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YG / Anabolic Pump = Berberine?

Jim Sadler

New member
Just curious. Berberine is in phellodendron. I started trying straight berberine (which comes in bright yellow caps) after the article describing how berberine activates AMPk. Not sure I noticed much.

I am also wondering -- if it is berberine, then given how AMPk works maybe it's better as a cutting supplement than a mass builder. Lyle McDonald wrote an article on AMPk and how it is sort of a double-edged sword from a mass building perspective (because it reduces protein synthesis).
 
Jim Sadler said:
Just curious. Berberine is in phellodendron. I started trying straight berberine (which comes in bright yellow caps) after the article describing how berberine activates AMPk. Not sure I noticed much.

I am also wondering -- if it is berberine, then given how AMPk works maybe it's better as a cutting supplement than a mass builder. Lyle McDonald wrote an article on AMPk and how it is sort of a double-edged sword from a mass building perspective (because it reduces protein synthesis).
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phellodendron is an extract we been working on for 16 months. We purchased and funded the research of phellodendron from a chinese scientist. yes, berberine is a small part of the whole.

I also like to point out my response is suspect. I suspect Jim adler is fishing. I could be 100% wrong, but my instincts are good.
 
He probably is just fishing...but you know, reading more and more about berberine (for instance, here Invalid Link Removed)
seems to fit perfectly with your claims for AP.

"Helping insulin work better" is the first that comes to mind. "Inhibiting lipogenesis" is another.

Not saying that berberine is the only thing in AP, but I can understand why people are making the assumption that AP=berberine.
 
Enigma76 said:
He probably is just fishing...but you know, reading more and more about berberine (for instance, here Invalid Link Removed)
seems to fit perfectly with your claims for AP.

"Helping insulin work better" is the first that comes to mind. "Inhibiting lipogenesis" is another.

Not saying that berberine is the only thing in AP, but I can understand why people are making the assumption that AP=berberine.
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Berberine is a sum of the effect.
 
Are you going to release any studies about phellodendron when it comes to final release?

Alot of the effects you mention would be accomplished by stimulating AMPK. Berberine is even compared to AICAR when noting levels of AMPK activation, so with berberine being a constituent of AP then AP must activate AMPK to some extent. However, if AP activates AMPK, then protein synthesis is diminished temporarily as AMPK stops protein synthesis. (Invalid Link Removed)

I like AP so far and am interested in seeing how it works.
 
Enigma76 said:
However, if AP activates AMPK, then protein synthesis is diminished temporarily as AMPK stops protein synthesis.
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I'm curious as well because I have been looking up this subject as well. From personal experience however I started getting bigger and stronger faster using AP. I bet USP found a way to separate the good from the bad.
 
Rivet said:
I'm curious as well because I have been looking up this subject as well. From personal experience however I started getting bigger and stronger faster using AP. I bet USP found a way to separate the good from the bad.
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No, I know thats why I'm so interested in the method of action of AP, because AMPK activation should decrease protein synthesis.

However, if AP helps increase glycogen synthesis and retention (as it is purported to do) then it also makes sense that AMPK is being stimulated; refer to that previous paper I posted regarding AMPK. AMPK seems to diminish glycogen production in resting muscle in single doses, but when AMPK is chronically activated it actually leads to an increase in glycogen content.

So if AP is stimulating AMPK, then it would make sense that people would "get bigger and stronger" as the muscle is loaded with glycogen; for a comparison of what glycogen loading can do, look at the first week of superdrol use, which is thought to be primarily caused by glycogen loading.

All still leading to AMPK activation.
 
I'm not trying to knock the product at all. I also don't claim to be an expert on AMPk. In the article I mentioned by Lyle McDonald, he even speculates that one might be able to offset the reduced protein synthesis from AICAR (or presumably berberine) with other agents. Maybe YG manages to achieve this, I don't know.
 
Enigma76 said:
No, I know thats why I'm so interested in the method of action of AP, because AMPK activation should decrease protein synthesis.

However, if AP helps increase glycogen synthesis and retention (as it is purported to do) then it also makes sense that AMPK is being stimulated; refer to that previous paper I posted regarding AMPK. AMPK seems to diminish glycogen production in resting muscle in single doses, but when AMPK is chronically activated it actually leads to an increase in glycogen content.

