... Wonder how it would do on a bulk, Anything natural that "helps" me build muscle is something i'm definitely interested in.

**Edit**

Just read that it shouldn't be used for bulking, Any particular reason to that?
Click to expand...

I responded to the guy below you tiny. But I think it just has to do with it's ability to dry/lean you out. All out bulking wouldn't benefit from this product. You wouldn't get the water retention benefits or the overall mass gaining aspects of most other bulking compounds. But for recomping and over all physique enhancements I don't see how this could be a problem taking even for you on a bulk.

That is provided this stuff is legit. Perhaps I'll try running it in November after two other logging jobs. ;)
 
mattrag said:
I responded to the guy below you tiny. But I think it just has to do with it's ability to dry/lean you out. All out bulking wouldn't benefit from this product. You wouldn't get the water retention benefits or the overall mass gaining aspects of most other bulking compounds. But for recomping and over all physique enhancements I don't see how this could be a problem taking even for you on a bulk.

That is provided this stuff is legit. Perhaps I'll try running it in November after two other logging jobs. ;)
Click to expand...

Yeah that makes sense, :( sadpanda.jpeg

Well anyways after i finish the TestoPro log i have a Lit-Up/DRIVE log i'll be doing too. :D
 
Tomahawk88 said:
Ehh I dont want to look like a dumbass but where can we pick this up? I checked the online retailers listed but none seem to carry it.
Click to expand...

It should be out next week.

mattrag said:
And yes it is natural. 50mgs of this chemical are found in an apple peal. So eating three apples with the peals will be equal to 150mgs of this. Which I believe is the product's suggested dose.
Click to expand...

I think that's the dose per cap. The suggested dose per day is going to be something like 6 - 9 caps I believe.

mattrag said:
I responded to the guy below you tiny. But I think it just has to do with it's ability to dry/lean you out. All out bulking wouldn't benefit from this product. You wouldn't get the water retention benefits or the overall mass gaining aspects of most other bulking compounds. But for recomping and over all physique enhancements I don't see how this could be a problem taking even for you on a bulk.
Click to expand...

Yeah, agreed.
 
thetinyguy said:
Yeah that makes sense, :( sadpanda.jpeg

Well anyways after i finish the TestoPro log i have a Lit-Up/DRIVE log i'll be doing too. :D
Click to expand...

Link me when you get the lit-up/Drive log going
 
henryv said:
Ursolic Acid is believed to:

Reduce fat storage and increase fat burning, through inhibition of pancreatic lipase and enhanced lipolysis in fat cells. [1]
Click to expand...

It inhibits pancreatic alpha-amylase as well. Whereas pancreatic lipase breaks down fats, alpha-amylase breaks down sugars, so inhibition of this enzyme is believed to contribute to ursolic acid's purported anti-diabetic properties.

Ethnopharmacol. 2006, 107, 449–455.
α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus
 
henryv said:
It inhibits pancreatic alpha-amylase as well. Whereas pancreatic lipase breaks down fats, alpha-amylase breaks down sugars, so inhibition of this enzyme is believed to contribute to ursolic acid's purported anti-diabetic properties.

Ethnopharmacol. 2006, 107, 449–455.
α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus
Click to expand...

A very interesting, so it is believed to spare glucose in the blood system. I could see some good synergies with some of the fat liberating compounds found in many fat burners available today.
 
What r the negative side efeects to this. Can it be stacked with Sims or with say. Dcp. I'd like to grab some. How long can it be ran for
 
It may also help control blood sugar levels by competitive inhibition of alpha-glucosidase.

Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(4):406-9.
Alpha-glucosidase inhibitors from Luculia pinciana
 
henryv said:
It may also help control blood sugar levels by competitive inhibition of alpha-glucosidase.

Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(4):406-9.
Alpha-glucosidase inhibitors from Luculia pinciana
Click to expand...

This is the feature I am most interest in.
 
Hmmmm, wondering what the price or intro price for AM might be and when available? I see elsewhere a bottle of 120caps runs about $21...dosing 3-6 caps 3x/day...
 
schizm said:
Hmmmm, wondering what the price or intro price for AM might be and when available? I see elsewhere a bottle of 120caps runs about $21...dosing 3-6 caps 3x/day...
Click to expand...

The best I can offer is "I don't know" and "soon".

We'll be switching to bigger bottles once this run's done.
 
You must log in or register to reply here.
Back
Top