So if AP is stimulating AMPK, then it would make sense that people would "get bigger and stronger" as the muscle is loaded with glycogen; for a comparison of what glycogen loading can do, look at the first week of superdrol use, which is thought to be primarily caused by glycogen loading.

All still leading to AMPK activation.
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I learned alot about this industry. I can not release all the information until product release. We already have 2 companies frantic to bulk it and one to copy it.

Anabolic PumP has a little hydroxyl in it and another tannin. There was a little smoke and mirrors with this marketing to retard the competition and from the looks of it, righteously so! Call me overly sensitive to the snakes in the industry. USPlabs has become a company other companies loves to hate...innovation does that.

stay tuned or sign up and support innovation. Support a company whoes only Purpose in the industry is to formulate products that WORK and ofcourse the money follows.

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take care
 
The reduction in protein synthesis involved with chronic AMPK induction, IMO, is not nearly enough to offset the glycogen retention and synthesis the same process carries.
 
Mulletsoldier said:
The reduction in protein synthesis involved with chronic AMPK induction, IMO, is not nearly enough to offset the glycogen retention and synthesis the same process carries.
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It will be all addressed in the final article but protein synthesis is increased in a hydrated cell that has Amino acids forced feed into them. Insulin is super powerful anabolic...
 
Mulletsoldier said:
The reduction in protein synthesis involved with chronic AMPK induction, IMO, is not nearly enough to offset the glycogen retention and synthesis the same process carries.
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anabolic pump + tukestrone or a good ecdy product comes to mind after reading this.
 
WannaBeHulk said:
anabolic pump + tukestrone or a good ecdy product comes to mind after reading this.
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Been on AP for over 3 months and protein synthesis is not inhibited. I am stronger, leaner, and more vasucular than ever.
 
USPLabs said:
Been on AP for over 3 months and protein synthesis is not inhibited. I am stronger, leaner, and more vasucular than ever.
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alright!!! definitely reassuring to hear. i have yet to experience anything negative from AP. USP always picks winners with your supp line
 
WannaBeHulk said:
anabolic pump + tukestrone or a good ecdy product comes to mind after reading this.
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already running this.ap + turk@4 grams.my diet hasnt been as strict as i would like it because of the holidays tightening it up today and i damn sure didnt even look like i worked out before i started this stack 9 days ago because of a extended layoff.pretty amazed at my results thus fardef leaning and feeling and looking fuller
 
I just noticed that this berbrine stuff is in Syntrax' Fyre.

One of my fellow IBE mods (I'm forgetting which one at the moment) lost about 15 lbs on Fyre.
 
jmh80 said:
I just noticed that this berbrine stuff is in Syntrax' Fyre.

One of my fellow IBE mods (I'm forgetting which one at the moment) lost about 15 lbs on Fyre.
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that would be bodebldr2000. im doing a fyre log over at bb.com and hes helping me out giving good advice. his before/after pics showed great results
 
CHAPS said:
All i know is this stuff is as much of a staple to me as whey protein now :head:.
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I gather it shall also be so for many people when it comes out capped...same thing with cialabol, or Neovar as my recent cialabol bottle says.

USP, I feel that once the information is released along with the final, many of the "haters" will quiet down...I'm talking consumers, not competitors. I feel like as it stands, berberine will be making its way into alot of products, regardless of whether AP exerts its effects because of it.

I'm looking foward to the capped YG (getting sick of parachuting) and the writeup.
 
Enigma76 said:
I gather it shall also be so for many people when it comes out capped...same thing with cialabol, or Neovar as my recent cialabol bottle says.
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cialabol still avail anywhere?
 
wojo said:
i want rep perks:( :think: :nutkick: :sad:
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No you really do not, Mullet washes the ride. Chaps cuts the grass and Ziri teaches my dog spanish.
 
Hey , I bought a special roll of toilet paper just because Mullet started this whole thing...I actually can't believe this works. My wife can't believe i'm swallowing toilet paper. I guess we're all in amazement :)
 
Jayhawkk said:
Hey , I bought a special roll of toilet paper just because Mullet started this whole thing...I actually can't believe this works. My wife can't believe i'm swallowing toilet paper. I guess we're all in amazement :)
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recycled paper?
 
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